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The map label for this gene is ung

Identifier: 126207846

GI number: 126207846

Start: 403081

End: 403758

Strand: Direct

Name: ung

Synonym: APL_0362

Alternate gene names: 126207846

Gene position: 403081-403758 (Clockwise)

Preceding gene: 126207843

Following gene: 126207852

Centisome position: 17.72

GC content: 41.15

Gene sequence:

>678_bases
ATGAATAATTGGACAGAAGCACTGGGCGAAGAAAAACAACAACCTTATTTTCAGCATATCTTACAACAAGTACATCAAGA
AAGAATGAATGGTGTAACGGTTTTCCCACCGCAAAAAGAAGTATTTAGTGCCTTTGCTTTAACGGAGTTTAAAGATGTGA
AAGTGGTGATCTTGGGGCAAGATCCTTACCATGGTCCAAACCAAGCGCACGGTTTAGCATTTTCGGTAAAACCACCGGTC
GCGCCGCCACCTTCTTTAGTTAATATGTATAAAGAATTGGCGCAGGATGTTGAGGGCTTTCAAATTCCAAATCACGGATA
TTTGGTTGATTGGGCAAAGCAAGGCGTGTTGTTGCTGAATACTGTACTCACAGTGCGTCAAGGACAAGCACATTCACACG
CCAATTTCGGTTGGGAAATTTTCACCGATAAAGTGATTGCTCAACTTAACCAACACCGTGAAAATTTAGTCTTTTTATTA
TGGGGGAGCCATGCGCAGAAAAAAGGGCAGTTTATTGACCGCTCTCGCCACTGCGTATTGACTGCACCGCATCCATCACC
GCTTTCTGCTTATCGTGGATTTTTTGGATGTAAGCATTTTTCAAAAACCAATAGATATTTGCTTTCGAAAGGAATAGCTC
CGATTAATTGGCAATTACGACTAGAAATAGATTATTAA

Upstream 100 bases:

>100_bases
AGTTGAGTGAATATAGTTTAAATATTACTAATTGAATAAAAAATAAGCTAAAATGTGAAAAAAACTTAAAAATTTTTAAC
ACGCTTTAACAGGAGAAGTA

Downstream 100 bases:

>100_bases
TAACAGTATTGCATAATATTTACGTAAAAGACCAATCTAATAAAAGATTGGTCTTTTACGTAAGAGAAATAAATTTGTCT
AGATTATTATATGTATATTA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MNNWTEALGEEKQQPYFQHILQQVHQERMNGVTVFPPQKEVFSAFALTEFKDVKVVILGQDPYHGPNQAHGLAFSVKPPV
APPPSLVNMYKELAQDVEGFQIPNHGYLVDWAKQGVLLLNTVLTVRQGQAHSHANFGWEIFTDKVIAQLNQHRENLVFLL
WGSHAQKKGQFIDRSRHCVLTAPHPSPLSAYRGFFGCKHFSKTNRYLLSKGIAPINWQLRLEIDY

Sequences:

>Translated_225_residues
MNNWTEALGEEKQQPYFQHILQQVHQERMNGVTVFPPQKEVFSAFALTEFKDVKVVILGQDPYHGPNQAHGLAFSVKPPV
APPPSLVNMYKELAQDVEGFQIPNHGYLVDWAKQGVLLLNTVLTVRQGQAHSHANFGWEIFTDKVIAQLNQHRENLVFLL
WGSHAQKKGQFIDRSRHCVLTAPHPSPLSAYRGFFGCKHFSKTNRYLLSKGIAPINWQLRLEIDY
>Mature_225_residues
MNNWTEALGEEKQQPYFQHILQQVHQERMNGVTVFPPQKEVFSAFALTEFKDVKVVILGQDPYHGPNQAHGLAFSVKPPV
APPPSLVNMYKELAQDVEGFQIPNHGYLVDWAKQGVLLLNTVLTVRQGQAHSHANFGWEIFTDKVIAQLNQHRENLVFLL
WGSHAQKKGQFIDRSRHCVLTAPHPSPLSAYRGFFGCKHFSKTNRYLLSKGIAPINWQLRLEIDY

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family

Homologues:

Organism=Homo sapiens, GI19718751, Length=216, Percent_Identity=61.1111111111111, Blast_Score=264, Evalue=6e-71,
Organism=Homo sapiens, GI6224979, Length=216, Percent_Identity=61.1111111111111, Blast_Score=263, Evalue=8e-71,
Organism=Escherichia coli, GI1788934, Length=215, Percent_Identity=69.7674418604651, Blast_Score=320, Evalue=5e-89,
Organism=Caenorhabditis elegans, GI17556304, Length=216, Percent_Identity=50.462962962963, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6323620, Length=234, Percent_Identity=48.7179487179487, Blast_Score=196, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UNG_ACTP2 (A3MZ80)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001053071.1
- ProteinModelPortal:   A3MZ80
- SMR:   A3MZ80
- STRING:   A3MZ80
- GeneID:   4848615
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0362
- eggNOG:   COG0692
- HOGENOM:   HBG605450
- OMA:   GAHAQKK
- PhylomeDB:   A3MZ80
- ProtClustDB:   PRK05254
- BioCyc:   APLE416269:APL_0362-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00148
- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122
- Gene3D:   G3DSA:3.40.470.10
- PANTHER:   PTHR11264
- TIGRFAMs:   TIGR00628

Pfam domain/function: PF03167 UDG; SSF52141 UDNA_glycsylseSF

EC number: =3.2.2.27

Molecular weight: Translated: 25694; Mature: 25694

Theoretical pI: Translated: 9.03; Mature: 9.03

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: ACT_SITE 61-61

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNWTEALGEEKQQPYFQHILQQVHQERMNGVTVFPPQKEVFSAFALTEFKDVKVVILGQ
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCCEEEEEECC
DPYHGPNQAHGLAFSVKPPVAPPPSLVNMYKELAQDVEGFQIPNHGYLVDWAKQGVLLLN
CCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHHH
TVLTVRQGQAHSHANFGWEIFTDKVIAQLNQHRENLVFLLWGSHAQKKGQFIDRSRHCVL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCCCCEEE
TAPHPSPLSAYRGFFGCKHFSKTNRYLLSKGIAPINWQLRLEIDY
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC
>Mature Secondary Structure
MNNWTEALGEEKQQPYFQHILQQVHQERMNGVTVFPPQKEVFSAFALTEFKDVKVVILGQ
CCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHCCCCCEEEEEECC
DPYHGPNQAHGLAFSVKPPVAPPPSLVNMYKELAQDVEGFQIPNHGYLVDWAKQGVLLLN
CCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCHHHH
TVLTVRQGQAHSHANFGWEIFTDKVIAQLNQHRENLVFLLWGSHAQKKGQFIDRSRHCVL
HHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCHHCCCCCEEE
TAPHPSPLSAYRGFFGCKHFSKTNRYLLSKGIAPINWQLRLEIDY
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA