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The map label for this gene is tmk

Identifier: 126695487

GI number: 126695487

Start: 137848

End: 138486

Strand: Reverse

Name: tmk

Synonym: P9301_01491

Alternate gene names: 126695487

Gene position: 138486-137848 (Counterclockwise)

Preceding gene: 126695488

Following gene: 126695486

Centisome position: 8.43

GC content: 30.67

Gene sequence:

>639_bases
ATGAAAGGAAAATTTATCGTTATTGAGGGTATTGATGGATGTGGTAAAACTACCCAAATAGATGAACTATCTAAATGGCT
TCCTATTAGTGGTCTACTAAAGAAAGAGTCTAAATTAATCACAACTAGAGAACCTGGAGGCAGTCTTTTAGGAAAAAAAC
TTAGAAGACTGATTCTTGATAATAATGAAAATAACAAGCCTTCATCTCTTGCAGAATTATTGCTTTATTCAGCGGATAGA
GCTGAACACGTTTCAAAAATTATTTTGCCAGCATTAAATAATAATGATTGGGTAATAAGTGATAGATTTTCCGATTCCAC
ACTGGCTTATCAAGGTTATGGAAGAAATATAAATTTAGAAATAATTAAAAATATTGAATCTATTGTGTGTCAAGGAGCAT
CTCCAGATCTCACTTTCTTCTTAGAAATTTCTCCAGAAGAGAGCATATTCCGAAGAAAAAATGAAATTCCAGACAGAATA
GAATCAGAAGGTATTAGATTTTTAGAAAGAGTAAATGAAGGCTTCAAACTAATTGCCAAACAAAAAAACTGGAAAGTAAT
ATCTGCTTCACAAAATATTAAAACTATTTCTAATCAAATTAAAGAGACTTTGCTAAACAATTTTTCCAATGCCAAATGA

Upstream 100 bases:

>100_bases
ATTCCCTAAATACGGTATTCTTCTTACTCCCTCAATAGCAGCATTATTGATGGCTATTAGCTCTATTACAGTTGTAATTA
ATGCTTTATCTTTGGATTAA

Downstream 100 bases:

>100_bases
TTGAGGTTAAAAAAAATAATTTTTTCTTAAATGAAGAAGTCAATACTATTCTTAAGAACATAATTAAAAACAAATCATTT
ACTAATGGCTATATATTTTA

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MKGKFIVIEGIDGCGKTTQIDELSKWLPISGLLKKESKLITTREPGGSLLGKKLRRLILDNNENNKPSSLAELLLYSADR
AEHVSKIILPALNNNDWVISDRFSDSTLAYQGYGRNINLEIIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRI
ESEGIRFLERVNEGFKLIAKQKNWKVISASQNIKTISNQIKETLLNNFSNAK

Sequences:

>Translated_212_residues
MKGKFIVIEGIDGCGKTTQIDELSKWLPISGLLKKESKLITTREPGGSLLGKKLRRLILDNNENNKPSSLAELLLYSADR
AEHVSKIILPALNNNDWVISDRFSDSTLAYQGYGRNINLEIIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRI
ESEGIRFLERVNEGFKLIAKQKNWKVISASQNIKTISNQIKETLLNNFSNAK
>Mature_212_residues
MKGKFIVIEGIDGCGKTTQIDELSKWLPISGLLKKESKLITTREPGGSLLGKKLRRLILDNNENNKPSSLAELLLYSADR
AEHVSKIILPALNNNDWVISDRFSDSTLAYQGYGRNINLEIIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRI
ESEGIRFLERVNEGFKLIAKQKNWKVISASQNIKTISNQIKETLLNNFSNAK

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family

Homologues:

Organism=Escherichia coli, GI1787340, Length=211, Percent_Identity=36.4928909952607, Blast_Score=131, Evalue=4e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KTHY_PROM0 (A3PAJ7)

Other databases:

- EMBL:   CP000576
- RefSeq:   YP_001090373.1
- ProteinModelPortal:   A3PAJ7
- SMR:   A3PAJ7
- STRING:   A3PAJ7
- GeneID:   4912788
- GenomeReviews:   CP000576_GR
- KEGG:   pmg:P9301_01491
- eggNOG:   COG0125
- HOGENOM:   HBG626009
- OMA:   LFITLEG
- ProtClustDB:   PRK13974
- BioCyc:   PMAR167546:P9301ORF_0151-MONOMER
- HAMAP:   MF_00165
- InterPro:   IPR018095
- InterPro:   IPR018094
- PANTHER:   PTHR10344
- TIGRFAMs:   TIGR00041

Pfam domain/function: PF02223 Thymidylate_kin

EC number: =2.7.4.9

Molecular weight: Translated: 23934; Mature: 23934

Theoretical pI: Translated: 9.43; Mature: 9.43

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGKFIVIEGIDGCGKTTQIDELSKWLPISGLLKKESKLITTREPGGSLLGKKLRRLILD
CCCCEEEEECCCCCCCCCCHHHHHHHCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCC
NNENNKPSSLAELLLYSADRAEHVSKIILPALNNNDWVISDRFSDSTLAYQGYGRNINLE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHEECCCCCEEEECCCCCCEEEEECCCCCCCHH
IIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRIESEGIRFLERVNEGFKLIAK
HHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEC
QKNWKVISASQNIKTISNQIKETLLNNFSNAK
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKGKFIVIEGIDGCGKTTQIDELSKWLPISGLLKKESKLITTREPGGSLLGKKLRRLILD
CCCCEEEEECCCCCCCCCCHHHHHHHCCHHHHHHCCCEEEEECCCCHHHHHHHHHHHHCC
NNENNKPSSLAELLLYSADRAEHVSKIILPALNNNDWVISDRFSDSTLAYQGYGRNINLE
CCCCCCHHHHHHHHHHCCCHHHHHHHHHHEECCCCCEEEECCCCCCEEEEECCCCCCCHH
IIKNIESIVCQGASPDLTFFLEISPEESIFRRKNEIPDRIESEGIRFLERVNEGFKLIAK
HHHHHHHHHCCCCCCCEEEEEEECCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHEEEEC
QKNWKVISASQNIKTISNQIKETLLNNFSNAK
CCCCEEEECCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA