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The map label for this gene is trm1

Identifier: 124485616

GI number: 124485616

Start: 776372

End: 777511

Strand: Reverse

Name: trm1

Synonym: Mlab_0794

Alternate gene names: 124485616

Gene position: 777511-776372 (Counterclockwise)

Preceding gene: 124485620

Following gene: 124485609

Centisome position: 43.08

GC content: 53.95

Gene sequence:

>1140_bases
ATGGAATGCAGGGAGATCACGGAAGGGAGCACTACGTTTACCGCTCCGGTGCAGGATGAAACTACGCAGTTTCCACCAGG
GTCGGCGCCGGTTTTTTACAATACCAAAATGGAGTTCAACCGTGATATGACGGTGCTCTTAACAAAAATCGTTCAGCCGG
AGGATTATCTGGACGCGATGGCGGCGACGGGAGTCCGCGGACTTAGGATCGCCAACGAGGCAAAGATTCCGGTCACGATC
AATGACCGGGACGAGCAGGCGGTCAAAATCATCAAATACAATGCAGAGAAGCTCGGCGGCGATATCAGTGTGACCTGCGA
TGATGCGAACCGGCTGATGTGCACGTCCCGGTTCGATTCGATCGACCTCGATCCGTTCGGAACGCCTGTTCCTTTTCTCG
ATGCCGCGTCCAGGGCCGCAAAACATTATCTTTTTGTCACGGCGACGGATACGGCCCCTCTCTGCGGAGCTCATTTCAAA
GCCGGGTGCCGCAGATATTTTGCGACGCCGAGAAACACAGAGTATCACGCAGAAGTGGGCCTTCGGATGATGATGGGGAC
GATGGCCCGGGAACTCGTGAAATACGACCGCGGCATGAAGCCGATCCTGAGTTATGCGAAGTCCCACTACTTCCGCTCGC
ATGTCAGGGTTTTAGGCAAAGTCACGGCCGCCGACGAAACACTTGCACAGATCGGTTTTGTCATGCAGTGCCCAAAGTGT
CTCTACCGGGAAGAACAGAAAGGCTCTCTCTACCCGAAAATGCATATCTGTCCCCACTGCGGCGTCGAGACCGTACCTGT
TGGGCCCTTGTGGATGGGACCTCTGCAGGAAAAGGAGATCCTTGCCGAAATGCAGACCGCCCTCGCAGAGCTGCAGTTTG
GAACCAAACGGCAGATGGAAAAAATGCTGACGTTTCTGCTCGCAGAACCCGAGACCTGCACGTATTACGATTATCACATC
ATTTCCCGGAACATGAAGGTCTCGCCGCCCAATATGGAAGAGCTGATCGCAAGCCTGAATGAGGCCGGGTATTATACGAC
CCGAACCCATTTCTGCGATACCGGGATAAAAACGACGGCTCCTCTGCCTCTTATCGAGGAGAAGATCCGTCTCTGGAATG
CCAAAAATCTTCAGATGTAG

Upstream 100 bases:

>100_bases
TCAGGACATGTAGCCAAGCCAGGATATGGCATCAGCCTCCTAAGCTGAAGATCTAGGGTTCGAATCCCTACATGCCCGTT
TACATTTTTGGGGTTCAATC

Downstream 100 bases:

>100_bases
TCGCCGATGTCCATCTCGCAGGAGATGAGGGAATCACAGTACTGACAGCGGAATCCCCGCGGGTGTACTACGAATCTGCT
CTGGACCGGCTCTTTGGTAT

Product: hypothetical protein

Products: NA

Alternate protein names: tRNA 2,2-dimethylguanosine-26 methyltransferase; tRNA(guanine-26,N(2)-N(2)) methyltransferase; tRNA(m(2,2)G26)dimethyltransferase

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MECREITEGSTTFTAPVQDETTQFPPGSAPVFYNTKMEFNRDMTVLLTKIVQPEDYLDAMAATGVRGLRIANEAKIPVTI
NDRDEQAVKIIKYNAEKLGGDISVTCDDANRLMCTSRFDSIDLDPFGTPVPFLDAASRAAKHYLFVTATDTAPLCGAHFK
AGCRRYFATPRNTEYHAEVGLRMMMGTMARELVKYDRGMKPILSYAKSHYFRSHVRVLGKVTAADETLAQIGFVMQCPKC
LYREEQKGSLYPKMHICPHCGVETVPVGPLWMGPLQEKEILAEMQTALAELQFGTKRQMEKMLTFLLAEPETCTYYDYHI
ISRNMKVSPPNMEELIASLNEAGYYTTRTHFCDTGIKTTAPLPLIEEKIRLWNAKNLQM

Sequences:

>Translated_379_residues
MECREITEGSTTFTAPVQDETTQFPPGSAPVFYNTKMEFNRDMTVLLTKIVQPEDYLDAMAATGVRGLRIANEAKIPVTI
NDRDEQAVKIIKYNAEKLGGDISVTCDDANRLMCTSRFDSIDLDPFGTPVPFLDAASRAAKHYLFVTATDTAPLCGAHFK
AGCRRYFATPRNTEYHAEVGLRMMMGTMARELVKYDRGMKPILSYAKSHYFRSHVRVLGKVTAADETLAQIGFVMQCPKC
LYREEQKGSLYPKMHICPHCGVETVPVGPLWMGPLQEKEILAEMQTALAELQFGTKRQMEKMLTFLLAEPETCTYYDYHI
ISRNMKVSPPNMEELIASLNEAGYYTTRTHFCDTGIKTTAPLPLIEEKIRLWNAKNLQM
>Mature_379_residues
MECREITEGSTTFTAPVQDETTQFPPGSAPVFYNTKMEFNRDMTVLLTKIVQPEDYLDAMAATGVRGLRIANEAKIPVTI
NDRDEQAVKIIKYNAEKLGGDISVTCDDANRLMCTSRFDSIDLDPFGTPVPFLDAASRAAKHYLFVTATDTAPLCGAHFK
AGCRRYFATPRNTEYHAEVGLRMMMGTMARELVKYDRGMKPILSYAKSHYFRSHVRVLGKVTAADETLAQIGFVMQCPKC
LYREEQKGSLYPKMHICPHCGVETVPVGPLWMGPLQEKEILAEMQTALAELQFGTKRQMEKMLTFLLAEPETCTYYDYHI
ISRNMKVSPPNMEELIASLNEAGYYTTRTHFCDTGIKTTAPLPLIEEKIRLWNAKNLQM

Specific function: Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups

COG id: COG1867

COG function: function code J; N2,N2-dimethylguanosine tRNA methyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TRM1 family

Homologues:

Organism=Homo sapiens, GI8923219, Length=348, Percent_Identity=27.5862068965517, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI209862871, Length=348, Percent_Identity=27.5862068965517, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI216548445, Length=335, Percent_Identity=28.3582089552239, Blast_Score=120, Evalue=3e-27,
Organism=Homo sapiens, GI163792194, Length=441, Percent_Identity=27.891156462585, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17564890, Length=438, Percent_Identity=26.4840182648402, Blast_Score=141, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6320325, Length=353, Percent_Identity=26.628895184136, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI19921190, Length=426, Percent_Identity=26.5258215962441, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): TRM1_METLZ (A2SRK9)

Other databases:

- EMBL:   CP000559
- RefSeq:   YP_001030232.1
- ProteinModelPortal:   A2SRK9
- SMR:   A2SRK9
- STRING:   A2SRK9
- GeneID:   4795339
- GenomeReviews:   CP000559_GR
- KEGG:   mla:Mlab_0794
- eggNOG:   arNOG04822
- HOGENOM:   HBG577872
- OMA:   DAPVFYN
- PhylomeDB:   A2SRK9
- ProtClustDB:   CLSK949477
- BioCyc:   MLAB410358:MLAB_0794-MONOMER
- HAMAP:   MF_00290
- InterPro:   IPR022923
- InterPro:   IPR002905
- PANTHER:   PTHR10631
- TIGRFAMs:   TIGR00308

Pfam domain/function: PF02005 TRM

EC number: =2.1.1.32

Molecular weight: Translated: 42752; Mature: 42752

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
7.9 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
7.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MECREITEGSTTFTAPVQDETTQFPPGSAPVFYNTKMEFNRDMTVLLTKIVQPEDYLDAM
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHH
AATGVRGLRIANEAKIPVTINDRDEQAVKIIKYNAEKLGGDISVTCDDANRLMCTSRFDS
HHCCCCCEEECCCCEEEEEECCCCHHHHHHHEECHHHHCCCEEEEECCCCEEEEECCCCC
IDLDPFGTPVPFLDAASRAAKHYLFVTATDTAPLCGAHFKAGCRRYFATPRNTEYHAEVG
CCCCCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
LRMMMGTMARELVKYDRGMKPILSYAKSHYFRSHVRVLGKVTAADETLAQIGFVMQCPKC
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LYREEQKGSLYPKMHICPHCGVETVPVGPLWMGPLQEKEILAEMQTALAELQFGTKRQME
HHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
KMLTFLLAEPETCTYYDYHIISRNMKVSPPNMEELIASLNEAGYYTTRTHFCDTGIKTTA
HHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEECEEECCCCCCCC
PLPLIEEKIRLWNAKNLQM
CCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MECREITEGSTTFTAPVQDETTQFPPGSAPVFYNTKMEFNRDMTVLLTKIVQPEDYLDAM
CCCCCCCCCCCEEEECCCCCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHCCCHHHHHHH
AATGVRGLRIANEAKIPVTINDRDEQAVKIIKYNAEKLGGDISVTCDDANRLMCTSRFDS
HHCCCCCEEECCCCEEEEEECCCCHHHHHHHEECHHHHCCCEEEEECCCCEEEEECCCCC
IDLDPFGTPVPFLDAASRAAKHYLFVTATDTAPLCGAHFKAGCRRYFATPRNTEYHAEVG
CCCCCCCCCCCHHHHHHHHCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHH
LRMMMGTMARELVKYDRGMKPILSYAKSHYFRSHVRVLGKVTAADETLAQIGFVMQCPKC
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LYREEQKGSLYPKMHICPHCGVETVPVGPLWMGPLQEKEILAEMQTALAELQFGTKRQME
HHCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHH
KMLTFLLAEPETCTYYDYHIISRNMKVSPPNMEELIASLNEAGYYTTRTHFCDTGIKTTA
HHHHHHHCCCCCCEEEEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEECEEECCCCCCCC
PLPLIEEKIRLWNAKNLQM
CCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA