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The map label for this gene is glcA [H]

Identifier: 126446153

GI number: 126446153

Start: 822458

End: 824176

Strand: Direct

Name: glcA [H]

Synonym: BMA10247_A0870

Alternate gene names: 126446153

Gene position: 822458-824176 (Clockwise)

Preceding gene: 126447772

Following gene: 126446218

Centisome position: 34.96

GC content: 69.17

Gene sequence:

>1719_bases
GTGCAGGTTTGGAACCAGGTCTATCTGCCGCTCGGCGGCGTCGGCTGGTCGGCGCTCGCCGCCGGCGCGCCGATCATTCT
GTTCTTCGTGTCGCTCGCGGTGCTGCGGCTCAAGGGGCACGTCGCGGGCGCGCTCACGCTCGCGCTCGCGCTCGTCATCG
CGATCGCCGTCTACGGGATGCCCGCCGAGCGCGCGTTCGCATCGGCGGCTTACGGCTTCGCGTACGGCCTTTGGCCGATC
GCATGGATCATCGTCACCGCGGTGTTCCTCTACAAGATCGTCGTGAAGAGCGGCCAGTTCGACGTGATCCGCAGCTCGAT
CGTGTCGCTGACCGACGATCAGCGCTTGCAGATGCTGTTGATCGGCTTCTCGTTCGGCGCGTTCCTCGAAGGCGCGGCGG
GCTTCGGCGCGCCGGTCGCGATCACGGCCGCGCTGCTCGTCGGCCTTGGCTTCAATCCGCTCTATGCGGCGGGCCTGTGC
CTGATCGCGGATACCGCGCCCGTCGCGTTCGGCGCGCTCGGGATTCCGGTGATCGTCGCGGGGCAGGTGTCGGGCCTCGA
TCCGATGGCGGTCGGCGCGATGGCGGGACGCCAGTTGCCGTTCCTGTCGTTCTTTTTGCCGTTCTGGCTCGTGTTCGTGA
TGGACGGCGTAAAGGGCGTGCGCGAGACGTGGCCCGCCGCGCTCGTCGCGGGCGGCAGCTTCGCGCTCGTGCAGTTCTTC
ACGTCGAACTACATCGGGCCCGAGCTGCCCGACGTGACCTCGGCGCTCGCGAGCCTCGTCGCGCTCGCGTCGTTCCTGAA
GGTGTGGCGGCCGTTGCGCGCGCGCGAGGCCGCGCGCGCGCAACGGCTCGTGTCGGCGGGCGGCGGCGCGCTCGCGCTCG
GCGGCATGCCGGGGGGGCTGGGCGGCGCGCGCGCGACGGGCGGCCGGGAGCCTTCGCCGTATTCGTTCGCGCAGATCGCG
CGCGCGTGGTCGCCGTTCGTCGTGCTCACCGTGATGGTGACGATCTGGAGCATGAAGCCTTTCAAGGCGCTGTTCGCCAA
GGGCGGCGCGCTCGCGTTCACGACGCTGCAGTTCCACGTCGCGCATCTCGACAAGCTCACGCAGAAGATGGCGCCCGTCG
TCGCGCATCCGACGCCCGTGCCCGCCGTGTTCAACTGGGATCTGCTCGCGGCGACGGGCACCGCGATCCTGCTGTCGGCG
ATCGTATCGATGGCAATCCTGAACGTTCCGGCGCGCACCGGCGTGCGCACGTTCTTCGAGGTGCTGAAGGACCTGAAGCG
CCCGGTGCTGTCGATCGGCCTCGTGCTCGCGTTCGCGTTCGTCGAGAACTATTCGGGGATGTCGACGACGCTCGCGCTGC
TGCTCGCGGGCACGGGCGCGGCGTTCCCGTTCTTCTCGCCGCTGCTCGGCTGGATCGGCGTGTTCCTGACGGGCTCGGAC
ACGTCGTCGAACGCGCTGTTCTGTTCGCTGCAGGCGACCACCGCGCAGCAGATCGGCGTGCCGAGCACGCTGCTCGTCGC
GGCGAACACGACGGGCGGCGTCGCGGGCAAGATGATCTCGCCGCAGTCGATCGCGGTCGCATGCGCGGCGGTCGGCCTCG
TCGGCCACGAGGCGGATCTGTTCCGCTTCACGCTGCGGCATAGCCTGTTCTTCGCGCTCGTCGTCGGTGTGATGACCTGC
GTGCAGGCGTATTGGCTCACGGGGATGATCGTGCACTGA

Upstream 100 bases:

>100_bases
CGCCGCACCGACAACAAAGCGCCGGCACCGACCGGCGCGCCGATACGAACGGCCCGCGAGGCCGTCGCCCATTCAGGTTC
ATTCAAGGAAGGAGACACAC

Downstream 100 bases:

>100_bases
ATGCGGACGGAACGCGCGGGCGGCGAGCGCGTTCGCGTGTTCGCCGTCGTTCGCGGCCGCGCGCGGTTTTGTTCGAATCG
CCCGAATCGCCCGAATCGCC

Product: lactate permease (LctP) family protein

Products: lactate [Cytoplasm]; Proton [Cytoplasm]; glycolate [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 572; Mature: 572

Protein sequence:

>572_residues
MQVWNQVYLPLGGVGWSALAAGAPIILFFVSLAVLRLKGHVAGALTLALALVIAIAVYGMPAERAFASAAYGFAYGLWPI
AWIIVTAVFLYKIVVKSGQFDVIRSSIVSLTDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIADTAPVAFGALGIPVIVAGQVSGLDPMAVGAMAGRQLPFLSFFLPFWLVFVMDGVKGVRETWPAALVAGGSFALVQFF
TSNYIGPELPDVTSALASLVALASFLKVWRPLRAREAARAQRLVSAGGGALALGGMPGGLGGARATGGREPSPYSFAQIA
RAWSPFVVLTVMVTIWSMKPFKALFAKGGALAFTTLQFHVAHLDKLTQKMAPVVAHPTPVPAVFNWDLLAATGTAILLSA
IVSMAILNVPARTGVRTFFEVLKDLKRPVLSIGLVLAFAFVENYSGMSTTLALLLAGTGAAFPFFSPLLGWIGVFLTGSD
TSSNALFCSLQATTAQQIGVPSTLLVAANTTGGVAGKMISPQSIAVACAAVGLVGHEADLFRFTLRHSLFFALVVGVMTC
VQAYWLTGMIVH

Sequences:

>Translated_572_residues
MQVWNQVYLPLGGVGWSALAAGAPIILFFVSLAVLRLKGHVAGALTLALALVIAIAVYGMPAERAFASAAYGFAYGLWPI
AWIIVTAVFLYKIVVKSGQFDVIRSSIVSLTDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIADTAPVAFGALGIPVIVAGQVSGLDPMAVGAMAGRQLPFLSFFLPFWLVFVMDGVKGVRETWPAALVAGGSFALVQFF
TSNYIGPELPDVTSALASLVALASFLKVWRPLRAREAARAQRLVSAGGGALALGGMPGGLGGARATGGREPSPYSFAQIA
RAWSPFVVLTVMVTIWSMKPFKALFAKGGALAFTTLQFHVAHLDKLTQKMAPVVAHPTPVPAVFNWDLLAATGTAILLSA
IVSMAILNVPARTGVRTFFEVLKDLKRPVLSIGLVLAFAFVENYSGMSTTLALLLAGTGAAFPFFSPLLGWIGVFLTGSD
TSSNALFCSLQATTAQQIGVPSTLLVAANTTGGVAGKMISPQSIAVACAAVGLVGHEADLFRFTLRHSLFFALVVGVMTC
VQAYWLTGMIVH
>Mature_572_residues
MQVWNQVYLPLGGVGWSALAAGAPIILFFVSLAVLRLKGHVAGALTLALALVIAIAVYGMPAERAFASAAYGFAYGLWPI
AWIIVTAVFLYKIVVKSGQFDVIRSSIVSLTDDQRLQMLLIGFSFGAFLEGAAGFGAPVAITAALLVGLGFNPLYAAGLC
LIADTAPVAFGALGIPVIVAGQVSGLDPMAVGAMAGRQLPFLSFFLPFWLVFVMDGVKGVRETWPAALVAGGSFALVQFF
TSNYIGPELPDVTSALASLVALASFLKVWRPLRAREAARAQRLVSAGGGALALGGMPGGLGGARATGGREPSPYSFAQIA
RAWSPFVVLTVMVTIWSMKPFKALFAKGGALAFTTLQFHVAHLDKLTQKMAPVVAHPTPVPAVFNWDLLAATGTAILLSA
IVSMAILNVPARTGVRTFFEVLKDLKRPVLSIGLVLAFAFVENYSGMSTTLALLLAGTGAAFPFFSPLLGWIGVFLTGSD
TSSNALFCSLQATTAQQIGVPSTLLVAANTTGGVAGKMISPQSIAVACAAVGLVGHEADLFRFTLRHSLFFALVVGVMTC
VQAYWLTGMIVH

Specific function: Transports glycolate across the membrane. Can also transport L-lactate and D-lactate. Seems to be driven by a proton motive force [H]

COG id: COG1620

COG function: function code C; L-lactate permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lactate permease family [H]

Homologues:

Organism=Escherichia coli, GI1789347, Length=571, Percent_Identity=68.3012259194396, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI1790031, Length=570, Percent_Identity=59.4736842105263, Blast_Score=640, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003804 [H]

Pfam domain/function: PF02652 Lactate_perm [H]

EC number: NA

Molecular weight: Translated: 59720; Mature: 59720

Theoretical pI: Translated: 9.99; Mature: 9.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCEECC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: lactate [Periplasm]; Proton [Periplasm]; glycolate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + lactate [Periplasm] = Proton [Cytoplasm] + lactate [Cytoplasm] Proton [Periplasm] + glycolate [Periplasm] = Proton [Cytoplasm] + glycolate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 11283302; 11785976 [H]