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The map label for this gene is mutT [H]

Identifier: 126207729

GI number: 126207729

Start: 259316

End: 259714

Strand: Direct

Name: mutT [H]

Synonym: APL_0241

Alternate gene names: 126207729

Gene position: 259316-259714 (Clockwise)

Preceding gene: 126207728

Following gene: 126207730

Centisome position: 11.4

GC content: 43.86

Gene sequence:

>399_bases
ATGAATAAACCCGTAATCCAAGTTGCAGCCGGTATTATCCGTAATGAATTTGGACAGATTTATTTAACGCAAAGGCTTGA
AGGACAAGATTTTGCACAAGCGTTAGAATTCCCCGGCGGTAAAGTCGATGCGGGAGAAACGCCGGAAGAAGCGTTAAAAC
GCGAGCTGGAAGAAGAAATCGGTATTCACATATTAAGTGCGTTTCCCTATGAATCGTTCCGATTTGATTATCCGACCAAA
GTAATTGAGTTTTTCTTTTATTTAGTGGAAGAATGGGTTGGCGAACCCTTTGGGCGTGAAGGTCAAGAAGGCTTTTGGGT
GGCTCAAGCCGATTTGGACGAGAGCGAATTTCCGCCGGCGAATAGCCGTTTAATCCAGCGTTTAAAATCCGAAGTTTAA

Upstream 100 bases:

>100_bases
ATGACAGCGTGAAACTTTTTCGCCAAGACGCTAGTCTGAATTGGCAATCCGTGATAAAAAATATTCAACAACAACTACAA
CACATACTCAAGGAAAATAC

Downstream 100 bases:

>100_bases
AAATGAACGGCATTTTATTAGAAATGCCGTTTTTTATGTCATAAAAAAATTTAAATTATCATTAATAAGAAATACTTGGA
AAAGTATAAATTCTTTTTAA

Product: mutator mutT protein

Products: NA

Alternate protein names: 7,8-dihydro-8-oxoguanine-triphosphatase; 8-oxo-dGTPase; dGTP pyrophosphohydrolase [H]

Number of amino acids: Translated: 132; Mature: 132

Protein sequence:

>132_residues
MNKPVIQVAAGIIRNEFGQIYLTQRLEGQDFAQALEFPGGKVDAGETPEEALKRELEEEIGIHILSAFPYESFRFDYPTK
VIEFFFYLVEEWVGEPFGREGQEGFWVAQADLDESEFPPANSRLIQRLKSEV

Sequences:

>Translated_132_residues
MNKPVIQVAAGIIRNEFGQIYLTQRLEGQDFAQALEFPGGKVDAGETPEEALKRELEEEIGIHILSAFPYESFRFDYPTK
VIEFFFYLVEEWVGEPFGREGQEGFWVAQADLDESEFPPANSRLIQRLKSEV
>Mature_132_residues
MNKPVIQVAAGIIRNEFGQIYLTQRLEGQDFAQALEFPGGKVDAGETPEEALKRELEEEIGIHILSAFPYESFRFDYPTK
VIEFFFYLVEEWVGEPFGREGQEGFWVAQADLDESEFPPANSRLIQRLKSEV

Specific function: Involved in the GO system responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with almost equal efficiency thus lea

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1786288, Length=124, Percent_Identity=46.7741935483871, Blast_Score=124, Evalue=2e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003561
- InterPro:   IPR020476
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.-

Molecular weight: Translated: 15134; Mature: 15134

Theoretical pI: Translated: 4.11; Mature: 4.11

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKPVIQVAAGIIRNEFGQIYLTQRLEGQDFAQALEFPGGKVDAGETPEEALKRELEEEI
CCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GIHILSAFPYESFRFDYPTKVIEFFFYLVEEWVGEPFGREGQEGFWVAQADLDESEFPPA
CEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCC
NSRLIQRLKSEV
HHHHHHHHHHCC
>Mature Secondary Structure
MNKPVIQVAAGIIRNEFGQIYLTQRLEGQDFAQALEFPGGKVDAGETPEEALKRELEEEI
CCCHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
GIHILSAFPYESFRFDYPTKVIEFFFYLVEEWVGEPFGREGQEGFWVAQADLDESEFPPA
CEEHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCC
NSRLIQRLKSEV
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on acid anhydrides; In phosphorus-containing anhydrides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]