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The map label for this gene is tolC [H]

Identifier: 126445988

GI number: 126445988

Start: 1295697

End: 1297037

Strand: Direct

Name: tolC [H]

Synonym: BMA10247_A1327

Alternate gene names: 126445988

Gene position: 1295697-1297037 (Clockwise)

Preceding gene: 126447557

Following gene: 126447605

Centisome position: 55.07

GC content: 67.04

Gene sequence:

>1341_bases
GTGGCCTACGTTACCGTTTGCGCGGTGCTTGCCGCACTCGGCACCGGTTCCGAATCCGCACGTGCGTTCTGTCTCGACGA
GGCTTATCAGCACGCAATATCGAACGATCCGAAATTTCTCCAGGCGCGGGCGGAATACGACGCCGCGCGGCAGAAGTTTC
CGCAGGCGCGCGCGCAGATGCTGCCGCAGGTGAGCGCGCAGCTCGAATGGGGCCGCTACGGCACGCACGCGAACCTGTTC
GGCATCGACGTGAGCGGCAACAGCACCGCCGCGTACGGCGCCGCGCAGCTCTCGCAGGCGCTGTTCAACATGCCGTATTT
GTACGACATGAGCCGCGCGAAGGAATTCGAGGAATCCGCGCGGCAGCAGCTCGAAGTCGCGAAGCAGGAGCTGATCATGC
GCGTCGCGAACGCGTGCTTCGATCTGCTGTCCGCACGCGAGAAGCTGCAGCTCGCCGACGACGAGGTCGGCGCGCTCACG
CGCCTGGAGAGCGATACCCGCCGCATGGCGCAGCTCGGCATGAAGACCATCGGCGACACGGCCGAGATCGAGGCGCGCAG
GAGCCTCGCGCAGTCGGACGAGGCGCTCGCGCGCACCGACGTCGAGGCGCGGCGCGCCCGCTACGAGACGCTGCTCGGCT
CCGCGATCGACTTCACGCGCTGGCCGCGGCTCGCGATGCACGGCACGTCGCCGCGCATTCCGACGGGCGACTACCAGCCG
CAGGACAACCCGTCGTACCAGCAGGCGTATCGCGACCTGCGCGTCGCGCGGCTCGCGTCCAAGCGCATCAACGCGGAGCA
CCTGCCGAGCGTCGACCTGTTCGCGACGTACTCGCGCGGCCTCAATCCGAACCTGCGCGGCCTCACCGACAAGAACGACT
TCCACCAGAGCGCAGTCGGCGTGCAGGTGACGATTCCGATCTTCTCGGGCGGCAGCGTGCACTACCGGAAGATCGAGGCC
GACCACGTCGCGACGCAGTACCAGAACCGGCTGCGCGAGGTCGAGCAGCAACTGAGCACCGATCATCGCGAGACGCTCGC
GGCGCTGCAGTCGATCGGCACGCGGATCCGCGCGCTGCAGCAATCGCTGCAGGCGGCGCGGCTCGCGTACGATTCGTCGA
TGAAGGCGCACCAGGTCGGCTACAGCACGACGTACGAGACGCTGAACCTGCGCACCGACATCTCGAACATCCGCCAGAAG
CTGTTCGAGAGCTACCTCGACGCGCTGAAGCTCCAGCTGAAGCTCAAGGGCATTCTCGGCACGCTGGACGAGCAGTCGCT
CGTCGCGGTCGACAGCTTCCTCGCGAGCAACGCGGCGCCCGCCGATCAGAAGAGCGAATGA

Upstream 100 bases:

>100_bases
GGAGACGGAGATGTTTGAAACAGAGAATTTGGGTGCCTCGTCTAAATTTCGGCATGCGGGTTTTCACTTAACGACAAAAT
CTTTTCGGCTTCGCGCCAAT

Downstream 100 bases:

>100_bases
GCGTGTGGCGGTGCGGCCGCGCGGCGGCGTGGGCGTGACGCGCGCGAGCGCGTGAGAGAAGCCGGGCCGGCGCTCAAACC
GAAAGCGCGCCGAAAGCACG

Product: putative outer membrane protein TolC

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MAYVTVCAVLAALGTGSESARAFCLDEAYQHAISNDPKFLQARAEYDAARQKFPQARAQMLPQVSAQLEWGRYGTHANLF
GIDVSGNSTAAYGAAQLSQALFNMPYLYDMSRAKEFEESARQQLEVAKQELIMRVANACFDLLSAREKLQLADDEVGALT
RLESDTRRMAQLGMKTIGDTAEIEARRSLAQSDEALARTDVEARRARYETLLGSAIDFTRWPRLAMHGTSPRIPTGDYQP
QDNPSYQQAYRDLRVARLASKRINAEHLPSVDLFATYSRGLNPNLRGLTDKNDFHQSAVGVQVTIPIFSGGSVHYRKIEA
DHVATQYQNRLREVEQQLSTDHRETLAALQSIGTRIRALQQSLQAARLAYDSSMKAHQVGYSTTYETLNLRTDISNIRQK
LFESYLDALKLQLKLKGILGTLDEQSLVAVDSFLASNAAPADQKSE

Sequences:

>Translated_446_residues
MAYVTVCAVLAALGTGSESARAFCLDEAYQHAISNDPKFLQARAEYDAARQKFPQARAQMLPQVSAQLEWGRYGTHANLF
GIDVSGNSTAAYGAAQLSQALFNMPYLYDMSRAKEFEESARQQLEVAKQELIMRVANACFDLLSAREKLQLADDEVGALT
RLESDTRRMAQLGMKTIGDTAEIEARRSLAQSDEALARTDVEARRARYETLLGSAIDFTRWPRLAMHGTSPRIPTGDYQP
QDNPSYQQAYRDLRVARLASKRINAEHLPSVDLFATYSRGLNPNLRGLTDKNDFHQSAVGVQVTIPIFSGGSVHYRKIEA
DHVATQYQNRLREVEQQLSTDHRETLAALQSIGTRIRALQQSLQAARLAYDSSMKAHQVGYSTTYETLNLRTDISNIRQK
LFESYLDALKLQLKLKGILGTLDEQSLVAVDSFLASNAAPADQKSE
>Mature_445_residues
AYVTVCAVLAALGTGSESARAFCLDEAYQHAISNDPKFLQARAEYDAARQKFPQARAQMLPQVSAQLEWGRYGTHANLFG
IDVSGNSTAAYGAAQLSQALFNMPYLYDMSRAKEFEESARQQLEVAKQELIMRVANACFDLLSAREKLQLADDEVGALTR
LESDTRRMAQLGMKTIGDTAEIEARRSLAQSDEALARTDVEARRARYETLLGSAIDFTRWPRLAMHGTSPRIPTGDYQPQ
DNPSYQQAYRDLRVARLASKRINAEHLPSVDLFATYSRGLNPNLRGLTDKNDFHQSAVGVQVTIPIFSGGSVHYRKIEAD
HVATQYQNRLREVEQQLSTDHRETLAALQSIGTRIRALQQSLQAARLAYDSSMKAHQVGYSTTYETLNLRTDISNIRQKL
FESYLDALKLQLKLKGILGTLDEQSLVAVDSFLASNAAPADQKSE

Specific function: Required for proper expression of outer membrane protein genes such as ompF, nmpC, protein 2, hemolysin, colicin V, or colicin E1. May be specialized for signal sequence independent, extracellular secretion in Gram-negative bacteria [H]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI87082199, Length=446, Percent_Identity=27.5784753363229, Blast_Score=107, Evalue=2e-24,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010130 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 49651; Mature: 49520

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYVTVCAVLAALGTGSESARAFCLDEAYQHAISNDPKFLQARAEYDAARQKFPQARAQM
CHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LPQVSAQLEWGRYGTHANLFGIDVSGNSTAAYGAAQLSQALFNMPYLYDMSRAKEFEESA
HHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RQQLEVAKQELIMRVANACFDLLSAREKLQLADDEVGALTRLESDTRRMAQLGMKTIGDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
AEIEARRSLAQSDEALARTDVEARRARYETLLGSAIDFTRWPRLAMHGTSPRIPTGDYQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCC
QDNPSYQQAYRDLRVARLASKRINAEHLPSVDLFATYSRGLNPNLRGLTDKNDFHQSAVG
CCCCCHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCC
VQVTIPIFSGGSVHYRKIEADHVATQYQNRLREVEQQLSTDHRETLAALQSIGTRIRALQ
EEEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QSLQAARLAYDSSMKAHQVGYSTTYETLNLRTDISNIRQKLFESYLDALKLQLKLKGILG
HHHHHHHHHHHCCCHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLDEQSLVAVDSFLASNAAPADQKSE
CCCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
AYVTVCAVLAALGTGSESARAFCLDEAYQHAISNDPKFLQARAEYDAARQKFPQARAQM
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
LPQVSAQLEWGRYGTHANLFGIDVSGNSTAAYGAAQLSQALFNMPYLYDMSRAKEFEESA
HHHHHHHCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
RQQLEVAKQELIMRVANACFDLLSAREKLQLADDEVGALTRLESDTRRMAQLGMKTIGDT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCH
AEIEARRSLAQSDEALARTDVEARRARYETLLGSAIDFTRWPRLAMHGTSPRIPTGDYQP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCCCCCCCC
QDNPSYQQAYRDLRVARLASKRINAEHLPSVDLFATYSRGLNPNLRGLTDKNDFHQSAVG
CCCCCHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHCC
VQVTIPIFSGGSVHYRKIEADHVATQYQNRLREVEQQLSTDHRETLAALQSIGTRIRALQ
EEEEEEEECCCCEEEEEECHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
QSLQAARLAYDSSMKAHQVGYSTTYETLNLRTDISNIRQKLFESYLDALKLQLKLKGILG
HHHHHHHHHHHCCCHHHHCCCCCHHHHEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TLDEQSLVAVDSFLASNAAPADQKSE
CCCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6312426; 2216730; 9278503; 6303857; 9298646; 9629924; 10879525 [H]