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The map label for this gene is emrA [H]

Identifier: 126446292

GI number: 126446292

Start: 1915596

End: 1916969

Strand: Reverse

Name: emrA [H]

Synonym: BMA10247_A1987

Alternate gene names: 126446292

Gene position: 1916969-1915596 (Counterclockwise)

Preceding gene: 126446509

Following gene: 126447259

Centisome position: 81.48

GC content: 73.22

Gene sequence:

>1374_bases
GTGTATACGAGAGATTCGACCGAGACCGAGCATCGAAGCGTCCCGCGCCGCGCCGCAGCGGCGCCCGGGCCCGTCCGATC
CGCGCCTGCCGGCGCCACCGACATCACGCACGCCACCATCTTGAACGACACCGCCACCGACACTGCGCGCGCGAAGGCGC
CCACCGATCCGGCCGTTTCCGACGGCGCGCCCGCGAGCGGGCACGGCTTGCCTGCGTCGCCCGAAACCGCCGCGACGCTT
GCCGCGCGCCGGGCCACGCGCCGCCGCCGCTTCGCATGGTTCTTCGGAGTGCTGGCGATCGTCGCGCTGGGCGCGGCGCT
CTACTGGTTCATCGTGGGCCGCTTCAGCGAAGAGACGGACGATGCGTACGTGGCGGGCAACGTCGTGCAGATCGCCGCGC
AGATCCAGGGGACGGTGACCGACGTGCTGGTGGCCGACACGCAGCAGGTAAAGGCGGGGCAGGCGCTGGTGCGGCTCGAC
GACGCGGAGGCGGCGGCGGCGTTCGCGCAGGCGCAGGCGCAGCTCGCGCAGGCGGTGCGGCAAGTGGCGAACACGCGGCT
GTCGATGCAGACGTACGAGCAGACGGTGAAGGCGCGCGAGGCGGATCTGAAGCTCGCGCAGCAGGCGTATCGGGCGCGGG
CGGGGGCGTCGGTGGAGGTGGTGGCGCCGGAGGAGCTGGCGCGGGCGAAGTCGTCGCTGGCGAACGCGCAGGCGGCGCTG
GCGGGAGCGCAGGCGCAACGGGAGGCGGCGCGCGCGCTGGGCAGCGAGCGGCCGGTCGGGCAGAACCCGGCGGTGCAGCA
GGCGGCCGCGCAGTTCAAGCTGGCGTACCGGAACCTGAAGCGCACGACGATCGTGTCGCCGGTGGACGGGACGGTCGGGC
AGCGGTCGGTGCAGATCGGGCAGCAGGTGGGGCCGGGGGTGCCGCTGATGTCGGTGGTGCAGTTGCGGCAGGTGTGGGTG
GAGGCGAACTTCAAGGAAGGGCAGTTGCGGCACATGCGGGTGGGCCAGCCGGTGCGGCTCGAATCGGACCTGTACGGCGC
GCGGGTGACGTATCACGGCCGAGTGGAGGGCTTCTCGGCGGGCACGGGCAGCGCGTTCTCGATGCTGCCGTCGCAGAACG
CGGCGGGGAACTGGATCAAGGTGGTGCAGCGCTTGCCGGTGGTGATCTCGCTGGAGCCGTCGGAGCTGGCGGCGCACCCG
TTGCGGGTGGGGCTGTCGATGCGCGCGACGGTGCAGACGAAGGCGCGCGGCGGGCATCTGCTGGACGGCGACGCGCCGCT
GCCGGCGCAGCGCACGCGGGTGCACGAAATGCACGCGGGCGAGGCGGAGGCGGCGGCCGAGGCGGTGATCCGCGCGAACG
ACGGTGGGCAGTGA

Upstream 100 bases:

>100_bases
CGCGGCCGCGCCGTCCGTGAGCGGCCGAGACGACGCACGCACGAGCGCATCGGGTGAGTGCCGCGAGCGCGAAAACGTCA
ACCCCAACGCCTCCTTCACC

Downstream 100 bases:

>100_bases
CGGGCCGGGGGGATCGCGGGGGGCGCGGTGGGGCTGGGACGGGCGCAGGCGTCGATCGAGTCGGGCGGGGCGCTGGAGCG
ATCGGCGTGATTGCGCTGCT

Product: putative multidrug resistance protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 457; Mature: 457

Protein sequence:

>457_residues
MYTRDSTETEHRSVPRRAAAAPGPVRSAPAGATDITHATILNDTATDTARAKAPTDPAVSDGAPASGHGLPASPETAATL
AARRATRRRRFAWFFGVLAIVALGAALYWFIVGRFSEETDDAYVAGNVVQIAAQIQGTVTDVLVADTQQVKAGQALVRLD
DAEAAAAFAQAQAQLAQAVRQVANTRLSMQTYEQTVKAREADLKLAQQAYRARAGASVEVVAPEELARAKSSLANAQAAL
AGAQAQREAARALGSERPVGQNPAVQQAAAQFKLAYRNLKRTTIVSPVDGTVGQRSVQIGQQVGPGVPLMSVVQLRQVWV
EANFKEGQLRHMRVGQPVRLESDLYGARVTYHGRVEGFSAGTGSAFSMLPSQNAAGNWIKVVQRLPVVISLEPSELAAHP
LRVGLSMRATVQTKARGGHLLDGDAPLPAQRTRVHEMHAGEAEAAAEAVIRANDGGQ

Sequences:

>Translated_457_residues
MYTRDSTETEHRSVPRRAAAAPGPVRSAPAGATDITHATILNDTATDTARAKAPTDPAVSDGAPASGHGLPASPETAATL
AARRATRRRRFAWFFGVLAIVALGAALYWFIVGRFSEETDDAYVAGNVVQIAAQIQGTVTDVLVADTQQVKAGQALVRLD
DAEAAAAFAQAQAQLAQAVRQVANTRLSMQTYEQTVKAREADLKLAQQAYRARAGASVEVVAPEELARAKSSLANAQAAL
AGAQAQREAARALGSERPVGQNPAVQQAAAQFKLAYRNLKRTTIVSPVDGTVGQRSVQIGQQVGPGVPLMSVVQLRQVWV
EANFKEGQLRHMRVGQPVRLESDLYGARVTYHGRVEGFSAGTGSAFSMLPSQNAAGNWIKVVQRLPVVISLEPSELAAHP
LRVGLSMRATVQTKARGGHLLDGDAPLPAQRTRVHEMHAGEAEAAAEAVIRANDGGQ
>Mature_457_residues
MYTRDSTETEHRSVPRRAAAAPGPVRSAPAGATDITHATILNDTATDTARAKAPTDPAVSDGAPASGHGLPASPETAATL
AARRATRRRRFAWFFGVLAIVALGAALYWFIVGRFSEETDDAYVAGNVVQIAAQIQGTVTDVLVADTQQVKAGQALVRLD
DAEAAAAFAQAQAQLAQAVRQVANTRLSMQTYEQTVKAREADLKLAQQAYRARAGASVEVVAPEELARAKSSLANAQAAL
AGAQAQREAARALGSERPVGQNPAVQQAAAQFKLAYRNLKRTTIVSPVDGTVGQRSVQIGQQVGPGVPLMSVVQLRQVWV
EANFKEGQLRHMRVGQPVRLESDLYGARVTYHGRVEGFSAGTGSAFSMLPSQNAAGNWIKVVQRLPVVISLEPSELAAHP
LRVGLSMRATVQTKARGGHLLDGDAPLPAQRTRVHEMHAGEAEAAAEAVIRANDGGQ

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=371, Percent_Identity=41.2398921832884, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI1788711, Length=333, Percent_Identity=45.3453453453453, Blast_Score=278, Evalue=5e-76,
Organism=Escherichia coli, GI1790519, Length=322, Percent_Identity=28.8819875776398, Blast_Score=108, Evalue=8e-25,
Organism=Escherichia coli, GI87081951, Length=306, Percent_Identity=25.1633986928105, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789637, Length=309, Percent_Identity=27.5080906148867, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1787013, Length=326, Percent_Identity=28.2208588957055, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 48296; Mature: 48296

Theoretical pI: Translated: 10.24; Mature: 10.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTRDSTETEHRSVPRRAAAAPGPVRSAPAGATDITHATILNDTATDTARAKAPTDPAVS
CCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
DGAPASGHGLPASPETAATLAARRATRRRRFAWFFGVLAIVALGAALYWFIVGRFSEETD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DAYVAGNVVQIAAQIQGTVTDVLVADTQQVKAGQALVRLDDAEAAAAFAQAQAQLAQAVR
CEEECCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHH
QVANTRLSMQTYEQTVKAREADLKLAQQAYRARAGASVEVVAPEELARAKSSLANAQAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHH
AGAQAQREAARALGSERPVGQNPAVQQAAAQFKLAYRNLKRTTIVSPVDGTVGQRSVQIG
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHH
QQVGPGVPLMSVVQLRQVWVEANFKEGQLRHMRVGQPVRLESDLYGARVTYHGRVEGFSA
HHCCCCCHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCEEECCCCCCCEEEEECCCCCCCC
GTGSAFSMLPSQNAAGNWIKVVQRLPVVISLEPSELAAHPLRVGLSMRATVQTKARGGHL
CCCCHHEECCCCCCCCHHHHHHHHCCEEEEECHHHHHHHHHHHCCEEEEEEEECCCCCEE
LDGDAPLPAQRTRVHEMHAGEAEAAAEAVIRANDGGQ
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHEECCCCCC
>Mature Secondary Structure
MYTRDSTETEHRSVPRRAAAAPGPVRSAPAGATDITHATILNDTATDTARAKAPTDPAVS
CCCCCCCCHHHHHCCHHHCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCC
DGAPASGHGLPASPETAATLAARRATRRRRFAWFFGVLAIVALGAALYWFIVGRFSEETD
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
DAYVAGNVVQIAAQIQGTVTDVLVADTQQVKAGQALVRLDDAEAAAAFAQAQAQLAQAVR
CEEECCHHHHHHHHHHHHHHHHHHHCHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHH
QVANTRLSMQTYEQTVKAREADLKLAQQAYRARAGASVEVVAPEELARAKSSLANAQAAL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHH
AGAQAQREAARALGSERPVGQNPAVQQAAAQFKLAYRNLKRTTIVSPVDGTVGQRSVQIG
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCHHHHHHH
QQVGPGVPLMSVVQLRQVWVEANFKEGQLRHMRVGQPVRLESDLYGARVTYHGRVEGFSA
HHCCCCCHHHHHHHHHHHHHHCCCCCCCEEHCCCCCCEEECCCCCCCEEEEECCCCCCCC
GTGSAFSMLPSQNAAGNWIKVVQRLPVVISLEPSELAAHPLRVGLSMRATVQTKARGGHL
CCCCHHEECCCCCCCCHHHHHHHHCCEEEEECHHHHHHHHHHHCCEEEEEEEECCCCCEE
LDGDAPLPAQRTRVHEMHAGEAEAAAEAVIRANDGGQ
CCCCCCCCHHHHHHHHHCCCCHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]