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The map label for this gene is hemE

Identifier: 126207600

GI number: 126207600

Start: 130046

End: 131110

Strand: Direct

Name: hemE

Synonym: APL_0112

Alternate gene names: 126207600

Gene position: 130046-131110 (Clockwise)

Preceding gene: 126207599

Following gene: 126207601

Centisome position: 5.72

GC content: 46.67

Gene sequence:

>1065_bases
ATGAACCAATTAAAAAATGATCGTTACTTAAAAGCGTTACTACGTGAACCAGTTGATATGACACCGGTATGGATGATGCG
TCAAGCGGGGCGTTATCTACCGGAATATAAAGCGACACGTGCGGAAGCCGGCGATTTTATGGCTTTATGTCGCAATGCAG
ATTTAGCTTGTGAAGTGACGTTACAGCCGCTACGCCGCTATGCATTGGATGCGGCGATTTTATTCTCCGATATTTTAACC
GTTCCGGATGCAATGGGCTTAGGTTTAAGTTTCGGTGCGGGTGAAGGGCCTAAATTTGCTCGCCCGATTGAAAATAAAGC
GCAGGTGGACAACTTACCGATTCCGGATCCGGAAAGCGAATTACAATATGTGATGAATGCGGTACGTACTATTCGCCGTG
AATTAAAAGGCGAAGTGCCGTTAATCGGTTTTTCAGGCAGCCCGTGGACATTGGCGACTTATATGGTGGAAGGCGGCTCA
AGCAAAGCGTTCACCAAAATTAAAAAAATGATGTATGCCGATCCGAAAATTTTACACGCATTATTAGATAAATTAGCCGA
TAGCGTGATCTTATATCTGAATGCACAAATTAAAGCCGGCGCGCAAGCGGTGATGGTGTTCGATACTTGGGGCGGCGTGT
TGGCGCATAACGAATATAAAGAGTTCTCGCTACGTTATATGCACAAAATCGTGGACGGTTTAATTCGTGAAAACGAAGGC
AGAAAAGTGCCGGTAACTTTATTTACCAAAGGCGGCGGTTTATGGTTGGAAGCGATTGCGGAAACCGGTTGTGATGCGGT
CGGTTTAGACTGGACGGTCGATATTGCCGATGCGCGTCGTCGTGTCGGACATAAAGTGGCGTTACAAGGCAATATGGATC
CGAGCGTATTGTATGCGCAGCCGGAGCGTATCGAGCTGGAAGTGAAACAAATCTTAGCCGGTTTCGGTCAAGGCTCCGGT
CATGTGTTCAACCTCGGACACGGTATTCATCAAGACGTGCCGGAACAAAGCCCGAAAGTGTTTGTTGATGCGGTCCACGA
GTATTCAAAACAATACCATAAGTAA

Upstream 100 bases:

>100_bases
ACGAGTTATATACAAGCGGTGACTTTCTGGCAAAATTTTGCAAATTTTTTATAAAATTTAACCGCTTGTTTCTACTTTGA
ATTGATATGCAAGGAATATT

Downstream 100 bases:

>100_bases
TCTTCTAGCCGATTTGGCTTAAACAAGCGGTTAAATTTCCGAAAGATTTTGCAAAAAATGATGAAAATTCGACCGCTTGC
GTTAAAGGAAAATTGTCTTT

Product: uroporphyrinogen decarboxylase

Products: NA

Alternate protein names: UPD; URO-D

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MNQLKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYKATRAEAGDFMALCRNADLACEVTLQPLRRYALDAAILFSDILT
VPDAMGLGLSFGAGEGPKFARPIENKAQVDNLPIPDPESELQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMMYADPKILHALLDKLADSVILYLNAQIKAGAQAVMVFDTWGGVLAHNEYKEFSLRYMHKIVDGLIRENEG
RKVPVTLFTKGGGLWLEAIAETGCDAVGLDWTVDIADARRRVGHKVALQGNMDPSVLYAQPERIELEVKQILAGFGQGSG
HVFNLGHGIHQDVPEQSPKVFVDAVHEYSKQYHK

Sequences:

>Translated_354_residues
MNQLKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYKATRAEAGDFMALCRNADLACEVTLQPLRRYALDAAILFSDILT
VPDAMGLGLSFGAGEGPKFARPIENKAQVDNLPIPDPESELQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMMYADPKILHALLDKLADSVILYLNAQIKAGAQAVMVFDTWGGVLAHNEYKEFSLRYMHKIVDGLIRENEG
RKVPVTLFTKGGGLWLEAIAETGCDAVGLDWTVDIADARRRVGHKVALQGNMDPSVLYAQPERIELEVKQILAGFGQGSG
HVFNLGHGIHQDVPEQSPKVFVDAVHEYSKQYHK
>Mature_354_residues
MNQLKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYKATRAEAGDFMALCRNADLACEVTLQPLRRYALDAAILFSDILT
VPDAMGLGLSFGAGEGPKFARPIENKAQVDNLPIPDPESELQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGS
SKAFTKIKKMMYADPKILHALLDKLADSVILYLNAQIKAGAQAVMVFDTWGGVLAHNEYKEFSLRYMHKIVDGLIRENEG
RKVPVTLFTKGGGLWLEAIAETGCDAVGLDWTVDIADARRRVGHKVALQGNMDPSVLYAQPERIELEVKQILAGFGQGSG
HVFNLGHGIHQDVPEQSPKVFVDAVHEYSKQYHK

Specific function: Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III

COG id: COG0407

COG function: function code H; Uroporphyrinogen-III decarboxylase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uroporphyrinogen decarboxylase family

Homologues:

Organism=Homo sapiens, GI71051616, Length=354, Percent_Identity=46.8926553672316, Blast_Score=314, Evalue=9e-86,
Organism=Escherichia coli, GI2367337, Length=354, Percent_Identity=82.7683615819209, Blast_Score=615, Evalue=1e-177,
Organism=Saccharomyces cerevisiae, GI6320252, Length=351, Percent_Identity=40.1709401709402, Blast_Score=267, Evalue=2e-72,
Organism=Drosophila melanogaster, GI19921920, Length=347, Percent_Identity=43.8040345821326, Blast_Score=291, Evalue=4e-79,
Organism=Drosophila melanogaster, GI221330099, Length=347, Percent_Identity=43.8040345821326, Blast_Score=291, Evalue=5e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DCUP_ACTP2 (A3MYI4)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052825.1
- ProteinModelPortal:   A3MYI4
- SMR:   A3MYI4
- STRING:   A3MYI4
- GeneID:   4849940
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0112
- eggNOG:   COG0407
- HOGENOM:   HBG628392
- OMA:   AVQLFDS
- PhylomeDB:   A3MYI4
- ProtClustDB:   PRK00115
- BioCyc:   APLE416269:APL_0112-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00218
- InterPro:   IPR006361
- InterPro:   IPR000257
- PANTHER:   PTHR21091:SF2
- TIGRFAMs:   TIGR01464

Pfam domain/function: PF01208 URO-D

EC number: =4.1.1.37

Molecular weight: Translated: 39361; Mature: 39361

Theoretical pI: Translated: 7.02; Mature: 7.02

Prosite motif: PS00906 UROD_1; PS00907 UROD_2

Important sites: BINDING 77-77 BINDING 154-154 BINDING 209-209 BINDING 327-327

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQLKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYKATRAEAGDFMALCRNADLACEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEE
LQPLRRYALDAAILFSDILTVPDAMGLGLSFGAGEGPKFARPIENKAQVDNLPIPDPESE
HHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHH
LQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYADPKILHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADSVILYLNAQIKAGAQAVMVFDTWGGVLAHNEYKEFSLRYMHKIVDGLIRENEG
HHHHHHHHEEEEEECEECCCCEEEEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCC
RKVPVTLFTKGGGLWLEAIAETGCDAVGLDWTVDIADARRRVGHKVALQGNMDPSVLYAQ
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCCEEEEC
PERIELEVKQILAGFGQGSGHVFNLGHGIHQDVPEQSPKVFVDAVHEYSKQYHK
CCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNQLKNDRYLKALLREPVDMTPVWMMRQAGRYLPEYKATRAEAGDFMALCRNADLACEVT
CCCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHHHHCCHHHHHHHCCCCCEEEEE
LQPLRRYALDAAILFSDILTVPDAMGLGLSFGAGEGPKFARPIENKAQVDNLPIPDPESE
HHHHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCHHCCCCCCCCCCHHH
LQYVMNAVRTIRRELKGEVPLIGFSGSPWTLATYMVEGGSSKAFTKIKKMMYADPKILHA
HHHHHHHHHHHHHHHCCCCCEEECCCCCCEEEEEEEECCCCHHHHHHHHHHHCCHHHHHH
LLDKLADSVILYLNAQIKAGAQAVMVFDTWGGVLAHNEYKEFSLRYMHKIVDGLIRENEG
HHHHHHHHEEEEEECEECCCCEEEEEEECCCCHHCCCCHHHHHHHHHHHHHHHHHHCCCC
RKVPVTLFTKGGGLWLEAIAETGCDAVGLDWTVDIADARRRVGHKVALQGNMDPSVLYAQ
CEEEEEEEECCCCHHHHHHHHCCCCEECCCEEEEHHHHHHHCCCEEEEECCCCCCEEEEC
PERIELEVKQILAGFGQGSGHVFNLGHGIHQDVPEQSPKVFVDAVHEYSKQYHK
CCHHHHHHHHHHHHCCCCCCEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA