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The map label for this gene is mdeA [H]

Identifier: 126446192

GI number: 126446192

Start: 939237

End: 940538

Strand: Direct

Name: mdeA [H]

Synonym: BMA10247_A0992

Alternate gene names: 126446192

Gene position: 939237-940538 (Clockwise)

Preceding gene: 126447862

Following gene: 126446353

Centisome position: 39.92

GC content: 66.13

Gene sequence:

>1302_bases
ATGACGTATTCGAGCTATCACAAGAAGGACATCGAGGGCCGTCCGCTGCACCCGGAAACGCAGATGATGTCGTACGGATT
CGATCCGTTCTTGTCCGAAGGCGCGGTGAAGCCTCCGGTATTCCTCACGTCGACGTTCGCGTTCCGCTCGGCGGAGGACG
GCGCCGATTTCTTCGATATCGTCTCGGGCCGCAAGCCGTTGCCGCAGGGCGAGGCGGCGGGCCTCGTCTACAGCCGCTTC
AATCATCCGAATCTCGAGATCGTCGAGGATCGCCTCGCGCTGCTCGACGGCTCCGAGGCGGCCGTCGTCACGTCGAGCGG
GATGTCGGCGATCAGCGCGATCTTTCTCGCGTTCCTGCGGCCGGGCGATCAGCTCGTGCAATCGGTGCCGCTGTACGGCG
GCACGGAAACGCTGATCGCGAAATACTTCCGCGAATGGGGTGTCGGCGCGCATTCGATCGACAACGGCCTGTCGCCGCAA
GCGATCGGCGCGGCGCTTGAAGCCGCCGCGCAGCAGGGGCCCGTGCGGCTCTGCTACGTCGAGACGCCAGCGAATCCGAC
GAACGCGCTGATCGACCTCGACGGCATGCGCCGCGAGCTCGACGCGTTCGAGGCGCGACACGGCTATCGTCCGATTTCGG
TGTGCGACAACACGCTGCTCGGGCCGATCTTCCAGAAGCCGAGCGAGCACGGCGTCGACATGTCGGTGTACTCGCTGACC
AAGTACGTCGGCGGCCACAGCGATCTCGTCGGGGGCGGCGTGACGGGGCGGCGGGATCTCGTCGCGAAGGTCCGCGCGGT
GCGCAGCGCATTCGGCTCGCAGCTCGATCCGCATTCGTCGTGGATGCTGATCCGTTCGATGGAAACGGTCGTGCTGCGGA
TGAAGCAGGCGGCGCGCACCGCGTCGGCGGTCGCGAAGTGGCTCGCGACGAATCCGCATCAGAAGGTCGACGTGTACCAC
CCGGAGCTGATCGTCGACGATGCGTATCAGGCCGTGTACAAGCGGCAATGCACGGGCGCCGGCTCGACGTTCGCGTTCGT
GCTGAACGGCGGCCGCGCGGAAGCATTCCGCTTCATCAACGCGTTGCATCTGTTCAAGTCCGCGGTGAGTCTCGGCGGCA
CCGAATCGTTGATCTGCCATCCGGCGTCGACGACGCACTCCGGCGTGCCGGAGGCGGCGCGCAAGGCGGCGGGCGTGTCG
GAAGGGTTGATTCGCGTGTCGATCGGGCTCGAGCACGAGGAGGACCTGATCGCCGATCTCGATCACGCGTTTCGCCGGTC
CGGCCTCGCGACGGGCGTCTGA

Upstream 100 bases:

>100_bases
CTGCTAGCTTTCTTACACTGAGTCGATTGGCGACAGGCGCCGCGCGGCTTGCCGCACGCCGGAGGGCCGGATCACATTCA
CCGTACAAAGGAGCCACCGC

Downstream 100 bases:

>100_bases
CGCAGCGACGGCGGCGCGTCACGGATCGATCGGCCCGGCTGCGTCGGTGCGCTTGAACGCGTGCCGCGCCGGGCGCGTTC
GCATTTTCGGGCGCGAACGC

Product: methionine gamma-lyase

Products: NA

Alternate protein names: L-methioninase [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTYSSYHKKDIEGRPLHPETQMMSYGFDPFLSEGAVKPPVFLTSTFAFRSAEDGADFFDIVSGRKPLPQGEAAGLVYSRF
NHPNLEIVEDRLALLDGSEAAVVTSSGMSAISAIFLAFLRPGDQLVQSVPLYGGTETLIAKYFREWGVGAHSIDNGLSPQ
AIGAALEAAAQQGPVRLCYVETPANPTNALIDLDGMRRELDAFEARHGYRPISVCDNTLLGPIFQKPSEHGVDMSVYSLT
KYVGGHSDLVGGGVTGRRDLVAKVRAVRSAFGSQLDPHSSWMLIRSMETVVLRMKQAARTASAVAKWLATNPHQKVDVYH
PELIVDDAYQAVYKRQCTGAGSTFAFVLNGGRAEAFRFINALHLFKSAVSLGGTESLICHPASTTHSGVPEAARKAAGVS
EGLIRVSIGLEHEEDLIADLDHAFRRSGLATGV

Sequences:

>Translated_433_residues
MTYSSYHKKDIEGRPLHPETQMMSYGFDPFLSEGAVKPPVFLTSTFAFRSAEDGADFFDIVSGRKPLPQGEAAGLVYSRF
NHPNLEIVEDRLALLDGSEAAVVTSSGMSAISAIFLAFLRPGDQLVQSVPLYGGTETLIAKYFREWGVGAHSIDNGLSPQ
AIGAALEAAAQQGPVRLCYVETPANPTNALIDLDGMRRELDAFEARHGYRPISVCDNTLLGPIFQKPSEHGVDMSVYSLT
KYVGGHSDLVGGGVTGRRDLVAKVRAVRSAFGSQLDPHSSWMLIRSMETVVLRMKQAARTASAVAKWLATNPHQKVDVYH
PELIVDDAYQAVYKRQCTGAGSTFAFVLNGGRAEAFRFINALHLFKSAVSLGGTESLICHPASTTHSGVPEAARKAAGVS
EGLIRVSIGLEHEEDLIADLDHAFRRSGLATGV
>Mature_432_residues
TYSSYHKKDIEGRPLHPETQMMSYGFDPFLSEGAVKPPVFLTSTFAFRSAEDGADFFDIVSGRKPLPQGEAAGLVYSRFN
HPNLEIVEDRLALLDGSEAAVVTSSGMSAISAIFLAFLRPGDQLVQSVPLYGGTETLIAKYFREWGVGAHSIDNGLSPQA
IGAALEAAAQQGPVRLCYVETPANPTNALIDLDGMRRELDAFEARHGYRPISVCDNTLLGPIFQKPSEHGVDMSVYSLTK
YVGGHSDLVGGGVTGRRDLVAKVRAVRSAFGSQLDPHSSWMLIRSMETVVLRMKQAARTASAVAKWLATNPHQKVDVYHP
ELIVDDAYQAVYKRQCTGAGSTFAFVLNGGRAEAFRFINALHLFKSAVSLGGTESLICHPASTTHSGVPEAARKAAGVSE
GLIRVSIGLEHEEDLIADLDHAFRRSGLATGV

Specific function: Methionine biosynthesis; second step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=396, Percent_Identity=33.5858585858586, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI299473759, Length=400, Percent_Identity=31, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI25453487, Length=396, Percent_Identity=29.040404040404, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1790375, Length=396, Percent_Identity=36.8686868686869, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1789383, Length=419, Percent_Identity=28.1622911694511, Blast_Score=122, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI71980708, Length=413, Percent_Identity=30.2663438256659, Blast_Score=179, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17538055, Length=382, Percent_Identity=30.8900523560209, Blast_Score=168, Evalue=5e-42,
Organism=Caenorhabditis elegans, GI17560056, Length=344, Percent_Identity=30.8139534883721, Blast_Score=162, Evalue=4e-40,
Organism=Saccharomyces cerevisiae, GI6319307, Length=399, Percent_Identity=32.5814536340852, Blast_Score=189, Evalue=1e-48,
Organism=Saccharomyces cerevisiae, GI6323333, Length=432, Percent_Identity=25.2314814814815, Blast_Score=127, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6321904, Length=403, Percent_Identity=27.2952853598015, Blast_Score=121, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321254, Length=409, Percent_Identity=24.4498777506112, Blast_Score=112, Evalue=8e-26,
Organism=Saccharomyces cerevisiae, GI6321170, Length=356, Percent_Identity=26.123595505618, Blast_Score=112, Evalue=1e-25,
Organism=Drosophila melanogaster, GI19922554, Length=395, Percent_Identity=33.6708860759494, Blast_Score=203, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006237
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.11 [H]

Molecular weight: Translated: 46679; Mature: 46548

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTYSSYHKKDIEGRPLHPETQMMSYGFDPFLSEGAVKPPVFLTSTFAFRSAEDGADFFDI
CCCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCEEEEEHHHHCCCCCCCHHHHH
VSGRKPLPQGEAAGLVYSRFNHPNLEIVEDRLALLDGSEAAVVTSSGMSAISAIFLAFLR
HCCCCCCCCCCCCCEEHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHC
PGDQLVQSVPLYGGTETLIAKYFREWGVGAHSIDNGLSPQAIGAALEAAAQQGPVRLCYV
CHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEEEE
ETPANPTNALIDLDGMRRELDAFEARHGYRPISVCDNTLLGPIFQKPSEHGVDMSVYSLT
ECCCCCCCEEEECHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHCCCCCCCCCHHHHHHH
KYVGGHSDLVGGGVTGRRDLVAKVRAVRSAFGSQLDPHSSWMLIRSMETVVLRMKQAART
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASAVAKWLATNPHQKVDVYHPELIVDDAYQAVYKRQCTGAGSTFAFVLNGGRAEAFRFIN
HHHHHHHHHCCCCCEEEEECCCEEHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHH
ALHLFKSAVSLGGTESLICHPASTTHSGVPEAARKAAGVSEGLIRVSIGLEHEEDLIADL
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHH
DHAFRRSGLATGV
HHHHHHCCCCCCC
>Mature Secondary Structure 
TYSSYHKKDIEGRPLHPETQMMSYGFDPFLSEGAVKPPVFLTSTFAFRSAEDGADFFDI
CCCCCCCCCCCCCCCCCHHHHHHCCCCHHHHCCCCCCCEEEEEHHHHCCCCCCCHHHHH
VSGRKPLPQGEAAGLVYSRFNHPNLEIVEDRLALLDGSEAAVVTSSGMSAISAIFLAFLR
HCCCCCCCCCCCCCEEHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHC
PGDQLVQSVPLYGGTETLIAKYFREWGVGAHSIDNGLSPQAIGAALEAAAQQGPVRLCYV
CHHHHHHHCCCCCCHHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCEEEEEE
ETPANPTNALIDLDGMRRELDAFEARHGYRPISVCDNTLLGPIFQKPSEHGVDMSVYSLT
ECCCCCCCEEEECHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHCCCCCCCCCHHHHHHH
KYVGGHSDLVGGGVTGRRDLVAKVRAVRSAFGSQLDPHSSWMLIRSMETVVLRMKQAART
HHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHH
ASAVAKWLATNPHQKVDVYHPELIVDDAYQAVYKRQCTGAGSTFAFVLNGGRAEAFRFIN
HHHHHHHHHCCCCCEEEEECCCEEHHHHHHHHHHHHCCCCCCEEEEEEECCHHHHHHHHH
ALHLFKSAVSLGGTESLICHPASTTHSGVPEAARKAAGVSEGLIRVSIGLEHEEDLIADL
HHHHHHHHHHCCCCCCEEEECCCCCCCCCCHHHHHHCCCCCCEEEEEECCCCHHHHHHHH
DHAFRRSGLATGV
HHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8586629; 9190812; 3365412 [H]