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The map label for this gene is hisS

Identifier: 126175191

GI number: 126175191

Start: 3515783

End: 3517063

Strand: Reverse

Name: hisS

Synonym: Sbal_2989

Alternate gene names: 126175191

Gene position: 3517063-3515783 (Counterclockwise)

Preceding gene: 126175192

Following gene: 126175190

Centisome position: 68.59

GC content: 47.38

Gene sequence:

>1281_bases
GTGGCAAAACAGATCCAAGCGATTCGCGGAATGAATGACATTCTGCCAACTCAAAGTCCTCTATGGCAAAAAGTGGAAGC
GGTACTACGTTCGAGCGTCAGTGCTTACGGTTACAGCGAAATCCGCACTCCAATAGTGGAAAATACCGATCTCTTTAAAC
GCTCTATCGGTGAAGTGACTGATATTGTTGAAAAAGAAATGTATACCTTCGCAGATAATAACGGTGACAGCTTAACGCTG
CGCCCAGAAGGTACGGCATCGACAGTGCGGGCGGGTAACGAAAACGGTCTGCTGTATAACCAAGAACAACGTCTTTGGTA
TATGGGTCCTATGTTCCGCCACGAGCGTCCACAAAAAGGCCGTTATCGCCAATTTAACCAATTTGGCGTGGAAGTGTATG
GCATAGGCACGGCGGATATTGATGCTGAAGTCTTGATGCTTTCGGCACGCCTGTGGGAAAAACTCGGTATTAGCGATCAC
GTATCGTTAGAGCTGAACACCTTAGGCGATCCTGCTGAGCGCGCGGTTTACCGTGATGCCTTGATTGCGTTTTTAGAACA
GCATAAAGATGCGCTCGATGAAGACAGCAAGCGTCGCATGTACAGCAATCCGCTGCGGGTATTGGATTCAAAAGATCAAA
ATGTCCAAGCGATTTTGGCTGGTGCACCTGAGTTGATGGATTTCCTCGGTGAAGAATCGAAGACACATTTTTCACAATTG
CGTGAACTACTTGACGCAGTGGGTATCAAATACACCATTAATCCGCGCCTTGTTCGTGGTTTAGATTACTATAATCGCAC
TGTATTTGAATGGGTTACATCGAGTTTAGGCTCGCAAGGTACAGTACTTGCGGGTGGTCGCTACGATGGCTTAGTTGCCC
AATTAGGCGGTAAAGATACCCCAGCGGTGGGTTTCGCTATGGGCTTAGAGCGCATTGTCTTGTTGCTTGAAACCTTAGAG
CTAAACAAAGATATTCCGTCAGAAGTGGATGTGTATGTCACTGCAATGGGCGATAGCTGTCTAGTTGAAGCGATTAAAAT
TGCGCAGGAATTACGCAGCGCGCTGCCAAACCTTAAAGTGATGAGTCACTGCGGTGGCGGCAACGTGAAGAAACAAATGA
AACGTGCCGACAAAAGCGGTGCGAGTGTGGCGTTACTGATAGGCGAAGATGAACTTGCCGAAGGTATGGTGACGGTTAAA
CATTTACGCAATGACATCGAACAACAACGGGTAGCTCGAAGTGCCTTAGGCGCATTTTTAGCTGAACTGGCCATTAAGTA
A

Upstream 100 bases:

>100_bases
TAGGCCCCGAAACCGACGGGGTCGTTTTACGTTTTACGTTCAAAAGCCTATAATGCGTGACATTTTTTATTAATTTAGCT
AAATCGGACGAGTCGATACA

Downstream 100 bases:

>100_bases
TAGATCATATAAGGGGACGTGCGCGTGGAAATTTATAGCACAGAAGAACAACAAGTTGATGCTATCAAGCAGTTCTGGAC
AGATTACGGAAATTCAATTT

Product: histidyl-tRNA synthetase

Products: NA

Alternate protein names: Histidine--tRNA ligase; HisRS

Number of amino acids: Translated: 426; Mature: 425

Protein sequence:

>426_residues
MAKQIQAIRGMNDILPTQSPLWQKVEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVTDIVEKEMYTFADNNGDSLTL
RPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDH
VSLELNTLGDPAERAVYRDALIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDTPAVGFAMGLERIVLLLETLE
LNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKVMSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVK
HLRNDIEQQRVARSALGAFLAELAIK

Sequences:

>Translated_426_residues
MAKQIQAIRGMNDILPTQSPLWQKVEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVTDIVEKEMYTFADNNGDSLTL
RPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDH
VSLELNTLGDPAERAVYRDALIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDTPAVGFAMGLERIVLLLETLE
LNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKVMSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVK
HLRNDIEQQRVARSALGAFLAELAIK
>Mature_425_residues
AKQIQAIRGMNDILPTQSPLWQKVEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVTDIVEKEMYTFADNNGDSLTLR
PEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKGRYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDHV
SLELNTLGDPAERAVYRDALIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQLR
ELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDTPAVGFAMGLERIVLLLETLEL
NKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKVMSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVKH
LRNDIEQQRVARSALGAFLAELAIK

Specific function: Unknown

COG id: COG0124

COG function: function code J; Histidyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI6996014, Length=459, Percent_Identity=25.4901960784314, Blast_Score=103, Evalue=4e-22,
Organism=Homo sapiens, GI15029520, Length=449, Percent_Identity=24.9443207126949, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1788861, Length=423, Percent_Identity=64.7754137115839, Blast_Score=564, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI71993693, Length=458, Percent_Identity=26.2008733624454, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71993686, Length=458, Percent_Identity=26.2008733624454, Blast_Score=92, Evalue=5e-19,
Organism=Saccharomyces cerevisiae, GI6325290, Length=456, Percent_Identity=25, Blast_Score=90, Evalue=7e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYH_SHEB2 (B8E9S8)

Other databases:

- EMBL:   CP001252
- RefSeq:   YP_002357305.1
- ProteinModelPortal:   B8E9S8
- SMR:   B8E9S8
- GeneID:   7088799
- GenomeReviews:   CP001252_GR
- KEGG:   sbp:Sbal223_1374
- HOGENOM:   HBG616575
- OMA:   VFEWVTT
- ProtClustDB:   PRK00037
- GO:   GO:0005737
- HAMAP:   MF_00127
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR015807
- InterPro:   IPR004516
- Gene3D:   G3DSA:3.40.50.800
- PANTHER:   PTHR11476
- PIRSF:   PIRSF001549
- TIGRFAMs:   TIGR00442

Pfam domain/function: PF03129 HGTP_anticodon; PF00587 tRNA-synt_2b; SSF52954 Anticodon_bd

EC number: =6.1.1.21

Molecular weight: Translated: 47304; Mature: 47172

Theoretical pI: Translated: 5.13; Mature: 5.13

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKQIQAIRGMNDILPTQSPLWQKVEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVT
CCCHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHH
DIVEKEMYTFADNNGDSLTLRPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKG
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCEECCCCCEEEECCHHHCCCCCCC
RYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDHVSLELNTLGDPAERAVYRDA
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
LIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
HHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCHHEEECCCHHHHHHHCCCCHHHHHHH
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDT
HHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHCCCCCC
PAVGFAMGLERIVLLLETLELNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEE
MSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVKHLRNDIEQQRVARSALGAFL
HHCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELAIK
HHHHCC
>Mature Secondary Structure 
AKQIQAIRGMNDILPTQSPLWQKVEAVLRSSVSAYGYSEIRTPIVENTDLFKRSIGEVT
CCHHHHHHCCHHHCCCCCHHHHHHHHHHHHHHHHCCHHHHCCCCCCCHHHHHHHHHHHH
DIVEKEMYTFADNNGDSLTLRPEGTASTVRAGNENGLLYNQEQRLWYMGPMFRHERPQKG
HHHHHHHHHHCCCCCCEEEECCCCCHHHHHCCCCCCCEECCCCCEEEECCHHHCCCCCCC
RYRQFNQFGVEVYGIGTADIDAEVLMLSARLWEKLGISDHVSLELNTLGDPAERAVYRDA
HHHHHHHCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHH
LIAFLEQHKDALDEDSKRRMYSNPLRVLDSKDQNVQAILAGAPELMDFLGEESKTHFSQL
HHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCHHEEECCCHHHHHHHCCCCHHHHHHH
RELLDAVGIKYTINPRLVRGLDYYNRTVFEWVTSSLGSQGTVLAGGRYDGLVAQLGGKDT
HHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCHHHHCCCCCC
PAVGFAMGLERIVLLLETLELNKDIPSEVDVYVTAMGDSCLVEAIKIAQELRSALPNLKV
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHCCCCEE
MSHCGGGNVKKQMKRADKSGASVALLIGEDELAEGMVTVKHLRNDIEQQRVARSALGAFL
HHCCCCCCHHHHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AELAIK
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA