BacMap

Definition	Burkholderia mallei NCTC 10247 chromosome II, complete genome.
Accession	NC_009079
Length	2,352,693

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The map label for this gene is budC [H]

Identifier: 126445878

GI number: 126445878

Start: 889861

End: 890694

Strand: Direct

Name: budC [H]

Synonym: BMA10247_A0940

Alternate gene names: 126445878

Gene position: 889861-890694 (Clockwise)

Preceding gene: 126446429

Following gene: 126447459

Centisome position: 37.82

GC content: 75.66

Gene sequence:

>834_bases
ATGAACGGCGTCGATTCGAGGCGCGCGGCACCGCCGCGCGGCGGGCTCGCCGCCGATTTTCGCGGCCGCACCGCGCTCGT
GACGGGCGCGGCGCAGGGCATCGGCGCGGCGATCGCCGATGCGTTCGCCGCCGCCGGCGCGAGTGTCGCGATCGCGGATG
TGCAGGGCGACGCGGCGGCCGCGTTCGCCGCGCGGCTTGCCGCGCGAGGCGCCGCCGATGGGCAGACGGTGCGCGCGTAC
CGCGTCGACGCCGCGCGGCGCGACGAACTGTTCGGGCTCGTCGCGCAGGCGGAGGCGGATAGCGGGCGGCTCGACATCGT
CGTGCACAACGCCGCGTACTTTCCGCTGACGCCGTTCGGCGCGATCGCGCCCGACGTGCTTGAGCGCACGCTGGCGGTCA
ATCTGTCCGCGCTGTTCTGGCTCACGCAGGCGGCGCTGCCGGCGTTCGAGCGCGTGGGGCGGGGGCGCGTGCTGGCGACG
TCGTCGGTGACGGGGCCGCGCGTCGCGTACCCGGGGCTTGCGCACTACGCGGCGTCGAAGGCGGGGGTGAACGGCTTCAT
CCGCGCGGCGGCGCTCGAGCTCGCGCGCCGGAACGTGACCGTCAACGGTGTCGAGCCGGGAATGATCCGCACGCCGGCCG
CCGGCAATCTCGGCGATGCGGCGCACGGCGAGCGCATCGCGCGCGGCGTGCCGCTCGGCCGCCTCGGCGAGCCGGAGGAC
ATCGCGGCCGCGATGCTGTTTCTCGCGTCCGACGCGGCGGGCTACATCACCGGGCAGACGATCGTCGTCGACGGCGGCGC
GACGCTGCCGGAGACCGCCGCAGCGCTCGGATAG

Upstream 100 bases:

>100_bases
AGATCTTCGGCTATCGCGAGGGCGATTTCGGCGCGCTGTCGAATTTCGCGATCGGCGCGCACGCGCAGGTGCTGAACGAA
ACCATGCATCCGCTCGCGCG

Downstream 100 bases:

>100_bases
CGCGTCGCGGCCTGGACGCCGGCTCGTCGGGCGGCCCACGCTTGCAGGCGACAGGCGACAGGCGACAGGCGACAGGCGAC
AGGCGGCGAGCGAAGGGCGA

Product: 3-ketoacyl-(acyl-carrier-protein) reductase

Products: NA

Alternate protein names: Acetoin(diacetyl) reductase; AR; Meso-2,3-butanediol dehydrogenase [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
MNGVDSRRAAPPRGGLAADFRGRTALVTGAAQGIGAAIADAFAAAGASVAIADVQGDAAAAFAARLAARGAADGQTVRAY
RVDAARRDELFGLVAQAEADSGRLDIVVHNAAYFPLTPFGAIAPDVLERTLAVNLSALFWLTQAALPAFERVGRGRVLAT
SSVTGPRVAYPGLAHYAASKAGVNGFIRAAALELARRNVTVNGVEPGMIRTPAAGNLGDAAHGERIARGVPLGRLGEPED
IAAAMLFLASDAAGYITGQTIVVDGGATLPETAAALG

Sequences:

>Translated_277_residues
MNGVDSRRAAPPRGGLAADFRGRTALVTGAAQGIGAAIADAFAAAGASVAIADVQGDAAAAFAARLAARGAADGQTVRAY
RVDAARRDELFGLVAQAEADSGRLDIVVHNAAYFPLTPFGAIAPDVLERTLAVNLSALFWLTQAALPAFERVGRGRVLAT
SSVTGPRVAYPGLAHYAASKAGVNGFIRAAALELARRNVTVNGVEPGMIRTPAAGNLGDAAHGERIARGVPLGRLGEPED
IAAAMLFLASDAAGYITGQTIVVDGGATLPETAAALG
>Mature_277_residues
MNGVDSRRAAPPRGGLAADFRGRTALVTGAAQGIGAAIADAFAAAGASVAIADVQGDAAAAFAARLAARGAADGQTVRAY
RVDAARRDELFGLVAQAEADSGRLDIVVHNAAYFPLTPFGAIAPDVLERTLAVNLSALFWLTQAALPAFERVGRGRVLAT
SSVTGPRVAYPGLAHYAASKAGVNGFIRAAALELARRNVTVNGVEPGMIRTPAAGNLGDAAHGERIARGVPLGRLGEPED
IAAAMLFLASDAAGYITGQTIVVDGGATLPETAAALG

Specific function: Catalyzes the reversible reduction of (S)-acetoin to 2,3-butanediol in the presence of NADH [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI32483357, Length=249, Percent_Identity=36.144578313253, Blast_Score=126, Evalue=3e-29,
Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=36.71875, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI19923817, Length=254, Percent_Identity=28.740157480315, Blast_Score=102, Evalue=3e-22,
Organism=Homo sapiens, GI126723750, Length=253, Percent_Identity=32.0158102766798, Blast_Score=101, Evalue=8e-22,
Organism=Homo sapiens, GI5031737, Length=261, Percent_Identity=32.5670498084291, Blast_Score=95, Evalue=6e-20,
Organism=Homo sapiens, GI142976729, Length=249, Percent_Identity=28.5140562248996, Blast_Score=94, Evalue=1e-19,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=29.718875502008, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI10190704, Length=253, Percent_Identity=30.4347826086957, Blast_Score=90, Evalue=3e-18,
Organism=Homo sapiens, GI59889578, Length=242, Percent_Identity=33.0578512396694, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=30.241935483871, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI310128830, Length=200, Percent_Identity=30.5, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI310115468, Length=200, Percent_Identity=30.5, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI210032110, Length=262, Percent_Identity=25.5725190839695, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI4504505, Length=218, Percent_Identity=32.1100917431193, Blast_Score=78, Evalue=7e-15,
Organism=Homo sapiens, GI31542939, Length=247, Percent_Identity=30.3643724696356, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI126723191, Length=219, Percent_Identity=31.5068493150685, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI4503301, Length=254, Percent_Identity=27.5590551181102, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI40807363, Length=205, Percent_Identity=27.3170731707317, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI20149619, Length=203, Percent_Identity=29.5566502463054, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI66933014, Length=261, Percent_Identity=26.4367816091954, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI33667109, Length=203, Percent_Identity=33.0049261083744, Blast_Score=72, Evalue=6e-13,
Organism=Homo sapiens, GI32455239, Length=199, Percent_Identity=29.1457286432161, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI5031765, Length=199, Percent_Identity=29.1457286432161, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI109715829, Length=250, Percent_Identity=28, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI25282469, Length=194, Percent_Identity=26.2886597938144, Blast_Score=68, Evalue=9e-12,
Organism=Homo sapiens, GI224922801, Length=176, Percent_Identity=33.5227272727273, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI7657478, Length=198, Percent_Identity=28.2828282828283, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082100, Length=264, Percent_Identity=35.2272727272727, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1787335, Length=251, Percent_Identity=36.2549800796813, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787905, Length=245, Percent_Identity=35.9183673469388, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1790717, Length=250, Percent_Identity=30.8, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1786812, Length=263, Percent_Identity=34.6007604562738, Blast_Score=107, Evalue=7e-25,
Organism=Escherichia coli, GI1789208, Length=255, Percent_Identity=29.0196078431373, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI2367365, Length=250, Percent_Identity=33.2, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788459, Length=252, Percent_Identity=29.7619047619048, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1789378, Length=265, Percent_Identity=30.9433962264151, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI2367175, Length=246, Percent_Identity=28.4552845528455, Blast_Score=90, Evalue=2e-19,
Organism=Escherichia coli, GI87082160, Length=258, Percent_Identity=28.6821705426357, Blast_Score=87, Evalue=8e-19,
Organism=Escherichia coli, GI1789057, Length=261, Percent_Identity=29.1187739463602, Blast_Score=82, Evalue=3e-17,
Organism=Escherichia coli, GI1787526, Length=253, Percent_Identity=29.2490118577075, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=35.7976653696498, Blast_Score=130, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17555706, Length=255, Percent_Identity=34.1176470588235, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=33.3333333333333, Blast_Score=116, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17561402, Length=254, Percent_Identity=32.6771653543307, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17562904, Length=268, Percent_Identity=30.5970149253731, Blast_Score=113, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=32.319391634981, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17562906, Length=267, Percent_Identity=34.0823970037453, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17562908, Length=265, Percent_Identity=32.0754716981132, Blast_Score=107, Evalue=6e-24,
Organism=Caenorhabditis elegans, GI17560150, Length=267, Percent_Identity=31.0861423220974, Blast_Score=105, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71994600, Length=247, Percent_Identity=31.1740890688259, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17562990, Length=267, Percent_Identity=31.4606741573034, Blast_Score=104, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=28.4644194756554, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI193204405, Length=265, Percent_Identity=30.9433962264151, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17559104, Length=274, Percent_Identity=28.8321167883212, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI72000259, Length=268, Percent_Identity=30.9701492537313, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562910, Length=269, Percent_Identity=28.6245353159851, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI71994604, Length=247, Percent_Identity=31.1740890688259, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17563726, Length=264, Percent_Identity=29.9242424242424, Blast_Score=98, Evalue=6e-21,
Organism=Caenorhabditis elegans, GI17551412, Length=274, Percent_Identity=29.1970802919708, Blast_Score=97, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17560220, Length=265, Percent_Identity=28.6792452830189, Blast_Score=95, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17538480, Length=275, Percent_Identity=28.3636363636364, Blast_Score=93, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI115534694, Length=253, Percent_Identity=32.0158102766798, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17560332, Length=277, Percent_Identity=28.8808664259928, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI193203115, Length=211, Percent_Identity=28.9099526066351, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17565030, Length=272, Percent_Identity=29.0441176470588, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17538486, Length=279, Percent_Identity=27.5985663082437, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17536025, Length=261, Percent_Identity=29.5019157088123, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI193203117, Length=192, Percent_Identity=28.6458333333333, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17508651, Length=261, Percent_Identity=28.3524904214559, Blast_Score=80, Evalue=8e-16,
Organism=Caenorhabditis elegans, GI17564282, Length=213, Percent_Identity=28.6384976525822, Blast_Score=80, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17567345, Length=195, Percent_Identity=28.7179487179487, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17536651, Length=254, Percent_Identity=27.1653543307087, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI193207185, Length=153, Percent_Identity=31.3725490196078, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17561272, Length=285, Percent_Identity=30.5263157894737, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17568967, Length=213, Percent_Identity=30.0469483568075, Blast_Score=68, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17508895, Length=215, Percent_Identity=25.5813953488372, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=249, Percent_Identity=28.5140562248996, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322861, Length=237, Percent_Identity=26.5822784810127, Blast_Score=74, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323882, Length=199, Percent_Identity=27.6381909547739, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=34.5238095238095, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=33.984375, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI28571526, Length=254, Percent_Identity=33.4645669291339, Blast_Score=117, Evalue=8e-27,
Organism=Drosophila melanogaster, GI24644337, Length=266, Percent_Identity=33.4586466165414, Blast_Score=111, Evalue=5e-25,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=33.0677290836653, Blast_Score=108, Evalue=4e-24,
Organism=Drosophila melanogaster, GI23397609, Length=254, Percent_Identity=34.251968503937, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24639444, Length=248, Percent_Identity=33.4677419354839, Blast_Score=101, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24643142, Length=256, Percent_Identity=28.90625, Blast_Score=95, Evalue=6e-20,
Organism=Drosophila melanogaster, GI281364892, Length=209, Percent_Identity=29.1866028708134, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24581726, Length=176, Percent_Identity=30.6818181818182, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24640492, Length=211, Percent_Identity=26.5402843601896, Blast_Score=85, Evalue=7e-17,
Organism=Drosophila melanogaster, GI21355631, Length=178, Percent_Identity=30.3370786516854, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21358495, Length=204, Percent_Identity=29.4117647058824, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI221331218, Length=207, Percent_Identity=33.8164251207729, Blast_Score=74, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24665243, Length=207, Percent_Identity=33.8164251207729, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI18859837, Length=195, Percent_Identity=31.7948717948718, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24649181, Length=195, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24665247, Length=208, Percent_Identity=33.6538461538462, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI221331216, Length=208, Percent_Identity=33.6538461538462, Blast_Score=69, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014007
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.1.1.304 [H]

Molecular weight: Translated: 27920; Mature: 27920

Theoretical pI: Translated: 7.77; Mature: 7.77

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNGVDSRRAAPPRGGLAADFRGRTALVTGAAQGIGAAIADAFAAAGASVAIADVQGDAAA
CCCCCCCCCCCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCHHH
AFAARLAARGAADGQTVRAYRVDAARRDELFGLVAQAEADSGRLDIVVHNAAYFPLTPFG
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCEECCCCCCH
AIAPDVLERTLAVNLSALFWLTQAALPAFERVGRGRVLATSSVTGPRVAYPGLAHYAASK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
AGVNGFIRAAALELARRNVTVNGVEPGMIRTPAAGNLGDAAHGERIARGVPLGRLGEPED
CCHHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
IAAAMLFLASDAAGYITGQTIVVDGGATLPETAAALG
HHHHHHHHHCCCCCEEECCEEEEECCCCCCHHHHHCC
>Mature Secondary Structure
MNGVDSRRAAPPRGGLAADFRGRTALVTGAAQGIGAAIADAFAAAGASVAIADVQGDAAA
CCCCCCCCCCCCCCCCEECCCCCEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCCHHH
AFAARLAARGAADGQTVRAYRVDAARRDELFGLVAQAEADSGRLDIVVHNAAYFPLTPFG
HHHHHHHHCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCCCCEEEEEECCEECCCCCCH
AIAPDVLERTLAVNLSALFWLTQAALPAFERVGRGRVLATSSVTGPRVAYPGLAHYAASK
HCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHH
AGVNGFIRAAALELARRNVTVNGVEPGMIRTPAAGNLGDAAHGERIARGVPLGRLGEPED
CCHHHHHHHHHHHHHHCCCEEECCCCCCEECCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
IAAAMLFLASDAAGYITGQTIVVDGGATLPETAAALG
HHHHHHHHHCCCCCEEECCEEEEECCCCCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11173520 [H]