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The map label for this gene is norM [H]

Identifier: 126207853

GI number: 126207853

Start: 414627

End: 416018

Strand: Direct

Name: norM [H]

Synonym: APL_0369

Alternate gene names: 126207853

Gene position: 414627-416018 (Clockwise)

Preceding gene: 126207852

Following gene: 126207854

Centisome position: 18.23

GC content: 42.53

Gene sequence:

>1392_bases
ATGAATCTGCAATGGCAAAGATATCCGGAAAACACACGTAAACTATTTAAACTCACGCTGCCGATTTTTATTTCTCAGCT
CTCGGTAGCGGGGATGGGGCTTGCCGATATTGTGATGGCTGGGCTGGTGAGTGACGATGATGTGTCTGCGATTGCGGTGA
GTAATTCCATTTATTTCCCTCTCTTTTTATTTGTATTAGGTTTGCTTAATGTGATTACCCCGACCGTTTCTTACTTAAAC
GGCTCAAACCAACGTCATTTAATTGCCCATCAAATTCGCCAAGGCTTTTGGTTGGTTTTAGTATGTTCCGTTCCGTTGAT
TATCGTATTTCTAAATAGCCATTGGATTTTAGACTATATGAATACGCCGCAAGCCTTTTCGACTAAATCGCAGCAATATT
TGGCGATTATGGCGATTGGGGTAGTGCCGGCATTATTAGGCATTAATTTACGTTGTATGAATGACGGCTTATCCAATCCG
AAGCCGGCAATGCGTATTATGTTCTTCGGGTTATTGCTGAATATTCCGCTTAATTATATTTTTATTTTCGGTAAATTCGG
TTTACCGGAAATGGGGGCGGTCGGTTGCGGTATGGCGACTGCGATAGTGAACTGGATAATGTTCTTATTACTATTTCATT
ACAGTTATACAAACAAATCCCAAAAAGATATCGGCTTATTTAACCGTTGGTTTGAAATGCCAAGCGGTCAAACTTTGTTG
AAAATTTGCAAATTGGGTTTACCGATCGGCTTTGCAACGTTTACCGAAGTGATGTTGTTCTCCACATCTGCTTTACTGCT
TTCACCGCTCGGCTCGCAAGTGGTGGCAAGTCATCAGGCGGCACTGCAAACCAGTTCGTTATTATTTATGATCCCGATGT
CTTTCAGTATTGCGACCACGATTGTGGTAGGAAAAACCTTGGGGCAGAAACAAGTTGAACAGGCAAAAATTATTAGCTAT
CACGCGCTGATTACCGGAGCGCTATTTGCGTTAGCGGCAGCGGTCGTGATTGTTATTTTAGATGAAATTATTCCGCTGGC
GTTTACCAGCGATCCGGTGTCGATTGCAATTGCGGCGCATTTATTGTTGTTTGCGGCGGTGTATCAAATTCCGGATTCGT
TACAAGCGGTGGCAAACGGTATTCTGCGTGGCTATAAACATACCAAACCGATTTTATATGTCACGATGTTCTGTTACTGG
GTGATTGGTATGCCGTTCGGCTATATTTTAGCGAGAACGGATTGGATTGTTGAACCGATGGCGGCATCAGGCTTTTGGTT
TATTTTCTGCGTCAGTTTAAGTATCGCTGCCGGTTTGTTAATTTACCAAATGCACAAAATTCAACAGATTCCTGCAGAAC
AGCTGCTGGCAAAATTAGAACGAATAAAGTAA

Upstream 100 bases:

>100_bases
GGGCTTTTCGTTTTTACAAGCGGTCTAATTTTGCAAAATTTTTGCGAAAAACAGCCGCTTGTTGCCGTATAATAACCTCC
GTATTTTGAAAGAGGTAATT

Downstream 100 bases:

>100_bases
GAAGTATTGAGAGTCATGAAAACCCTTTCTCCGATTGAATTGCCGTTAAATTGTACCGCATTAATTGAAGCGTCCGCCGG
TACCGGTAAAACCTTTACCA

Product: putative multidrug resistance protein NorM

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MNLQWQRYPENTRKLFKLTLPIFISQLSVAGMGLADIVMAGLVSDDDVSAIAVSNSIYFPLFLFVLGLLNVITPTVSYLN
GSNQRHLIAHQIRQGFWLVLVCSVPLIIVFLNSHWILDYMNTPQAFSTKSQQYLAIMAIGVVPALLGINLRCMNDGLSNP
KPAMRIMFFGLLLNIPLNYIFIFGKFGLPEMGAVGCGMATAIVNWIMFLLLFHYSYTNKSQKDIGLFNRWFEMPSGQTLL
KICKLGLPIGFATFTEVMLFSTSALLLSPLGSQVVASHQAALQTSSLLFMIPMSFSIATTIVVGKTLGQKQVEQAKIISY
HALITGALFALAAAVVIVILDEIIPLAFTSDPVSIAIAAHLLLFAAVYQIPDSLQAVANGILRGYKHTKPILYVTMFCYW
VIGMPFGYILARTDWIVEPMAASGFWFIFCVSLSIAAGLLIYQMHKIQQIPAEQLLAKLERIK

Sequences:

>Translated_463_residues
MNLQWQRYPENTRKLFKLTLPIFISQLSVAGMGLADIVMAGLVSDDDVSAIAVSNSIYFPLFLFVLGLLNVITPTVSYLN
GSNQRHLIAHQIRQGFWLVLVCSVPLIIVFLNSHWILDYMNTPQAFSTKSQQYLAIMAIGVVPALLGINLRCMNDGLSNP
KPAMRIMFFGLLLNIPLNYIFIFGKFGLPEMGAVGCGMATAIVNWIMFLLLFHYSYTNKSQKDIGLFNRWFEMPSGQTLL
KICKLGLPIGFATFTEVMLFSTSALLLSPLGSQVVASHQAALQTSSLLFMIPMSFSIATTIVVGKTLGQKQVEQAKIISY
HALITGALFALAAAVVIVILDEIIPLAFTSDPVSIAIAAHLLLFAAVYQIPDSLQAVANGILRGYKHTKPILYVTMFCYW
VIGMPFGYILARTDWIVEPMAASGFWFIFCVSLSIAAGLLIYQMHKIQQIPAEQLLAKLERIK
>Mature_463_residues
MNLQWQRYPENTRKLFKLTLPIFISQLSVAGMGLADIVMAGLVSDDDVSAIAVSNSIYFPLFLFVLGLLNVITPTVSYLN
GSNQRHLIAHQIRQGFWLVLVCSVPLIIVFLNSHWILDYMNTPQAFSTKSQQYLAIMAIGVVPALLGINLRCMNDGLSNP
KPAMRIMFFGLLLNIPLNYIFIFGKFGLPEMGAVGCGMATAIVNWIMFLLLFHYSYTNKSQKDIGLFNRWFEMPSGQTLL
KICKLGLPIGFATFTEVMLFSTSALLLSPLGSQVVASHQAALQTSSLLFMIPMSFSIATTIVVGKTLGQKQVEQAKIISY
HALITGALFALAAAVVIVILDEIIPLAFTSDPVSIAIAAHLLLFAAVYQIPDSLQAVANGILRGYKHTKPILYVTMFCYW
VIGMPFGYILARTDWIVEPMAASGFWFIFCVSLSIAAGLLIYQMHKIQQIPAEQLLAKLERIK

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=412, Percent_Identity=24.2718446601942, Blast_Score=86, Evalue=6e-17,
Organism=Escherichia coli, GI48994890, Length=457, Percent_Identity=43.7636761487965, Blast_Score=357, Evalue=1e-99,
Organism=Escherichia coli, GI226510954, Length=442, Percent_Identity=21.4932126696833, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 51192; Mature: 51192

Theoretical pI: Translated: 9.06; Mature: 9.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLQWQRYPENTRKLFKLTLPIFISQLSVAGMGLADIVMAGLVSDDDVSAIAVSNSIYFP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEECCCHHHH
LFLFVLGLLNVITPTVSYLNGSNQRHLIAHQIRQGFWLVLVCSVPLIIVFLNSHWILDYM
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEC
NTPQAFSTKSQQYLAIMAIGVVPALLGINLRCMNDGLSNPKPAMRIMFFGLLLNIPLNYI
CCCCHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCHHEE
FIFGKFGLPEMGAVGCGMATAIVNWIMFLLLFHYSYTNKSQKDIGLFNRWFEMPSGQTLL
EEEECCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHH
KICKLGLPIGFATFTEVMLFSTSALLLSPLGSQVVASHQAALQTSSLLFMIPMSFSIATT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECHHHHHHH
IVVGKTLGQKQVEQAKIISYHALITGALFALAAAVVIVILDEIIPLAFTSDPVSIAIAAH
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
LLLFAAVYQIPDSLQAVANGILRGYKHTKPILYVTMFCYWVIGMPFGYILARTDWIVEPM
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCH
AASGFWFIFCVSLSIAAGLLIYQMHKIQQIPAEQLLAKLERIK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC
>Mature Secondary Structure
MNLQWQRYPENTRKLFKLTLPIFISQLSVAGMGLADIVMAGLVSDDDVSAIAVSNSIYFP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCEEEECCCHHHH
LFLFVLGLLNVITPTVSYLNGSNQRHLIAHQIRQGFWLVLVCSVPLIIVFLNSHWILDYM
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHCCCEEEEEC
NTPQAFSTKSQQYLAIMAIGVVPALLGINLRCMNDGLSNPKPAMRIMFFGLLLNIPLNYI
CCCCHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHCCHHEE
FIFGKFGLPEMGAVGCGMATAIVNWIMFLLLFHYSYTNKSQKDIGLFNRWFEMPSGQTLL
EEEECCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHH
KICKLGLPIGFATFTEVMLFSTSALLLSPLGSQVVASHQAALQTSSLLFMIPMSFSIATT
HHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCEEEEEECHHHHHHH
IVVGKTLGQKQVEQAKIISYHALITGALFALAAAVVIVILDEIIPLAFTSDPVSIAIAAH
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCHHHHHHHH
LLLFAAVYQIPDSLQAVANGILRGYKHTKPILYVTMFCYWVIGMPFGYILARTDWIVEPM
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCH
AASGFWFIFCVSLSIAAGLLIYQMHKIQQIPAEQLLAKLERIK
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA