Click here to switch to the map view.

The map label for this gene is liaR [H]

Identifier: 126446602

GI number: 126446602

Start: 2293592

End: 2294239

Strand: Direct

Name: liaR [H]

Synonym: BMA10247_A2364

Alternate gene names: 126446602

Gene position: 2293592-2294239 (Clockwise)

Preceding gene: 126446931

Following gene: 126446069

Centisome position: 97.49

GC content: 67.75

Gene sequence:

>648_bases
ATGACTCCTGCCTCTTCCACGCCCCGCACCGCGCGCCTCTTGCTCGTCGACGATCATCCGCTCGTGCGCGACGGCCTGAA
GATGCGCCTCGAAGCGGCGCCCGGCCTCGCCGTGGTCGGCGAAGCGGGCAATGCGGACGAAGCGCTCACGCTCGCCGAGG
CGCTCGCGCCCGATCTCGCGCTGATGGACATCGGCATGCAGGGCATGAACGGAATCGCGCTCGCGGGCGTCTTTCACGAG
CGCTTTCCGGCGATTCGCGTGCTGATGCTGTCGATGCACGACAACGTCGAATACGTGACGCAGGCGGTGCGCGCGGGCGC
GAGCGGCTATCTGCTGAAGGATTCGCCCGCAACCGAGATCGTGCGCGCGATCGGCGCGGTGCTCGCCGGGCAGACGTTCT
TCAGCGAGGGAATCGCCGCCCGGATGATTCATGCGAGCGCCGAAGCGTCGCCGCTCGATCGGCTCACGCCGCGCGAGCGG
GACATCCTCGACGCGCTCGCGCAAGGATTGTCGAGCAAGCAGATCGCGCAGCGCAACGGCCTGTCGGTGCGCACGGTCGA
GACGCATCGGCTGAACCTGAAGCGCAAGCTCGACATCGAGGGGCAGGCGGAACTGATCAAGTTCGCGGTCGAGCATCGCA
GGCGGTAG

Upstream 100 bases:

>100_bases
ACGCGCTCGGCGGCACGCTCGAGATCAGCTCGCAGATCGGCCATACCGTCGTCGCCGCGCGCGTGCCGCTGCGCGGCACG
GACTCACCAGGAACCCCGCG

Downstream 100 bases:

>100_bases
GGGCGCGGTGGCGAGCGCCGTTGCCGAGGATAAGAGCGGCCAGCGGGAGCGGTCGACGCTGACCGATAAGCGGCATGCCG
CGCGCGATGCGGCGGGCGGC

Product: LuxR family DNA-binding response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MTPASSTPRTARLLLVDDHPLVRDGLKMRLEAAPGLAVVGEAGNADEALTLAEALAPDLALMDIGMQGMNGIALAGVFHE
RFPAIRVLMLSMHDNVEYVTQAVRAGASGYLLKDSPATEIVRAIGAVLAGQTFFSEGIAARMIHASAEASPLDRLTPRER
DILDALAQGLSSKQIAQRNGLSVRTVETHRLNLKRKLDIEGQAELIKFAVEHRRR

Sequences:

>Translated_215_residues
MTPASSTPRTARLLLVDDHPLVRDGLKMRLEAAPGLAVVGEAGNADEALTLAEALAPDLALMDIGMQGMNGIALAGVFHE
RFPAIRVLMLSMHDNVEYVTQAVRAGASGYLLKDSPATEIVRAIGAVLAGQTFFSEGIAARMIHASAEASPLDRLTPRER
DILDALAQGLSSKQIAQRNGLSVRTVETHRLNLKRKLDIEGQAELIKFAVEHRRR
>Mature_214_residues
TPASSTPRTARLLLVDDHPLVRDGLKMRLEAAPGLAVVGEAGNADEALTLAEALAPDLALMDIGMQGMNGIALAGVFHER
FPAIRVLMLSMHDNVEYVTQAVRAGASGYLLKDSPATEIVRAIGAVLAGQTFFSEGIAARMIHASAEASPLDRLTPRERD
ILDALAQGLSSKQIAQRNGLSVRTVETHRLNLKRKLDIEGQAELIKFAVEHRRR

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=191, Percent_Identity=39.7905759162304, Blast_Score=123, Evalue=7e-30,
Organism=Escherichia coli, GI1788222, Length=204, Percent_Identity=33.8235294117647, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1787473, Length=190, Percent_Identity=39.4736842105263, Blast_Score=119, Evalue=1e-28,
Organism=Escherichia coli, GI1790102, Length=191, Percent_Identity=36.6492146596859, Blast_Score=107, Evalue=8e-25,
Organism=Escherichia coli, GI1786747, Length=199, Percent_Identity=30.1507537688442, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788546, Length=200, Percent_Identity=25, Blast_Score=84, Evalue=6e-18,
Organism=Escherichia coli, GI1788712, Length=200, Percent_Identity=24, Blast_Score=78, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23177; Mature: 23046

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPASSTPRTARLLLVDDHPLVRDGLKMRLEAAPGLAVVGEAGNADEALTLAEALAPDLA
CCCCCCCCCEEEEEEECCCCHHHHHHHEEEECCCCEEEEECCCCCHHHHHHHHHHCCCHH
LMDIGMQGMNGIALAGVFHERFPAIRVLMLSMHDNVEYVTQAVRAGASGYLLKDSPATEI
EEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCCCHHHH
VRAIGAVLAGQTFFSEGIAARMIHASAEASPLDRLTPRERDILDALAQGLSSKQIAQRNG
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCHHHHHHHCC
LSVRTVETHRLNLKRKLDIEGQAELIKFAVEHRRR
CEEEEEHHHHCCCEEECCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure 
TPASSTPRTARLLLVDDHPLVRDGLKMRLEAAPGLAVVGEAGNADEALTLAEALAPDLA
CCCCCCCCEEEEEEECCCCHHHHHHHEEEECCCCEEEEECCCCCHHHHHHHHHHCCCHH
LMDIGMQGMNGIALAGVFHERFPAIRVLMLSMHDNVEYVTQAVRAGASGYLLKDSPATEI
EEHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCEEECCCCHHHH
VRAIGAVLAGQTFFSEGIAARMIHASAEASPLDRLTPRERDILDALAQGLSSKQIAQRNG
HHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHCCCCHHHHHHHHHHCCCHHHHHHHCC
LSVRTVETHRLNLKRKLDIEGQAELIKFAVEHRRR
CEEEEEHHHHCCCEEECCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]