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The map label for this gene is lysC [H]

Identifier: 126175315

GI number: 126175315

Start: 3645730

End: 3646986

Strand: Reverse

Name: lysC [H]

Synonym: Sbal_3114

Alternate gene names: 126175315

Gene position: 3646986-3645730 (Counterclockwise)

Preceding gene: 126175316

Following gene: 126175314

Centisome position: 71.13

GC content: 48.05

Gene sequence:

>1257_bases
GTGCCCCAAAAACGAAAGCTTAGTGGTAGCAAGCTTTTTGTGAAAAAGTTCGGCGGCACTTCGGTGGGTTCTATTGAACG
TATCGAAGCGGTCGCTGAGCAGATTACAAAGTCAGCTCACAATGGTGAGCAGCAAGTCTTAGTCTTATCTGCAATGGCGG
GTGAGACTAATCGCCTATTTGCACTGGCAGCACAAATTAATCCGCGGGCCTCGGCGCGCGAATTAGACATGTTAGTGTCA
ACGGGTGAGCAAGTGAGCATTGCCTTGATGTCGATGGCGTTACAGCGCCGCGGTATTAAGGCGAAATCCCTTACGGGCGA
TCAGGTACAAATTCATACTAATAGTCAATTCGGCCGTGCCAGCATCGAGCGAGTGGATACTGAGTATTTGCAATCCCTGC
TAGCCGATGGTGTTGTGCCGATCGTTGCAGGGTTTCAAGGCATCGATCCTCAAGGCGAAGTCACAACCTTAGGACGCGGT
GGTTCAGATACCACAGCTGTAGCCTTAGCGGCGGCATTAGAAGCCGATGAATGCCAGATTTTTACCGATGTGGCAGGGGT
ATTCACCACAGATCCGAATATTGATAGCAGTGCTCGTCGTCTCGATGTGATTGGGTTTGATGTGATGCTCGAAATGGCAA
AGTTAGGCGCTAAAGTACTGCATCCCGATTCTGTTGAATACGCCGAGCGTTTTCGCGTGCCATTGCGAGTCCTGTCGAGT
TTTGAAGCTGGGCAGGGTACGTTAATCCAATTTGGCGACGAGTCTGAACTCACTATTGCCTCGTTAGTCCAAGGTATTGC
GATTAATAAGGCGCTGGCAACGCTGACGATTGAAGGGCTGTTTACCACCAGTGAACGCTATCAAGCGCTGTTAGGCTGTT
TAACGCGATTGGAAATCGATGTGGAATTTATTTCCCCATTGAGGATCCACGAGGATGATCCTTCGGGTCGAGTCAGTTTT
ATGCTCGCTGAAGCTAAGGTTGATACTCTGCTTAATGAGCTCGAAGGCTTAAGCGAAAGCCTTGCTCTCGGACCATTGAT
TATCGAACGGCAACGTGCAAAAGTATCTTTAGTTGGCAAAGGTTTACAGGCAAAAATGGGATTATTGACTAAGATGTTAG
AAGTCTTGGGTAATGAAACTATTCATGCTAAGTTACTCACGACGTCAGAGAGTAAATTGTCAACCGTTATCGATGAAAGG
GACTTACACAAGGCGGTTCGGGCGTTACATCACGCTTTCGAGCTAAATAAGGTGTAA

Upstream 100 bases:

>100_bases
TGATATGGCTCAAGCGGGCGGTAGCCAGCCAGAAAATCTGGATGCGGCATTGGCTCAAGTATTACCTTGGATTACTGAGC
GTCTAGCTTAAGAGGTTGCT

Downstream 100 bases:

>100_bases
TTAAATAACCGTTTGAGTATTGAATACTATTAATTTGTACTAAGCTGACCTTATAATAAGCCCATCTACCGGATGAGTGC
CGTGTGTAAGCTGAATTAAG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MPQKRKLSGSKLFVKKFGGTSVGSIERIEAVAEQITKSAHNGEQQVLVLSAMAGETNRLFALAAQINPRASARELDMLVS
TGEQVSIALMSMALQRRGIKAKSLTGDQVQIHTNSQFGRASIERVDTEYLQSLLADGVVPIVAGFQGIDPQGEVTTLGRG
GSDTTAVALAAALEADECQIFTDVAGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
FEAGQGTLIQFGDESELTIASLVQGIAINKALATLTIEGLFTTSERYQALLGCLTRLEIDVEFISPLRIHEDDPSGRVSF
MLAEAKVDTLLNELEGLSESLALGPLIIERQRAKVSLVGKGLQAKMGLLTKMLEVLGNETIHAKLLTTSESKLSTVIDER
DLHKAVRALHHAFELNKV

Sequences:

>Translated_418_residues
MPQKRKLSGSKLFVKKFGGTSVGSIERIEAVAEQITKSAHNGEQQVLVLSAMAGETNRLFALAAQINPRASARELDMLVS
TGEQVSIALMSMALQRRGIKAKSLTGDQVQIHTNSQFGRASIERVDTEYLQSLLADGVVPIVAGFQGIDPQGEVTTLGRG
GSDTTAVALAAALEADECQIFTDVAGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
FEAGQGTLIQFGDESELTIASLVQGIAINKALATLTIEGLFTTSERYQALLGCLTRLEIDVEFISPLRIHEDDPSGRVSF
MLAEAKVDTLLNELEGLSESLALGPLIIERQRAKVSLVGKGLQAKMGLLTKMLEVLGNETIHAKLLTTSESKLSTVIDER
DLHKAVRALHHAFELNKV
>Mature_417_residues
PQKRKLSGSKLFVKKFGGTSVGSIERIEAVAEQITKSAHNGEQQVLVLSAMAGETNRLFALAAQINPRASARELDMLVST
GEQVSIALMSMALQRRGIKAKSLTGDQVQIHTNSQFGRASIERVDTEYLQSLLADGVVPIVAGFQGIDPQGEVTTLGRGG
SDTTAVALAAALEADECQIFTDVAGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSSF
EAGQGTLIQFGDESELTIASLVQGIAINKALATLTIEGLFTTSERYQALLGCLTRLEIDVEFISPLRIHEDDPSGRVSFM
LAEAKVDTLLNELEGLSESLALGPLIIERQRAKVSLVGKGLQAKMGLLTKMLEVLGNETIHAKLLTTSESKLSTVIDERD
LHKAVRALHHAFELNKV

Specific function: Lysine biosynthesis; first step. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1790455, Length=461, Percent_Identity=30.1518438177874, Blast_Score=124, Evalue=1e-29,
Organism=Escherichia coli, GI1786183, Length=353, Percent_Identity=28.8951841359773, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790376, Length=207, Percent_Identity=30.9178743961353, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320893, Length=498, Percent_Identity=24.8995983935743, Blast_Score=120, Evalue=6e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 45106; Mature: 44975

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPQKRKLSGSKLFVKKFGGTSVGSIERIEAVAEQITKSAHNGEQQVLVLSAMAGETNRLF
CCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEE
ALAAQINPRASARELDMLVSTGEQVSIALMSMALQRRGIKAKSLTGDQVQIHTNSQFGRA
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHH
SIERVDTEYLQSLLADGVVPIVAGFQGIDPQGEVTTLGRGGSDTTAVALAAALEADECQI
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEE
FTDVAGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
EEHHHHEEECCCCCCCCHHEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
FEAGQGTLIQFGDESELTIASLVQGIAINKALATLTIEGLFTTSERYQALLGCLTRLEID
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEHEECCHHHHHHHHHHHHHHEEE
VEFISPLRIHEDDPSGRVSFMLAEAKVDTLLNELEGLSESLALGPLIIERQRAKVSLVGK
EEEECCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEEEEECC
GLQAKMGLLTKMLEVLGNETIHAKLLTTSESKLSTVIDERDLHKAVRALHHAFELNKV
CHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
PQKRKLSGSKLFVKKFGGTSVGSIERIEAVAEQITKSAHNGEQQVLVLSAMAGETNRLF
CCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCEEE
ALAAQINPRASARELDMLVSTGEQVSIALMSMALQRRGIKAKSLTGDQVQIHTNSQFGRA
EEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCHH
SIERVDTEYLQSLLADGVVPIVAGFQGIDPQGEVTTLGRGGSDTTAVALAAALEADECQI
HHHHHHHHHHHHHHHCCCHHHHHCCCCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCEE
FTDVAGVFTTDPNIDSSARRLDVIGFDVMLEMAKLGAKVLHPDSVEYAERFRVPLRVLSS
EEHHHHEEECCCCCCCCHHEEEEHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHC
FEAGQGTLIQFGDESELTIASLVQGIAINKALATLTIEGLFTTSERYQALLGCLTRLEID
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHEEEEEHEECCHHHHHHHHHHHHHHEEE
VEFISPLRIHEDDPSGRVSFMLAEAKVDTLLNELEGLSESLALGPLIIERQRAKVSLVGK
EEEECCEEEECCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEEEEECC
GLQAKMGLLTKMLEVLGNETIHAKLLTTSESKLSTVIDERDLHKAVRALHHAFELNKV
CHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]