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The map label for this gene is penA [H]

Identifier: 126446756

GI number: 126446756

Start: 1207622

End: 1209334

Strand: Direct

Name: penA [H]

Synonym: BMA10247_A1244

Alternate gene names: 126446756

Gene position: 1207622-1209334 (Clockwise)

Preceding gene: 126446511

Following gene: 126446154

Centisome position: 51.33

GC content: 74.26

Gene sequence:

>1713_bases
ATGCCGAAACCCGCCGAACCGCTCCACCGCCGCCCGCCGCTCACGCCCGCCGCGCTCCCCCGCTGGCGCTCGCGCTGCGT
GCTCGCGCTCCTCTGCGCGGGATTCGGCGCGCTCGCCGCGCGTGCGCTCTGGGTGCAGGTCGTACGCAGCGATTTCTACA
TCACGCAGGGAATCAAACGATACCGGCACACGTTCGAAGCCGCCCCGGCACGCGGGCGCATCGTCGATCGCAACGGCGCC
GAACTCGCGATCGACGAGCCCGTCGCCGACGTCTGGATCGCGCCCGACGCGTTCCGCCGCGCGACGCACGCCCAGATGCG
CGCGCTCGCGTCGCTGCTCGGCGTGCCGATCGACACGCTCGCCGCGAAAGCGCTCGGCACGCGGCAGTTCCTGTACCTGA
AGCGCTGGATCGCGCCGGAGCTGGCCGCTCGCATCGAGCGGCTCGCCGTGCCCGGCGTTCATGTCGCCGCCGCGACGCGG
CGCTATTACCCGAGCGGCGGCGACGCCGCGCAGCTCGTCGGCTTCGTCGGCGCGGACGGCCACGGGCTCGAGGGCGTCGA
GCGCACGGCCGACGCCGCGCTCGCCGGCGTCGGCGCGAAGCGCGACATGATCGTCGACCGGATGGGCCGCCCGGTGCAGG
CCGGCGACGCCGCGTCGGCGGGCGTGCCCGGCGCGGACGTCCGACTGTCGATCGACCGCCGGGTCCAGCATCTCGCGCAG
CGCGCCGTCGAGCGCGCGGTGGCGCGCACCGCGGCGGCGGCCGGCTGCGCGATCGTGGTCGACGCGAAGACGGGCGAGAT
CCTCGCGCTCGTGAACGCGCCCACGTTCGATCCGAACGAACGCACGGCCGCCGCCGACGACGGCCGCTTGCGCGAGCGCG
TGCTGACCGACGTCTTCGAGCCGGCGTCGACGCTCAAGCCCGTCACGGTCGCGCTCGCGCTGAGCGAAGGCGTCGTCGCG
CCGGACACGCGCATCGACACGTCGCCCGGCGTGCTCGACATCGAAGGCGCGACGATTCACGACACCGGCGACTTCGGCGA
GCTGACGGTCACGCAGATCATCGCGAAATCGAGCAACATCGGCATGGCGAAGATCGCCGAGCGGCTGCGCGCGCAGGACA
TGTGGCGGACGTTCGCGCGCGCGGGCATCGGCGCGCGGCCGCTCGCCGGCCTGCCGGCCGTCGCCCGCGGCACGCTGCGG
CCGGCGCGCAGCTGGAAGCCCATCGAGCGGCTGACGATGTCCTACGGCTACGGGCTGTCGGTGTCGCTCGCGCAACTCGC
GGACGTCTATACGGCGTTCGCCGGCGACGGCAGCCGGATACCGCTGTCGCTCGCGCATGCGGGCGCGCTGGCCGCGCGGG
TGCGCGTCGTGCCGCCCGCGGTCGCGCGGCAGATCCGCGCGATGCTCGAAACGGACGGCGAAGAAGGCACCGCGCGCATC
GCGCGGCTACCCGATTACCGGATCGGCGCGAAGACCGGCACCGCGCGCAAGCTGTGCGGCAAGCGGTACGCGCGCGGCAA
GTACCGGGCGCTCTTCGTCGGCCTCGCGCCGATGAGCGACCCGCGCCTGATCGTCGCGGTGATGATCGACGAGCCGTCGC
GCGGCTCGTACTACGGCGGCCCCGCGGCGGGGCCCGCATGGGCGGAGATCATGGACAACGCGTTGCATCTGCTCGGCGTG
CCGCCCGACCGGCCGGCGGCGCGGCACGCCTGA

Upstream 100 bases:

>100_bases
CGGCGCCGGGACAGCGCTCCGATCGCGCCGCCCCGCGTCACGATCGCCCGCCGCCGTGCCGATCCGTTCGCCCTCCCGCC
ATCTCGCCGCTCAACCGACC

Downstream 100 bases:

>100_bases
CGAGCGGCGGCGCCGGCCGGTCGCCGCTGCGCGGCGGCCGTGGCGCGCCTTGCTGTCTTATCGTCTCGCCGTCTCGCCGT
CTCGCCGTCGAAGCGTCGAA

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 570; Mature: 569

Protein sequence:

>570_residues
MPKPAEPLHRRPPLTPAALPRWRSRCVLALLCAGFGALAARALWVQVVRSDFYITQGIKRYRHTFEAAPARGRIVDRNGA
ELAIDEPVADVWIAPDAFRRATHAQMRALASLLGVPIDTLAAKALGTRQFLYLKRWIAPELAARIERLAVPGVHVAAATR
RYYPSGGDAAQLVGFVGADGHGLEGVERTADAALAGVGAKRDMIVDRMGRPVQAGDAASAGVPGADVRLSIDRRVQHLAQ
RAVERAVARTAAAAGCAIVVDAKTGEILALVNAPTFDPNERTAAADDGRLRERVLTDVFEPASTLKPVTVALALSEGVVA
PDTRIDTSPGVLDIEGATIHDTGDFGELTVTQIIAKSSNIGMAKIAERLRAQDMWRTFARAGIGARPLAGLPAVARGTLR
PARSWKPIERLTMSYGYGLSVSLAQLADVYTAFAGDGSRIPLSLAHAGALAARVRVVPPAVARQIRAMLETDGEEGTARI
ARLPDYRIGAKTGTARKLCGKRYARGKYRALFVGLAPMSDPRLIVAVMIDEPSRGSYYGGPAAGPAWAEIMDNALHLLGV
PPDRPAARHA

Sequences:

>Translated_570_residues
MPKPAEPLHRRPPLTPAALPRWRSRCVLALLCAGFGALAARALWVQVVRSDFYITQGIKRYRHTFEAAPARGRIVDRNGA
ELAIDEPVADVWIAPDAFRRATHAQMRALASLLGVPIDTLAAKALGTRQFLYLKRWIAPELAARIERLAVPGVHVAAATR
RYYPSGGDAAQLVGFVGADGHGLEGVERTADAALAGVGAKRDMIVDRMGRPVQAGDAASAGVPGADVRLSIDRRVQHLAQ
RAVERAVARTAAAAGCAIVVDAKTGEILALVNAPTFDPNERTAAADDGRLRERVLTDVFEPASTLKPVTVALALSEGVVA
PDTRIDTSPGVLDIEGATIHDTGDFGELTVTQIIAKSSNIGMAKIAERLRAQDMWRTFARAGIGARPLAGLPAVARGTLR
PARSWKPIERLTMSYGYGLSVSLAQLADVYTAFAGDGSRIPLSLAHAGALAARVRVVPPAVARQIRAMLETDGEEGTARI
ARLPDYRIGAKTGTARKLCGKRYARGKYRALFVGLAPMSDPRLIVAVMIDEPSRGSYYGGPAAGPAWAEIMDNALHLLGV
PPDRPAARHA
>Mature_569_residues
PKPAEPLHRRPPLTPAALPRWRSRCVLALLCAGFGALAARALWVQVVRSDFYITQGIKRYRHTFEAAPARGRIVDRNGAE
LAIDEPVADVWIAPDAFRRATHAQMRALASLLGVPIDTLAAKALGTRQFLYLKRWIAPELAARIERLAVPGVHVAAATRR
YYPSGGDAAQLVGFVGADGHGLEGVERTADAALAGVGAKRDMIVDRMGRPVQAGDAASAGVPGADVRLSIDRRVQHLAQR
AVERAVARTAAAAGCAIVVDAKTGEILALVNAPTFDPNERTAAADDGRLRERVLTDVFEPASTLKPVTVALALSEGVVAP
DTRIDTSPGVLDIEGATIHDTGDFGELTVTQIIAKSSNIGMAKIAERLRAQDMWRTFARAGIGARPLAGLPAVARGTLRP
ARSWKPIERLTMSYGYGLSVSLAQLADVYTAFAGDGSRIPLSLAHAGALAARVRVVPPAVARQIRAMLETDGEEGTARIA
RLPDYRIGAKTGTARKLCGKRYARGKYRALFVGLAPMSDPRLIVAVMIDEPSRGSYYGGPAAGPAWAEIMDNALHLLGVP
PDRPAARHA

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=555, Percent_Identity=36.036036036036, Blast_Score=339, Evalue=3e-94,
Organism=Escherichia coli, GI1786854, Length=617, Percent_Identity=24.9594813614263, Blast_Score=117, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 60644; Mature: 60512

Theoretical pI: Translated: 10.46; Mature: 10.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKPAEPLHRRPPLTPAALPRWRSRCVLALLCAGFGALAARALWVQVVRSDFYITQGIKR
CCCCCCCHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRHTFEAAPARGRIVDRNGAELAIDEPVADVWIAPDAFRRATHAQMRALASLLGVPIDTL
HHHHHHCCCCCCEEEECCCCEEEECCCCHHEEECCHHHHHHHHHHHHHHHHHHCCCHHHH
AAKALGTRQFLYLKRWIAPELAARIERLAVPGVHVAAATRRYYPSGGDAAQLVGFVGADG
HHHHHCHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHEEECCCC
HGLEGVERTADAALAGVGAKRDMIVDRMGRPVQAGDAASAGVPGADVRLSIDRRVQHLAQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHH
RAVERAVARTAAAAGCAIVVDAKTGEILALVNAPTFDPNERTAAADDGRLRERVLTDVFE
HHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHC
PASTLKPVTVALALSEGVVAPDTRIDTSPGVLDIEGATIHDTGDFGELTVTQIIAKSSNI
CHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEECCCCCCCHHHHHHHHCCCCC
GMAKIAERLRAQDMWRTFARAGIGARPLAGLPAVARGTLRPARSWKPIERLTMSYGYGLS
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCCC
VSLAQLADVYTAFAGDGSRIPLSLAHAGALAARVRVVPPAVARQIRAMLETDGEEGTARI
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCCHHHH
ARLPDYRIGAKTGTARKLCGKRYARGKYRALFVGLAPMSDPRLIVAVMIDEPSRGSYYGG
HCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCC
PAAGPAWAEIMDNALHLLGVPPDRPAARHA
CCCCHHHHHHHHHHHHEECCCCCCCCCCCC
>Mature Secondary Structure 
PKPAEPLHRRPPLTPAALPRWRSRCVLALLCAGFGALAARALWVQVVRSDFYITQGIKR
CCCCCCHHCCCCCCHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRHTFEAAPARGRIVDRNGAELAIDEPVADVWIAPDAFRRATHAQMRALASLLGVPIDTL
HHHHHHCCCCCCEEEECCCCEEEECCCCHHEEECCHHHHHHHHHHHHHHHHHHCCCHHHH
AAKALGTRQFLYLKRWIAPELAARIERLAVPGVHVAAATRRYYPSGGDAAQLVGFVGADG
HHHHHCHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCCHHHHHEEECCCC
HGLEGVERTADAALAGVGAKRDMIVDRMGRPVQAGDAASAGVPGADVRLSIDRRVQHLAQ
CCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHH
RAVERAVARTAAAAGCAIVVDAKTGEILALVNAPTFDPNERTAAADDGRLRERVLTDVFE
HHHHHHHHHHHHHCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHC
PASTLKPVTVALALSEGVVAPDTRIDTSPGVLDIEGATIHDTGDFGELTVTQIIAKSSNI
CHHHCCCEEEEEEECCCCCCCCCCCCCCCCEEEECCCEEECCCCCCCHHHHHHHHCCCCC
GMAKIAERLRAQDMWRTFARAGIGARPLAGLPAVARGTLRPARSWKPIERLTMSYGYGLS
CHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCHHHHHHHHCCCCCC
VSLAQLADVYTAFAGDGSRIPLSLAHAGALAARVRVVPPAVARQIRAMLETDGEEGTARI
HHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHEEECCHHHHHHHHHHHHCCCCCCHHHH
ARLPDYRIGAKTGTARKLCGKRYARGKYRALFVGLAPMSDPRLIVAVMIDEPSRGSYYGG
HCCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEEEECCCCCCCEEEEEEECCCCCCCCCCC
PAAGPAWAEIMDNALHLLGVPPDRPAARHA
CCCCHHHHHHHHHHHHEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]