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The map label for this gene is serS [H]

Identifier: 126174377

GI number: 126174377

Start: 2505618

End: 2506904

Strand: Direct

Name: serS [H]

Synonym: Sbal_2160

Alternate gene names: 126174377

Gene position: 2505618-2506904 (Clockwise)

Preceding gene: 126174376

Following gene: 126174378

Centisome position: 48.87

GC content: 47.79

Gene sequence:

>1287_bases
ATGTTAGATCCTAAATTTTTGCGTAACGAATTAGAAGTTACCGCTGAGCGACTGGCCACCCGTGGCTTTATTTTAGACAT
AGCTCACCTCACTCAATTAGAAGAAAAGCGTAAGTCACTGCAAGTGGCTACCGAAGAATTACAAGCGTCGCGTAATGCCA
TCTCCAAATCCATTGGCCAAGCTAAAGCCCGTGGTGAAGATGTTGACGCGATCATGGCGCAAGTGGGCGATTTAGGTTCA
CAGCTGGATGCCAAAAAGATTGAACTGGCGGCCGTGCTTGAAGAAGTCAATGCCATTGCCATGTCAATGCCCAACCTGCC
AGACGAATCCGCGCCAATCGGTGCCGATGAAACGGAGAATGTTGAAGTTCGCCGCTGGGGTACGCCACGCACGTTTGATT
TCCCAATTAAAGATCATATCGATTTAGGCGAAGGCCTAAACGGTTTAGATTTTAAAAATGCAGTGAAAATCACTGGCTCA
CGTTTTATCGTGATGAAAGGCCAAGTTGCCCGCTTAAACCGCGCCATTGGTCAGTTCATGCTGGACTTGCACACCACAGA
GCACGGTTATACCGAAGCCTATGTGCCGTTACTGGTTAACGAAGCAAGCTTACTGGGCACAGGTCAACTGCCTAAGTTTG
GTGAAGACTTGTTCCACACTAAACCTGCCACCGAAGAAGGTCAGGGTTTGAGCTTGATCCCAACGGCCGAAGTGCCATTA
ACCAACTTAGTGCGCGATAGCATTGTTGATGAAGACGAGCTGCCGATTAAATTAACCGCGCATACCGCATGTTTCCGCAG
CGAAGCGGGCTCATACGGCAAAGATACTCGCGGTCTGATCCGTCAGCATCAGTTCGATAAAGTTGAAATGGTGCAAATCG
TTAAGCCGGAAGATTCAATGGCGGCGCTCGAAGCGCTAACAGGTCATGCTGAAACTGTATTGCAACGTTTAGGTCTGCCA
TACCGTACTGTTATTTTATGTACTGGTGATATGGGCTTTGGCTCAAGCAAAACCTACGACATCGAAGTCTGGTTACCGGC
ACAAAACACTTATCGTGAAATTTCTTCTTGCTCAAACATGAAGGATTTCCAAGCCCGTCGTATGCAAGCACGTTACCGCG
TGAAAGCTGATAATAAGCCCGCGTTACTGCATACCTTAAACGGTTCCGGTTTAGCTGTGGGTCGTACCTTAGTGGCTATT
TTAGAAAACTATCAAAATGCCGATGGCAGTATCACAATCCCAGAAGTGCTGCGTCCCTACATGGGCGGCTTGACTAAAAT
AGGCTAA

Upstream 100 bases:

>100_bases
GACTTTGAATGTGGTGTTGAATCTAAGTCTATGTTTATTCATGGTGTACTTAGGTCAGCAACTGGTTTTTTCTCGCATTT
AACTATTAAGAATATATCAC

Downstream 100 bases:

>100_bases
TGGAACGCAAAATAATACTATGGATAAAGGCCAGCGCTATCTCCGTTGGCTTTCCTATACCGCTGTCATTGCAGTATTTT
TTGCGGTGATGTTGGCGACC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MLDPKFLRNELEVTAERLATRGFILDIAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVDAIMAQVGDLGS
QLDAKKIELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEVRRWGTPRTFDFPIKDHIDLGEGLNGLDFKNAVKITGS
RFIVMKGQVARLNRAIGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPEDSMAALEALTGHAETVLQRLGLP
YRTVILCTGDMGFGSSKTYDIEVWLPAQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSITIPEVLRPYMGGLTKIG

Sequences:

>Translated_428_residues
MLDPKFLRNELEVTAERLATRGFILDIAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVDAIMAQVGDLGS
QLDAKKIELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEVRRWGTPRTFDFPIKDHIDLGEGLNGLDFKNAVKITGS
RFIVMKGQVARLNRAIGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPEDSMAALEALTGHAETVLQRLGLP
YRTVILCTGDMGFGSSKTYDIEVWLPAQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSITIPEVLRPYMGGLTKIG
>Mature_428_residues
MLDPKFLRNELEVTAERLATRGFILDIAHLTQLEEKRKSLQVATEELQASRNAISKSIGQAKARGEDVDAIMAQVGDLGS
QLDAKKIELAAVLEEVNAIAMSMPNLPDESAPIGADETENVEVRRWGTPRTFDFPIKDHIDLGEGLNGLDFKNAVKITGS
RFIVMKGQVARLNRAIGQFMLDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPEDSMAALEALTGHAETVLQRLGLP
YRTVILCTGDMGFGSSKTYDIEVWLPAQNTYREISSCSNMKDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAI
LENYQNADGSITIPEVLRPYMGGLTKIG

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=356, Percent_Identity=35.3932584269663, Blast_Score=201, Evalue=8e-52,
Organism=Homo sapiens, GI8923421, Length=407, Percent_Identity=29.4840294840295, Blast_Score=171, Evalue=1e-42,
Organism=Homo sapiens, GI225579074, Length=336, Percent_Identity=30.952380952381, Blast_Score=169, Evalue=5e-42,
Organism=Escherichia coli, GI1787120, Length=430, Percent_Identity=70, Blast_Score=637, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539260, Length=435, Percent_Identity=30.8045977011494, Blast_Score=205, Evalue=3e-53,
Organism=Caenorhabditis elegans, GI17542084, Length=330, Percent_Identity=29.3939393939394, Blast_Score=143, Evalue=2e-34,
Organism=Saccharomyces cerevisiae, GI6320226, Length=398, Percent_Identity=30.6532663316583, Blast_Score=197, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=394, Percent_Identity=30.7106598984772, Blast_Score=192, Evalue=8e-50,
Organism=Drosophila melanogaster, GI24581334, Length=323, Percent_Identity=34.984520123839, Blast_Score=186, Evalue=3e-47,
Organism=Drosophila melanogaster, GI17737985, Length=299, Percent_Identity=36.7892976588629, Blast_Score=168, Evalue=7e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47073; Mature: 47073

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDPKFLRNELEVTAERLATRGFILDIAHLTQLEEKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDVDAIMAQVGDLGSQLDAKKIELAAVLEEVNAIAMSMPNLPDESAPIGADETEN
HHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRTFDFPIKDHIDLGEGLNGLDFKNAVKITGSRFIVMKGQVARLNRAIGQFM
EEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHCCCCCCCCCEEHHHEEECHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPEDSM
HHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHH
AALEALTGHAETVLQRLGLPYRTVILCTGDMGFGSSKTYDIEVWLPAQNTYREISSCSNM
HHHHHHHCHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSITIPEVLRPY
HHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLTKIG
HCCCCCCC
>Mature Secondary Structure
MLDPKFLRNELEVTAERLATRGFILDIAHLTQLEEKRKSLQVATEELQASRNAISKSIGQ
CCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AKARGEDVDAIMAQVGDLGSQLDAKKIELAAVLEEVNAIAMSMPNLPDESAPIGADETEN
HHHCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEVRRWGTPRTFDFPIKDHIDLGEGLNGLDFKNAVKITGSRFIVMKGQVARLNRAIGQFM
EEEEECCCCCEECCCCCCCCCCCCCCCCCCCCCEEEECCCEEEEECCHHHHHHHHHHHHH
LDLHTTEHGYTEAYVPLLVNEASLLGTGQLPKFGEDLFHTKPATEEGQGLSLIPTAEVPL
HHHCCCCCCCCCEEHHHEEECHHHCCCCCCCCHHHHHHCCCCCCCCCCCEEEEECCCCCH
TNLVRDSIVDEDELPIKLTAHTACFRSEAGSYGKDTRGLIRQHQFDKVEMVQIVKPEDSM
HHHHHHHHCCCCCCCEEEEHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEEEECCCHHH
AALEALTGHAETVLQRLGLPYRTVILCTGDMGFGSSKTYDIEVWLPAQNTYREISSCSNM
HHHHHHHCHHHHHHHHHCCCEEEEEEEECCCCCCCCCEEEEEEEECCCHHHHHHHHHCCC
KDFQARRMQARYRVKADNKPALLHTLNGSGLAVGRTLVAILENYQNADGSITIPEVLRPY
HHHHHHHHHHHHEECCCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCCCEEHHHHHHHH
MGGLTKIG
HCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA