Click here to switch to the map view.

The map label for this gene is bioA [H]

Identifier: 126173984

GI number: 126173984

Start: 2046526

End: 2047908

Strand: Reverse

Name: bioA [H]

Synonym: Sbal_1757

Alternate gene names: 126173984

Gene position: 2047908-2046526 (Counterclockwise)

Preceding gene: 126173989

Following gene: 126173983

Centisome position: 39.94

GC content: 50.54

Gene sequence:

>1383_bases
ATGCGCAATTTACTCGATTTTGATTTTGATAGCGCCCATATTTGGCATCCTTACACCTCAATGACCCGTTCTCTTCCTGT
TTTTGGTGTACATAGTGCGAAGGGCTGCGAGCTCGAACTCGTCGATGGCCGCAAGCTGGTCGATGGCACTAGCTCATGGT
GGGCCTGTGTGCACGGTTATGCGCATCCCGAGATATTAACCGCGATGGAAAAACAGCTGCATCAGCTGAGCCATGTGATG
TTTGGCGGCATCACCCATGAACCCGCCATTGAACTGTGTAAAAAACTTATCGCTATGACCTGCGAGCCGCTGACGAAAAT
CTTTTTATGCGACTCTGGCTCTATCTCAGTCGAAGTGGCGATCAAAATGGCGTTGCAATATTGGCAAGGTCAAAGTTTGC
AAGGTAAGAGTTTGCAAAGTAAGAGCTCGCAGGAGCAAGGCGCACATAAAGAGCGGCCGCTAAAACAACGCATTCTTACC
GTTAAGAAGGGTTACCACGGCGATACCTTTGCCGCCATGAGCGTGTGCGATCCCGAAGGTGGCATGCACACTATGTTTGG
CGATGCGCTGACAAAACAATCCTTTGTGCCTGCACCACAAACCGCCTTTGGCGAAGCCTTACAAGCCGATGATTTAACCG
CAATGCGCAGCATTTTAAGTGCAAATCACCATGATATTGCTGCTGTGATCATAGAACCGATCATGCAAGGCGCTGGCGGG
ATGCGTTTTTACAGCGCAGATTATTTAGCGGGTATTCGCGCCCTGTGCGATGAGTTTGATGTGCTATTAATCTTAGATGA
AATCGCTACTGGCTTTGGCCGCACAGGCAAGCTGTTCGCCTATGAACACGCCAATATCACTCCAGATATCTTATGTTTAG
GTAAAGCGCTAACGGGCGGTTACATCAGCCTAGCGGCAACGCTGTGTACCGATAAAGTCGCCCAAGGAATCAGCCAATCT
CCCGCTGGCGTGTTTATGCATGGGCCGACCTTTATGGGCAACCCGCTGGCCTGCGCGGCGGCGTGTGCGAGCTTAGACTT
AATTAACCGCAATGAATGGCAAACGCAAGTGGCCGCTATCGAGCAGCAAATGCGCTTAGAACTTAAGGATGCGATTGATT
TACCGAGTGTTAAGGACGTGCGAGTCCTCGGCGCTGTCGGCGTGTTAGAGATGCATGATCCCGTCAATACCGCTGAGCTA
CAGCAACAATTTGTTGATTTAGGGGTGTGGGTTCGCCCCTTCGCTAACCTTATCTATATCATGCCGCCCTATGTGATTAG
CTCGGCGCAATTAAGCCAACTCACCGGTGCGATGAAGCAAATTGCGGCAGGCATTAAGGCATCATCAAGCGGTGCTGAGC
AACAGCTTATCAGCCACGGTTAA

Upstream 100 bases:

>100_bases
TTTTATCTTGGCTAGGATAACCTCAGCCCTTAAACTGTCAACGCCAACCAGTGAATCCAGTTTACTAATGGCTATTTTAC
CACCAACTTAGTGAGCATTT

Downstream 100 bases:

>100_bases
TGCCAACAGCATAAGCCTTCAACGTAAGAATCCTTCAAATAGACAACACTCAGCGCACAGTTCTAGGTGCGCTGGGGTTT
AAACTGAGCAGTTGTGTTAA

Product: adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 460; Mature: 460

Protein sequence:

>460_residues
MRNLLDFDFDSAHIWHPYTSMTRSLPVFGVHSAKGCELELVDGRKLVDGTSSWWACVHGYAHPEILTAMEKQLHQLSHVM
FGGITHEPAIELCKKLIAMTCEPLTKIFLCDSGSISVEVAIKMALQYWQGQSLQGKSLQSKSSQEQGAHKERPLKQRILT
VKKGYHGDTFAAMSVCDPEGGMHTMFGDALTKQSFVPAPQTAFGEALQADDLTAMRSILSANHHDIAAVIIEPIMQGAGG
MRFYSADYLAGIRALCDEFDVLLILDEIATGFGRTGKLFAYEHANITPDILCLGKALTGGYISLAATLCTDKVAQGISQS
PAGVFMHGPTFMGNPLACAAACASLDLINRNEWQTQVAAIEQQMRLELKDAIDLPSVKDVRVLGAVGVLEMHDPVNTAEL
QQQFVDLGVWVRPFANLIYIMPPYVISSAQLSQLTGAMKQIAAGIKASSSGAEQQLISHG

Sequences:

>Translated_460_residues
MRNLLDFDFDSAHIWHPYTSMTRSLPVFGVHSAKGCELELVDGRKLVDGTSSWWACVHGYAHPEILTAMEKQLHQLSHVM
FGGITHEPAIELCKKLIAMTCEPLTKIFLCDSGSISVEVAIKMALQYWQGQSLQGKSLQSKSSQEQGAHKERPLKQRILT
VKKGYHGDTFAAMSVCDPEGGMHTMFGDALTKQSFVPAPQTAFGEALQADDLTAMRSILSANHHDIAAVIIEPIMQGAGG
MRFYSADYLAGIRALCDEFDVLLILDEIATGFGRTGKLFAYEHANITPDILCLGKALTGGYISLAATLCTDKVAQGISQS
PAGVFMHGPTFMGNPLACAAACASLDLINRNEWQTQVAAIEQQMRLELKDAIDLPSVKDVRVLGAVGVLEMHDPVNTAEL
QQQFVDLGVWVRPFANLIYIMPPYVISSAQLSQLTGAMKQIAAGIKASSSGAEQQLISHG
>Mature_460_residues
MRNLLDFDFDSAHIWHPYTSMTRSLPVFGVHSAKGCELELVDGRKLVDGTSSWWACVHGYAHPEILTAMEKQLHQLSHVM
FGGITHEPAIELCKKLIAMTCEPLTKIFLCDSGSISVEVAIKMALQYWQGQSLQGKSLQSKSSQEQGAHKERPLKQRILT
VKKGYHGDTFAAMSVCDPEGGMHTMFGDALTKQSFVPAPQTAFGEALQADDLTAMRSILSANHHDIAAVIIEPIMQGAGG
MRFYSADYLAGIRALCDEFDVLLILDEIATGFGRTGKLFAYEHANITPDILCLGKALTGGYISLAATLCTDKVAQGISQS
PAGVFMHGPTFMGNPLACAAACASLDLINRNEWQTQVAAIEQQMRLELKDAIDLPSVKDVRVLGAVGVLEMHDPVNTAEL
QQQFVDLGVWVRPFANLIYIMPPYVISSAQLSQLTGAMKQIAAGIKASSSGAEQQLISHG

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=432, Percent_Identity=29.6296296296296, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI284507298, Length=286, Percent_Identity=31.4685314685315, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI13994255, Length=384, Percent_Identity=28.3854166666667, Blast_Score=103, Evalue=5e-22,
Organism=Homo sapiens, GI226442709, Length=429, Percent_Identity=24.4755244755245, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI37574042, Length=429, Percent_Identity=24.4755244755245, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=23.9080459770115, Blast_Score=84, Evalue=2e-16,
Organism=Escherichia coli, GI1786991, Length=435, Percent_Identity=58.1609195402299, Blast_Score=503, Evalue=1e-144,
Organism=Escherichia coli, GI145693181, Length=424, Percent_Identity=32.7830188679245, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1789016, Length=427, Percent_Identity=29.7423887587822, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1788044, Length=328, Percent_Identity=33.2317073170732, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787560, Length=421, Percent_Identity=28.7410926365796, Blast_Score=149, Evalue=5e-37,
Organism=Escherichia coli, GI1789759, Length=348, Percent_Identity=30.7471264367816, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1786349, Length=324, Percent_Identity=28.7037037037037, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=27.1889400921659, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=303, Percent_Identity=30.03300330033, Blast_Score=121, Evalue=6e-28,
Organism=Caenorhabditis elegans, GI32564660, Length=430, Percent_Identity=23.7209302325581, Blast_Score=86, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=21.5130023640662, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541228, Length=393, Percent_Identity=24.4274809160305, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324386, Length=475, Percent_Identity=43.1578947368421, Blast_Score=396, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6323470, Length=440, Percent_Identity=30.4545454545455, Blast_Score=138, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=380, Percent_Identity=28.9473684210526, Blast_Score=134, Evalue=3e-32,
Organism=Saccharomyces cerevisiae, GI6321456, Length=313, Percent_Identity=23.6421725239617, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI21357415, Length=431, Percent_Identity=27.8422273781903, Blast_Score=140, Evalue=2e-33,
Organism=Drosophila melanogaster, GI21356575, Length=368, Percent_Identity=23.6413043478261, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI28574759, Length=437, Percent_Identity=25.1716247139588, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI161085790, Length=431, Percent_Identity=24.8259860788863, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281366494, Length=320, Percent_Identity=26.875, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667139, Length=320, Percent_Identity=26.875, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24667143, Length=320, Percent_Identity=26.875, Blast_Score=77, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 49892; Mature: 49892

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNLLDFDFDSAHIWHPYTSMTRSLPVFGVHSAKGCELELVDGRKLVDGTSSWWACVHGY
CCCCCCCCCCCCEEECCHHHHHHCCCEEECCCCCCCEEEEECCCEEECCCCHHHHHHCCC
AHPEILTAMEKQLHQLSHVMFGGITHEPAIELCKKLIAMTCEPLTKIFLCDSGSISVEVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHEEEEECCCCEEEHHH
IKMALQYWQGQSLQGKSLQSKSSQEQGAHKERPLKQRILTVKKGYHGDTFAAMSVCDPEG
HHHHHHHHCCCCCCCCCHHHCCCHHCCCHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCC
GMHTMFGDALTKQSFVPAPQTAFGEALQADDLTAMRSILSANHHDIAAVIIEPIMQGAGG
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
MRFYSADYLAGIRALCDEFDVLLILDEIATGFGRTGKLFAYEHANITPDILCLGKALTGG
CEEECHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCH
YISLAATLCTDKVAQGISQSPAGVFMHGPTFMGNPLACAAACASLDLINRNEWQTQVAAI
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
EQQMRLELKDAIDLPSVKDVRVLGAVGVLEMHDPVNTAELQQQFVDLGVWVRPFANLIYI
HHHHHHHHHHHCCCCCCCCCHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEE
MPPYVISSAQLSQLTGAMKQIAAGIKASSSGAEQQLISHG
CCCHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC
>Mature Secondary Structure
MRNLLDFDFDSAHIWHPYTSMTRSLPVFGVHSAKGCELELVDGRKLVDGTSSWWACVHGY
CCCCCCCCCCCCEEECCHHHHHHCCCEEECCCCCCCEEEEECCCEEECCCCHHHHHHCCC
AHPEILTAMEKQLHQLSHVMFGGITHEPAIELCKKLIAMTCEPLTKIFLCDSGSISVEVA
CCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCHHEEEEECCCCEEEHHH
IKMALQYWQGQSLQGKSLQSKSSQEQGAHKERPLKQRILTVKKGYHGDTFAAMSVCDPEG
HHHHHHHHCCCCCCCCCHHHCCCHHCCCHHCCCHHHHHHHHHCCCCCCCEEEEEEECCCC
GMHTMFGDALTKQSFVPAPQTAFGEALQADDLTAMRSILSANHHDIAAVIIEPIMQGAGG
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCC
MRFYSADYLAGIRALCDEFDVLLILDEIATGFGRTGKLFAYEHANITPDILCLGKALTGG
CEEECHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCCCEEEEECCCCCHHHHHHHHHHCCH
YISLAATLCTDKVAQGISQSPAGVFMHGPTFMGNPLACAAACASLDLINRNEWQTQVAAI
HHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHH
EQQMRLELKDAIDLPSVKDVRVLGAVGVLEMHDPVNTAELQQQFVDLGVWVRPFANLIYI
HHHHHHHHHHHCCCCCCCCCHHHHHHCEEEECCCCCHHHHHHHHHHHHHHHHHHHCEEEE
MPPYVISSAQLSQLTGAMKQIAAGIKASSSGAEQQLISHG
CCCHHHCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8890743 [H]