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The map label for this gene is zot [H]

Identifier: 126174412

GI number: 126174412

Start: 2541106

End: 2542473

Strand: Direct

Name: zot [H]

Synonym: Sbal_2196

Alternate gene names: 126174412

Gene position: 2541106-2542473 (Clockwise)

Preceding gene: 126174411

Following gene: 126174415

Centisome position: 49.56

GC content: 37.57

Gene sequence:

>1368_bases
GTGGCTTCTTCTATTTATCATGGCAAACCCGGCTCTTATAAGACCTCAACGGCGGTGTGGTTTCACATACTGCCAGCTTT
GAGGAAAGGCCGCTTTGTTTGTACAAATGTCGAAGGTCTTTTTTCTCTCGAAGAAATAGAAAAGATTTTAGGTGAGAAAT
TCCCTGAAACAGCTTATTTATTTAGGGTTTCAACGCTCAATGATATTGGTGTTAATACAATGGCAAAATGGTTTCATTGG
CTACCATTGGGCGCTTTTATTGTTATTGATGAAATTCAAAATTTATATAATTCTAAAGATAGAACTGATTTTAAAGTCCA
TGATACAAATCGCTCTGTTAATACTTTAGATAGGATTCTTGACTTTCCTAGCTTGCCTGAGAACGTCAAATATTTATCTC
AACAAGCTTTAATTTCTGTTATTGATGATGGTTATACCGATGATATGGGTATTTCTGAACGTGATTCTAATGGTCATGTT
CTTTATCCAGTTAATATTAAAGATGCGCTTATGAGACATCGTAAATACAATTGGGACATTATTGGTTGTACTCCTGAAAT
TGCTCATGTTCATACTCTTTATAGGGGTGTTTCTGAAAAAGCGGTGTCACATCGCAGTTTTGATTTTGTGCCTATTCCTT
GGTTTCAGCGTCGCCCTAGAACGCATGAACATAACCCAATGGAAAAAGGTATTCGCCCTGTTAAGGGTGAAACTGTTAAG
CGTCCTAAGATTCCTGTAAAGGTTTTCTCTTTATATAAATCAACACAAACTGGTAAAAATAATCGGAGTGGCGTTAATGA
AAACCCATTTAAAAATCGTGCTACGCTTTTTAAAATCTTTATTCCTTTATCCATTGTTCTTGGTTTCCTATCTTTGCCAT
TATTCTATGGTTCTGATCCAAAGGGTGCCGATTCTAAACAGGTTGGTTCAACGTCTCCAGCGGCTAATGGCCTTGTTTCT
AAAGCGCATAACACGATTGCTGGGCAGGGTGTTCCTGTTTCTTCTGGTGATACTCATAATCCGATTTTCAATGATGCACC
TGATTTCCTTGCTCAGTTGAAAGTTGAACAGCTTTTTATTGTTGGCCATGTTCAAAAAAGTAAGTTCTTAGGCATTGTTA
AGACGCAGAACGGCGCAGAGTCTCGCCAAACGATTACTGATTACTTTGTTTTCTCGGCATCTTCTAAGGATGCTCAATAC
ACTTTTAACAGTGAAGATTTAAAAGAGATGGGTTACACGATTAAGAAGATCACAAATTGCTATGTTCAAATAAACAATGT
TGTTCGAACCGTTCACAGCTTTTGCAATCCATCGTTGCCAGCTTCTGAACCTGATTCAAAGAACGAATCAATTTTAGCTG
GTATCTAG

Upstream 100 bases:

>100_bases
AAGCCCTTGTTTCTCAGCTCGGTTTGATACGTGCAATAAACATTGTTATCGAGGCTTATATAGCTCGATACGTCTTACAA
TATATGCTTTAGGGGGTTAT

Downstream 100 bases:

>100_bases
CCTGCACGCGCGAAGCCGAAGGCTGAGGCGCGCGCGTGTGCAGGCTGATACATTGCTTAATTACTTAAAGGATTATTATG
CAACCCATTTCTATAGTTGA

Product: zonular occludens toxin

Products: NA

Alternate protein names: Zonular occludens toxin; Zot [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MASSIYHGKPGSYKTSTAVWFHILPALRKGRFVCTNVEGLFSLEEIEKILGEKFPETAYLFRVSTLNDIGVNTMAKWFHW
LPLGAFIVIDEIQNLYNSKDRTDFKVHDTNRSVNTLDRILDFPSLPENVKYLSQQALISVIDDGYTDDMGISERDSNGHV
LYPVNIKDALMRHRKYNWDIIGCTPEIAHVHTLYRGVSEKAVSHRSFDFVPIPWFQRRPRTHEHNPMEKGIRPVKGETVK
RPKIPVKVFSLYKSTQTGKNNRSGVNENPFKNRATLFKIFIPLSIVLGFLSLPLFYGSDPKGADSKQVGSTSPAANGLVS
KAHNTIAGQGVPVSSGDTHNPIFNDAPDFLAQLKVEQLFIVGHVQKSKFLGIVKTQNGAESRQTITDYFVFSASSKDAQY
TFNSEDLKEMGYTIKKITNCYVQINNVVRTVHSFCNPSLPASEPDSKNESILAGI

Sequences:

>Translated_455_residues
MASSIYHGKPGSYKTSTAVWFHILPALRKGRFVCTNVEGLFSLEEIEKILGEKFPETAYLFRVSTLNDIGVNTMAKWFHW
LPLGAFIVIDEIQNLYNSKDRTDFKVHDTNRSVNTLDRILDFPSLPENVKYLSQQALISVIDDGYTDDMGISERDSNGHV
LYPVNIKDALMRHRKYNWDIIGCTPEIAHVHTLYRGVSEKAVSHRSFDFVPIPWFQRRPRTHEHNPMEKGIRPVKGETVK
RPKIPVKVFSLYKSTQTGKNNRSGVNENPFKNRATLFKIFIPLSIVLGFLSLPLFYGSDPKGADSKQVGSTSPAANGLVS
KAHNTIAGQGVPVSSGDTHNPIFNDAPDFLAQLKVEQLFIVGHVQKSKFLGIVKTQNGAESRQTITDYFVFSASSKDAQY
TFNSEDLKEMGYTIKKITNCYVQINNVVRTVHSFCNPSLPASEPDSKNESILAGI
>Mature_454_residues
ASSIYHGKPGSYKTSTAVWFHILPALRKGRFVCTNVEGLFSLEEIEKILGEKFPETAYLFRVSTLNDIGVNTMAKWFHWL
PLGAFIVIDEIQNLYNSKDRTDFKVHDTNRSVNTLDRILDFPSLPENVKYLSQQALISVIDDGYTDDMGISERDSNGHVL
YPVNIKDALMRHRKYNWDIIGCTPEIAHVHTLYRGVSEKAVSHRSFDFVPIPWFQRRPRTHEHNPMEKGIRPVKGETVKR
PKIPVKVFSLYKSTQTGKNNRSGVNENPFKNRATLFKIFIPLSIVLGFLSLPLFYGSDPKGADSKQVGSTSPAANGLVSK
AHNTIAGQGVPVSSGDTHNPIFNDAPDFLAQLKVEQLFIVGHVQKSKFLGIVKTQNGAESRQTITDYFVFSASSKDAQYT
FNSEDLKEMGYTIKKITNCYVQINNVVRTVHSFCNPSLPASEPDSKNESILAGI

Specific function: Increases the permeability of the small intestine mucosa by affecting the structure of intercellular tight junctions (zonula occludens) [H]

COG id: COG4128

COG function: function code R; Zonula occludens toxin

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008900 [H]

Pfam domain/function: PF05707 Zot [H]

EC number: NA

Molecular weight: Translated: 51062; Mature: 50930

Theoretical pI: Translated: 9.38; Mature: 9.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASSIYHGKPGSYKTSTAVWFHILPALRKGRFVCTNVEGLFSLEEIEKILGEKFPETAYL
CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEE
FRVSTLNDIGVNTMAKWFHWLPLGAFIVIDEIQNLYNSKDRTDFKVHDTNRSVNTLDRIL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
DFPSLPENVKYLSQQALISVIDDGYTDDMGISERDSNGHVLYPVNIKDALMRHRKYNWDI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCEE
IGCTPEIAHVHTLYRGVSEKAVSHRSFDFVPIPWFQRRPRTHEHNPMEKGIRPVKGETVK
EECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHCCCCCCCCCCHHHCCCCCCCCCCC
RPKIPVKVFSLYKSTQTGKNNRSGVNENPFKNRATLFKIFIPLSIVLGFLSLPLFYGSDP
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCC
KGADSKQVGSTSPAANGLVSKAHNTIAGQGVPVSSGDTHNPIFNDAPDFLAQLKVEQLFI
CCCCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEE
VGHVQKSKFLGIVKTQNGAESRQTITDYFVFSASSKDAQYTFNSEDLKEMGYTIKKITNC
EEEECCCCEEEEEECCCCCHHHHHHHHEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHH
YVQINNVVRTVHSFCNPSLPASEPDSKNESILAGI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCC
>Mature Secondary Structure 
ASSIYHGKPGSYKTSTAVWFHILPALRKGRFVCTNVEGLFSLEEIEKILGEKFPETAYL
CCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECHHHHHHHHHHHHHHHCCCCCCEEE
FRVSTLNDIGVNTMAKWFHWLPLGAFIVIDEIQNLYNSKDRTDFKVHDTNRSVNTLDRIL
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCHHHHHHHH
DFPSLPENVKYLSQQALISVIDDGYTDDMGISERDSNGHVLYPVNIKDALMRHRKYNWDI
CCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHCCCCEE
IGCTPEIAHVHTLYRGVSEKAVSHRSFDFVPIPWFQRRPRTHEHNPMEKGIRPVKGETVK
EECCHHHHHHHHHHHHHHHHHHHHCCCCEECCCHHHCCCCCCCCCCHHHCCCCCCCCCCC
RPKIPVKVFSLYKSTQTGKNNRSGVNENPFKNRATLFKIFIPLSIVLGFLSLPLFYGSDP
CCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCC
KGADSKQVGSTSPAANGLVSKAHNTIAGQGVPVSSGDTHNPIFNDAPDFLAQLKVEQLFI
CCCCCCCCCCCCCHHHHHHHHHCCHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHEEE
VGHVQKSKFLGIVKTQNGAESRQTITDYFVFSASSKDAQYTFNSEDLKEMGYTIKKITNC
EEEECCCCEEEEEECCCCCHHHHHHHHEEEEECCCCCCEEEECHHHHHHHHHHHHHHHHH
YVQINNVVRTVHSFCNPSLPASEPDSKNESILAGI
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1730472; 10952301; 2052603 [H]