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The map label for this gene is hbpA [H]

Identifier: 124485546

GI number: 124485546

Start: 696648

End: 698231

Strand: Reverse

Name: hbpA [H]

Synonym: Mlab_0723

Alternate gene names: 124485546

Gene position: 698231-696648 (Counterclockwise)

Preceding gene: 124485548

Following gene: 124485545

Centisome position: 38.68

GC content: 53.22

Gene sequence:

>1584_bases
ATGAAAAAACGTATTTTAGAGGGCTTATCCATCAACGGATTCGCCGCACTGTGTATTGCAGGCGTACTGATCGGCGCCAT
GGTGATTTGCGCCGGATGCGTCCAGTCAGGAAATGATGACAGTACGCTTCGCGTCGTCATGAACTTCGGTCCCGATTCAA
GCGGCAGTCTCGACCCGGCCAATGGGTGGGAAGGCTGGTATGTGCGGGAAGCGGGCCTCTTTGAGACGCTTTTCTATGAT
GATCAGAACATGGAACTCAAACCCGAACTGGCAACCGGCTACAAAGCATTGAGCGATACCGAATGGGAAATCACGCTTCG
CAAGGGCGTAGTCTTCCACGACGGAACGCCGTTCAACGCCGACGCGGTGATATATTCGTTCAACCGGGTCCTCGACCCCG
CAAACAGCCGTTCATCCGAGTACTCATTCATTAAAGAAGTGAGAAAGACTGACGACTATACGATCGTAATCGAAACGACC
GAACCGTATGCTCCGCTGATCGCATCGCTCGTTGATCCGGTCATGTCGATCATCAGTCCGAACATTGTCGATGTGGACAA
ACAGCCGGTCGGTACCGGACCCTATGCATTCGTTTCGTTTGAATCGGGTGCAAGCATGGATCTCGTCAGAAACGACAAGT
ATTGGGGCGGCACGCCGAAAGCTGCGAAACTCTCCATGACATACAACGCCGACGCGACCGCACGGACGCTTATGCTGAAG
TCCGGCGATGTCGATATCGCAAAGGATATTCTCCCAAGCGAGTATGCTTCCCTGAAATCAGACTCCTCGACCGATGTCGA
ATCCAAGGAGACGCTTCGAGCATACTTCATCTACATCAACGGCGGAAAAGCTCCGTTCGATGACGTGAACGTTCGTCAGG
CACTCAGCTACGCACTGAACCGTCAGGAAATCGTGGATACCGCGCTTGAAGGCGTGGCGGGTTCTCCTGCGGTAGGTATG
TTTACGAATACCATGCCGTGGAACGCAAACGACAAGATCGCCAGCTACGACAACGATCAGGCAAAAGCCCTTGAACTCCT
GGCCAAAGCAGGAATCACCAAAGGATCCGACGGAAAACTGTATTATAACGGCGAACCGTTCACCATCGAGATAATGACCT
ATACGAACCGTGCGGCCCTTCCGGCAAGCCTGGAAGTGATCGCGGCCCAGTATGAAAAGCTCGGTATCACGGTCACGACG
AAACACGCTGAATGGAGCGCGATCAAATCAACCGTGACATCGGGAACCTATGATATGGTACTCTATACCTGGGTCACGGC
ACCGACCGGAGACCCGGACTACTTCATCAGCGGTCACTATCTCTCGACCGGGGCATACGCTTCCGGCTGGACCCATTACT
CGAATCCGCAGATGGATGAATGGATCCTTGCCGCACGGTCGACCTTTGATCAGACCAAGCGAGCCGAGCTCTACGACAAG
ATCCAGGAACAGGCGCAGATCGATTGTCCGATCATCTACGTGTTCTATGCGATGGAAAACGATGCGATGAGTACCTCCGT
TAAGGGATTCACCATCTACCCCAACGACTACACGCTCGTCACAAAGAACATCGCGGTCGTATAA

Upstream 100 bases:

>100_bases
ACGTTCATCAAATTTCAACAAATATTTAACATATAATTATTCTGAATGTATTAATATAGTATTACAAATATAAAATTATT
CATAACTTTGGTGTGTTGAT

Downstream 100 bases:

>100_bases
CAGAGCGATTGCCGGATGAACCCGGCAGCTTCTTTTTTATTATTACGAATATAATATTTGTAGATTTTAAAAACATACGA
ATAAAAAGAGGCAATTAATA

Product: hypothetical protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: Hemin-binding lipoprotein [H]

Number of amino acids: Translated: 527; Mature: 527

Protein sequence:

>527_residues
MKKRILEGLSINGFAALCIAGVLIGAMVICAGCVQSGNDDSTLRVVMNFGPDSSGSLDPANGWEGWYVREAGLFETLFYD
DQNMELKPELATGYKALSDTEWEITLRKGVVFHDGTPFNADAVIYSFNRVLDPANSRSSEYSFIKEVRKTDDYTIVIETT
EPYAPLIASLVDPVMSIISPNIVDVDKQPVGTGPYAFVSFESGASMDLVRNDKYWGGTPKAAKLSMTYNADATARTLMLK
SGDVDIAKDILPSEYASLKSDSSTDVESKETLRAYFIYINGGKAPFDDVNVRQALSYALNRQEIVDTALEGVAGSPAVGM
FTNTMPWNANDKIASYDNDQAKALELLAKAGITKGSDGKLYYNGEPFTIEIMTYTNRAALPASLEVIAAQYEKLGITVTT
KHAEWSAIKSTVTSGTYDMVLYTWVTAPTGDPDYFISGHYLSTGAYASGWTHYSNPQMDEWILAARSTFDQTKRAELYDK
IQEQAQIDCPIIYVFYAMENDAMSTSVKGFTIYPNDYTLVTKNIAVV

Sequences:

>Translated_527_residues
MKKRILEGLSINGFAALCIAGVLIGAMVICAGCVQSGNDDSTLRVVMNFGPDSSGSLDPANGWEGWYVREAGLFETLFYD
DQNMELKPELATGYKALSDTEWEITLRKGVVFHDGTPFNADAVIYSFNRVLDPANSRSSEYSFIKEVRKTDDYTIVIETT
EPYAPLIASLVDPVMSIISPNIVDVDKQPVGTGPYAFVSFESGASMDLVRNDKYWGGTPKAAKLSMTYNADATARTLMLK
SGDVDIAKDILPSEYASLKSDSSTDVESKETLRAYFIYINGGKAPFDDVNVRQALSYALNRQEIVDTALEGVAGSPAVGM
FTNTMPWNANDKIASYDNDQAKALELLAKAGITKGSDGKLYYNGEPFTIEIMTYTNRAALPASLEVIAAQYEKLGITVTT
KHAEWSAIKSTVTSGTYDMVLYTWVTAPTGDPDYFISGHYLSTGAYASGWTHYSNPQMDEWILAARSTFDQTKRAELYDK
IQEQAQIDCPIIYVFYAMENDAMSTSVKGFTIYPNDYTLVTKNIAVV
>Mature_527_residues
MKKRILEGLSINGFAALCIAGVLIGAMVICAGCVQSGNDDSTLRVVMNFGPDSSGSLDPANGWEGWYVREAGLFETLFYD
DQNMELKPELATGYKALSDTEWEITLRKGVVFHDGTPFNADAVIYSFNRVLDPANSRSSEYSFIKEVRKTDDYTIVIETT
EPYAPLIASLVDPVMSIISPNIVDVDKQPVGTGPYAFVSFESGASMDLVRNDKYWGGTPKAAKLSMTYNADATARTLMLK
SGDVDIAKDILPSEYASLKSDSSTDVESKETLRAYFIYINGGKAPFDDVNVRQALSYALNRQEIVDTALEGVAGSPAVGM
FTNTMPWNANDKIASYDNDQAKALELLAKAGITKGSDGKLYYNGEPFTIEIMTYTNRAALPASLEVIAAQYEKLGITVTT
KHAEWSAIKSTVTSGTYDMVLYTWVTAPTGDPDYFISGHYLSTGAYASGWTHYSNPQMDEWILAARSTFDQTKRAELYDK
IQEQAQIDCPIIYVFYAMENDAMSTSVKGFTIYPNDYTLVTKNIAVV

Specific function: Important role in heme acquisition or metabolism [H]

COG id: COG0747

COG function: function code E; ABC-type dipeptide transport system, periplasmic component

Gene ontology:

Cell location: Cell inner membrane; Lipid-anchor [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the bacterial solute-binding protein 5 family [H]

Homologues:

Organism=Escherichia coli, GI1789966, Length=461, Percent_Identity=29.0672451193059, Blast_Score=177, Evalue=2e-45,
Organism=Escherichia coli, GI1787762, Length=447, Percent_Identity=26.8456375838926, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1787052, Length=524, Percent_Identity=29.7709923664122, Blast_Score=155, Evalue=5e-39,
Organism=Escherichia coli, GI1789887, Length=495, Percent_Identity=27.2727272727273, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787551, Length=466, Percent_Identity=25.1072961373391, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787495, Length=542, Percent_Identity=26.5682656826568, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI87081878, Length=534, Percent_Identity=23.0337078651685, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: 660 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 2980 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000914 [H]

Pfam domain/function: PF00496 SBP_bac_5 [H]

EC number: NA

Molecular weight: Translated: 57853; Mature: 57853

Theoretical pI: Translated: 4.36; Mature: 4.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRILEGLSINGFAALCIAGVLIGAMVICAGCVQSGNDDSTLRVVMNFGPDSSGSLDPA
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCC
NGWEGWYVREAGLFETLFYDDQNMELKPELATGYKALSDTEWEITLRKGVVFHDGTPFNA
CCCCCEEEECCCCEEEEEECCCCCEECCHHHHCCHHCCCCCEEEEEECCEEEECCCCCCC
DAVIYSFNRVLDPANSRSSEYSFIKEVRKTDDYTIVIETTEPYAPLIASLVDPVMSIISP
CEEEEEHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
NIVDVDKQPVGTGPYAFVSFESGASMDLVRNDKYWGGTPKAAKLSMTYNADATARTLMLK
CEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEE
SGDVDIAKDILPSEYASLKSDSSTDVESKETLRAYFIYINGGKAPFDDVNVRQALSYALN
CCCCHHHHHHCCHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHC
RQEIVDTALEGVAGSPAVGMFTNTMPWNANDKIASYDNDQAKALELLAKAGITKGSDGKL
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
YYNGEPFTIEIMTYTNRAALPASLEVIAAQYEKLGITVTTKHAEWSAIKSTVTSGTYDMV
EECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCEEEE
LYTWVTAPTGDPDYFISGHYLSTGAYASGWTHYSNPQMDEWILAARSTFDQTKRAELYDK
EEEEEECCCCCCCEEEECEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQEQAQIDCPIIYVFYAMENDAMSTSVKGFTIYPNDYTLVTKNIAVV
HHHHHCCCCCEEEEEEEECCCCCCCCCCEEEECCCCEEEEEEEEEEC
>Mature Secondary Structure
MKKRILEGLSINGFAALCIAGVLIGAMVICAGCVQSGNDDSTLRVVMNFGPDSSGSLDPA
CCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCC
NGWEGWYVREAGLFETLFYDDQNMELKPELATGYKALSDTEWEITLRKGVVFHDGTPFNA
CCCCCEEEECCCCEEEEEECCCCCEECCHHHHCCHHCCCCCEEEEEECCEEEECCCCCCC
DAVIYSFNRVLDPANSRSSEYSFIKEVRKTDDYTIVIETTEPYAPLIASLVDPVMSIISP
CEEEEEHHHHCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCC
NIVDVDKQPVGTGPYAFVSFESGASMDLVRNDKYWGGTPKAAKLSMTYNADATARTLMLK
CEEECCCCCCCCCCEEEEEECCCCCEEEEECCCCCCCCCCCEEEEEEECCCCCEEEEEEE
SGDVDIAKDILPSEYASLKSDSSTDVESKETLRAYFIYINGGKAPFDDVNVRQALSYALN
CCCCHHHHHHCCHHHHHCCCCCCCCCCCCCEEEEEEEEEECCCCCCCCCCHHHHHHHHHC
RQEIVDTALEGVAGSPAVGMFTNTMPWNANDKIASYDNDQAKALELLAKAGITKGSDGKL
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCEE
YYNGEPFTIEIMTYTNRAALPASLEVIAAQYEKLGITVTTKHAEWSAIKSTVTSGTYDMV
EECCCCEEEEEEEECCCCCCCHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCCCEEEE
LYTWVTAPTGDPDYFISGHYLSTGAYASGWTHYSNPQMDEWILAARSTFDQTKRAELYDK
EEEEEECCCCCCCEEEECEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
IQEQAQIDCPIIYVFYAMENDAMSTSVKGFTIYPNDYTLVTKNIAVV
HHHHHCCCCCEEEEEEEECCCCCCCCCCEEEECCCCEEEEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339409; 7542800; 2041470 [H]