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The map label for this gene is betC [H]

Identifier: 126446117

GI number: 126446117

Start: 1889171

End: 1890739

Strand: Reverse

Name: betC [H]

Synonym: BMA10247_A1966

Alternate gene names: 126446117

Gene position: 1890739-1889171 (Counterclockwise)

Preceding gene: 126447271

Following gene: 126447171

Centisome position: 80.36

GC content: 68.64

Gene sequence:

>1569_bases
ATGAGCGCCCAAGCGATGCCCGATACCGCCGAACCCACCGATATCCAGCCGAACATTCTCGTCCTGATGGCCGACCAGCT
CACGCCCTTCGCGTTGCGCGCGTACGGCCATCGCGCGACGCGTACGCCGACGATCGACCGGCTCGCCGCCGAGGGCGTCG
TCTTCGACGCCGCTTATTGCGCGAGCCCGCTCTGCGCGCCGTCGCGCTTCGCGCTGATGGCGGGCAAGCTGCCGTCGGCG
CTCGGCGCTTACGATAACGCCGCCGAATTGCCGGCGCAAACGCTGACGTTCGCGCACTACCTGCGCGCGGCCGGTTACCG
GACGATGCTGTCGGGCAAGATGCACTTCTGCGGGCCCGATCAGTTGCACGGCTTCGAGGAACGGCTCACGACCGACATCT
ATCCGGCCGATTTCGGCTGGGTGCCGGACTGGACGCGTCCCGCCGAGCGGCCGAGCTGGTATCACAACATGAGCTCGGTG
CTCGACGCCGGGCCTTGCGTGCGGACCAACCAGCTCGATTTCGACGACGATGCGACGTTCGCCGCGCGCCAGAAGATCTT
CGACGTCGCGCGCGAGCGCGCGGCCGGCCGGGACGCGCGGCCGTTCTGCATGGTCGTGTCGCTCACGCATCCGCACGATC
CGTATGCGATCACGCGCGAATACTGGGATCTGTACCGGGACGAGGACATCGATCTGCCCGCCGTGCGGATGGATTTCGAC
GCGAGCGACCCGCATTCGCGGCGGCTGCGCGCCGTATGCGAGGTCGATCGCACGCCGCCGGAGGACCTGCAGATCCGGCG
CGCGCGGCGCGCGTACTACGGCGCGACGTCCTATGTCGACGCGCAGTTCGGCGCGCTGCTCGCGACGCTCGAGCAATGCG
GGCTCGCCGACGACACGATCGTGATCGTCACCGCCGATCACGGCGACATGCTCGGCGAGCGCGGCCTCTGGTACAAGATG
ACGTTCTTCGAAGGCGCATGCCGCGTGCCGCTCATCGTGCACGCGCCGCGCCGGTTTCCGGCCGCGCGCGTGCCGGCGGC
CGTGTCGCACGTCGATCTGCTGCCGACGCTCGTCGAGCTCGCGACGGGCGAGCGCCGCGCCGACTGGCCCGACGCCGTCG
ACGGCCGCAGCCTCGTTCCCCATCTGCGCGGCGAAGGCGGCCATGACGAGGCGTTCGGCGAATATCTGGCCGAAGGCGCG
ATCGCGCCGATCGTGATGATGCGCCGCGGCAGCCACAAGTACATCCATTCGCCCGCGGATCCGGATCAGCTCTTCGATCT
GAGGAATGATCCGCGCGAGCTCGACAATCTCGCGAACACGCCCGCCGCGGCAAAGCACGTCGCCGCGTTTCGCATGGAGC
GCGTCGCGCGCTGGGATCTCGATGCGCTGCATCAGCAGGTGCTCGCGAGCCAGCGCAGGCGGCGCTTCCATTTCGAGGCG
ACGACCCAGGGGCGAATCCGGTCGTGGGACTGGCAGCCGTTCCAGGATGCGAGCCAGCGTTACATGCGCAATCACCTCGA
ACTCGACGCGCTCGAGGCAGCCGCGCGTTTTCCTCGTCCGCACGCATGA

Upstream 100 bases:

>100_bases
AAGCATTCGATGCCTTCACGGCCGCATTACGGCCGGCAATAGTGAGATCCGGCCGGCGGCGGCTGCCTGTCGCGCCGCCG
TTCCGATCCGACGATTCCAT

Downstream 100 bases:

>100_bases
CGCCCGGCGTCACGCATTTTCAAATGGAGCAAGCGATGAAACGATACGAATCCATTGCGCGGCGGCTCGCGCGCCGCGCG
GCAGCCGCATCGCCGGCGTT

Product: choline sulfatase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MSAQAMPDTAEPTDIQPNILVLMADQLTPFALRAYGHRATRTPTIDRLAAEGVVFDAAYCASPLCAPSRFALMAGKLPSA
LGAYDNAAELPAQTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTTDIYPADFGWVPDWTRPAERPSWYHNMSSV
LDAGPCVRTNQLDFDDDATFAARQKIFDVARERAAGRDARPFCMVVSLTHPHDPYAITREYWDLYRDEDIDLPAVRMDFD
ASDPHSRRLRAVCEVDRTPPEDLQIRRARRAYYGATSYVDAQFGALLATLEQCGLADDTIVIVTADHGDMLGERGLWYKM
TFFEGACRVPLIVHAPRRFPAARVPAAVSHVDLLPTLVELATGERRADWPDAVDGRSLVPHLRGEGGHDEAFGEYLAEGA
IAPIVMMRRGSHKYIHSPADPDQLFDLRNDPRELDNLANTPAAAKHVAAFRMERVARWDLDALHQQVLASQRRRRFHFEA
TTQGRIRSWDWQPFQDASQRYMRNHLELDALEAAARFPRPHA

Sequences:

>Translated_522_residues
MSAQAMPDTAEPTDIQPNILVLMADQLTPFALRAYGHRATRTPTIDRLAAEGVVFDAAYCASPLCAPSRFALMAGKLPSA
LGAYDNAAELPAQTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTTDIYPADFGWVPDWTRPAERPSWYHNMSSV
LDAGPCVRTNQLDFDDDATFAARQKIFDVARERAAGRDARPFCMVVSLTHPHDPYAITREYWDLYRDEDIDLPAVRMDFD
ASDPHSRRLRAVCEVDRTPPEDLQIRRARRAYYGATSYVDAQFGALLATLEQCGLADDTIVIVTADHGDMLGERGLWYKM
TFFEGACRVPLIVHAPRRFPAARVPAAVSHVDLLPTLVELATGERRADWPDAVDGRSLVPHLRGEGGHDEAFGEYLAEGA
IAPIVMMRRGSHKYIHSPADPDQLFDLRNDPRELDNLANTPAAAKHVAAFRMERVARWDLDALHQQVLASQRRRRFHFEA
TTQGRIRSWDWQPFQDASQRYMRNHLELDALEAAARFPRPHA
>Mature_521_residues
SAQAMPDTAEPTDIQPNILVLMADQLTPFALRAYGHRATRTPTIDRLAAEGVVFDAAYCASPLCAPSRFALMAGKLPSAL
GAYDNAAELPAQTLTFAHYLRAAGYRTMLSGKMHFCGPDQLHGFEERLTTDIYPADFGWVPDWTRPAERPSWYHNMSSVL
DAGPCVRTNQLDFDDDATFAARQKIFDVARERAAGRDARPFCMVVSLTHPHDPYAITREYWDLYRDEDIDLPAVRMDFDA
SDPHSRRLRAVCEVDRTPPEDLQIRRARRAYYGATSYVDAQFGALLATLEQCGLADDTIVIVTADHGDMLGERGLWYKMT
FFEGACRVPLIVHAPRRFPAARVPAAVSHVDLLPTLVELATGERRADWPDAVDGRSLVPHLRGEGGHDEAFGEYLAEGAI
APIVMMRRGSHKYIHSPADPDQLFDLRNDPRELDNLANTPAAAKHVAAFRMERVARWDLDALHQQVLASQRRRRFHFEAT
TQGRIRSWDWQPFQDASQRYMRNHLELDALEAAARFPRPHA

Specific function: Converts choline-O-sulfate into choline [H]

COG id: COG3119

COG function: function code P; Arylsulfatase A and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sulfatase family [H]

Homologues:

Organism=Homo sapiens, GI4557659, Length=397, Percent_Identity=29.2191435768262, Blast_Score=132, Evalue=1e-30,
Organism=Homo sapiens, GI39930577, Length=543, Percent_Identity=23.3885819521179, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI5360208, Length=317, Percent_Identity=27.7602523659306, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI71852584, Length=440, Percent_Identity=29.0909090909091, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI31742482, Length=434, Percent_Identity=26.9585253456221, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI58743319, Length=434, Percent_Identity=27.1889400921659, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI262118210, Length=316, Percent_Identity=28.7974683544304, Blast_Score=89, Evalue=8e-18,
Organism=Homo sapiens, GI4504061, Length=405, Percent_Identity=23.9506172839506, Blast_Score=83, Evalue=7e-16,
Organism=Homo sapiens, GI4503899, Length=400, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI53831991, Length=132, Percent_Identity=37.8787878787879, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI146229331, Length=111, Percent_Identity=40.5405405405405, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI146229329, Length=111, Percent_Identity=40.5405405405405, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI6005990, Length=111, Percent_Identity=40.5405405405405, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI146229324, Length=111, Percent_Identity=40.5405405405405, Blast_Score=76, Evalue=1e-13,
Organism=Homo sapiens, GI157266309, Length=112, Percent_Identity=39.2857142857143, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71852586, Length=122, Percent_Identity=39.344262295082, Blast_Score=74, Evalue=3e-13,
Organism=Escherichia coli, GI1790112, Length=435, Percent_Identity=29.8850574712644, Blast_Score=153, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17559078, Length=130, Percent_Identity=36.9230769230769, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24656835, Length=430, Percent_Identity=29.5348837209302, Blast_Score=127, Evalue=2e-29,
Organism=Drosophila melanogaster, GI281366397, Length=118, Percent_Identity=38.135593220339, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI281366395, Length=118, Percent_Identity=38.135593220339, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24666163, Length=118, Percent_Identity=38.135593220339, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017849
- InterPro:   IPR017850
- InterPro:   IPR017785
- InterPro:   IPR000917 [H]

Pfam domain/function: PF00884 Sulfatase [H]

EC number: =3.1.6.6 [H]

Molecular weight: Translated: 58721; Mature: 58590

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00523 SULFATASE_1 ; PS00149 SULFATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAQAMPDTAEPTDIQPNILVLMADQLTPFALRAYGHRATRTPTIDRLAAEGVVFDAAYC
CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHCCEEEEHHHH
ASPLCAPSRFALMAGKLPSALGAYDNAAELPAQTLTFAHYLRAAGYRTMLSGKMHFCGPD
CCCCCCCHHHHHHHCCCCHHHCCCCCHHHCCHHHHHHHHHHHHHCHHHHHCCCCCCCCCH
QLHGFEERLTTDIYPADFGWVPDWTRPAERPSWYHNMSSVLDAGPCVRTNQLDFDDDATF
HHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
AARQKIFDVARERAAGRDARPFCMVVSLTHPHDPYAITREYWDLYRDEDIDLPAVRMDFD
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCC
ASDPHSRRLRAVCEVDRTPPEDLQIRRARRAYYGATSYVDAQFGALLATLEQCGLADDTI
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEE
VIVTADHGDMLGERGLWYKMTFFEGACRVPLIVHAPRRFPAARVPAAVSHVDLLPTLVEL
EEEECCCCCHHCCCCCEEEEEEECCCCCCCEEEECCCCCCCHHCCHHHHHHHHHHHHHHH
ATGERRADWPDAVDGRSLVPHLRGEGGHDEAFGEYLAEGAIAPIVMMRRGSHKYIHSPAD
HCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCC
PDQLFDLRNDPRELDNLANTPAAAKHVAAFRMERVARWDLDALHQQVLASQRRRRFHFEA
HHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEE
TTQGRIRSWDWQPFQDASQRYMRNHLELDALEAAARFPRPHA
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SAQAMPDTAEPTDIQPNILVLMADQLTPFALRAYGHRATRTPTIDRLAAEGVVFDAAYC
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHCCCCCCCCCHHHHHHCCEEEEHHHH
ASPLCAPSRFALMAGKLPSALGAYDNAAELPAQTLTFAHYLRAAGYRTMLSGKMHFCGPD
CCCCCCCHHHHHHHCCCCHHHCCCCCHHHCCHHHHHHHHHHHHHCHHHHHCCCCCCCCCH
QLHGFEERLTTDIYPADFGWVPDWTRPAERPSWYHNMSSVLDAGPCVRTNQLDFDDDATF
HHCCHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHH
AARQKIFDVARERAAGRDARPFCMVVSLTHPHDPYAITREYWDLYRDEDIDLPAVRMDFD
HHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCEEEECCC
ASDPHSRRLRAVCEVDRTPPEDLQIRRARRAYYGATSYVDAQFGALLATLEQCGLADDTI
CCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCEE
VIVTADHGDMLGERGLWYKMTFFEGACRVPLIVHAPRRFPAARVPAAVSHVDLLPTLVEL
EEEECCCCCHHCCCCCEEEEEEECCCCCCCEEEECCCCCCCHHCCHHHHHHHHHHHHHHH
ATGERRADWPDAVDGRSLVPHLRGEGGHDEAFGEYLAEGAIAPIVMMRRGSHKYIHSPAD
HCCCCCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCC
PDQLFDLRNDPRELDNLANTPAAAKHVAAFRMERVARWDLDALHQQVLASQRRRRFHFEA
HHHHHHCCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHEEEEEE
TTQGRIRSWDWQPFQDASQRYMRNHLELDALEAAARFPRPHA
CCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9141699; 11481430; 9736747 [H]