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The map label for this gene is glmS [H]

Identifier: 125624320

GI number: 125624320

Start: 1489160

End: 1490977

Strand: Reverse

Name: glmS [H]

Synonym: llmg_1516

Alternate gene names: 125624320

Gene position: 1490977-1489160 (Counterclockwise)

Preceding gene: 125624321

Following gene: 125624319

Centisome position: 58.94

GC content: 38.28

Gene sequence:

>1818_bases
ATGTGTGGGATTGTTGGTGTTGTAGGTAGCAAAAATGCAACTGATATTTTGATGCAAGGACTTGAAAAACTCGAATATCG
TGGATACGATTCAGCAGGAATTTTTGTAAATGGTCAAAAAACGGCTGCAAAATTAGTTAAATCAGTTGGACGTATTGCAG
ATTTAAGAGCTAAGCTTGGGATTGATGTTTCGGGGACAAGTGGGATTGGACATACCCGTTGGGCAACTCATGGAAAACCA
ACAGAAGACAACGCTCATCCTCATACTTCAAGTTCTGGTCGTTTCGTTTTGGTTCATAATGGGGTCATTGAAAACTTTGT
AGAACTTAAAAATGAATTTTTGATGAATGACAGCTTTAAAGGACAAACTGATACTGAAATTGCTGTTCACTTAATTGCTA
AGTTTGCAGAAGAAGAAAATTTGACAACTCTTGAAGCGTTCAAAAAAGCTTTGAAATTAATTCAAGGATCATATGCTTTC
GCGCTCATGGACAGAGAAGATGCAGATTTAATCTATGTAGCAAAAAATAAATCTCCACTCCTCATTGGACTTGGCGATGG
TTATAATATGGTTTGTTCAGACGCAATGGCAATGATTCGTGAAACATCAGAATTTATGGAAATTCATGATAAAGAGCTCG
TTGTTTTGACAAAAGATAAGGTTGAAGTGATGGACTATGAAGGTCAAATAATTTCACGCGATTCTTATACTGCTGAACTT
GATTTGTCAGATATTGGAAAAGGAACTTATCCATTCTATATGCTTAAAGAGATTGATGAACAACCAGCTGTCATGCGTAA
ACTGATTGCGACTTATACCAATGAAGATGGCACGATGAAAGTTGATCAAGACATTATCAAAGGCATTCAAGAAGCAGACC
GTATCTATATTATTGCTGCTGGTACCTCTTATCATGCTGGTTTTGGTGCGAAGATGATGCTTGAAGCACTTACGGATACT
CCTGTTGAACTTGGTCTTGCATCAGAGTGGGGCTATGATATGCCATTATTGAGCAAAAAACCATTCTTTATCTTCCTTTC
ACAATCTGGGGAAACAGCAGATAGTCGCCAAGTTTTAGTAAAAGTAAATGAATTAGGACTTCCTAGCTTAACAGTTACAA
ATGTTCCGGGCTCTACCTTGTCTCGCGAAGCGACTTACACAATGTTAATTGGAGCTGGTCCTGAAATTGCGGTAGCTTCA
ACAAAAGCTTACACTGGTCAGATTGCAACTTTGGCTTTTCTTGCCAAGGCAGTTGGGGAAGCAGAGGGTCAAGCAAAAGC
TAAAGACTTTGATTTGGTTAAAGAACTCTCTTTAGTGGCTCAATCTATTGAGTCTACTTTATCTGAAAAAGATGAGATTG
CGGCTATTGTATCAGAACTATTGCCAACAACGCGTAGCGCCTTTTATATCGGTCGTAAACAAGACTATTATGTTGCAATG
GAAGCTTCGCTTAAATTAAAAGAAATTTCTTATATCCAATGTGAAGGATTTGCAGCTGGAGAATTAAAACATGGAACGAT
TTCATTGATTGAAAAAGGGACTCCAGTTCTTGCTTTGATTTCTAATAATGAAGAAGTAGCAGCCCATACTCGTGGTAATG
TGATGGAAACTGTGGCGCGTGGTGCCTCAGCAATTACAATCGTTGAAGAAGGAGTGGCACGTGAAGATGATACAATTGTA
ATCAATCAAGTTCACCCTTATTTGTCAGCAATTTCAATGGTTATCCCAACACAATTGATTGCTTACTATGCCTCAATGCA
ACGTGGTCTTGATGTTGATAAACCTCGTAATTTGGCTAAAGCAGTAACAGTAGAATAA

Upstream 100 bases:

>100_bases
GACATGAACCAAAAAGTGTATTATAATGCTATTTATAAATAAAAAATTAGAAAATAATTAACTATACCAATTTAATTGGT
GAGTTAAGTGGAGCTTTATT

Downstream 100 bases:

>100_bases
AAATTTACTGACAGAAAGGTCAGTAATAAAATATAAAAAAGTTCTGATTCTGTCAGAACTTTTTTATATTTTTTAATTTG
TCAGTGACAAACGATTTATT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 605; Mature: 605

Protein sequence:

>605_residues
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQKTAAKLVKSVGRIADLRAKLGIDVSGTSGIGHTRWATHGKP
TEDNAHPHTSSSGRFVLVHNGVIENFVELKNEFLMNDSFKGQTDTEIAVHLIAKFAEEENLTTLEAFKKALKLIQGSYAF
ALMDREDADLIYVAKNKSPLLIGLGDGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDKVEVMDYEGQIISRDSYTAEL
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYTNEDGTMKVDQDIIKGIQEADRIYIIAAGTSYHAGFGAKMMLEALTDT
PVELGLASEWGYDMPLLSKKPFFIFLSQSGETADSRQVLVKVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVAS
TKAYTGQIATLAFLAKAVGEAEGQAKAKDFDLVKELSLVAQSIESTLSEKDEIAAIVSELLPTTRSAFYIGRKQDYYVAM
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVARGASAITIVEEGVAREDDTIV
INQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAKAVTVE

Sequences:

>Translated_605_residues
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQKTAAKLVKSVGRIADLRAKLGIDVSGTSGIGHTRWATHGKP
TEDNAHPHTSSSGRFVLVHNGVIENFVELKNEFLMNDSFKGQTDTEIAVHLIAKFAEEENLTTLEAFKKALKLIQGSYAF
ALMDREDADLIYVAKNKSPLLIGLGDGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDKVEVMDYEGQIISRDSYTAEL
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYTNEDGTMKVDQDIIKGIQEADRIYIIAAGTSYHAGFGAKMMLEALTDT
PVELGLASEWGYDMPLLSKKPFFIFLSQSGETADSRQVLVKVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVAS
TKAYTGQIATLAFLAKAVGEAEGQAKAKDFDLVKELSLVAQSIESTLSEKDEIAAIVSELLPTTRSAFYIGRKQDYYVAM
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVARGASAITIVEEGVAREDDTIV
INQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAKAVTVE
>Mature_605_residues
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQKTAAKLVKSVGRIADLRAKLGIDVSGTSGIGHTRWATHGKP
TEDNAHPHTSSSGRFVLVHNGVIENFVELKNEFLMNDSFKGQTDTEIAVHLIAKFAEEENLTTLEAFKKALKLIQGSYAF
ALMDREDADLIYVAKNKSPLLIGLGDGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDKVEVMDYEGQIISRDSYTAEL
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYTNEDGTMKVDQDIIKGIQEADRIYIIAAGTSYHAGFGAKMMLEALTDT
PVELGLASEWGYDMPLLSKKPFFIFLSQSGETADSRQVLVKVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVAS
TKAYTGQIATLAFLAKAVGEAEGQAKAKDFDLVKELSLVAQSIESTLSEKDEIAAIVSELLPTTRSAFYIGRKQDYYVAM
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVARGASAITIVEEGVAREDDTIV
INQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAKAVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI205277386, Length=687, Percent_Identity=32.1688500727802, Blast_Score=308, Evalue=8e-84,
Organism=Homo sapiens, GI4826742, Length=686, Percent_Identity=31.9241982507289, Blast_Score=305, Evalue=7e-83,
Organism=Escherichia coli, GI1790167, Length=617, Percent_Identity=37.2771474878444, Blast_Score=390, Evalue=1e-109,
Organism=Escherichia coli, GI1788651, Length=173, Percent_Identity=29.4797687861272, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17539970, Length=429, Percent_Identity=31.002331002331, Blast_Score=207, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17532899, Length=429, Percent_Identity=30.5361305361305, Blast_Score=199, Evalue=4e-51,
Organism=Caenorhabditis elegans, GI17532897, Length=429, Percent_Identity=30.5361305361305, Blast_Score=198, Evalue=6e-51,
Organism=Saccharomyces cerevisiae, GI6322745, Length=436, Percent_Identity=31.8807339449541, Blast_Score=212, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6323731, Length=411, Percent_Identity=26.7639902676399, Blast_Score=144, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323730, Length=206, Percent_Identity=34.9514563106796, Blast_Score=100, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6323958, Length=267, Percent_Identity=25.0936329588015, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI21357745, Length=694, Percent_Identity=30.6916426512968, Blast_Score=306, Evalue=4e-83,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 65828; Mature: 65828

Theoretical pI: Translated: 4.75; Mature: 4.75

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQKTAAKLVKSVGRIADLRAKLG
CCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHC
IDVSGTSGIGHTRWATHGKPTEDNAHPHTSSSGRFVLVHNGVIENFVELKNEFLMNDSFK
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCC
GQTDTEIAVHLIAKFAEEENLTTLEAFKKALKLIQGSYAFALMDREDADLIYVAKNKSPL
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCE
LIGLGDGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDKVEVMDYEGQIISRDSYTAEL
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCEEECCCCEEEE
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYTNEDGTMKVDQDIIKGIQEADRIYIIAA
EHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEE
GTSYHAGFGAKMMLEALTDTPVELGLASEWGYDMPLLSKKPFFIFLSQSGETADSRQVLV
CCCCCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
KVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVASTKAYTGQIATLAFLAKAVGE
EEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCC
AEGQAKAKDFDLVKELSLVAQSIESTLSEKDEIAAIVSELLPTTRSAFYIGRKQDYYVAM
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEE
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVAR
ECCEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEECCCCHHHHHHHC
GASAITIVEEGVAREDDTIVINQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAK
CCCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVTVE
EEECC
>Mature Secondary Structure
MCGIVGVVGSKNATDILMQGLEKLEYRGYDSAGIFVNGQKTAAKLVKSVGRIADLRAKLG
CCCEEEECCCCCHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHHC
IDVSGTSGIGHTRWATHGKPTEDNAHPHTSSSGRFVLVHNGVIENFVELKNEFLMNDSFK
EEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHCCCCCC
GQTDTEIAVHLIAKFAEEENLTTLEAFKKALKLIQGSYAFALMDREDADLIYVAKNKSPL
CCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCCCE
LIGLGDGYNMVCSDAMAMIRETSEFMEIHDKELVVLTKDKVEVMDYEGQIISRDSYTAEL
EEEECCCCHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCEEEEECCCCEEECCCCEEEE
DLSDIGKGTYPFYMLKEIDEQPAVMRKLIATYTNEDGTMKVDQDIIKGIQEADRIYIIAA
EHHHCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCEEECHHHHHHHHCCCEEEEEEE
GTSYHAGFGAKMMLEALTDTPVELGLASEWGYDMPLLSKKPFFIFLSQSGETADSRQVLV
CCCCCCCCCHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCEEEE
KVNELGLPSLTVTNVPGSTLSREATYTMLIGAGPEIAVASTKAYTGQIATLAFLAKAVGE
EEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCEEEEECCCCCCHHHHHHHHHHHHCC
AEGQAKAKDFDLVKELSLVAQSIESTLSEKDEIAAIVSELLPTTRSAFYIGRKQDYYVAM
CCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCEEEECCCCCEEEEE
EASLKLKEISYIQCEGFAAGELKHGTISLIEKGTPVLALISNNEEVAAHTRGNVMETVAR
ECCEEEEEEEEEEECCEECCCCCCCEEEEEECCCCEEEEEECCCEEEECCCCHHHHHHHC
GASAITIVEEGVAREDDTIVINQVHPYLSAISMVIPTQLIAYYASMQRGLDVDKPRNLAK
CCCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHH
AVTVE
EEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]