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The map label for this gene is oprC [H]

Identifier: 126447589

GI number: 126447589

Start: 766197

End: 767729

Strand: Direct

Name: oprC [H]

Synonym: BMA10247_A0829

Alternate gene names: 126447589

Gene position: 766197-767729 (Clockwise)

Preceding gene: 126447052

Following gene: 126445722

Centisome position: 32.57

GC content: 71.89

Gene sequence:

>1533_bases
ATGAACAAGACCAACATCAACGAACGCATCGCGCGCGTCGCGAAGATCGCGGCGGCGAGCGGGTTGCTCGTCGCGCTGCT
CGCCGCGTGCGCGGTGGGGCCCGACTACCGGCGGCCCGATGTCGCGACGCCCGCGGCGTTCAAGGAAGCGCCGGCGCTCG
CGCCGGGCGAGCAGGCCGGCACGTGGAAGGCGGCCGAGCCGGCCGACGCCGCGCATCGCGGCGAATGGTGGCGCGTATTC
GGCGATCCGGTGCTCGATGCGCTCGAAACGCAGGCGCTTGCCGCGAACCAGAACCTGAAGGCCGCGGCGGCGCGCGTCGA
GCAGGCGCGCGCGGCGACCCGCGCCGCGCGCTCGCAGTGGTTCCCGCAAGTGGGCGTGGGCTTCGGGCCGACGCGCGAGG
GGCTGTCGTCGGCGTCGCAGTTCCAGCCGCAGGGCAGCGGCCCGACGAACGCGACGCTCTGGCGCGCGCAGGGCACGGTG
TCGTACGAAGCGGACCTGTTCGGCCGCGTCGGCCGCAACGTCGAAGCGTCGCGCGCGGACGAAGCGCAGAGCCAGGCGCT
GTTCCGCTCGGTGCAGCTCGCGTTGCAGGCGGACGTCGCGCAGAACTACTTCGAGCTGCGCCGGCTCGATTCCGACCAGG
ATCTGTACCGGCGCACGGTCGGGCTGCGCGAGGAGGCGCTCAAGCTCGTGCAGCGGCGCTTTGCCGAAGGCGACATCAGC
GAGCTCGACGTGTCGCGCGCGAAGAACGAACTGGCGACCGCGCAGGCGGACGCGGTGGGCGTCGCGCGGCGGCGCGCCGC
ATCGGAGCATGCGCTCGCGATCCTGCTCGGCAAGGCGCCCGCGGATTTCTCGTTCAGCGAGACGCCGATCGCGCCGGTGG
CGGTGCGCGTGCCGGCGGGGCTGCCGTCGGCATTGCTCGAGAGGCGGCCCGACATCGCGGCGGCCGAGCGCGCGATGATG
GCCGCGAACGCGCGCATCGGCCTCGCGAAGTCCGCGTACTTCCCGAAGCTCGACATCACCGGCGCGTTCGGCTATGAGGC
GGCGACGCTCGGCAACCTGTTCCTGTGGTCGAGCCGCACGTTCCTGCTCGGGCCGTTCGCGGGCACGGCGCTCACGCTGC
CGATCTTCGACGGCGGGCGCCGCAGCGCGGGCGTCGCGCAGGCGCGCGCGAAGTATGACGAGGAAGTCGCGAACTACCGG
CAGCAGGTGCTCGTCGCGTTCCGCGAAGTGGAGGACAACCTTGCCGATCTGCGTCTGCTCGACGATCAGATCCGCGCGCA
AAGCGACGCCGTCAACGCGTCGCGGCGCGCGGCGAAGCTGTCGCGCACGCAGTATCAGGAAGGCGCGGTCAGCTATCTCG
ACGTGATCGACAGCGAGCGCTCGGTGCTCGAATCGCAACTGCAATCGAACCAGTTGACGGGCACGCAGGCGGTATCGACG
GTCAACCTGATTCGCGCGCTCGGCGGCGGCTGGGGGAGCGATGCGGCGCTCGGCTCGCGCGAGCCGGGCAAGCAGGACGT
CGCGGCGCGTTGA

Upstream 100 bases:

>100_bases
TACGTGGTGCTGCGTACGCTCGCGGGCGGCAAGATTCACGTCGCGCAGAAGGATTCGGCGGGCTACGGCGTGCCGGCTCC
GGACGCTTGAGGATAGAAAG

Downstream 100 bases:

>100_bases
ACATGCGGCGGCGGCCCGTTTCGGCGGGCTGCCGCCGCATTCGCCGCGCCGATGCCTGCCGGCGCGCATGGCCGACGAAA
TGCGAATGTCGGGCGGGGCG

Product: outer membrane efflux protein OprC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MNKTNINERIARVAKIAAASGLLVALLAACAVGPDYRRPDVATPAAFKEAPALAPGEQAGTWKAAEPADAAHRGEWWRVF
GDPVLDALETQALAANQNLKAAAARVEQARAATRAARSQWFPQVGVGFGPTREGLSSASQFQPQGSGPTNATLWRAQGTV
SYEADLFGRVGRNVEASRADEAQSQALFRSVQLALQADVAQNYFELRRLDSDQDLYRRTVGLREEALKLVQRRFAEGDIS
ELDVSRAKNELATAQADAVGVARRRAASEHALAILLGKAPADFSFSETPIAPVAVRVPAGLPSALLERRPDIAAAERAMM
AANARIGLAKSAYFPKLDITGAFGYEAATLGNLFLWSSRTFLLGPFAGTALTLPIFDGGRRSAGVAQARAKYDEEVANYR
QQVLVAFREVEDNLADLRLLDDQIRAQSDAVNASRRAAKLSRTQYQEGAVSYLDVIDSERSVLESQLQSNQLTGTQAVST
VNLIRALGGGWGSDAALGSREPGKQDVAAR

Sequences:

>Translated_510_residues
MNKTNINERIARVAKIAAASGLLVALLAACAVGPDYRRPDVATPAAFKEAPALAPGEQAGTWKAAEPADAAHRGEWWRVF
GDPVLDALETQALAANQNLKAAAARVEQARAATRAARSQWFPQVGVGFGPTREGLSSASQFQPQGSGPTNATLWRAQGTV
SYEADLFGRVGRNVEASRADEAQSQALFRSVQLALQADVAQNYFELRRLDSDQDLYRRTVGLREEALKLVQRRFAEGDIS
ELDVSRAKNELATAQADAVGVARRRAASEHALAILLGKAPADFSFSETPIAPVAVRVPAGLPSALLERRPDIAAAERAMM
AANARIGLAKSAYFPKLDITGAFGYEAATLGNLFLWSSRTFLLGPFAGTALTLPIFDGGRRSAGVAQARAKYDEEVANYR
QQVLVAFREVEDNLADLRLLDDQIRAQSDAVNASRRAAKLSRTQYQEGAVSYLDVIDSERSVLESQLQSNQLTGTQAVST
VNLIRALGGGWGSDAALGSREPGKQDVAAR
>Mature_510_residues
MNKTNINERIARVAKIAAASGLLVALLAACAVGPDYRRPDVATPAAFKEAPALAPGEQAGTWKAAEPADAAHRGEWWRVF
GDPVLDALETQALAANQNLKAAAARVEQARAATRAARSQWFPQVGVGFGPTREGLSSASQFQPQGSGPTNATLWRAQGTV
SYEADLFGRVGRNVEASRADEAQSQALFRSVQLALQADVAQNYFELRRLDSDQDLYRRTVGLREEALKLVQRRFAEGDIS
ELDVSRAKNELATAQADAVGVARRRAASEHALAILLGKAPADFSFSETPIAPVAVRVPAGLPSALLERRPDIAAAERAMM
AANARIGLAKSAYFPKLDITGAFGYEAATLGNLFLWSSRTFLLGPFAGTALTLPIFDGGRRSAGVAQARAKYDEEVANYR
QQVLVAFREVEDNLADLRLLDDQIRAQSDAVNASRRAAKLSRTQYQEGAVSYLDVIDSERSVLESQLQSNQLTGTQAVST
VNLIRALGGGWGSDAALGSREPGKQDVAAR

Specific function: The ability to export antibiotics and solvents is dramatically decreased in the presence of the proton conductor carbonyl cyanide m-chlorophenylhydrazone (CCCP), showing that an energized inner membrane is required for efflux. It is thought that the mexB

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor. Note=Attached to the outer membrane by a lipid anchor and via the transmembrane beta-barrel. The membrane anchor is not necessary for antibiotic efflux. In one report (PubMed:10889211) the Cys-18- Gly mutant is reported

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=481, Percent_Identity=31.3929313929314, Blast_Score=201, Evalue=8e-53,
Organism=Escherichia coli, GI2367348, Length=434, Percent_Identity=27.6497695852535, Blast_Score=135, Evalue=8e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 54643; Mature: 54643

Theoretical pI: Translated: 8.85; Mature: 8.85

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTNINERIARVAKIAAASGLLVALLAACAVGPDYRRPDVATPAAFKEAPALAPGEQAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
TWKAAEPADAAHRGEWWRVFGDPVLDALETQALAANQNLKAAAARVEQARAATRAARSQW
CCCCCCCCCHHHCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
FPQVGVGFGPTREGLSSASQFQPQGSGPTNATLWRAQGTVSYEADLFGRVGRNVEASRAD
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEHHHHHHHHCCCCCHHHHH
EAQSQALFRSVQLALQADVAQNYFELRRLDSDQDLYRRTVGLREEALKLVQRRFAEGDIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
ELDVSRAKNELATAQADAVGVARRRAASEHALAILLGKAPADFSFSETPIAPVAVRVPAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCC
LPSALLERRPDIAAAERAMMAANARIGLAKSAYFPKLDITGAFGYEAATLGNLFLWSSRT
CHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCCCCCEECCCCCCCHHHHHCCEEEECCCC
FLLGPFAGTALTLPIFDGGRRSAGVAQARAKYDEEVANYRQQVLVAFREVEDNLADLRLL
EEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDQIRAQSDAVNASRRAAKLSRTQYQEGAVSYLDVIDSERSVLESQLQSNQLTGTQAVST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VNLIRALGGGWGSDAALGSREPGKQDVAAR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKTNINERIARVAKIAAASGLLVALLAACAVGPDYRRPDVATPAAFKEAPALAPGEQAG
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHCCCCCCCCCCCC
TWKAAEPADAAHRGEWWRVFGDPVLDALETQALAANQNLKAAAARVEQARAATRAARSQW
CCCCCCCCCHHHCCCCEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
FPQVGVGFGPTREGLSSASQFQPQGSGPTNATLWRAQGTVSYEADLFGRVGRNVEASRAD
CCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCEEEEECCCEEEHHHHHHHHCCCCCHHHHH
EAQSQALFRSVQLALQADVAQNYFELRRLDSDQDLYRRTVGLREEALKLVQRRFAEGDIS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
ELDVSRAKNELATAQADAVGVARRRAASEHALAILLGKAPADFSFSETPIAPVAVRVPAG
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCEEEECCCC
LPSALLERRPDIAAAERAMMAANARIGLAKSAYFPKLDITGAFGYEAATLGNLFLWSSRT
CHHHHHHCCCCHHHHHHHHHHHCCCCCCHHCCCCCCEECCCCCCCHHHHHCCEEEECCCC
FLLGPFAGTALTLPIFDGGRRSAGVAQARAKYDEEVANYRQQVLVAFREVEDNLADLRLL
EEEECCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DDQIRAQSDAVNASRRAAKLSRTQYQEGAVSYLDVIDSERSVLESQLQSNQLTGTQAVST
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHH
VNLIRALGGGWGSDAALGSREPGKQDVAAR
HHHHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8226684; 10889211; 10984043; 7968531; 8540696; 9401051; 9603892; 10952562 [H]