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The map label for this gene is nadR [H]

Identifier: 126207534

GI number: 126207534

Start: 52696

End: 53976

Strand: Direct

Name: nadR [H]

Synonym: APL_0046

Alternate gene names: 126207534

Gene position: 52696-53976 (Clockwise)

Preceding gene: 126207529

Following gene: 126207535

Centisome position: 2.32

GC content: 40.2

Gene sequence:

>1281_bases
ATGACAAATTTTGCTTACCTTCAACAAAAACGCAAACAATTAAAAATGAAAGTAAATGATGTTTGTGAGCAAGCCGGCGT
AACTCGCGCTTATTTTAATCAATTGGTAAGCGGGAAAATTAAAAATCCGAGCGCAAATAAATTAAAAGCGTTACATCAAG
TATTAAATATCGTGGAAGATATGAATCAGCGTGTCGGGGTCATTTTCGGTAAATTTTATCCGGTTCATACCGGTCATATT
CATATGATCTACGAAGCCTTCAGTAAAGTGGACATTTTACATGTGGTGGTTTGTACCGATGCGGAGCGTGATCTGCAACT
TTTCAAAGACAGTAAGATGAAGCGTATGCCGACCAATGAAGACAGACTTCGTTGGATGCAACAAATCTTTAAATACCAGC
AAAAGCAAATTTTTATTCATCACCTCAAAGAAGACGGCATTCCGAGCTATCCGAACGGATGGCAAGGTTGGGCGGATCGC
GTAAAAGAATTATTCAATGAGAAGAATATTCGTCCGTCGCTTGTGTTTAGCAGTGAGGTTCAAGATAAAGAACCGTATGA
GAAATATTTGGATTTGGAAGTTCATCTGGTTGATCCTAAACGAGAGTCTTTCAATGTGTCCGCCACTAAAATTCGTAATA
ATCCGTTCCAATATTGGCGATTTATCCCGAAAGAAGTACGTCCTTTCTTTGTAAAAACCATTGCGATTTTAGGCGGGGAA
AGTAGCGGTAAATCGGTCTTGGTCAGCAAACTTGCCAACGTATTTAATACTACTTCCGCTTGGGAATACGGACGAGAATT
CGTGTTTGAGCGTTTAGGCGGTAATGAGCAGGCAATGCAATATTCCGATTATCCGCTCATGGCGTTAGGTCATCAGCGGT
ATATCGACTATGCGATGAAACACGCGCATAAAGTGGCATTGATTGATACCGACTATATTACTACGCAGGCGTTTTGTATT
CAGTACGAAGGTAAATCACATCCTTTCTTAGATTCGATGATCAAGGAATATCCTTTTGACGTCACGATTTTATTGTCCAA
TAACACCAAGTGGGTGGACGACGGAATGCGTAGCCTTGGCTCGGTCAAGCAACGTCAGCGTTTTCAACAGTTGTTGAAGA
AACTGCTCGAAAAATACAATGTGCCTTATATCGAAATTGAGTCGCCGAGCTACTTGGATCGATATAATCAAGCGAAAGAA
GTGGTTGAAGCCATTTTGAAAGAAGAAGAAATTCCATTGCAATTTAAACAGTATAATCATACGACGGAAGATAAAGAATG
A

Upstream 100 bases:

>100_bases
GTCGAAAAATAGCGCATCCATATAATATTTTTTAGATAAATCAATACTCAAATGCTACATTTTGTTTTATTATAACAAAA
GTTATTTTGAGGAAAAAATT

Downstream 100 bases:

>100_bases
TACTTTTTGCGGGCGATCCTCACGGTAGTTACCGGCATCTTTATCCTGTACTACAGGAATATAAAGGTGAGGAAATCGCA
TTGGTCATTTTAGGTGATCT

Product: nicotinamide-nucleotide adenylyltransferase

Products: NA

Alternate protein names: Nicotinamide mononucleotide adenylyltransferase; NMN adenylyltransferase; NMN-AT; NMNAT; Nicotinamide ribonucleotide adenylyltransferase; Nicotinamide-nucleotide adenylyltransferase; Ribosylnicotinamide kinase; RNK; Nicotinamide riboside kinase; NRK; NmR-K [H]

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MTNFAYLQQKRKQLKMKVNDVCEQAGVTRAYFNQLVSGKIKNPSANKLKALHQVLNIVEDMNQRVGVIFGKFYPVHTGHI
HMIYEAFSKVDILHVVVCTDAERDLQLFKDSKMKRMPTNEDRLRWMQQIFKYQQKQIFIHHLKEDGIPSYPNGWQGWADR
VKELFNEKNIRPSLVFSSEVQDKEPYEKYLDLEVHLVDPKRESFNVSATKIRNNPFQYWRFIPKEVRPFFVKTIAILGGE
SSGKSVLVSKLANVFNTTSAWEYGREFVFERLGGNEQAMQYSDYPLMALGHQRYIDYAMKHAHKVALIDTDYITTQAFCI
QYEGKSHPFLDSMIKEYPFDVTILLSNNTKWVDDGMRSLGSVKQRQRFQQLLKKLLEKYNVPYIEIESPSYLDRYNQAKE
VVEAILKEEEIPLQFKQYNHTTEDKE

Sequences:

>Translated_426_residues
MTNFAYLQQKRKQLKMKVNDVCEQAGVTRAYFNQLVSGKIKNPSANKLKALHQVLNIVEDMNQRVGVIFGKFYPVHTGHI
HMIYEAFSKVDILHVVVCTDAERDLQLFKDSKMKRMPTNEDRLRWMQQIFKYQQKQIFIHHLKEDGIPSYPNGWQGWADR
VKELFNEKNIRPSLVFSSEVQDKEPYEKYLDLEVHLVDPKRESFNVSATKIRNNPFQYWRFIPKEVRPFFVKTIAILGGE
SSGKSVLVSKLANVFNTTSAWEYGREFVFERLGGNEQAMQYSDYPLMALGHQRYIDYAMKHAHKVALIDTDYITTQAFCI
QYEGKSHPFLDSMIKEYPFDVTILLSNNTKWVDDGMRSLGSVKQRQRFQQLLKKLLEKYNVPYIEIESPSYLDRYNQAKE
VVEAILKEEEIPLQFKQYNHTTEDKE
>Mature_425_residues
TNFAYLQQKRKQLKMKVNDVCEQAGVTRAYFNQLVSGKIKNPSANKLKALHQVLNIVEDMNQRVGVIFGKFYPVHTGHIH
MIYEAFSKVDILHVVVCTDAERDLQLFKDSKMKRMPTNEDRLRWMQQIFKYQQKQIFIHHLKEDGIPSYPNGWQGWADRV
KELFNEKNIRPSLVFSSEVQDKEPYEKYLDLEVHLVDPKRESFNVSATKIRNNPFQYWRFIPKEVRPFFVKTIAILGGES
SGKSVLVSKLANVFNTTSAWEYGREFVFERLGGNEQAMQYSDYPLMALGHQRYIDYAMKHAHKVALIDTDYITTQAFCIQ
YEGKSHPFLDSMIKEYPFDVTILLSNNTKWVDDGMRSLGSVKQRQRFQQLLKKLLEKYNVPYIEIESPSYLDRYNQAKEV
VEAILKEEEIPLQFKQYNHTTEDKE

Specific function: This enzyme has two activities:nicotinamide mononucleotide (NMN) adenylyltransferase and ribosylnicotinamide (RN) kinase. The RN kinase activity catalyzes the phosphorylation of RN to form nicotinamide ribonucleotide. The NMN adenylyltransferase activity

COG id: COG3172

COG function: function code H; Predicted ATPase/kinase involved in NAD metabolism

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein. Cytoplasm. Note=Found as a soluble cytoplasmic protein as well as a membrane-associated protein. In combination with corepressor (NAD), the cytoplasmic form of NadR would be capable of acting as a transcriptiona

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the bacterial RNK family [H]

Homologues:

Organism=Escherichia coli, GI87082440, Length=410, Percent_Identity=51.9512195121951, Blast_Score=460, Evalue=1e-130,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016429
- InterPro:   IPR004821
- InterPro:   IPR006417
- InterPro:   IPR014729 [H]

Pfam domain/function: NA

EC number: =2.7.7.1; =2.7.1.22 [H]

Molecular weight: Translated: 50101; Mature: 49970

Theoretical pI: Translated: 9.11; Mature: 9.11

Prosite motif: PS50943 HTH_CROC1 ; PS00687 ALDEHYDE_DEHYDR_GLU

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTNFAYLQQKRKQLKMKVNDVCEQAGVTRAYFNQLVSGKIKNPSANKLKALHQVLNIVED
CCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
MNQRVGVIFGKFYPVHTGHIHMIYEAFSKVDILHVVVCTDAERDLQLFKDSKMKRMPTNE
HHHHHEEEEECEEEECCCHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHCHHHCCCCCH
DRLRWMQQIFKYQQKQIFIHHLKEDGIPSYPNGWQGWADRVKELFNEKNIRPSLVFSSEV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
QDKEPYEKYLDLEVHLVDPKRESFNVSATKIRNNPFQYWRFIPKEVRPFFVKTIAILGGE
CCCCHHHHHCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCC
SSGKSVLVSKLANVFNTTSAWEYGREFVFERLGGNEQAMQYSDYPLMALGHQRYIDYAMK
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHCEECCCCHHHHHHHHHHHHHHH
HAHKVALIDTDYITTQAFCIQYEGKSHPFLDSMIKEYPFDVTILLSNNTKWVDDGMRSLG
HHCEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
SVKQRQRFQQLLKKLLEKYNVPYIEIESPSYLDRYNQAKEVVEAILKEEEIPLQFKQYNH
HHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
TTEDKE
CCCCCC
>Mature Secondary Structure 
TNFAYLQQKRKQLKMKVNDVCEQAGVTRAYFNQLVSGKIKNPSANKLKALHQVLNIVED
CCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
MNQRVGVIFGKFYPVHTGHIHMIYEAFSKVDILHVVVCTDAERDLQLFKDSKMKRMPTNE
HHHHHEEEEECEEEECCCHHHHHHHHHHHHCEEEEEEECCCHHHHHHHHHCHHHCCCCCH
DRLRWMQQIFKYQQKQIFIHHLKEDGIPSYPNGWQGWADRVKELFNEKNIRPSLVFSSEV
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEECCCC
QDKEPYEKYLDLEVHLVDPKRESFNVSATKIRNNPFQYWRFIPKEVRPFFVKTIAILGGE
CCCCHHHHHCCCEEEEECCCCCCCCCCHHHHCCCHHHHHHHCHHHHHHHHHHHHHHHCCC
SSGKSVLVSKLANVFNTTSAWEYGREFVFERLGGNEQAMQYSDYPLMALGHQRYIDYAMK
CCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCHHHCEECCCCHHHHHHHHHHHHHHH
HAHKVALIDTDYITTQAFCIQYEGKSHPFLDSMIKEYPFDVTILLSNNTKWVDDGMRSLG
HHCEEEEEECCCCEEEEEEEEECCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
SVKQRQRFQQLLKKLLEKYNVPYIEIESPSYLDRYNQAKEVVEAILKEEEIPLQFKQYNH
HHHHHHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHCCC
TTEDKE
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800; 12446641 [H]