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The map label for this gene is pth

Identifier: 126207521

GI number: 126207521

Start: 38520

End: 39104

Strand: Direct

Name: pth

Synonym: APL_0033

Alternate gene names: 126207521

Gene position: 38520-39104 (Clockwise)

Preceding gene: 126207520

Following gene: 126207522

Centisome position: 1.69

GC content: 42.74

Gene sequence:

>585_bases
ATGTCGCAAATTAAACTTATTGTCGGTTTGGCAAATCCGGGGACGAAATACGAAGATACTCGCCATAATGCCGGTGAATG
GCTGATTAATGAAATCGCTCGTCAATTTAATGTCAGCTTAAAAGAAGAAGCGAAATTCTTCGGAAAAGTCGCAAAAATTA
ATGCGGCAGGCGGTGAAGTTCGTTTACTTGTACCGACGACCTTTATGAATTTAAGCGGTAAAGCGGTCGGTGCTTTAGCG
AATTTTTATCGAATCAAACCGGAAGAAATTTTAGTCGCTCATGATGAATTGGATTTACCGCCCGGTGTGGCAAAAATTAA
GCAGGGCGGCGGTCACGGCGGTCATAACGGTTTGAAAGATATTATTGCCAGCCTTGGCAACAGTAATAATTTTTACCGTG
TGCGTATCGGTATCGGACATCCGGGCAGTAAAGAATTGGTTGCCGGTTATGTGTTGGGTAAACCAAGTCCGCAAGATCAA
GAAAAAATTAATGCGGCGGTGGATGAAGCCGGTCGCTGTGTTGATCTTTTACTGAAAGATGGTATTACAAAAGCGACTAA
TCGATTAAATGCGTTTAAAGCTTGA

Upstream 100 bases:

>100_bases
TGTGGAAAATGCCCTTTTTGCCTACAATAATAACTTTTCATTTTAGGTTAGGGCTTTTTCCCGTTAATCGAGTAGGACAG
ATAATTAAATAGGACAGAAA

Downstream 100 bases:

>100_bases
AACTTTTAGCTATCTGACAGAATTATGATAAGCGGTCAAATTTAGACCGTTTTTTACCAATTTATTTCGAGGTAAAATTG
TGACCTCGTATCTTTAATAG

Product: peptidyl-tRNA hydrolase

Products: NA

Alternate protein names: PTH

Number of amino acids: Translated: 194; Mature: 193

Protein sequence:

>194_residues
MSQIKLIVGLANPGTKYEDTRHNAGEWLINEIARQFNVSLKEEAKFFGKVAKINAAGGEVRLLVPTTFMNLSGKAVGALA
NFYRIKPEEILVAHDELDLPPGVAKIKQGGGHGGHNGLKDIIASLGNSNNFYRVRIGIGHPGSKELVAGYVLGKPSPQDQ
EKINAAVDEAGRCVDLLLKDGITKATNRLNAFKA

Sequences:

>Translated_194_residues
MSQIKLIVGLANPGTKYEDTRHNAGEWLINEIARQFNVSLKEEAKFFGKVAKINAAGGEVRLLVPTTFMNLSGKAVGALA
NFYRIKPEEILVAHDELDLPPGVAKIKQGGGHGGHNGLKDIIASLGNSNNFYRVRIGIGHPGSKELVAGYVLGKPSPQDQ
EKINAAVDEAGRCVDLLLKDGITKATNRLNAFKA
>Mature_193_residues
SQIKLIVGLANPGTKYEDTRHNAGEWLINEIARQFNVSLKEEAKFFGKVAKINAAGGEVRLLVPTTFMNLSGKAVGALAN
FYRIKPEEILVAHDELDLPPGVAKIKQGGGHGGHNGLKDIIASLGNSNNFYRVRIGIGHPGSKELVAGYVLGKPSPQDQE
KINAAVDEAGRCVDLLLKDGITKATNRLNAFKA

Specific function: The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis

COG id: COG0193

COG function: function code J; Peptidyl-tRNA hydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTH family

Homologues:

Organism=Homo sapiens, GI50897284, Length=175, Percent_Identity=36, Blast_Score=103, Evalue=1e-22,
Organism=Escherichia coli, GI1787455, Length=191, Percent_Identity=66.4921465968586, Blast_Score=248, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PTH_ACTP2 (A3MYA5)

Other databases:

- EMBL:   CP000569
- RefSeq:   YP_001052746.1
- ProteinModelPortal:   A3MYA5
- SMR:   A3MYA5
- STRING:   A3MYA5
- GeneID:   4850373
- GenomeReviews:   CP000569_GR
- KEGG:   apl:APL_0033
- eggNOG:   COG0193
- HOGENOM:   HBG610927
- OMA:   AMHRLHS
- PhylomeDB:   A3MYA5
- ProtClustDB:   PRK05426
- BioCyc:   APLE416269:APL_0033-MONOMER
- GO:   GO:0005737
- GO:   GO:0006412
- HAMAP:   MF_00083
- InterPro:   IPR001328
- InterPro:   IPR018171
- Gene3D:   G3DSA:3.40.50.1470
- PANTHER:   PTHR17224
- TIGRFAMs:   TIGR00447

Pfam domain/function: PF01195 Pept_tRNA_hydro; SSF53178 Pept_tRNA_hydro

EC number: =3.1.1.29

Molecular weight: Translated: 20825; Mature: 20694

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: PS01195 PEPT_TRNA_HYDROL_1; PS01196 PEPT_TRNA_HYDROL_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQIKLIVGLANPGTKYEDTRHNAGEWLINEIARQFNVSLKEEAKFFGKVAKINAAGGEV
CCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCEE
RLLVPTTFMNLSGKAVGALANFYRIKPEEILVAHDELDLPPGVAKIKQGGGHGGHNGLKD
EEEEEEEEECCCCHHHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHCCCCCCCCHHHHH
IIASLGNSNNFYRVRIGIGHPGSKELVAGYVLGKPSPQDQEKINAAVDEAGRCVDLLLKD
HHHHHCCCCCEEEEEEEECCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
GITKATNRLNAFKA
CCHHHHHHHHHCCC
>Mature Secondary Structure 
SQIKLIVGLANPGTKYEDTRHNAGEWLINEIARQFNVSLKEEAKFFGKVAKINAAGGEV
CCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCEE
RLLVPTTFMNLSGKAVGALANFYRIKPEEILVAHDELDLPPGVAKIKQGGGHGGHNGLKD
EEEEEEEEECCCCHHHHHHHHHHCCCHHHEEEECCCCCCCCCHHHHHCCCCCCCCHHHHH
IIASLGNSNNFYRVRIGIGHPGSKELVAGYVLGKPSPQDQEKINAAVDEAGRCVDLLLKD
HHHHHCCCCCEEEEEEEECCCCCHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHC
GITKATNRLNAFKA
CCHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA