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The map label for this gene is pyrC [H]

Identifier: 126175542

GI number: 126175542

Start: 3909414

End: 3910445

Strand: Direct

Name: pyrC [H]

Synonym: Sbal_3344

Alternate gene names: 126175542

Gene position: 3909414-3910445 (Clockwise)

Preceding gene: 126175531

Following gene: 126175543

Centisome position: 76.25

GC content: 50.78

Gene sequence:

>1032_bases
ATGACCACAATAACAATCACTCGCCCAGACGACTGGCATATTCATTTAAGAGACGGCGCCCAGCTTAAAGATACCGTGCG
CGACATCAGCCGCTATATGGGCCGCGCCATCGTGATGCCAAACTTAGTGCCCCCCGCTATCGATACCGAAACCGCACTGA
CTTATTACGACCGCATTAAAGCGCAGGTGCCAGCGGGCTCACAGTTCGAACCTTTGATGGTGCTGTATTTAACCGACAAA
ACCAGCCCAGATGAAATCCGCAAAGCCAAAGCTTCGGGTAAAATTGTCGCCGCGAAACTCTACCCTGCGGGCGCGACGAC
CAACTCGGATTCAGGCGTAACCGAATTGAAGAACATCTACCCAGCCCTCGAAGCCATGCAAGAAGTCGGTATGTTGTTTT
TAGTGCACGGTGAAGTCACGGATTCATCGATTGATATTTTCGACCGCGAGCGCGTCTTTATCGAAAATATCCTCAGCAAA
ATCGTTGCCGATTTCCCAGAACTTAAAATCGTGCTTGAACATATCACCACTAAAGATGCGGTCGATTTTGTCACCCAAGC
CTCTGATAATGTGGCCGCGACTATTACAGCCCACCATTTGCTGTATAACCGCAACCACATGCTGGCTGGCGGTATTCGCC
CACATTTTTACTGCCTACCGATTTTAAAACGCAATACCCACCAGCAGGCGTTATTGGCCGCTGCAGCAAGCGGTAGCAAG
AAGTTCTTCTTAGGCACAGATTCGGCGCCCCACGCTAAAGATAAGAAAGAAGCCGCCTGTGGCTGCGCGGGTTCGTACAC
GGCCCATGCCGCAATTGAGCTGTATGCCGAAGCCTTCGAATCGGTGAATGCGCTAGATAAACTCGAAGCATTTGCAAGCT
TCAATGGCCCAGATTTTTACAATCTGCCACGTAACGCCGACACGATCACGCTAGTGAAAAAACCATGGAATGTCCCTGCA
ACTTACCCGCTGGGCGACACTAACGTAGTGCCGATTCGTGCAGGCGAAGCCATTGATTGGCAAGTTGAGTAA

Upstream 100 bases:

>100_bases
ATTTATTGGCCGAAACTACCGAGTTTCCCTTTACAGTAAAATCCTTGCCACATAAGATCCTGCCACCCTCGCAGCAAAAA
CGATCAAAAGACCAAACCCT

Downstream 100 bases:

>100_bases
GCCTTAAGTCTTTAACATCAGGTCGCCTACGGGCGACCTTTTTTACACCCTAGGTTCATTTTGATTTTCAATCCAACTTA
TTACCTTTTAAGAGAAAATA

Product: dihydroorotase

Products: NA

Alternate protein names: DHOase [H]

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTTITITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALTYYDRIKAQVPAGSQFEPLMVLYLTDK
TSPDEIRKAKASGKIVAAKLYPAGATTNSDSGVTELKNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSK
IVADFPELKIVLEHITTKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAAASGSK
KFFLGTDSAPHAKDKKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFYNLPRNADTITLVKKPWNVPA
TYPLGDTNVVPIRAGEAIDWQVE

Sequences:

>Translated_343_residues
MTTITITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALTYYDRIKAQVPAGSQFEPLMVLYLTDK
TSPDEIRKAKASGKIVAAKLYPAGATTNSDSGVTELKNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSK
IVADFPELKIVLEHITTKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAAASGSK
KFFLGTDSAPHAKDKKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFYNLPRNADTITLVKKPWNVPA
TYPLGDTNVVPIRAGEAIDWQVE
>Mature_342_residues
TTITITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALTYYDRIKAQVPAGSQFEPLMVLYLTDKT
SPDEIRKAKASGKIVAAKLYPAGATTNSDSGVTELKNIYPALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSKI
VADFPELKIVLEHITTKDAVDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAAASGSKK
FFLGTDSAPHAKDKKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFYNLPRNADTITLVKKPWNVPAT
YPLGDTNVVPIRAGEAIDWQVE

Specific function: Pyrimidine biosynthesis; third step. [C]

COG id: COG0418

COG function: function code F; Dihydroorotase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHOase family. Type 1 subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787301, Length=340, Percent_Identity=54.4117647058823, Blast_Score=385, Evalue=1e-108,
Organism=Saccharomyces cerevisiae, GI6323452, Length=356, Percent_Identity=35.6741573033708, Blast_Score=180, Evalue=3e-46,

Paralogues:

None

Copy number: 340 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR004721
- InterPro:   IPR002195 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.2.3 [H]

Molecular weight: Translated: 37715; Mature: 37584

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00482 DIHYDROOROTASE_1 ; PS00483 DIHYDROOROTASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTITITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALTYYDRIK
CCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHH
AQVPAGSQFEPLMVLYLTDKTSPDEIRKAKASGKIVAAKLYPAGATTNSDSGVTELKNIY
EECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
PALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSKIVADFPELKIVLEHITTKDA
HHHHHHHHCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
VDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAAASGSK
HHHHHHCCCCEEEEEEEEHHEECCCCEEECCCCCCEEEEEHHHCCCHHHHHHHHHCCCCC
KFFLGTDSAPHAKDKKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFY
EEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NLPRNADTITLVKKPWNVPATYPLGDTNVVPIRAGEAIDWQVE
CCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEC
>Mature Secondary Structure 
TTITITRPDDWHIHLRDGAQLKDTVRDISRYMGRAIVMPNLVPPAIDTETALTYYDRIK
CEEEEECCCCCEEEECCCCHHHHHHHHHHHHHCCEEECCCCCCCCCCCCHHHHHHHHHH
AQVPAGSQFEPLMVLYLTDKTSPDEIRKAKASGKIVAAKLYPAGATTNSDSGVTELKNIY
EECCCCCCCCCEEEEEEECCCCHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHH
PALEAMQEVGMLFLVHGEVTDSSIDIFDRERVFIENILSKIVADFPELKIVLEHITTKDA
HHHHHHHHCCEEEEEECCCCCCCCCHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCHHH
VDFVTQASDNVAATITAHHLLYNRNHMLAGGIRPHFYCLPILKRNTHQQALLAAAASGSK
HHHHHHCCCCEEEEEEEEHHEECCCCEEECCCCCCEEEEEHHHCCCHHHHHHHHHCCCCC
KFFLGTDSAPHAKDKKEAACGCAGSYTAHAAIELYAEAFESVNALDKLEAFASFNGPDFY
EEEEECCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NLPRNADTITLVKKPWNVPATYPLGDTNVVPIRAGEAIDWQVE
CCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA