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The map label for this gene is cysM [C]

Identifier: 126174469

GI number: 126174469

Start: 2607135

End: 2608280

Strand: Direct

Name: cysM [C]

Synonym: Sbal_2253

Alternate gene names: 126174469

Gene position: 2607135-2608280 (Clockwise)

Preceding gene: 126174465

Following gene: 126174471

Centisome position: 50.85

GC content: 49.65

Gene sequence:

>1146_bases
ATGATCCCTTTCGAAGTGACTATGATGATTTCTAACACGATTCAACCGCCAGTGGACTCACACAGCGCTCACAGACTCTG
CCCAACGTGGGAAGCCCTTGCGATAGGCAAGATTGAAGCGGATTTTCAGCGCAGCGCCGATACCCATTTGATTAAACTTG
AATTACCTATGCTCGATGGCATAGATATTTATCTTAAAGATGAAAGTACCCACCCGACAGGAAGCTTAAAGCATCGCCTC
GCCCGCTCACTCTTCCTCTATGCCCTGTGTAACGGCTGGATTAAGCAAGGCACGCCCATTATCGAATCCTCATCGGGCAG
CACGGCGATTTCTGAAGCCTATTTTGCCCGCTTACTCGGTTTACCTTTTATTGCCGTGATGCCTAAAAGCACGGCTAAAA
AGAAGATTGAACAGATCACTTTCTATGGCGGCCAATGTCATTTTGTCGACCATTCCAGTGAGATTTACGCCGAATCGGCG
CGCCTAGCCGCAGAGCTGGGCGGCCATTACATGGATCAATTCACCTACGCCGAGCGCGCAACAGACTGGCGCGGCAATAA
CAATATTGCCAATTCTATTTTCAATCAGATGGAACGCGAGCCACACACAATCCCGCGTTGGATAGTGATGAGTCCGGGTA
CAGGCGGCACATCGGCGACCATAGGCCGCTACATCCGCTATCAAAGGTTGGCGACCCAGCTTTGCGTAGTTGATCCGCAA
AACTCGGTATTTTTTGATTTTTATCAGAGCGGCGATGCCAGCTTAACCTGTTGCAATGGCAGTAAAATTGAAGGCATAGG
TCGACCAAGAGTCGAGCCATCGTTTATTCCTGGCGTTGTGGATTCTATGCTGCAAATCCCCGACGCGGCTTCCGTAGCGA
CGATTCATTGGTTAGAGCAACTGATTGGCCGTAAAACCGGCGCATCGACAGGCACTAACCTTTACGGCGCATTGCAACTT
GCCGTACAAATGCAAGCGCGTGGAGAACAAGGCTCAATCGTGACCCTAATTTGCGACTCGGGTGAACGTTACCTCGATAC
CTATTACGATGCTGATTGGATTGCGGCTAATATTGGTGATATTGCCCCCTATCAGCGCCAACTTGCGGCATTTAATCATT
TTGGTCAGCTAAGCGAGCTTGATTAA

Upstream 100 bases:

>100_bases
CAATCACGCCTCGCGCGACTTCAAGCTAATGCCCCCAAGCGAGTAACGCAAAGCAGATCCAATAAAACCGCTTTGCCCGT
CCCTGTGATATGCTCTAAAA

Downstream 100 bases:

>100_bases
CCGACGAGATTAAATTCCTTGAGTCGATGGCTTCAAAGTCCACCGCTAAACGTCAGCCATAAAAAACGCCCCACAATTGT
GAGGCGTTTTTTTATCGTTT

Product: pyridoxal-5'-phosphate-dependent protein subunit beta

Products: NA

Alternate protein names: O-acetylserine (Thiol)-lyase; O-acetylserine sulfhydrylase; CSase [H]

Number of amino acids: Translated: 381; Mature: 381

Protein sequence:

>381_residues
MIPFEVTMMISNTIQPPVDSHSAHRLCPTWEALAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRL
ARSLFLYALCNGWIKQGTPIIESSSGSTAISEAYFARLLGLPFIAVMPKSTAKKKIEQITFYGGQCHFVDHSSEIYAESA
RLAAELGGHYMDQFTYAERATDWRGNNNIANSIFNQMEREPHTIPRWIVMSPGTGGTSATIGRYIRYQRLATQLCVVDPQ
NSVFFDFYQSGDASLTCCNGSKIEGIGRPRVEPSFIPGVVDSMLQIPDAASVATIHWLEQLIGRKTGASTGTNLYGALQL
AVQMQARGEQGSIVTLICDSGERYLDTYYDADWIAANIGDIAPYQRQLAAFNHFGQLSELD

Sequences:

>Translated_381_residues
MIPFEVTMMISNTIQPPVDSHSAHRLCPTWEALAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRL
ARSLFLYALCNGWIKQGTPIIESSSGSTAISEAYFARLLGLPFIAVMPKSTAKKKIEQITFYGGQCHFVDHSSEIYAESA
RLAAELGGHYMDQFTYAERATDWRGNNNIANSIFNQMEREPHTIPRWIVMSPGTGGTSATIGRYIRYQRLATQLCVVDPQ
NSVFFDFYQSGDASLTCCNGSKIEGIGRPRVEPSFIPGVVDSMLQIPDAASVATIHWLEQLIGRKTGASTGTNLYGALQL
AVQMQARGEQGSIVTLICDSGERYLDTYYDADWIAANIGDIAPYQRQLAAFNHFGQLSELD
>Mature_381_residues
MIPFEVTMMISNTIQPPVDSHSAHRLCPTWEALAIGKIEADFQRSADTHLIKLELPMLDGIDIYLKDESTHPTGSLKHRL
ARSLFLYALCNGWIKQGTPIIESSSGSTAISEAYFARLLGLPFIAVMPKSTAKKKIEQITFYGGQCHFVDHSSEIYAESA
RLAAELGGHYMDQFTYAERATDWRGNNNIANSIFNQMEREPHTIPRWIVMSPGTGGTSATIGRYIRYQRLATQLCVVDPQ
NSVFFDFYQSGDASLTCCNGSKIEGIGRPRVEPSFIPGVVDSMLQIPDAASVATIHWLEQLIGRKTGASTGTNLYGALQL
AVQMQARGEQGSIVTLICDSGERYLDTYYDADWIAANIGDIAPYQRQLAAFNHFGQLSELD

Specific function: As it is highly similar to bacterial and plant cysteine synthases, it is possible that it catalyzes a related reaction [H]

COG id: COG0031

COG function: function code E; Cysteine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cysteine synthase/cystathionine beta- synthase family [H]

Homologues:

Organism=Homo sapiens, GI295821202, Length=300, Percent_Identity=24, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI295821200, Length=300, Percent_Identity=24, Blast_Score=70, Evalue=3e-12,
Organism=Homo sapiens, GI4557415, Length=300, Percent_Identity=24, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI2367138, Length=317, Percent_Identity=29.6529968454259, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71996324, Length=350, Percent_Identity=33.1428571428571, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17539800, Length=355, Percent_Identity=31.5492957746479, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17539640, Length=359, Percent_Identity=28.9693593314763, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI32566674, Length=302, Percent_Identity=27.1523178807947, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562970, Length=311, Percent_Identity=26.6881028938907, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI115535073, Length=294, Percent_Identity=25.5102040816327, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17534315, Length=329, Percent_Identity=27.355623100304, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6321449, Length=330, Percent_Identity=24.2424242424242, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24643623, Length=324, Percent_Identity=26.8518518518519, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI20129101, Length=324, Percent_Identity=26.8518518518519, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001216
- InterPro:   IPR001926 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =2.5.1.47 [H]

Molecular weight: Translated: 42143; Mature: 42143

Theoretical pI: Translated: 5.76; Mature: 5.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPFEVTMMISNTIQPPVDSHSAHRLCPTWEALAIGKIEADFQRSADTHLIKLELPMLDG
CCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHEECCCHHHHHCCCCCEEEEEEECCCCC
IDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKQGTPIIESSSGSTAISEAYFARLLG
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHC
LPFIAVMPKSTAKKKIEQITFYGGQCHFVDHSSEIYAESARLAAELGGHYMDQFTYAERA
CCEEEECCCHHHHHHHHHEEEECCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHC
TDWRGNNNIANSIFNQMEREPHTIPRWIVMSPGTGGTSATIGRYIRYQRLATQLCVVDPQ
CCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEECCC
NSVFFDFYQSGDASLTCCNGSKIEGIGRPRVEPSFIPGVVDSMLQIPDAASVATIHWLEQ
CCEEEEEECCCCCEEEEECCCEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
LIGRKTGASTGTNLYGALQLAVQMQARGEQGSIVTLICDSGERYLDTYYDADWIAANIGD
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCEEECCCC
IAPYQRQLAAFNHFGQLSELD
CCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIPFEVTMMISNTIQPPVDSHSAHRLCPTWEALAIGKIEADFQRSADTHLIKLELPMLDG
CCCEEEEEEECCCCCCCCCCCCCCCCCCCHHHHEECCCHHHHHCCCCCEEEEEEECCCCC
IDIYLKDESTHPTGSLKHRLARSLFLYALCNGWIKQGTPIIESSSGSTAISEAYFARLLG
EEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHC
LPFIAVMPKSTAKKKIEQITFYGGQCHFVDHSSEIYAESARLAAELGGHYMDQFTYAERA
CCEEEECCCHHHHHHHHHEEEECCEEEEECCCHHHHHHHHHHHHHHCCHHHHHHHHHHHC
TDWRGNNNIANSIFNQMEREPHTIPRWIVMSPGTGGTSATIGRYIRYQRLATQLCVVDPQ
CCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHEEEECCC
NSVFFDFYQSGDASLTCCNGSKIEGIGRPRVEPSFIPGVVDSMLQIPDAASVATIHWLEQ
CCEEEEEECCCCCEEEEECCCEECCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHH
LIGRKTGASTGTNLYGALQLAVQMQARGEQGSIVTLICDSGERYLDTYYDADWIAANIGD
HHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHCCCCCEEECCCC
IAPYQRQLAAFNHFGQLSELD
CCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]