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The map label for this gene is prpC [H]

Identifier: 126446197

GI number: 126446197

Start: 2073129

End: 2074301

Strand: Reverse

Name: prpC [H]

Synonym: BMA10247_A2142

Alternate gene names: 126446197

Gene position: 2074301-2073129 (Counterclockwise)

Preceding gene: 126446728

Following gene: 126445847

Centisome position: 88.17

GC content: 64.88

Gene sequence:

>1173_bases
ATGAGCGAGACGAAGGAAGCAGCGGCAACGGGCGCTGCGGGCGGTTTCAAGCCGAAGAAGTCGGTTGCGCTGTCGGGCGT
CGCGGCGGGCAATACCGCGCTCTGCACGGTCGGCAAGACCGGCAACGATCTGCATTACCGCGGCTACGACATTCTCGATA
TCGCCGGCTCGAGCGAATTCGAGGAAATCGCGCACCTGCTCGTGCACGAGACGCTGCCGAACGTGACCGAGCTGGCCGCG
TACAAGGCGAAGCTGCGCGCGATGCGCGGGCTGCCCGCGAACGTGAAGGCGGCGCTCGAATGGATTCCGGCGTCCGCGCA
CCCGATGGACGTGATGCGCACCGGCGTATCGGTGCTCGGCACCGTGCTGCCCGAGAAGGACGACCACAACCTGCCGGGCG
CGCGCGACATCGCGGACCGGCTGATGGCCTCGCTCGGCTCGATGCTGCTGTACTGGTATCACTATTCGCACAACGGCCGG
CGCATCGAAACCGAAACCGACGACGATTCGATCGGCGGGCATTTCCTGCACCTGCTGCACGGCAAGACGCCGTCGAAATC
GTGGATCGACGCGATGCACACGTCGCTGATCCTGTACGCGGAGCACGAGTTCAATGCCTCGACGTTCACCGCGCGCGTGA
TCGCCGGCACGGGCTCGGACATGTATTCGTCGATCACGGGCGCGATCGGCGCGCTGCGCGGGCCGAAGCACGGCGGCGCG
AACGAGGTCGCCTACGAGATCCAGAACCGCTACCGCACGCCCGACGAAGCGCAGGCCGACATCCGCCGCCGCGTCGAGAA
CAAGGAAGTCGTGATCGGCTTCGGCCACCCGGTGTACACGATCTCCGATCCGCGCAACAAGGTGATCAAGGAAGTCGCGC
GCAAGCTGTCGAAGGAAGCGGGCGACCTGAAGCTCTTCAACATCGCCGAGCGGCTCGAATCGGTGATGTGGGAGATCAAG
AAGATGTTCCCGAACCTCGACTGGTTCAGCGCGGTGTCGTATCACATGATGGGCGTGCCGACCGCGATGTTCACGCCGCT
GTTCGTGATCGCGCGCACCGCCGGCTGGAGCGCGCACATCATCGAGCAGCGGGTCGACAACAAGATCATCCGCCCGAGCG
CGAACTACACCGGGCCGGAAGACCTGAAGTTCGTGCCGATCGAGAAGCGCTGA

Upstream 100 bases:

>100_bases
CTACGCGTACGAAGAGAAGCTGGACCAGCTTTTCAACCAAGGCCGCAACTGAAGCGCCGAAGCACGGATTCAAGGATTCG
AACCCCAGGAGAGTATAAGG

Downstream 100 bases:

>100_bases
TCGGCGGCACCCGGCGGCCGGGCGTCGCGCCCGGCCGTTTCGCGACGATCGTTACCCAGTCTGTCCCCACGCAATGAACA
CTGCCAACCGCAAACCCCTG

Product: methylcitrate synthase

Products: NA

Alternate protein names: Citrate synthase 2; Methylcitrate synthase [H]

Number of amino acids: Translated: 390; Mature: 389

Protein sequence:

>390_residues
MSETKEAAATGAAGGFKPKKSVALSGVAAGNTALCTVGKTGNDLHYRGYDILDIAGSSEFEEIAHLLVHETLPNVTELAA
YKAKLRAMRGLPANVKAALEWIPASAHPMDVMRTGVSVLGTVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHYSHNGR
RIETETDDDSIGGHFLHLLHGKTPSKSWIDAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALRGPKHGGA
NEVAYEIQNRYRTPDEAQADIRRRVENKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAGDLKLFNIAERLESVMWEIK
KMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTAGWSAHIIEQRVDNKIIRPSANYTGPEDLKFVPIEKR

Sequences:

>Translated_390_residues
MSETKEAAATGAAGGFKPKKSVALSGVAAGNTALCTVGKTGNDLHYRGYDILDIAGSSEFEEIAHLLVHETLPNVTELAA
YKAKLRAMRGLPANVKAALEWIPASAHPMDVMRTGVSVLGTVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHYSHNGR
RIETETDDDSIGGHFLHLLHGKTPSKSWIDAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALRGPKHGGA
NEVAYEIQNRYRTPDEAQADIRRRVENKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAGDLKLFNIAERLESVMWEIK
KMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTAGWSAHIIEQRVDNKIIRPSANYTGPEDLKFVPIEKR
>Mature_389_residues
SETKEAAATGAAGGFKPKKSVALSGVAAGNTALCTVGKTGNDLHYRGYDILDIAGSSEFEEIAHLLVHETLPNVTELAAY
KAKLRAMRGLPANVKAALEWIPASAHPMDVMRTGVSVLGTVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHYSHNGRR
IETETDDDSIGGHFLHLLHGKTPSKSWIDAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALRGPKHGGAN
EVAYEIQNRYRTPDEAQADIRRRVENKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEAGDLKLFNIAERLESVMWEIKK
MFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTAGWSAHIIEQRVDNKIIRPSANYTGPEDLKFVPIEKR

Specific function: Catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate. Also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity [H]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786527, Length=375, Percent_Identity=78.4, Blast_Score=617, Evalue=1e-178,
Organism=Escherichia coli, GI1786939, Length=369, Percent_Identity=32.2493224932249, Blast_Score=166, Evalue=3e-42,
Organism=Caenorhabditis elegans, GI17555174, Length=359, Percent_Identity=24.2339832869081, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324328, Length=378, Percent_Identity=26.984126984127, Blast_Score=78, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6319850, Length=370, Percent_Identity=23.5135135135135, Blast_Score=68, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21356863, Length=242, Percent_Identity=26.8595041322314, Blast_Score=73, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24640124, Length=330, Percent_Identity=23.030303030303, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI24640126, Length=330, Percent_Identity=23.030303030303, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011278
- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.5 [H]

Molecular weight: Translated: 42956; Mature: 42825

Theoretical pI: Translated: 7.58; Mature: 7.58

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETKEAAATGAAGGFKPKKSVALSGVAAGNTALCTVGKTGNDLHYRGYDILDIAGSSEF
CCCCHHHHHCCCCCCCCCCHHHEEECEECCCEEEEEECCCCCCCEECCEEEEEECCCCCH
EEIAHLLVHETLPNVTELAAYKAKLRAMRGLPANVKAALEWIPASAHPMDVMRTGVSVLG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
TVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHYSHNGRRIETETDDDSIGGHFLHLLH
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCCCCHHHHHHHC
GKTPSKSWIDAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALRGPKHGGA
CCCCCHHHHHHHHHEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCH
NEVAYEIQNRYRTPDEAQADIRRRVENKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCC
GDLKLFNIAERLESVMWEIKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTAGWSAHI
CCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
IEQRVDNKIIRPSANYTGPEDLKFVPIEKR
HHHHHCCCEECCCCCCCCCCCCEEEECCCC
>Mature Secondary Structure 
SETKEAAATGAAGGFKPKKSVALSGVAAGNTALCTVGKTGNDLHYRGYDILDIAGSSEF
CCCHHHHHCCCCCCCCCCHHHEEECEECCCEEEEEECCCCCCCEECCEEEEEECCCCCH
EEIAHLLVHETLPNVTELAAYKAKLRAMRGLPANVKAALEWIPASAHPMDVMRTGVSVLG
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHH
TVLPEKDDHNLPGARDIADRLMASLGSMLLYWYHYSHNGRRIETETDDDSIGGHFLHLLH
HHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHEEECCCCCEEECCCCCCCCCHHHHHHHC
GKTPSKSWIDAMHTSLILYAEHEFNASTFTARVIAGTGSDMYSSITGAIGALRGPKHGGA
CCCCCHHHHHHHHHEEEEEEECCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCCH
NEVAYEIQNRYRTPDEAQADIRRRVENKEVVIGFGHPVYTISDPRNKVIKEVARKLSKEA
HHHHHHHHHHCCCCCHHHHHHHHHCCCCEEEEECCCEEEEECCHHHHHHHHHHHHHHHCC
GDLKLFNIAERLESVMWEIKKMFPNLDWFSAVSYHMMGVPTAMFTPLFVIARTAGWSAHI
CCEEHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
IEQRVDNKIIRPSANYTGPEDLKFVPIEKR
HHHHHCCCEECCCCCCCCCCCCEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 8508809; 9325432 [H]