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The map label for this gene is tyrB-2 [H]

Identifier: 126446693

GI number: 126446693

Start: 870106

End: 871305

Strand: Direct

Name: tyrB-2 [H]

Synonym: BMA10247_A0916

Alternate gene names: 126446693

Gene position: 870106-871305 (Clockwise)

Preceding gene: 126446566

Following gene: 126446075

Centisome position: 36.98

GC content: 66.5

Gene sequence:

>1200_bases
ATGTCGCTCTTCTCCGCTGTCGAACTTGCCCCCCGCGACCCTATCCTGGGCCTGAACGAAGCCTTCAACGCCGACACGCG
CCCGACCAAGGTGAACCTGGGCGTCGGCGTCTACACCAACGAGGACGGCAAGATTCCGCTGCTGCGCGCCGTGCGCGACG
CGGAAAAGGCACGGGTCGAAGCCGGCCTGCCGCGCGGCTACCTGCCGATCGACGGGATCGCCGCCTATGACGCATCGGTG
CAGAAGCTGCTGCTCGGCGACGATTCGCCGCTGATCGCGGCGGGCCGCGTCGTGACGGCGCAGGCGCTCGGCGGCACGGG
CGCGCTGAAGATCGGCGCGGATTTCCTGCGCACCCTGAACCCGAAGGCGAAGGTGGCGATCAGCGATCCGAGCTGGGAAA
ACCACCGTGCCCTGTTCGACATGGCGGGCTTCGAAGTCGTCGCGTACCCGTACTACGACGCGAAGACGAACGGCGTGAAC
TTCGACGGCATGCTGGCCGCGCTCAACGGCTACGAGCCGGGCACGATCGTCGTGCTGCACGCGTGCTGCCACAACCCGAC
GGGCGTGGACCTGAACGATGCGCAATGGGCGCAGGTGGTCGAGGTCGTGAAGGCGCGTCGGCTCGTGCCGTTCCTGGACA
TCGCCTATCAAGGCTTCGGCGAAAGCATCGAGGCCGACGCGGCCGCGGTGCGCCTGTTCGCGGCGGCCAATCTGAACGTG
TTCGTATCGTCGTCGTTCTCGAAGTCGTTCTCGCTGTATGGCGAGCGCGTCGGCGCGCTGTCGATCATCACCGACAGCAA
GGACGAAGCTGCACGCGTGCTGTCGCAACTGAAGCGCGTGATTCGCACGAACTATTCGAACCCGCCGACGCACGGCGGCG
CGATCGTTGCCGCGGTGCTCGCCTCGCCGGAACTGCGCGCTTCGTGGGTGCAGGAACTGGGCGAGATGCGCGATCGCATC
CGCGCAATGCGCAACGGCCTCGTCGAGCGCCTGAAGGCGGCCGGCATCGAGCGCGACTTCAGCTTCATCAACGCGCAACG
CGGGATGTTCTCGTACTCGGGCCTGACGTCCGCGCAAGTCGACCGTCTGCGCGAAGAATTCGGCATCTATGCGGTCAGCA
CCGGCCGGATCTGCGTCGCGGCGCTCAACACGCGCAACCTCGACGTCGTCGCGAACGCGATCGCCGCGGTGTTGAAGTAA

Upstream 100 bases:

>100_bases
TCTCGCCGGAGTTGCCGCGGCTCGGCCGCCCTGCCCGGTGATCGCCGGCCCGCATCGGCCCCGAAGCTGACCCTCTTTTC
ACAACTGCTGCGAATCAATC

Downstream 100 bases:

>100_bases
AACGACGGGGCCGGCGCCGCGACTTCGAGCTTGCGTAGTCGCTGTCGCGCCGCGCCGCGCAAATGAAAACGCGCTCCATT
CGGAGCGCCAGATTGCTGAC

Product: aromatic amino acid aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 399; Mature: 398

Protein sequence:

>399_residues
MSLFSAVELAPRDPILGLNEAFNADTRPTKVNLGVGVYTNEDGKIPLLRAVRDAEKARVEAGLPRGYLPIDGIAAYDASV
QKLLLGDDSPLIAAGRVVTAQALGGTGALKIGADFLRTLNPKAKVAISDPSWENHRALFDMAGFEVVAYPYYDAKTNGVN
FDGMLAALNGYEPGTIVVLHACCHNPTGVDLNDAQWAQVVEVVKARRLVPFLDIAYQGFGESIEADAAAVRLFAAANLNV
FVSSSFSKSFSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVAAVLASPELRASWVQELGEMRDRI
RAMRNGLVERLKAAGIERDFSFINAQRGMFSYSGLTSAQVDRLREEFGIYAVSTGRICVAALNTRNLDVVANAIAAVLK

Sequences:

>Translated_399_residues
MSLFSAVELAPRDPILGLNEAFNADTRPTKVNLGVGVYTNEDGKIPLLRAVRDAEKARVEAGLPRGYLPIDGIAAYDASV
QKLLLGDDSPLIAAGRVVTAQALGGTGALKIGADFLRTLNPKAKVAISDPSWENHRALFDMAGFEVVAYPYYDAKTNGVN
FDGMLAALNGYEPGTIVVLHACCHNPTGVDLNDAQWAQVVEVVKARRLVPFLDIAYQGFGESIEADAAAVRLFAAANLNV
FVSSSFSKSFSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVAAVLASPELRASWVQELGEMRDRI
RAMRNGLVERLKAAGIERDFSFINAQRGMFSYSGLTSAQVDRLREEFGIYAVSTGRICVAALNTRNLDVVANAIAAVLK
>Mature_398_residues
SLFSAVELAPRDPILGLNEAFNADTRPTKVNLGVGVYTNEDGKIPLLRAVRDAEKARVEAGLPRGYLPIDGIAAYDASVQ
KLLLGDDSPLIAAGRVVTAQALGGTGALKIGADFLRTLNPKAKVAISDPSWENHRALFDMAGFEVVAYPYYDAKTNGVNF
DGMLAALNGYEPGTIVVLHACCHNPTGVDLNDAQWAQVVEVVKARRLVPFLDIAYQGFGESIEADAAAVRLFAAANLNVF
VSSSFSKSFSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVAAVLASPELRASWVQELGEMRDRIR
AMRNGLVERLKAAGIERDFSFINAQRGMFSYSGLTSAQVDRLREEFGIYAVSTGRICVAALNTRNLDVVANAIAAVLK

Specific function: Biosynthesis of Phe, Tyr, Asp and Leu. [C]

COG id: COG1448

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI73486658, Length=398, Percent_Identity=44.7236180904523, Blast_Score=346, Evalue=3e-95,
Organism=Homo sapiens, GI4504067, Length=401, Percent_Identity=43.3915211970075, Blast_Score=321, Evalue=7e-88,
Organism=Homo sapiens, GI117414139, Length=399, Percent_Identity=27.8195488721804, Blast_Score=172, Evalue=7e-43,
Organism=Escherichia coli, GI1790488, Length=399, Percent_Identity=54.6365914786967, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1787159, Length=396, Percent_Identity=47.4747474747475, Blast_Score=392, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI71981858, Length=400, Percent_Identity=42.25, Blast_Score=349, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI25147133, Length=399, Percent_Identity=42.1052631578947, Blast_Score=332, Evalue=3e-91,
Organism=Caenorhabditis elegans, GI17569539, Length=402, Percent_Identity=39.3034825870647, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI17569537, Length=398, Percent_Identity=34.4221105527638, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17550384, Length=288, Percent_Identity=33.6805555555556, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI25147136, Length=213, Percent_Identity=40.8450704225352, Blast_Score=178, Evalue=5e-45,
Organism=Saccharomyces cerevisiae, GI6323055, Length=408, Percent_Identity=38.2352941176471, Blast_Score=294, Evalue=1e-80,
Organism=Saccharomyces cerevisiae, GI6322743, Length=437, Percent_Identity=32.9519450800915, Blast_Score=237, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24580972, Length=400, Percent_Identity=41.75, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI24580970, Length=400, Percent_Identity=41.75, Blast_Score=319, Evalue=2e-87,
Organism=Drosophila melanogaster, GI19920542, Length=393, Percent_Identity=41.7302798982188, Blast_Score=312, Evalue=2e-85,
Organism=Drosophila melanogaster, GI24654046, Length=401, Percent_Identity=39.9002493765586, Blast_Score=308, Evalue=3e-84,
Organism=Drosophila melanogaster, GI19922362, Length=401, Percent_Identity=39.9002493765586, Blast_Score=308, Evalue=4e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR000796
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 42862; Mature: 42731

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLFSAVELAPRDPILGLNEAFNADTRPTKVNLGVGVYTNEDGKIPLLRAVRDAEKARVE
CCCHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHH
AGLPRGYLPIDGIAAYDASVQKLLLGDDSPLIAAGRVVTAQALGGTGALKIGADFLRTLN
CCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEECCCEEEEECCCCCCEEHHHHHHHHHCC
PKAKVAISDPSWENHRALFDMAGFEVVAYPYYDAKTNGVNFDGMLAALNGYEPGTIVVLH
CCCEEEECCCCCCCCHHHEEECCCEEEEEECCCCCCCCCCCCHHEEEECCCCCCEEEEEE
ACCHNPTGVDLNDAQWAQVVEVVKARRLVPFLDIAYQGFGESIEADAAAVRLFAAANLNV
ECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHEEEEEECCCEE
FVSSSFSKSFSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVAAVL
EEECCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ASPELRASWVQELGEMRDRIRAMRNGLVERLKAAGIERDFSFINAQRGMFSYSGLTSAQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECCCCCHHHH
DRLREEFGIYAVSTGRICVAALNTRNLDVVANAIAAVLK
HHHHHHHCEEEEECCCEEEEEECCCCHHHHHHHHHHHHC
>Mature Secondary Structure 
SLFSAVELAPRDPILGLNEAFNADTRPTKVNLGVGVYTNEDGKIPLLRAVRDAEKARVE
CCHHHHHCCCCCCCCCCHHHCCCCCCCEEEEEEEEEEECCCCCCHHHHHHHHHHHHHHH
AGLPRGYLPIDGIAAYDASVQKLLLGDDSPLIAAGRVVTAQALGGTGALKIGADFLRTLN
CCCCCCCCCCCCCHHHHHHHHHHEECCCCCEEECCCEEEEECCCCCCEEHHHHHHHHHCC
PKAKVAISDPSWENHRALFDMAGFEVVAYPYYDAKTNGVNFDGMLAALNGYEPGTIVVLH
CCCEEEECCCCCCCCHHHEEECCCEEEEEECCCCCCCCCCCCHHEEEECCCCCCEEEEEE
ACCHNPTGVDLNDAQWAQVVEVVKARRLVPFLDIAYQGFGESIEADAAAVRLFAAANLNV
ECCCCCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHEEEEEECCCEE
FVSSSFSKSFSLYGERVGALSIITDSKDEAARVLSQLKRVIRTNYSNPPTHGGAIVAAVL
EEECCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHH
ASPELRASWVQELGEMRDRIRAMRNGLVERLKAAGIERDFSFINAQRGMFSYSGLTSAQV
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEECCCCCHHHH
DRLREEFGIYAVSTGRICVAALNTRNLDVVANAIAAVLK
HHHHHHHCEEEEECCCEEEEEECCCCHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043; 8808952 [H]