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The map label for this gene is ttcA1

Identifier: 126174427

GI number: 126174427

Start: 2556442

End: 2557374

Strand: Direct

Name: ttcA1

Synonym: Sbal_2211

Alternate gene names: 126174427

Gene position: 2556442-2557374 (Clockwise)

Preceding gene: 126174426

Following gene: 126174430

Centisome position: 49.86

GC content: 47.48

Gene sequence:

>933_bases
ATGTCTGAAGAATTATCAAAAAAACACACTAACCGTCTGAATAAATTACAGAAACGTCTGCGTCGTGAAGTGGGTAGCGC
AATCGCCGATTACAATATGATTGAAGATGGCGATAAGATCATGTGCTGCCTCAGTGGCGGTAAAGACAGCTATGCGATGC
TCGATATTTTGATGAATCTGCAGCAACGCGCGCCCATTCAGTTTGAAATCATTGCGGTTAATTTAGATCAGAAGCAACCC
GGCTTTCCTGAGCACGTGCTGCCCGCCTATTTAGAAAAGCTCAATGTGCCTTATCACATCCTCGAGAAAGACACTTACTC
GATAGTGAAAGATAAAATCCCTGAAGGTAAAACTACCTGCTCCCTGTGCTCTCGCCTACGCCGCGGTACGCTCTATGGCT
TTGCCCAGCGCATCGGCGCCACTAAAATCGCCCTAGGCCACCACAGGGATGACATTATCGAGACCTTGTTCTTGAACATG
TTCTTTGGCGGCAAGATGAAAGCTATGCCGCCAAAGCTACTGTCGGATGATGGCGCTAATGTGGTCATTCGCCCTCTTGC
CTATTGCCGTGAAAAAGATCTCGAAGAATATGCCAACTTAAAAGAATTCCCGATCATCCCCTGTAACTTGTGTGGCTCAC
AGGAAAACTTAAAGCGCGCCGCAGTCAAAGACATGCTGAATCAGTGGGATAGACAATACCCAGGTCGAATTGAAACGATT
TTCACAGCAATGCAGAACACCGCACCATCACAGGGTGTTGACCGTGAGCAGTTCGACTTTGTGTCTCTAACGCGTGACCC
AGATGCGCCTATGCGTGGTGATGTTGCCGAAGCCAATCTGCCCGCATTCGACTTCCTTGATATTGCCAACAGCGGTCGTA
TTGATTTGGATGCGGCAAAACGCATTGATATCGTTAACACTTATGAAGTCTAA

Upstream 100 bases:

>100_bases
TTTACCCCGCCAAAGATAGCTGGAATAATACGCGCCCTGAAACTGAGTTACTGGGCGCTTTTTTATGCTTGAAGCTATAT
CTGAAGTTACGGCAAATCCT

Downstream 100 bases:

>100_bases
CTAAGTGTGAATTAGCGCCTTAGTCAGTAAAAGAAGTTAACCCAACGAAAGTATGCAAGATAAATTAGCTAAACAAAAAT
GCCCACATTAAGTGGGCATT

Product: C32 tRNA thiolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 309

Protein sequence:

>310_residues
MSEELSKKHTNRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNLQQRAPIQFEIIAVNLDQKQP
GFPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNM
FFGGKMKAMPPKLLSDDGANVVIRPLAYCREKDLEEYANLKEFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
FTAMQNTAPSQGVDREQFDFVSLTRDPDAPMRGDVAEANLPAFDFLDIANSGRIDLDAAKRIDIVNTYEV

Sequences:

>Translated_310_residues
MSEELSKKHTNRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNLQQRAPIQFEIIAVNLDQKQP
GFPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNM
FFGGKMKAMPPKLLSDDGANVVIRPLAYCREKDLEEYANLKEFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
FTAMQNTAPSQGVDREQFDFVSLTRDPDAPMRGDVAEANLPAFDFLDIANSGRIDLDAAKRIDIVNTYEV
>Mature_309_residues
SEELSKKHTNRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNLQQRAPIQFEIIAVNLDQKQPG
FPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTCSLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMF
FGGKMKAMPPKLLSDDGANVVIRPLAYCREKDLEEYANLKEFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETIF
TAMQNTAPSQGVDREQFDFVSLTRDPDAPMRGDVAEANLPAFDFLDIANSGRIDLDAAKRIDIVNTYEV

Specific function: Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32)

COG id: COG0037

COG function: function code D; Predicted ATPase of the PP-loop superfamily implicated in cell cycle control

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TtcA family

Homologues:

Organism=Escherichia coli, GI1787606, Length=275, Percent_Identity=69.0909090909091, Blast_Score=411, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI193211090, Length=232, Percent_Identity=34.4827586206897, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17540090, Length=191, Percent_Identity=29.3193717277487, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24651972, Length=234, Percent_Identity=26.0683760683761, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TTCA_SHEB5 (A3D4P4)

Other databases:

- EMBL:   CP000563
- EMBL:   CP000564
- RefSeq:   YP_001041615.1
- RefSeq:   YP_001050576.1
- ProteinModelPortal:   A3D4P4
- SMR:   A3D4P4
- STRING:   A3D4P4
- GeneID:   4841249
- GeneID:   4843590
- GenomeReviews:   CP000563_GR
- GenomeReviews:   CP000564_GR
- KEGG:   sbl:Sbal_2211
- KEGG:   sbl:Sbal_4497
- NMPDR:   fig|325240.3.peg.3050
- eggNOG:   COG0037
- HOGENOM:   HBG347038
- OMA:   EHILPEY
- PhylomeDB:   A3D4P4
- ProtClustDB:   PRK10696
- GO:   GO:0005737
- HAMAP:   MF_01850
- InterPro:   IPR012089
- InterPro:   IPR014729
- InterPro:   IPR011063
- Gene3D:   G3DSA:3.40.50.620
- PIRSF:   PIRSF004976

Pfam domain/function: PF01171 ATP_bind_3

EC number: NA

Molecular weight: Translated: 35122; Mature: 34991

Theoretical pI: Translated: 6.37; Mature: 6.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEELSKKHTNRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
QQRAPIQFEIIAVNLDQKQPGFPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTC
HHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCCHHH
SLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFFGGKMKAMPPKLLSDDGAN
HHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
VVIRPLAYCREKDLEEYANLKEFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
EEEHHHHHHHHHHHHHHCCCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
FTAMQNTAPSQGVDREQFDFVSLTRDPDAPMRGDVAEANLPAFDFLDIANSGRIDLDAAK
HHHHHHCCCCCCCCHHHHCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEECHHH
RIDIVNTYEV
HCCCEECCCC
>Mature Secondary Structure 
SEELSKKHTNRLNKLQKRLRREVGSAIADYNMIEDGDKIMCCLSGGKDSYAMLDILMNL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCCHHHHHHHHHHH
QQRAPIQFEIIAVNLDQKQPGFPEHVLPAYLEKLNVPYHILEKDTYSIVKDKIPEGKTTC
HHCCCEEEEEEEEEECCCCCCCCHHHHHHHHHHCCCCEEECCCCHHHHHHHCCCCCCHHH
SLCSRLRRGTLYGFAQRIGATKIALGHHRDDIIETLFLNMFFGGKMKAMPPKLLSDDGAN
HHHHHHHHHHHHHHHHHHCCHHEEECCCHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCC
VVIRPLAYCREKDLEEYANLKEFPIIPCNLCGSQENLKRAAVKDMLNQWDRQYPGRIETI
EEEHHHHHHHHHHHHHHCCCCCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHH
FTAMQNTAPSQGVDREQFDFVSLTRDPDAPMRGDVAEANLPAFDFLDIANSGRIDLDAAK
HHHHHHCCCCCCCCHHHHCEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCCCCEEECHHH
RIDIVNTYEV
HCCCEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA