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The map label for this gene is arcA [H]

Identifier: 126207536

GI number: 126207536

Start: 54844

End: 55560

Strand: Direct

Name: arcA [H]

Synonym: APL_0048

Alternate gene names: 126207536

Gene position: 54844-55560 (Clockwise)

Preceding gene: 126207535

Following gene: 126207537

Centisome position: 2.41

GC content: 41.28

Gene sequence:

>717_bases
ATGCAGAACCCACAAATCTTGATTGTCGAAGATGAACTTGTTACGCGCAATACGCTCAAAAGTATATTCGAGGCGGAAGG
TTATGAAGTTTTTGAGGCGACGGACGGCACGGAAATGAACGCCATTCTTGCGCAACAAGAAATTAATCTTGTGATTATGG
ATATCAATCTTCCGGGTAAAAACGGTTTAATGTTGGCGCGCGAATTAAGAGAGAACACTAAAATTGCATTAATGTTCTTA
ACCGGACGCGATAATGAAGTGGATAAAATTCTCGGTTTGGAAATCGGTGCGGACGATTATATTACTAAACCGTTTAACCC
TCGTGAATTAACCATTCGTGCGCGTAATCTTTTACATCGTACGATGAATGAAAAAGAGAAAACGACGAAAGACATCGTAC
AGACGGACAGCTATCGTTTTAACGGCTGGGAGCTTGATGTTAATAGCCGTAGTCTAATTACACCGGAAGGTGTGGTAAAT
AAGTTACCTCGTAGCGAATTTAGAGCGTTACTCCATTTCTGTGAGAACCCGGGTAAAATTCAAACTCGAGAAGATTTATT
ACTGAAAATGACCGGTCGTGAATTAAAACCTCATGATCGTACTGTGGATGTGACGATTCGTCGTATTCGTAAACATTTTG
AAGATCACCCTAACACACCGGAAATTATCGTAACCATCCATGGTGAAGGTTACCGTTTTTGCGGCGAGTTAGAGTAG

Upstream 100 bases:

>100_bases
TTCTAGTAAGTCGGAAGATAGGTAAAATTGCCACAATTTTACAACAATAATTCAACAGATTGTAATAACGGATTTTTAAA
ATTAACAGAAGGCTTATACA

Downstream 100 bases:

>100_bases
TAATTAAACGCCTATAAGCGTTTAGCATCTTCTTTCTAAAAAGGACATTTTATGAAAAATTTAACAGTTTTAGCATTAGC
AGGTTTATTCTCTGCGTCGG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQNPQILIVEDELVTRNTLKSIFEAEGYEVFEATDGTEMNAILAQQEINLVIMDINLPGKNGLMLARELRENTKIALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLHRTMNEKEKTTKDIVQTDSYRFNGWELDVNSRSLITPEGVVN
KLPRSEFRALLHFCENPGKIQTREDLLLKMTGRELKPHDRTVDVTIRRIRKHFEDHPNTPEIIVTIHGEGYRFCGELE

Sequences:

>Translated_238_residues
MQNPQILIVEDELVTRNTLKSIFEAEGYEVFEATDGTEMNAILAQQEINLVIMDINLPGKNGLMLARELRENTKIALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLHRTMNEKEKTTKDIVQTDSYRFNGWELDVNSRSLITPEGVVN
KLPRSEFRALLHFCENPGKIQTREDLLLKMTGRELKPHDRTVDVTIRRIRKHFEDHPNTPEIIVTIHGEGYRFCGELE
>Mature_238_residues
MQNPQILIVEDELVTRNTLKSIFEAEGYEVFEATDGTEMNAILAQQEINLVIMDINLPGKNGLMLARELRENTKIALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLHRTMNEKEKTTKDIVQTDSYRFNGWELDVNSRSLITPEGVVN
KLPRSEFRALLHFCENPGKIQTREDLLLKMTGRELKPHDRTVDVTIRRIRKHFEDHPNTPEIIVTIHGEGYRFCGELE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=80.672268907563, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=42.7350427350427, Blast_Score=185, Evalue=3e-48,
Organism=Escherichia coli, GI1789809, Length=234, Percent_Identity=33.7606837606838, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1788394, Length=235, Percent_Identity=33.1914893617021, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=33.4763948497854, Blast_Score=123, Evalue=9e-30,
Organism=Escherichia coli, GI2367329, Length=231, Percent_Identity=32.4675324675325, Blast_Score=115, Evalue=4e-27,
Organism=Escherichia coli, GI1790860, Length=238, Percent_Identity=33.6134453781513, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786911, Length=229, Percent_Identity=32.7510917030568, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI87082012, Length=233, Percent_Identity=30.0429184549356, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=29.4372294372294, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI145693140, Length=234, Percent_Identity=29.9145299145299, Blast_Score=92, Evalue=2e-20,
Organism=Escherichia coli, GI1786784, Length=228, Percent_Identity=29.3859649122807, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1789402, Length=228, Percent_Identity=27.6315789473684, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1790552, Length=124, Percent_Identity=38.7096774193548, Blast_Score=80, Evalue=1e-16,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27487; Mature: 27487

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNPQILIVEDELVTRNTLKSIFEAEGYEVFEATDGTEMNAILAQQEINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHEEEECCCCEEEEEEECCCC
NGLMLARELRENTKIALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLHR
CCHHHHHHHCCCCEEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNEKEKTTKDIVQTDSYRFNGWELDVNSRSLITPEGVVNKLPRSEFRALLHFCENPGKI
HHCHHHHHHHHHHHCCCEEECCEEEECCCCCEECCHHHHHHCCHHHHHHHHHHHCCCCCC
QTREDLLLKMTGRELKPHDRTVDVTIRRIRKHFEDHPNTPEIIVTIHGEGYRFCGELE
CCHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCC
>Mature Secondary Structure
MQNPQILIVEDELVTRNTLKSIFEAEGYEVFEATDGTEMNAILAQQEINLVIMDINLPGK
CCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCHHHEEEECCCCEEEEEEECCCC
NGLMLARELRENTKIALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLHR
CCHHHHHHHCCCCEEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNEKEKTTKDIVQTDSYRFNGWELDVNSRSLITPEGVVNKLPRSEFRALLHFCENPGKI
HHCHHHHHHHHHHHCCCEEECCEEEECCCCCEECCHHHHHHCCHHHHHHHHHHHCCCCCC
QTREDLLLKMTGRELKPHDRTVDVTIRRIRKHFEDHPNTPEIIVTIHGEGYRFCGELE
CCHHHHEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]