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The map label for this gene is rocA [H]

Identifier: 126447745

GI number: 126447745

Start: 1832273

End: 1833979

Strand: Direct

Name: rocA [H]

Synonym: BMA10247_A1901

Alternate gene names: 126447745

Gene position: 1832273-1833979 (Clockwise)

Preceding gene: 126447094

Following gene: 126445826

Centisome position: 77.88

GC content: 66.55

Gene sequence:

>1707_bases
ATGACCCATCCTCTGTTCACGAAGCATGAAGACACGTTGAAGCACGCGCTCTCCACGATCGAAACGCGCGGCTACTGGAG
CCCGTTCGCCGAGATGCCGAGCCCCAAAGTGTACGGGGAAAGCGCCAATACAGACGGCGAAGCAGCATTCAAAGCCCAGT
TGGACAAGCCCTTTGAACTCGACCAACCCGCCTCGGGCGGAACGGTCGGCGCCGAGCGTTCGCCATACGGGTTTGCGCTC
GGCGTCCGCTACCCGAAGTCGACGCCCGACGAGCTCATCGCCGCCGCCGCGCAGGCGGAATGCGCGTGGCGCAAGGCCGG
GCCGACCGCGTGGGCTGGCGTGTGTCTCGAAATTCTCGCCCGGCTGAATCGCGCGAGCTTCGAGATCGCATACAGCGTGA
TGCACACCACGGGACAGGCGTTCATGATGGCGTTCCAGGCGGGCGGCCCGCACGCGCAGGATCGCGCGCTCGAAGCCGTC
GCCTATGCATGGCAAGAACTGCAGCGCATTCCCGCCGAAGCGCACTGGGAGAAGCCGCAGGGCAAGAACCCGCCGCTCGC
GATGCGCAAGCGCTACACGATCGTGCCGCGCGGGACGGGGCTCGTGCTCGGGTGCTGCACGTTCCCGACCTGGAACGGCT
ATCCCGGTCTGTTCGCCGATCTGGCGACCGGCAACACAGTCATCGTCAAGCCGCATCCCGGCGCGATCCTGCCGCTCGCG
ATCACCGTGCGCATCGCGCGCGACGTGCTGCGCGAAGCGGGCTTCGATCCGAACATCGTCACGCTGCTCGCGACCGAAGG
AAACGACGGCGCACTCGTCCAGAACCTGGCGCGCCGGCCGGAAATCAAGCTGATCGACTTCACCGGCAGCTCGCAAAACG
GCACCTGGCTCGAGCGCAATGCGTACCAGGCGCAGGTCTATACGGAGAAGGCGGGCGTCAACCAGATCGTGATCGACTCC
GTCGACGACCTGAAAGCCGCCGTCAAGAACATCGCGTTCTCGCTTGCGCTCTACTCCGGCCAGATGTGCACAGCGCCGCA
AAACATCTATGTGCCGCGTGACGGCATCCGCACCGCCGAAGGGCACGTCAGCTTCGACGACGTCGCGCGGGCGATCGCCG
ACGCCGTGCAAAAGCTGACGGGCGACCCGGCACGCTCGGTCGAACTCATCGGGGCGCTGCAGAACGCAGGCGTCGCGGCA
CGTATCGACGAAGCGCGCAAGCTCGGCCGCATTCTCGCCGACAGCCAGGCGCTCGAGCACCCGGCATTCAAGGACGCGCG
CGTGCGCACGCCGCTCGTGCTGCAACTCGACGTCGCGGACCGTGCGAAGTACACGCAGGAATGGTTCGGTCCGATCTCGT
TCGTCATCGCGACCGATTCGACTGCGCAATCACTCGATCTCGCCGGCTCGATCGCGGCCGAGCATGGCGCGCTCACGCTG
TCCGTCTATAGCACGGACGACGCCGTCGTCGAAGCGGCGCACGAAGCGGCGGTGCGCGGCGGCGTCGCGCTGTCGATCAA
TCTGACGGGCGGCGTGTTCGTCAATCAGTCGGCGGCGTTCTCCGACTTTCACGGCACGGGCGCCAATCCGGCCGCGAATG
CGTCGCTCGCCGACGCCGCGTTCGTCGCGAACCGCTTCCGCGTCGTTCAGAGCCGCCACCATGTTGCGCCGAAGGCGGCT
CCCGCGGAAGCCGGCCAAACGGCATAA

Upstream 100 bases:

>100_bases
TGCCGCACACGCACGGATGATTTGATGCTAACATTTTCCGACTAACCGGTCGGTTAATTAATGGCCACCGCTTCCCTCAA
CGTTCACCAAGCCTGCCGCC

Downstream 100 bases:

>100_bases
CCCGTTCGGCCGAGCTGCCGATCGCGCGACCGTTCACTACCATGAATGAACCCGCCCGCTCGCGGGTTCACCTTTGCCGG
AATTCGACATGACCGAAGCA

Product: aldehyde dehydrogenase family protein

Products: NA

Alternate protein names: P5C dehydrogenase [H]

Number of amino acids: Translated: 568; Mature: 567

Protein sequence:

>568_residues
MTHPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKAQLDKPFELDQPASGGTVGAERSPYGFAL
GVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAV
AYAWQELQRIPAEAHWEKPQGKNPPLAMRKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQNLARRPEIKLIDFTGSSQNGTWLERNAYQAQVYTEKAGVNQIVIDS
VDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAEGHVSFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAA
RIDEARKLGRILADSQALEHPAFKDARVRTPLVLQLDVADRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAAFVANRFRVVQSRHHVAPKAA
PAEAGQTA

Sequences:

>Translated_568_residues
MTHPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKAQLDKPFELDQPASGGTVGAERSPYGFAL
GVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAV
AYAWQELQRIPAEAHWEKPQGKNPPLAMRKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQNLARRPEIKLIDFTGSSQNGTWLERNAYQAQVYTEKAGVNQIVIDS
VDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAEGHVSFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAA
RIDEARKLGRILADSQALEHPAFKDARVRTPLVLQLDVADRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAAFVANRFRVVQSRHHVAPKAA
PAEAGQTA
>Mature_567_residues
THPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKAQLDKPFELDQPASGGTVGAERSPYGFALG
VRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILARLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVA
YAWQELQRIPAEAHWEKPQGKNPPLAMRKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLAI
TVRIARDVLREAGFDPNIVTLLATEGNDGALVQNLARRPEIKLIDFTGSSQNGTWLERNAYQAQVYTEKAGVNQIVIDSV
DDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAEGHVSFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAAR
IDEARKLGRILADSQALEHPAFKDARVRTPLVLQLDVADRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTLS
VYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAAFVANRFRVVQSRHHVAPKAAP
AEAGQTA

Specific function: Oxidizes Proline To Glutamate For Use As A Carbon And Nitrogen Source And Also Function As A Transcriptional Repressor Of The Put Operon. [C]

COG id: COG1012

COG function: function code C; NAD-dependent aldehyde dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldehyde dehydrogenase family. RocA subfamily [H]

Homologues:

Organism=Homo sapiens, GI115387104, Length=287, Percent_Identity=24.7386759581882, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1787250, Length=369, Percent_Identity=26.8292682926829, Blast_Score=70, Evalue=5e-13,
Organism=Escherichia coli, GI1787684, Length=276, Percent_Identity=26.4492753623188, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17551164, Length=285, Percent_Identity=25.9649122807018, Blast_Score=69, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI115534176, Length=305, Percent_Identity=24.9180327868852, Blast_Score=66, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321828, Length=342, Percent_Identity=25.7309941520468, Blast_Score=74, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320917, Length=191, Percent_Identity=31.413612565445, Blast_Score=67, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016160
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR005932 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.5.1.12 [H]

Molecular weight: Translated: 60634; Mature: 60503

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKAQLDKPFEL
CCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCCCCCCCCCHHHHHCCCCCCC
DQPASGGTVGAERSPYGFALGVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILA
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAWQELQRIPAEAHWEKPQ
HHCCCHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
GKNPPLAMRKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
CCCCCCHHCCCEEEEECCCCEEEEEECCCCCCCCCCHHHECCCCCEEEECCCCCCEEHHH
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQNLARRPEIKLIDFTGSSQNGTWLERN
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEECC
AYQAQVYTEKAGVNQIVIDSVDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAE
CEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHEECCCEECCCCCEEECCCCCCCCC
GHVSFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAARIDEARKLGRILADSQALEH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHCC
PAFKDARVRTPLVLQLDVADRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
CCCCCCCCCCCEEEEEECHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEE
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAA
EEECCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
FVANRFRVVQSRHHVAPKAAPAEAGQTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCC
>Mature Secondary Structure 
THPLFTKHEDTLKHALSTIETRGYWSPFAEMPSPKVYGESANTDGEAAFKAQLDKPFEL
CCCCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCEECCCCCCCCCCHHHHHCCCCCCC
DQPASGGTVGAERSPYGFALGVRYPKSTPDELIAAAAQAECAWRKAGPTAWAGVCLEILA
CCCCCCCCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
RLNRASFEIAYSVMHTTGQAFMMAFQAGGPHAQDRALEAVAYAWQELQRIPAEAHWEKPQ
HHCCCHHHHHHHHHHHCCHHHEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHCCCCCC
GKNPPLAMRKRYTIVPRGTGLVLGCCTFPTWNGYPGLFADLATGNTVIVKPHPGAILPLA
CCCCCCHHCCCEEEEECCCCEEEEEECCCCCCCCCCHHHECCCCCEEEECCCCCCEEHHH
ITVRIARDVLREAGFDPNIVTLLATEGNDGALVQNLARRPEIKLIDFTGSSQNGTWLERN
HHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHCCCEEEEEECCCCCCCCEEECC
AYQAQVYTEKAGVNQIVIDSVDDLKAAVKNIAFSLALYSGQMCTAPQNIYVPRDGIRTAE
CEEEEEEECCCCCCEEEECCHHHHHHHHHHHHHHHHEECCCEECCCCCEEECCCCCCCCC
GHVSFDDVARAIADAVQKLTGDPARSVELIGALQNAGVAARIDEARKLGRILADSQALEH
CCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHCCHHHCC
PAFKDARVRTPLVLQLDVADRAKYTQEWFGPISFVIATDSTAQSLDLAGSIAAEHGALTL
CCCCCCCCCCCEEEEEECHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEE
SVYSTDDAVVEAAHEAAVRGGVALSINLTGGVFVNQSAAFSDFHGTGANPAANASLADAA
EEECCCHHHHHHHHHHHHCCCEEEEEEECCCEEEECCCCCCCCCCCCCCCCCCCCHHHHH
FVANRFRVVQSRHHVAPKAAPAEAGQTA
HHHHHHHHHHHHHCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA