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The map label for this gene is penA [H]

Identifier: 126446235

GI number: 126446235

Start: 1181057

End: 1182841

Strand: Direct

Name: penA [H]

Synonym: BMA10247_A1212

Alternate gene names: 126446235

Gene position: 1181057-1182841 (Clockwise)

Preceding gene: 126446922

Following gene: 126445935

Centisome position: 50.2

GC content: 68.35

Gene sequence:

>1785_bases
ATGCGCCTGAACAAAAAACCGAAGTCATCCGATCCTTACGTCGCCGTCGCGAAAAATCCGATGCTGTCGTCGAGCCTGCC
GATGTGGCGCTCGAAATTCGTCGTGATCCTCGTGTTCCTCGCGTTCGGCGCGCTGATCGCCCGCGCGTTCTGGGTGCAGG
TGGCGAATCAGGATTTCTACGTCGGCCAGGGCCAGAAGCGCTATCAGCGCACCATCAAGCTCGGCGCGATGCGCGGCAGC
ATCGTCGATCGCAACGGCGCGCTGCTCGCCGTGAGCCTCACCACCTACGAAATCTGGGCGAACCCGAAGCAGGTCGACGA
AGCCGCGCACGCGCCGCTCGCGAAGCTGCTCGACATGCCGCTCGCCGAAGTGCGGCGGCGCCTGACGGGCGATCGCTCGT
TCGTGCTGCTCAAGCGCCAGGTCGATCCCGAAACGGCCGCGCGCATCGAAAAACTCGACATCGACGGCGTCACGCAGATC
GCCGATTCGAAGCGCTTCTATCCGGAAGGCGAATCGGCCGCGCACGTCGTCGGCTTCACGAACGTCGAGGATCGCGGGCA
GGAAGGCGTCGAGCTCGCCGCGAACGGGCGGCTGTCCGGCACCGCGGGCCAACGCCAGGTGATCCGCGACCGGCTCGGGC
GGATCGTCTCCGATACCGGCCCGCTCGTGCCCGCGCAGCACGGTGCGACGATCGAGCTGACGATCGACCGCCGGATCCAG
CAGCTCGCGTACGCGCAGCTGAAGTCGACGATCATCGCGAACAACGCGCAGGCAGGCAGCGTCGTCGTGCTGGACGCGCA
GAACGGCGAAATCCTCGCGCTCGCGAACTATCCGACGTTCGATCCGAACGATCGCGCGCGGCTGACGGGCCAGCAATTGC
GCAACCGCGCGGTGATCGACACGTTCGAGCCGGGCTCGACGATCAAGCCGGTCGTCGTCGCGCTATCGATCGACGCCGGC
AAGGTGCGGCCACAGACGATCATCGACACGTCGCCGGGCGCGTACAAGATCGGCCCGAACGTGATTCACGACACGTCGAA
CCACGGCGCGATCACCGTCGCGCAGGCGCTGCAGATGTCGAGCAACATCGCGCTCGCGAAGCTCGCGCTGAACCTGCCCG
CCGAGACGATCTGGAACAAGTACCAGGAATACGGCATCGGCCGCGCGCCGGAGCTGACATTCCCCGGCGTCGCGTCCGGG
CGGCTGCGCCCGTACAAGCGCTGGCGGCCGATCGAGCAGGCGACGATGGCGTACGGCTACGGGCTGTCGACATCGCTGCT
GCAGATCGCGCAGGTCTACACCGCGTATGCGGGCGACGGCACGATCCATCCGGTGTCGCTGCTCAAGGCGAGCGCCGATC
CGCAGTCGGCCGACGCGCACCGCGGCCACCGCGTGACGACGCCCGCCACCGCGGCCGCGATCCGCTCGATGCTCGAGATG
GCCGTCGGCCAAGGCGGCACCGGGCGCGCGGCGCGCGTCGACGGTTACCGCGTCGGCGGCAAGACGGGGACCGCGCGCAA
GCAAGTCGGCGCGTCGTACGTCAAGGGCAAGTATCGCGCGCTGTTCGCCGGGATGGCGCCGATGAGCAATCCGCGCCTCA
TCATCGCGGTGATGATCGACGAGCCGGCCGCGCGCAGCTACTACGGCGGCACGGTCGCGGGGCCGGTGTTCTCGTCGGTG
ATGAGCGGCTCGCTGCAACTGCTCGGCGTGCCGCCCGACGCGCCCGTCGCGGCGGACAAGCCGGCCGGCACCGGCGCGAA
GCCGCAGGCGAAGGCGAAAACGTGA

Upstream 100 bases:

>100_bases
TTCAACGATTTGGCGGCCAATCCAGACGAAATCATTACTCATTCATTACAATTCTATCTTCGGGATGCGATCCGCCGTCC
CGCCCAGCAATAGCGAGCCC

Downstream 100 bases:

>100_bases
CGGCGGCGGGCACGGGCGGCGAATCGTGCTTTTCCCGCGACGCCCCGCCGCCCTTCGCCCTTCGCCCTTCGCCCTTCGCC
CTTCGCCCTTCAACCTTCGA

Product: penicillin-binding protein

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 594; Mature: 594

Protein sequence:

>594_residues
MRLNKKPKSSDPYVAVAKNPMLSSSLPMWRSKFVVILVFLAFGALIARAFWVQVANQDFYVGQGQKRYQRTIKLGAMRGS
IVDRNGALLAVSLTTYEIWANPKQVDEAAHAPLAKLLDMPLAEVRRRLTGDRSFVLLKRQVDPETAARIEKLDIDGVTQI
ADSKRFYPEGESAAHVVGFTNVEDRGQEGVELAANGRLSGTAGQRQVIRDRLGRIVSDTGPLVPAQHGATIELTIDRRIQ
QLAYAQLKSTIIANNAQAGSVVVLDAQNGEILALANYPTFDPNDRARLTGQQLRNRAVIDTFEPGSTIKPVVVALSIDAG
KVRPQTIIDTSPGAYKIGPNVIHDTSNHGAITVAQALQMSSNIALAKLALNLPAETIWNKYQEYGIGRAPELTFPGVASG
RLRPYKRWRPIEQATMAYGYGLSTSLLQIAQVYTAYAGDGTIHPVSLLKASADPQSADAHRGHRVTTPATAAAIRSMLEM
AVGQGGTGRAARVDGYRVGGKTGTARKQVGASYVKGKYRALFAGMAPMSNPRLIIAVMIDEPAARSYYGGTVAGPVFSSV
MSGSLQLLGVPPDAPVAADKPAGTGAKPQAKAKT

Sequences:

>Translated_594_residues
MRLNKKPKSSDPYVAVAKNPMLSSSLPMWRSKFVVILVFLAFGALIARAFWVQVANQDFYVGQGQKRYQRTIKLGAMRGS
IVDRNGALLAVSLTTYEIWANPKQVDEAAHAPLAKLLDMPLAEVRRRLTGDRSFVLLKRQVDPETAARIEKLDIDGVTQI
ADSKRFYPEGESAAHVVGFTNVEDRGQEGVELAANGRLSGTAGQRQVIRDRLGRIVSDTGPLVPAQHGATIELTIDRRIQ
QLAYAQLKSTIIANNAQAGSVVVLDAQNGEILALANYPTFDPNDRARLTGQQLRNRAVIDTFEPGSTIKPVVVALSIDAG
KVRPQTIIDTSPGAYKIGPNVIHDTSNHGAITVAQALQMSSNIALAKLALNLPAETIWNKYQEYGIGRAPELTFPGVASG
RLRPYKRWRPIEQATMAYGYGLSTSLLQIAQVYTAYAGDGTIHPVSLLKASADPQSADAHRGHRVTTPATAAAIRSMLEM
AVGQGGTGRAARVDGYRVGGKTGTARKQVGASYVKGKYRALFAGMAPMSNPRLIIAVMIDEPAARSYYGGTVAGPVFSSV
MSGSLQLLGVPPDAPVAADKPAGTGAKPQAKAKT
>Mature_594_residues
MRLNKKPKSSDPYVAVAKNPMLSSSLPMWRSKFVVILVFLAFGALIARAFWVQVANQDFYVGQGQKRYQRTIKLGAMRGS
IVDRNGALLAVSLTTYEIWANPKQVDEAAHAPLAKLLDMPLAEVRRRLTGDRSFVLLKRQVDPETAARIEKLDIDGVTQI
ADSKRFYPEGESAAHVVGFTNVEDRGQEGVELAANGRLSGTAGQRQVIRDRLGRIVSDTGPLVPAQHGATIELTIDRRIQ
QLAYAQLKSTIIANNAQAGSVVVLDAQNGEILALANYPTFDPNDRARLTGQQLRNRAVIDTFEPGSTIKPVVVALSIDAG
KVRPQTIIDTSPGAYKIGPNVIHDTSNHGAITVAQALQMSSNIALAKLALNLPAETIWNKYQEYGIGRAPELTFPGVASG
RLRPYKRWRPIEQATMAYGYGLSTSLLQIAQVYTAYAGDGTIHPVSLLKASADPQSADAHRGHRVTTPATAAAIRSMLEM
AVGQGGTGRAARVDGYRVGGKTGTARKQVGASYVKGKYRALFAGMAPMSNPRLIIAVMIDEPAARSYYGGTVAGPVFSSV
MSGSLQLLGVPPDAPVAADKPAGTGAKPQAKAKT

Specific function: Synthesis of cross-linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786272, Length=561, Percent_Identity=37.6114081996435, Blast_Score=386, Evalue=1e-108,
Organism=Escherichia coli, GI1786854, Length=618, Percent_Identity=24.1100323624595, Blast_Score=119, Evalue=4e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 63641; Mature: 63641

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLNKKPKSSDPYVAVAKNPMLSSSLPMWRSKFVVILVFLAFGALIARAFWVQVANQDFY
CCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VGQGQKRYQRTIKLGAMRGSIVDRNGALLAVSLTTYEIWANPKQVDEAAHAPLAKLLDMP
ECCCHHHHHHHHHHHHHCCCEEECCCCEEEEEEEEEEEECCHHHHHHHHHCHHHHHHCCC
LAEVRRRLTGDRSFVLLKRQVDPETAARIEKLDIDGVTQIADSKRFYPEGESAAHVVGFT
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCEEEEEEC
NVEDRGQEGVELAANGRLSGTAGQRQVIRDRLGRIVSDTGPLVPAQHGATIELTIDRRIQ
CCHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
QLAYAQLKSTIIANNAQAGSVVVLDAQNGEILALANYPTFDPNDRARLTGQQLRNRAVID
HHHHHHHHHHHEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHCCHHHHCCCCEEE
TFEPGSTIKPVVVALSIDAGKVRPQTIIDTSPGAYKIGPNVIHDTSNHGAITVAQALQMS
ECCCCCCCCEEEEEEEECCCCCCCCEEEECCCCCEECCCCEEECCCCCCEEHHHHHHHHC
SNIALAKLALNLPAETIWNKYQEYGIGRAPELTFPGVASGRLRPYKRWRPIEQATMAYGY
CCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCC
GLSTSLLQIAQVYTAYAGDGTIHPVSLLKASADPQSADAHRGHRVTTPATAAAIRSMLEM
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHH
AVGQGGTGRAARVDGYRVGGKTGTARKQVGASYVKGKYRALFAGMAPMSNPRLIIAVMID
HHCCCCCCCEEEECCEEECCCCCCHHHHHCHHHHCCHHHHEEECCCCCCCCCEEEEEEEC
EPAARSYYGGTVAGPVFSSVMSGSLQLLGVPPDAPVAADKPAGTGAKPQAKAKT
CCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRLNKKPKSSDPYVAVAKNPMLSSSLPMWRSKFVVILVFLAFGALIARAFWVQVANQDFY
CCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VGQGQKRYQRTIKLGAMRGSIVDRNGALLAVSLTTYEIWANPKQVDEAAHAPLAKLLDMP
ECCCHHHHHHHHHHHHHCCCEEECCCCEEEEEEEEEEEECCHHHHHHHHHCHHHHHHCCC
LAEVRRRLTGDRSFVLLKRQVDPETAARIEKLDIDGVTQIADSKRFYPEGESAAHVVGFT
HHHHHHHHCCCCEEEEEEECCCHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCEEEEEEC
NVEDRGQEGVELAANGRLSGTAGQRQVIRDRLGRIVSDTGPLVPAQHGATIELTIDRRIQ
CCHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEHHHHHH
QLAYAQLKSTIIANNAQAGSVVVLDAQNGEILALANYPTFDPNDRARLTGQQLRNRAVID
HHHHHHHHHHHEECCCCCCCEEEEECCCCCEEEEECCCCCCCCCCHHCCHHHHCCCCEEE
TFEPGSTIKPVVVALSIDAGKVRPQTIIDTSPGAYKIGPNVIHDTSNHGAITVAQALQMS
ECCCCCCCCEEEEEEEECCCCCCCCEEEECCCCCEECCCCEEECCCCCCEEHHHHHHHHC
SNIALAKLALNLPAETIWNKYQEYGIGRAPELTFPGVASGRLRPYKRWRPIEQATMAYGY
CCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHCC
GLSTSLLQIAQVYTAYAGDGTIHPVSLLKASADPQSADAHRGHRVTTPATAAAIRSMLEM
CCHHHHHHHHHHHHHHCCCCCCCHHHHHCCCCCCCCCCCCCCCEECCCHHHHHHHHHHHH
AVGQGGTGRAARVDGYRVGGKTGTARKQVGASYVKGKYRALFAGMAPMSNPRLIIAVMID
HHCCCCCCCEEEECCEEECCCCCCHHHHHCHHHHCCHHHHEEECCCCCCCCCEEEEEEEC
EPAARSYYGGTVAGPVFSSVMSGSLQLLGVPPDAPVAADKPAGTGAKPQAKAKT
CCCCCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3126399 [H]