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The map label for this gene is acsA

Identifier: 126173981

GI number: 126173981

Start: 2038485

End: 2040437

Strand: Reverse

Name: acsA

Synonym: Sbal_1752

Alternate gene names: 126173981

Gene position: 2040437-2038485 (Counterclockwise)

Preceding gene: 126173983

Following gene: 126173980

Centisome position: 39.79

GC content: 50.03

Gene sequence:

>1953_bases
ATGAGCTCGCAGTCTCTCTACAAAGTCTCCGGCAATATCGCTGCCAATGCACTTGTAAACAACGATAAATATAAAACAAT
GTACCAAGAGTCGATTGTCAATCCTGAAGGTTTCTGGAGAGAACACGGCAAGCGTATTGATTGGATAAAACCCTATACCA
AAATTAAAAAAACCTCTTTTGATGATCATAATTTATCGATCAACTGGTTTTACGACGGCACCCTAAATGCTTCTGCCAAC
TGTTTAGATCGTCACTTAGCCGAGCACAGTGATCGCGTGGCGATTATTTGGGAAGGCGACAACGCCAGCGAACAACGCAA
AATCACCTACGGTGAATTACATGCAGATGTGTGTAAATTCGCCAACGCATTACGCAGCCAAGGCGTGCGCCGCGGTGACA
TAGTCACAATTTACATGCCTATGGTGCCAGAAGCCGCAGTGGCTATGCTCGCCTGTGCCCGTATCGGCGCGGTGCACTCT
GTGGTCTTCGGTGGTTTCTCACCGGATTCTATCGCCTCTCGCGTCATTGATGGCAAATCAAAAGTCATTATTACCTCAGA
TGAAGGTATGCGCGGTGGCCGTGCTATCCCACTGAAACGCAACATCGATGATGCCTTAAAAAATCCTGATGTCACTACCG
TTGAAAAAGTCATCGTGCTTAAACGCACGGGTGGCAAAGTGGATTGGGTAGAAGGCCGAGATGTGTGGTGGCACTCACTG
ATGGAAACCGCATCTGAGTACTGTCAACCAGAGGAAATGGACGCAGAAGCGCCGTTATTCCTGCTGTATACCTCAGGTTC
AACCGGTAACCCCAAGGGCGTATTGCACACCACTGGTGGCTACATGGTTTATGCGTCTATGACCCATGAGTATGTGTTCG
ACTACAAAGCGGGCGAAGTGTACTGGTGTACCGCCGATGTGGGTTGGATCACAGGCCACTCTTATATGGTTTACGGCCCA
CTCGCCAATGGTGCGACTGTGCTTATCCATGAAGGCGTACCGAATCATCCAAGCCCTGCCCGTTTAGGCGAAATGATTGA
CCGCCATAAAGTGAGCATTCTTTACACAGCGCCAACCTTAATTCGCGCGCTGATGGCCGAAGGTAAGCAACACTTCGATA
AGTTCGATGGTAGCAGCTTGAGGATCATGGGCTCGGTAGGCGAACCCATCAACCCAGAAGCATGGCGTTGGTACCATGAG
GTCATAGGTCATGAACATTGCCCTATCGTCGATACTTGGTGGCAAACTGAAACTGGCGGTATTTTGATCACGCCACTGCC
TGGGGCGACCGACACTAAACCTGGTTCAGCAACCCGTCCGTTCTTTGGTGTTCAACCCGCCTTAGTCGATAACATGGGTA
ATATTTTAGAAGGTGAGAACGAAGGTAACTTAGTGTTACTCGACTCTTGGCCGGGCCAAATGCGAACTGTGTATGGCGAC
CACGAACGATTCGTACTGACCTATTTTAAAACTTTCCGCGGCATGTATTTTACCGGTGACGGTGCCCGCCGCGATGAAGA
TGGCTACTACTGGATAACAGGCCGCGTCGATGACGTAATCAACGTATCCGGCCACAGATTAGGTACGGCAGAGGTCGAAA
GTGCGCTGGTATCACATGAACTGGTTGCAGAAGCGGCAGTAGTTGGCTACCCACACGATATTAAAGGCCAAGGTATTTAT
GCGTACGTCACGCTAACCCGCGGCACTGAAGAAACCGAAGAGCTACGTCAAGAGCTGCGTCAATGGGTGCGTAAAGAAAT
TGGTGCGCTGGCAACCCCAGATCTTATCCAATGGGCAACGGGCTTACCTAAGACACGTTCGGGCAAGATCATGCGCCGCT
TCCTGCGTAAGATTGCCGCTAACGAAGTGACCAACTTAGGGGATGCATCAACCTTGGCCGATCCAGCGGTGATCGAGACC
TTGATTGAATCACGCTTGAATCGTACTGAGTAA

Upstream 100 bases:

>100_bases
AAATATAAAGGAAAATTTAAAACTAGACCAAGGTCTAATGGAGTTGCCGCCCCCTTGCATACCATACTCAGTCCACGCAA
TTTTTCAAAAGGGAAGCCCT

Downstream 100 bases:

>100_bases
TATCCGAGTTACGAACAACGTCCACAACGCTTAGTCTATGCCCAATAGGCTAAGCGTAACCTGAACCTCCCTTTTTAAAC
CTCAGGTTAAAAGTGAACCC

Product: acetyl-CoA synthetase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme

Number of amino acids: Translated: 650; Mature: 649

Protein sequence:

>650_residues
MSSQSLYKVSGNIAANALVNNDKYKTMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTSFDDHNLSINWFYDGTLNASAN
CLDRHLAEHSDRVAIIWEGDNASEQRKITYGELHADVCKFANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHS
VVFGGFSPDSIASRVIDGKSKVIITSDEGMRGGRAIPLKRNIDDALKNPDVTTVEKVIVLKRTGGKVDWVEGRDVWWHSL
METASEYCQPEEMDAEAPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKAGEVYWCTADVGWITGHSYMVYGP
LANGATVLIHEGVPNHPSPARLGEMIDRHKVSILYTAPTLIRALMAEGKQHFDKFDGSSLRIMGSVGEPINPEAWRWYHE
VIGHEHCPIVDTWWQTETGGILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGENEGNLVLLDSWPGQMRTVYGD
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHELVAEAAVVGYPHDIKGQGIY
AYVTLTRGTEETEELRQELRQWVRKEIGALATPDLIQWATGLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIET
LIESRLNRTE

Sequences:

>Translated_650_residues
MSSQSLYKVSGNIAANALVNNDKYKTMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTSFDDHNLSINWFYDGTLNASAN
CLDRHLAEHSDRVAIIWEGDNASEQRKITYGELHADVCKFANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHS
VVFGGFSPDSIASRVIDGKSKVIITSDEGMRGGRAIPLKRNIDDALKNPDVTTVEKVIVLKRTGGKVDWVEGRDVWWHSL
METASEYCQPEEMDAEAPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKAGEVYWCTADVGWITGHSYMVYGP
LANGATVLIHEGVPNHPSPARLGEMIDRHKVSILYTAPTLIRALMAEGKQHFDKFDGSSLRIMGSVGEPINPEAWRWYHE
VIGHEHCPIVDTWWQTETGGILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGENEGNLVLLDSWPGQMRTVYGD
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHELVAEAAVVGYPHDIKGQGIY
AYVTLTRGTEETEELRQELRQWVRKEIGALATPDLIQWATGLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIET
LIESRLNRTE
>Mature_649_residues
SSQSLYKVSGNIAANALVNNDKYKTMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTSFDDHNLSINWFYDGTLNASANC
LDRHLAEHSDRVAIIWEGDNASEQRKITYGELHADVCKFANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHSV
VFGGFSPDSIASRVIDGKSKVIITSDEGMRGGRAIPLKRNIDDALKNPDVTTVEKVIVLKRTGGKVDWVEGRDVWWHSLM
ETASEYCQPEEMDAEAPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKAGEVYWCTADVGWITGHSYMVYGPL
ANGATVLIHEGVPNHPSPARLGEMIDRHKVSILYTAPTLIRALMAEGKQHFDKFDGSSLRIMGSVGEPINPEAWRWYHEV
IGHEHCPIVDTWWQTETGGILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGENEGNLVLLDSWPGQMRTVYGDH
ERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHELVAEAAVVGYPHDIKGQGIYA
YVTLTRGTEETEELRQELRQWVRKEIGALATPDLIQWATGLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIETL
IESRLNRTE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family

Homologues:

Organism=Homo sapiens, GI8923896, Length=654, Percent_Identity=52.7522935779816, Blast_Score=685, Evalue=0.0,
Organism=Homo sapiens, GI253970489, Length=668, Percent_Identity=51.7964071856287, Blast_Score=681, Evalue=0.0,
Organism=Homo sapiens, GI28416953, Length=623, Percent_Identity=49.1171749598716, Blast_Score=627, Evalue=1e-179,
Organism=Homo sapiens, GI13375727, Length=634, Percent_Identity=36.1198738170347, Blast_Score=390, Evalue=1e-108,
Organism=Homo sapiens, GI42544132, Length=564, Percent_Identity=29.0780141843972, Blast_Score=201, Evalue=2e-51,
Organism=Homo sapiens, GI122937307, Length=552, Percent_Identity=28.804347826087, Blast_Score=199, Evalue=8e-51,
Organism=Homo sapiens, GI38505220, Length=541, Percent_Identity=29.7597042513863, Blast_Score=189, Evalue=6e-48,
Organism=Homo sapiens, GI31982927, Length=648, Percent_Identity=24.8456790123457, Blast_Score=179, Evalue=7e-45,
Organism=Homo sapiens, GI115511026, Length=534, Percent_Identity=28.6516853932584, Blast_Score=176, Evalue=5e-44,
Organism=Homo sapiens, GI58082049, Length=525, Percent_Identity=26.0952380952381, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI157311624, Length=525, Percent_Identity=25.5238095238095, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI157311622, Length=525, Percent_Identity=25.5238095238095, Blast_Score=152, Evalue=9e-37,
Organism=Homo sapiens, GI195947378, Length=441, Percent_Identity=24.7165532879819, Blast_Score=102, Evalue=2e-21,
Organism=Homo sapiens, GI42544134, Length=383, Percent_Identity=25.065274151436, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI187761345, Length=500, Percent_Identity=25.4, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI187761343, Length=500, Percent_Identity=25.4, Blast_Score=98, Evalue=2e-20,
Organism=Homo sapiens, GI156151445, Length=572, Percent_Identity=23.4265734265734, Blast_Score=89, Evalue=1e-17,
Organism=Escherichia coli, GI1790505, Length=645, Percent_Identity=69.4573643410853, Blast_Score=974, Evalue=0.0,
Organism=Escherichia coli, GI1786529, Length=634, Percent_Identity=37.6971608832808, Blast_Score=404, Evalue=1e-114,
Organism=Escherichia coli, GI1788107, Length=576, Percent_Identity=23.7847222222222, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI221142682, Length=528, Percent_Identity=21.2121212121212, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI145693145, Length=380, Percent_Identity=25.5263157894737, Blast_Score=82, Evalue=1e-16,
Organism=Escherichia coli, GI1786810, Length=548, Percent_Identity=21.7153284671533, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1789201, Length=460, Percent_Identity=23.2608695652174, Blast_Score=78, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71982997, Length=640, Percent_Identity=50.625, Blast_Score=628, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI71983001, Length=640, Percent_Identity=50.625, Blast_Score=627, Evalue=1e-180,
Organism=Caenorhabditis elegans, GI17569507, Length=621, Percent_Identity=23.3494363929147, Blast_Score=137, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI17558820, Length=518, Percent_Identity=24.1312741312741, Blast_Score=109, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI32563687, Length=557, Percent_Identity=22.8007181328546, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17538037, Length=142, Percent_Identity=31.6901408450704, Blast_Score=76, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17557194, Length=132, Percent_Identity=32.5757575757576, Blast_Score=71, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323182, Length=641, Percent_Identity=49.9219968798752, Blast_Score=631, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319264, Length=641, Percent_Identity=46.6458658346334, Blast_Score=572, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6319699, Length=373, Percent_Identity=23.0563002680965, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI24667955, Length=664, Percent_Identity=52.710843373494, Blast_Score=683, Evalue=0.0,
Organism=Drosophila melanogaster, GI62472339, Length=562, Percent_Identity=56.7615658362989, Blast_Score=636, Evalue=0.0,
Organism=Drosophila melanogaster, GI24667959, Length=520, Percent_Identity=57.6923076923077, Blast_Score=597, Evalue=1e-171,
Organism=Drosophila melanogaster, GI21355225, Length=659, Percent_Identity=33.8391502276176, Blast_Score=360, Evalue=2e-99,
Organism=Drosophila melanogaster, GI21355181, Length=526, Percent_Identity=23.7642585551331, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI18859661, Length=554, Percent_Identity=22.5631768953069, Blast_Score=97, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24581924, Length=527, Percent_Identity=22.3908918406072, Blast_Score=77, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24656500, Length=367, Percent_Identity=23.9782016348774, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ACSA_SHEB5 (A3D3E8)

Other databases:

- EMBL:   CP000563
- RefSeq:   YP_001050130.1
- ProteinModelPortal:   A3D3E8
- SMR:   A3D3E8
- STRING:   A3D3E8
- GeneID:   4845127
- GenomeReviews:   CP000563_GR
- KEGG:   sbl:Sbal_1752
- NMPDR:   fig|325240.3.peg.3752
- eggNOG:   COG0365
- HOGENOM:   HBG547964
- OMA:   ETASEHC
- PhylomeDB:   A3D3E8
- ProtClustDB:   PRK00174
- HAMAP:   MF_01123
- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873
- TIGRFAMs:   TIGR02188

Pfam domain/function: PF00501 AMP-binding

EC number: =6.2.1.1

Molecular weight: Translated: 72397; Mature: 72266

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: PS00455 AMP_BINDING

Important sites: ACT_SITE 517-517

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSQSLYKVSGNIAANALVNNDKYKTMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTSF
CCCCCEEEECCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHCCCC
DDHNLSINWFYDGTLNASANCLDRHLAEHSDRVAIIWEGDNASEQRKITYGELHADVCKF
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
ANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHSVVFGGFSPDSIASRVIDGKS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
KVIITSDEGMRGGRAIPLKRNIDDALKNPDVTTVEKVIVLKRTGGKVDWVEGRDVWWHSL
EEEEECCCCCCCCEEECCCCCCHHHHCCCCCCEEEEEEEEEECCCEEEEECCCHHHHHHH
METASEYCQPEEMDAEAPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKAGEV
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEECCEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNHPSPARLGEMIDRHKVSILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHH
IRALMAEGKQHFDKFDGSSLRIMGSVGEPINPEAWRWYHEVIGHEHCPIVDTWWQTETGG
HHHHHHHCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCC
ILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGENEGNLVLLDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEEECCCCCEEEEECC
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHE
CCHHHHEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
LVAEAAVVGYPHDIKGQGIYAYVTLTRGTEETEELRQELRQWVRKEIGALATPDLIQWAT
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIETLIESRLNRTE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SSQSLYKVSGNIAANALVNNDKYKTMYQESIVNPEGFWREHGKRIDWIKPYTKIKKTSF
CCCCEEEECCCEEEEEEECCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCCHHHHHCCCC
DDHNLSINWFYDGTLNASANCLDRHLAEHSDRVAIIWEGDNASEQRKITYGELHADVCKF
CCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHH
ANALRSQGVRRGDIVTIYMPMVPEAAVAMLACARIGAVHSVVFGGFSPDSIASRVIDGKS
HHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCC
KVIITSDEGMRGGRAIPLKRNIDDALKNPDVTTVEKVIVLKRTGGKVDWVEGRDVWWHSL
EEEEECCCCCCCCEEECCCCCCHHHHCCCCCCEEEEEEEEEECCCEEEEECCCHHHHHHH
METASEYCQPEEMDAEAPLFLLYTSGSTGNPKGVLHTTGGYMVYASMTHEYVFDYKAGEV
HHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEECCEEEEEEECCCEE
YWCTADVGWITGHSYMVYGPLANGATVLIHEGVPNHPSPARLGEMIDRHKVSILYTAPTL
EEEECCCCEEECCCEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHCCEEEEEECHHH
IRALMAEGKQHFDKFDGSSLRIMGSVGEPINPEAWRWYHEVIGHEHCPIVDTWWQTETGG
HHHHHHHCHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCCEEECCCCCCCCC
ILITPLPGATDTKPGSATRPFFGVQPALVDNMGNILEGENEGNLVLLDSWPGQMRTVYGD
EEEECCCCCCCCCCCCCCCCCCCCCHHHHHCCHHHHCCCCCCCEEEEECCCCCEEEEECC
HERFVLTYFKTFRGMYFTGDGARRDEDGYYWITGRVDDVINVSGHRLGTAEVESALVSHE
CCHHHHEEHHHHCCEEEECCCCCCCCCCEEEEECCCCCEEECCCCCCCHHHHHHHHHHHH
LVAEAAVVGYPHDIKGQGIYAYVTLTRGTEETEELRQELRQWVRKEIGALATPDLIQWAT
HHHHHHHCCCCCCCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
GLPKTRSGKIMRRFLRKIAANEVTNLGDASTLADPAVIETLIESRLNRTE
CCCCCCCCHHHHHHHHHHHHHHHCCCCCCHHCCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA