Click here to switch to the map view.

The map label for this gene is parE [H]

Identifier: 125624342

GI number: 125624342

Start: 1510604

End: 1512538

Strand: Reverse

Name: parE [H]

Synonym: llmg_1539

Alternate gene names: 125624342

Gene position: 1512538-1510604 (Counterclockwise)

Preceding gene: 125624348

Following gene: 125624341

Centisome position: 59.8

GC content: 38.71

Gene sequence:

>1935_bases
ATGGTAATAGATATTAATAATTACGATGACAGTGCAATTCAGGTCCTTGAAGGTTTGGACGCGGTCAGAAAGCGCCCCGG
GATGTATATCGGATCAACTGATGGAACAGGTTTGCACCATTTGGTTTGGGAAATTGTAGATAATGCAGTCGATGAGGCCT
TATCTGGTTTTGGGAATAAAATTACAGTGACCATTAATGCTGATGGTTCTTTATCTGTAGAAGATGAAGGACGTGGAATG
CCTGTCGGAAAACACGCGATGGGAATTCCAACTGTTGAGGTTATTTTCACTATTCTTCATGCTGGTGGTAAATTTGGTCA
AGGGGGATATAAAACTTCTGGTGGATTGCATGGTGTAGGATCTTCGGTGGTAAATGCTCTTTCTACTTGGTTAGAAGTTG
AAATCACTCGTGATGGGACTGTTTATCGCCAACGTTTTGAAAATGGAGGACATCCAGCAACTACTTTGGAAAAAATAGGG
AAAGCTCCGAAATCAAAAACGGGGACAAAAGTGACTTTCATGCCCGATTCTACTATTTTTTCAACAACTGAATTTAAATA
TAACATCATTTCCGAGCGTTTAAATGAATCGGCCTTTCTTTTGAAAGAAGTAACGATTAGTCTTGAAGATAAACGTACGG
ATGAAAAAGAAGAATTTCATTATGAAAATGGAGTTCAGGATTTTGTAGCCTACCTGAATGAAGACAAAGATAGCTTAACT
CCAGTTCTTTATTTTGAAGGAAAGCAAGATGGTTTTGAAGTTGAAGTTGCCCTCCAATATAATGATGGCTATTCAGAAAA
TATTCTTTCGTTTGTCAATAATGTTCGAACTAAAGATGGCGGAACGCACGAAGCAGGTTTAAAAACAGCTATCACTAAGG
CAATGAACGAATATGCTCGTAAAGTCAATTTGCTTAAAGATAAAGATAAAAATCTGGAAGGGTCTGATTATCGTGAAGGT
TTAACGGCAGTTTTATCTGTATTAATTCCAGAGGAACATCTCCAATTTGAAGGACAAACCAAAGATAAATTGGGTTCACC
TTTGGCTCGTCCAGTGGTGGACAGCCTCGTTTCTGAAAAATTAAGTTTTTATTTGATGGAAAATGGTGAATTGGCTCAAA
ACCTGATTCGTAAAGCAATCAAAGCGCGTGAAGCACGTGAAGCAGCTCGTAAAGCACGCGAAGATTCTCGAAATGGTAAA
AAATCTAAAAAAGATAAGGGTCTTTTGTCAGGGAAATTAACACCTGCCCAAACAAAAAATCCAAATAAAAATGAACTTTA
TTTGGTCGAAGGGGATTCAGCGGGCGGCTCTGCCAAACAAGGACGAGACCGAAAATTTCAAGCCATTTTGCCTTTACGTG
GGAAAGTAATTAATACCGAAAAAGCAAAAATGCAAGATATTCTCAAAAATGAGGAAATCAATACCATGATTTACACTATT
GGTGCTGGTGTTGGTGCAGATTTTACTTTGGCTGACCGTAATTATGATAAAGTGATTATCATGACCGATGCGGATACTGA
TGGGGCACACATTCAAACACTTTTATTGACTTTCTTCTATCGCTATATGAAACCTCTTGTAGAAGCTGGACATGTTTATA
TTGCGCTTCCTCCACTTTATAAAATGAGTGAAGGAAAAGGGAAAAAAGAGAAGATAGAGTACGCTTGGACAGATGGCGAG
CTAGCAGAACTTCGTAAGCAGTTTGGTAAAAATGCAAATCTTCAACGTTATAAAGGACTTGGGGAAATGAACGCTGACCA
ACTTTGGGAAACAACGATGGACCCAGAAACTCGGACACTGATTCAAGTAACAATTGATGATGTAGCGCAAGCAGAAAAGC
GTGTTTCCGTGCTGATGGGTGATAAAGTTGAACCACGTCGTAAATGGATTGAAAATAATGTGAAATTTACGATGGAAGAA
GATACAGCTTTCTAA

Upstream 100 bases:

>100_bases
TACAATAATCAAGATGAATATTTTTTGTCAGTAAATTGCGAACAAAGCGAGTGATGATCTTGCTGATAAAAGATATGGGC
TTTCGATGAGAGGAAAATAG

Downstream 100 bases:

>100_bases
ACAATTTTATTCAAATAATTACCTCGATTTTTCGAGGTTTTTTGTTTTAATTTGTGATAAAATGGAAGAAAATCTAAAAG
ACTTTCTTATAACGAAAAGA

Product: DNA topoisomerase IV subunit B

Products: NA

Alternate protein names: Topoisomerase IV subunit B [H]

Number of amino acids: Translated: 644; Mature: 644

Protein sequence:

>644_residues
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNKITVTINADGSLSVEDEGRGM
PVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLEKIG
KAPKSKTGTKVTFMPDSTIFSTTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVAYLNEDKDSLT
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYARKVNLLKDKDKNLEGSDYREG
LTAVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEKLSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGK
KSKKDKGLLSGKLTPAQTKNPNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
GAGVGADFTLADRNYDKVIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLYKMSEGKGKKEKIEYAWTDGE
LAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTLIQVTIDDVAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEE
DTAF

Sequences:

>Translated_644_residues
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNKITVTINADGSLSVEDEGRGM
PVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLEKIG
KAPKSKTGTKVTFMPDSTIFSTTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVAYLNEDKDSLT
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYARKVNLLKDKDKNLEGSDYREG
LTAVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEKLSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGK
KSKKDKGLLSGKLTPAQTKNPNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
GAGVGADFTLADRNYDKVIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLYKMSEGKGKKEKIEYAWTDGE
LAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTLIQVTIDDVAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEE
DTAF
>Mature_644_residues
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNKITVTINADGSLSVEDEGRGM
PVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVGSSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLEKIG
KAPKSKTGTKVTFMPDSTIFSTTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVAYLNEDKDSLT
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYARKVNLLKDKDKNLEGSDYREG
LTAVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEKLSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGK
KSKKDKGLLSGKLTPAQTKNPNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
GAGVGADFTLADRNYDKVIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLYKMSEGKGKKEKIEYAWTDGE
LAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTLIQVTIDDVAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEE
DTAF

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0187

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), B subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Toprim domain [H]

Homologues:

Organism=Homo sapiens, GI19913406, Length=670, Percent_Identity=25.3731343283582, Blast_Score=122, Evalue=1e-27,
Organism=Homo sapiens, GI19913408, Length=670, Percent_Identity=24.6268656716418, Blast_Score=118, Evalue=2e-26,
Organism=Escherichia coli, GI48994957, Length=546, Percent_Identity=53.2967032967033, Blast_Score=526, Evalue=1e-150,
Organism=Escherichia coli, GI1789408, Length=637, Percent_Identity=40.6593406593407, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17535065, Length=660, Percent_Identity=26.8181818181818, Blast_Score=144, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI212645845, Length=589, Percent_Identity=25.2971137521222, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI212645657, Length=209, Percent_Identity=29.6650717703349, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6324241, Length=641, Percent_Identity=26.3650546021841, Blast_Score=122, Evalue=2e-28,
Organism=Drosophila melanogaster, GI17136538, Length=676, Percent_Identity=26.9230769230769, Blast_Score=139, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR020568
- InterPro:   IPR014721
- InterPro:   IPR001241
- InterPro:   IPR013759
- InterPro:   IPR002288
- InterPro:   IPR013506
- InterPro:   IPR013760
- InterPro:   IPR018522
- InterPro:   IPR005740
- InterPro:   IPR006171 [H]

Pfam domain/function: PF00204 DNA_gyraseB; PF00986 DNA_gyraseB_C; PF02518 HATPase_c; PF01751 Toprim [H]

EC number: 5.99.1.-

Molecular weight: Translated: 71663; Mature: 71663

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: PS00177 TOPOISOMERASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNK
CEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ITVTINADGSLSVEDEGRGMPVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEECCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
SSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLEKIGKAPKSKTGTKVTFMPDSTIF
HHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEE
STTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVAYLNEDKDSLT
ECCCHHHHHHHHHCCCHHHEEHHHEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCC
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYAR
EEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KVNLLKDKDKNLEGSDYREGLTAVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHH
LSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGKKSKKDKGLLSGKLTPAQTKN
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCC
PNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
CCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCEEEEEE
GAGVGADFTLADRNYDKVIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLY
CCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
KMSEGKGKKEKIEYAWTDGELAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTL
ECCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHCCCCCCCEEE
IQVTIDDVAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEEDTAF
EEEEHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCCCC
>Mature Secondary Structure
MVIDINNYDDSAIQVLEGLDAVRKRPGMYIGSTDGTGLHHLVWEIVDNAVDEALSGFGNK
CEEECCCCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCE
ITVTINADGSLSVEDEGRGMPVGKHAMGIPTVEVIFTILHAGGKFGQGGYKTSGGLHGVG
EEEEEECCCCEEECCCCCCCCCCCHHCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCH
SSVVNALSTWLEVEITRDGTVYRQRFENGGHPATTLEKIGKAPKSKTGTKVTFMPDSTIF
HHHHHHHHHHEEEEEECCCHHHHHHHHCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCEE
STTEFKYNIISERLNESAFLLKEVTISLEDKRTDEKEEFHYENGVQDFVAYLNEDKDSLT
ECCCHHHHHHHHHCCCHHHEEHHHEEEECCCCCCCHHHHHHHCCHHHHHHHHCCCCCCCC
PVLYFEGKQDGFEVEVALQYNDGYSENILSFVNNVRTKDGGTHEAGLKTAITKAMNEYAR
EEEEECCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHH
KVNLLKDKDKNLEGSDYREGLTAVLSVLIPEEHLQFEGQTKDKLGSPLARPVVDSLVSEK
HHHHHHCCCCCCCCCHHHHHHHHHHHHHCCHHHHCCCCCCHHHHCCCHHHHHHHHHHHHH
LSFYLMENGELAQNLIRKAIKAREAREAARKAREDSRNGKKSKKDKGLLSGKLTPAQTKN
HEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCCCCCCCCCCCCC
PNKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTEKAKMQDILKNEEINTMIYTI
CCCCEEEEEECCCCCCCCCCCCCCCEEEECCCCCEEECCHHHHHHHHHCCCCCCEEEEEE
GAGVGADFTLADRNYDKVIIMTDADTDGAHIQTLLLTFFYRYMKPLVEAGHVYIALPPLY
CCCCCCCEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCE
KMSEGKGKKEKIEYAWTDGELAELRKQFGKNANLQRYKGLGEMNADQLWETTMDPETRTL
ECCCCCCCCCEEEEEECCCHHHHHHHHHCCCCCHHHHCCCCCCCHHHHHHCCCCCCCEEE
IQVTIDDVAQAEKRVSVLMGDKVEPRRKWIENNVKFTMEEDTAF
EEEEHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8763932; 11463916; 8891124 [H]