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The map label for this gene is glpA [H]

Identifier: 126207863

GI number: 126207863

Start: 431205

End: 432890

Strand: Direct

Name: glpA [H]

Synonym: APL_0379

Alternate gene names: 126207863

Gene position: 431205-432890 (Clockwise)

Preceding gene: 126207859

Following gene: 126207864

Centisome position: 18.96

GC content: 46.56

Gene sequence:

>1686_bases
ATGAACATTTCACCTCAGATGTATCAAAATGTTGCAGACTTTTCGCCGATTAATACCGATGTGATTATTATCGGTGGCGG
CGCAACGGGAGCCGGTATTGCGCGAGATTGCGCATTACGCGGTTTAAAATGCGTATTACTTGAACGTAGAGACATTGCAA
CCGGTGCGACCGGTCGTAATCATGGTTTACTACATAGCGGCGCACGTTATGCGGTGAATGATAGGGAATCTGCCGAAGAG
TGCATTAAAGAAAATCTAATCCTTAAACAAATCGCCCGTCATTGCGTAGATGATACCAAAGGGCTTTTCATAACCCTGCC
GGAAGATGATCTTAATTATCAGAAAAACTTTATCCAAGCCTGTACCGATTCTGGTATAGAAGCGGTCGAAATTGAGCCGG
ATCTTGCAAAATATATGGAGCCGTCCGTTAATCCGTCGTTAGTCGGTGCGGTGGTTGTGCCGGACGGTTCTATTGACCCG
TTCCGCTTAACCGCTTCCAATATGTTGGATGCAACCGAAAACGGCGCGCAGATTTTTACTTATTGTGAAGTAAAAGGTTT
GATCCGTGAGGGCGGACGAGTGATCGGGGTAAATGTGTACGATCACAGAAATCGTATTGATCGCCAATTTTTTGCGCTAA
TTGTGGTGAATGCAGGCGGGATTTGGGGGCAGGGTATCGCCGAATACGCTGATCTTAAAATTAAAATGTTCCCAGCGAAA
GGTTCGTTACTGGTAATGGGACACCGTATTAACAATATGGTGATCAACCGTTGTCGTAAACCGGCAAATGCCGACATTTT
GGTGCCGGGTGATACCATTTGTGTTATCGGGACGACTTCCGACCGTATTCCTTATGATCAAATTGACAATATGGCGGTAA
CACCGGAAGAAGTGGATGTGTTATTCCGTGAAGGGGAAAAATTAGCACCGAGTTTACGTCATACCCGTGTATTACGTGCT
TATGCGGGGGTTCGTCCATTAGTGGCAACGGACGATGATCCGTCCGGTCGTAACGTGAGCCGCGGTATCGTCTTGCTGGA
TCACGCGGAACGTGACGGTTTAGACGGTTTTATTACGATTACCGGCGGTAAACTAATGACTTATCGTTTGATGGCGGAAT
GGGCAACCGATTTGGTTTGCAAAAAATTGAATAAATCCGACCGCTTATGTAGCACGGCGGAGCGTCCGCTTCCTGGGTCA
AATGAAAGCCGTGAAGAGACCAGTAAAAAAATCATTTCGCTACCGAATACGATTCGTCATTCTGCGGTTTATCGTCACGG
TTCCAGAGCATTACGTTTACTCGAAACCGAGCGTTTAGATAAAACTTTAGTGTGTGAATGTGAAGCGGTGACCGCTGGTG
AAGTTCGCTATGCGGTTGATGAGCTGAATGTGAATAATTTAGTTGATTTACGCCGCCGTACTCGTGTCGGTATGGGAACT
TGCCAAGCGGAGCTTTGTGCTTGCCGTGCTGCAGGTCTGATGAGTCGTTTTAAAGTGGCGACACCGAAAGAATCAACCAC
ACAATTAGCCTCATTTATGGAAGAACGTTGGCGTGGAATTCAACCGATTGCATGGGGGGATGCAATGCGAGAAGCGGAAT
TTACCAGTTGGATTTACTACAGCCTACTCGGATTGAATGATGTGCCGATGGACAAAGAGCAGGGAGTGAATAGCAATGAA
TTTTGA

Upstream 100 bases:

>100_bases
CTTTTTTGCTCATTTGCTTGTTCAAAAACGCTCATTTTAATACAATGCAGTTATTTTAATTTGTTCGTTTCATTTCATTT
AAGTGTGGGAGAGGTTGAGT

Downstream 100 bases:

>100_bases
TGTAGTGATTATTGGCGGCGGGCTTGCCGGTTTAACCTGTGGGATTGCGCTTCAAGAACAAGGTAAACGCTGTGTGATTA
TCAACAACGGACAGGCGGCA

Product: sn-glycerol-3-phosphate dehydrogenase subunit A

Products: NA

Alternate protein names: G-3-P dehydrogenase [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MNISPQMYQNVADFSPINTDVIIIGGGATGAGIARDCALRGLKCVLLERRDIATGATGRNHGLLHSGARYAVNDRESAEE
CIKENLILKQIARHCVDDTKGLFITLPEDDLNYQKNFIQACTDSGIEAVEIEPDLAKYMEPSVNPSLVGAVVVPDGSIDP
FRLTASNMLDATENGAQIFTYCEVKGLIREGGRVIGVNVYDHRNRIDRQFFALIVVNAGGIWGQGIAEYADLKIKMFPAK
GSLLVMGHRINNMVINRCRKPANADILVPGDTICVIGTTSDRIPYDQIDNMAVTPEEVDVLFREGEKLAPSLRHTRVLRA
YAGVRPLVATDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDLVCKKLNKSDRLCSTAERPLPGS
NESREETSKKIISLPNTIRHSAVYRHGSRALRLLETERLDKTLVCECEAVTAGEVRYAVDELNVNNLVDLRRRTRVGMGT
CQAELCACRAAGLMSRFKVATPKESTTQLASFMEERWRGIQPIAWGDAMREAEFTSWIYYSLLGLNDVPMDKEQGVNSNE
F

Sequences:

>Translated_561_residues
MNISPQMYQNVADFSPINTDVIIIGGGATGAGIARDCALRGLKCVLLERRDIATGATGRNHGLLHSGARYAVNDRESAEE
CIKENLILKQIARHCVDDTKGLFITLPEDDLNYQKNFIQACTDSGIEAVEIEPDLAKYMEPSVNPSLVGAVVVPDGSIDP
FRLTASNMLDATENGAQIFTYCEVKGLIREGGRVIGVNVYDHRNRIDRQFFALIVVNAGGIWGQGIAEYADLKIKMFPAK
GSLLVMGHRINNMVINRCRKPANADILVPGDTICVIGTTSDRIPYDQIDNMAVTPEEVDVLFREGEKLAPSLRHTRVLRA
YAGVRPLVATDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDLVCKKLNKSDRLCSTAERPLPGS
NESREETSKKIISLPNTIRHSAVYRHGSRALRLLETERLDKTLVCECEAVTAGEVRYAVDELNVNNLVDLRRRTRVGMGT
CQAELCACRAAGLMSRFKVATPKESTTQLASFMEERWRGIQPIAWGDAMREAEFTSWIYYSLLGLNDVPMDKEQGVNSNE
F
>Mature_561_residues
MNISPQMYQNVADFSPINTDVIIIGGGATGAGIARDCALRGLKCVLLERRDIATGATGRNHGLLHSGARYAVNDRESAEE
CIKENLILKQIARHCVDDTKGLFITLPEDDLNYQKNFIQACTDSGIEAVEIEPDLAKYMEPSVNPSLVGAVVVPDGSIDP
FRLTASNMLDATENGAQIFTYCEVKGLIREGGRVIGVNVYDHRNRIDRQFFALIVVNAGGIWGQGIAEYADLKIKMFPAK
GSLLVMGHRINNMVINRCRKPANADILVPGDTICVIGTTSDRIPYDQIDNMAVTPEEVDVLFREGEKLAPSLRHTRVLRA
YAGVRPLVATDDDPSGRNVSRGIVLLDHAERDGLDGFITITGGKLMTYRLMAEWATDLVCKKLNKSDRLCSTAERPLPGS
NESREETSKKIISLPNTIRHSAVYRHGSRALRLLETERLDKTLVCECEAVTAGEVRYAVDELNVNNLVDLRRRTRVGMGT
CQAELCACRAAGLMSRFKVATPKESTTQLASFMEERWRGIQPIAWGDAMREAEFTSWIYYSLLGLNDVPMDKEQGVNSNE
F

Specific function: Conversion Of Glycerol 3-Phosphate To Dihydroxyacetone. Uses Fumarate Or Nitrate As Electron Acceptor. [C]

COG id: COG0578

COG function: function code C; Glycerol-3-phosphate dehydrogenase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=Loosely bound to the cytoplasmic membrane often occurring in vesicles associated with fumarate reductase (By similarity) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI285002233, Length=539, Percent_Identity=26.530612244898, Blast_Score=114, Evalue=3e-25,
Organism=Homo sapiens, GI285002231, Length=539, Percent_Identity=26.530612244898, Blast_Score=114, Evalue=3e-25,
Organism=Escherichia coli, GI1788574, Length=520, Percent_Identity=69.6153846153846, Blast_Score=745, Evalue=0.0,
Organism=Caenorhabditis elegans, GI115534726, Length=391, Percent_Identity=27.1099744245524, Blast_Score=87, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI17509253, Length=416, Percent_Identity=28.6057692307692, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI161077125, Length=404, Percent_Identity=28.7128712871287, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24653942, Length=404, Percent_Identity=28.7128712871287, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI24653944, Length=404, Percent_Identity=28.7128712871287, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20130025, Length=404, Percent_Identity=28.7128712871287, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20130091, Length=243, Percent_Identity=30.4526748971193, Blast_Score=86, Evalue=9e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007419
- InterPro:   IPR006076
- InterPro:   IPR017752
- InterPro:   IPR000447 [H]

Pfam domain/function: PF01266 DAO; PF04324 Fer2_BFD [H]

EC number: =1.1.5.3 [H]

Molecular weight: Translated: 61957; Mature: 61957

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00977 FAD_G3PDH_1 ; PS00978 FAD_G3PDH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNISPQMYQNVADFSPINTDVIIIGGGATGAGIARDCALRGLKCVLLERRDIATGATGRN
CCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCC
HGLLHSGARYAVNDRESAEECIKENLILKQIARHCVDDTKGLFITLPEDDLNYQKNFIQA
CCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
CTDSGIEAVEIEPDLAKYMEPSVNPSLVGAVVVPDGSIDPFRLTASNMLDATENGAQIFT
HHCCCCEEEEECHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEHHHHHCCCCCCCEEEE
YCEVKGLIREGGRVIGVNVYDHRNRIDRQFFALIVVNAGGIWGQGIAEYADLKIKMFPAK
EEHHHHHHHCCCEEEEEEEEHHHHHHHHEEEEEEEEECCCCCCCCHHHHHCEEEEEECCC
GSLLVMGHRINNMVINRCRKPANADILVPGDTICVIGTTSDRIPYDQIDNMAVTPEEVDV
CCEEEEECHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHCCCCCCCHHHHHH
LFREGEKLAPSLRHTRVLRAYAGVRPLVATDDDPSGRNVSRGIVLLDHAERDGLDGFITI
HHHCCCHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEE
TGGKLMTYRLMAEWATDLVCKKLNKSDRLCSTAERPLPGSNESREETSKKIISLPNTIRH
ECCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHH
SAVYRHGSRALRLLETERLDKTLVCECEAVTAGEVRYAVDELNVNNLVDLRRRTRVGMGT
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCH
CQAELCACRAAGLMSRFKVATPKESTTQLASFMEERWRGIQPIAWGDAMREAEFTSWIYY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHH
SLLGLNDVPMDKEQGVNSNEF
HHHCCCCCCCCHHCCCCCCCC
>Mature Secondary Structure
MNISPQMYQNVADFSPINTDVIIIGGGATGAGIARDCALRGLKCVLLERRDIATGATGRN
CCCCHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHCCCEEEEEECCCCCCCCCCCC
HGLLHSGARYAVNDRESAEECIKENLILKQIARHCVDDTKGLFITLPEDDLNYQKNFIQA
CCCEECCCCEEECCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHH
CTDSGIEAVEIEPDLAKYMEPSVNPSLVGAVVVPDGSIDPFRLTASNMLDATENGAQIFT
HHCCCCEEEEECHHHHHHCCCCCCCCCEEEEEECCCCCCCEEEEHHHHHCCCCCCCEEEE
YCEVKGLIREGGRVIGVNVYDHRNRIDRQFFALIVVNAGGIWGQGIAEYADLKIKMFPAK
EEHHHHHHHCCCEEEEEEEEHHHHHHHHEEEEEEEEECCCCCCCCHHHHHCEEEEEECCC
GSLLVMGHRINNMVINRCRKPANADILVPGDTICVIGTTSDRIPYDQIDNMAVTPEEVDV
CCEEEEECHHHHHHHHHCCCCCCCEEEECCCEEEEEECCCCCCCHHHCCCCCCCHHHHHH
LFREGEKLAPSLRHTRVLRAYAGVRPLVATDDDPSGRNVSRGIVLLDHAERDGLDGFITI
HHHCCCHHCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCEEEEECCCCCCCCEEEEE
TGGKLMTYRLMAEWATDLVCKKLNKSDRLCSTAERPLPGSNESREETSKKIISLPNTIRH
ECCCEEHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCHHHHH
SAVYRHGSRALRLLETERLDKTLVCECEAVTAGEVRYAVDELNVNNLVDLRRRTRVGMGT
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCEEEEHHHCCCHHHHHHHHHHHCCCCH
CQAELCACRAAGLMSRFKVATPKESTTQLASFMEERWRGIQPIAWGDAMREAEFTSWIYY
HHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHH
SLLGLNDVPMDKEQGVNSNEF
HHHCCCCCCCCHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]