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The map label for this gene is fadR [H]

Identifier: 126207807

GI number: 126207807

Start: 360456

End: 361184

Strand: Direct

Name: fadR [H]

Synonym: APL_0323

Alternate gene names: 126207807

Gene position: 360456-361184 (Clockwise)

Preceding gene: 126207803

Following gene: 126207808

Centisome position: 15.85

GC content: 39.37

Gene sequence:

>729_bases
ATGGACAACTCTTATATTTTAAAAGCTCAAAGTCCTGCGGCACTGGCAGAAGAATATATTGTCAGAAGTATTTGGAATAA
TAAATTTCCGGCGGGGACGGATTTGCCTGCCGAACGTGAGTTGGCGGATAAAATCGGAGTAACCAGAACAACATTACGAG
AAGTGTTACAAAGACTGGCGCGTGACGGTTGGTTACATATTCAGCATGGAAAACCGACCCGAGTGAATGACGTGTGGGAA
ACGGCAGGGCCGAATATAATCAGCACGATTATTAAATTAGATAGATCATACCTTCCGGTTATTATTGCGAATGTAGTTTC
ACTACGAACTCGTATGGCGGAATCTTATATTCCGGAGGCGGTAAGATTAAATGCGGAAGCATGTGTCGCATTTTTTAATC
AATTGGATGAATTGGAAGATACGGCGGATGCATTTGCCACTTTTGATTATAAACTGTTTAGACAATTTACTTTTACCGCA
AATAAACCAGTATATGCCTTGATTTTAAACAGCTTTAAAGGTATGTATCATCAAGTCGCAAGTATTTTCTTTGCCGATCC
CGTTTGCCGTCAGCTGACATTAAAATTTTATCGTGACTTATTAAATGCGTGTGTAGAAAAAGATCATGAGAAAGCCTCAT
TGATTATGGCGCAAAATCGCCAATCAAGCAGCGAAATTTGGGGAAAACTTTTACAAAGTATTCCGGAAAATTTCGGTGAA
TTAAAATAG

Upstream 100 bases:

>100_bases
GCCTTTATCTCATTTTTTACGAGATTTTTTTTGATTTTGAATAAAAATTGTTTCTTTTTTTAAATTTTGGGTCACTTTTG
CGGAGCAGGGAATTTTATAC

Downstream 100 bases:

>100_bases
GATATGTTTTGAACGAAATTCTCTTCACTTTAGAACCACAGGATAACGCTCGTTTACAATCGCTTTGCGGCGCATTTGAC
GAGCATTTAACTTTAATTGA

Product: fatty acid metabolism regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 242; Mature: 242

Protein sequence:

>242_residues
MDNSYILKAQSPAALAEEYIVRSIWNNKFPAGTDLPAERELADKIGVTRTTLREVLQRLARDGWLHIQHGKPTRVNDVWE
TAGPNIISTIIKLDRSYLPVIIANVVSLRTRMAESYIPEAVRLNAEACVAFFNQLDELEDTADAFATFDYKLFRQFTFTA
NKPVYALILNSFKGMYHQVASIFFADPVCRQLTLKFYRDLLNACVEKDHEKASLIMAQNRQSSSEIWGKLLQSIPENFGE
LK

Sequences:

>Translated_242_residues
MDNSYILKAQSPAALAEEYIVRSIWNNKFPAGTDLPAERELADKIGVTRTTLREVLQRLARDGWLHIQHGKPTRVNDVWE
TAGPNIISTIIKLDRSYLPVIIANVVSLRTRMAESYIPEAVRLNAEACVAFFNQLDELEDTADAFATFDYKLFRQFTFTA
NKPVYALILNSFKGMYHQVASIFFADPVCRQLTLKFYRDLLNACVEKDHEKASLIMAQNRQSSSEIWGKLLQSIPENFGE
LK
>Mature_242_residues
MDNSYILKAQSPAALAEEYIVRSIWNNKFPAGTDLPAERELADKIGVTRTTLREVLQRLARDGWLHIQHGKPTRVNDVWE
TAGPNIISTIIKLDRSYLPVIIANVVSLRTRMAESYIPEAVRLNAEACVAFFNQLDELEDTADAFATFDYKLFRQFTFTA
NKPVYALILNSFKGMYHQVASIFFADPVCRQLTLKFYRDLLNACVEKDHEKASLIMAQNRQSSSEIWGKLLQSIPENFGE
LK

Specific function: Multifunctional regulator of fatty acid metabolism [H]

COG id: COG2186

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH gntR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787436, Length=233, Percent_Identity=48.4978540772532, Blast_Score=245, Evalue=2e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014178
- InterPro:   IPR008920
- InterPro:   IPR000524
- InterPro:   IPR011991 [H]

Pfam domain/function: PF07840 FadR_C; PF00392 GntR [H]

EC number: NA

Molecular weight: Translated: 27579; Mature: 27579

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDNSYILKAQSPAALAEEYIVRSIWNNKFPAGTDLPAERELADKIGVTRTTLREVLQRLA
CCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
RDGWLHIQHGKPTRVNDVWETAGPNIISTIIKLDRSYLPVIIANVVSLRTRMAESYIPEA
HCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VRLNAEACVAFFNQLDELEDTADAFATFDYKLFRQFTFTANKPVYALILNSFKGMYHQVA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SIFFADPVCRQLTLKFYRDLLNACVEKDHEKASLIMAQNRQSSSEIWGKLLQSIPENFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
LK
CC
>Mature Secondary Structure
MDNSYILKAQSPAALAEEYIVRSIWNNKFPAGTDLPAERELADKIGVTRTTLREVLQRLA
CCCCEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHH
RDGWLHIQHGKPTRVNDVWETAGPNIISTIIKLDRSYLPVIIANVVSLRTRMAESYIPEA
HCCCEEEECCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
VRLNAEACVAFFNQLDELEDTADAFATFDYKLFRQFTFTANKPVYALILNSFKGMYHQVA
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SIFFADPVCRQLTLKFYRDLLNACVEKDHEKASLIMAQNRQSSSEIWGKLLQSIPENFGE
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
LK
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA; DNA [C]

Specific reaction: Activates transcription of at least two genes required for unsaturated fatty acid biosynthesis; activates the iclR gene encoding the transcription regulator of the aceBAKoperon which in turn encodes the glyoxylate shunt enzymes Protein + DNA = Protein-DN

General reaction: NA

Inhibitor: Fatty acyl CoA compounds [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA