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The map label for this gene is appD [H]

Identifier: 124485540

GI number: 124485540

Start: 690838

End: 691776

Strand: Reverse

Name: appD [H]

Synonym: Mlab_0717

Alternate gene names: 124485540

Gene position: 691776-690838 (Counterclockwise)

Preceding gene: 124485541

Following gene: 124485539

Centisome position: 38.33

GC content: 54.1

Gene sequence:

>939_bases
ATGACCTGCATACTGAAAGTGACGGATGTCTGCGTCCATCTGACCACGGAAAACGGATCGGTCCGGGCAGTGGACAATGC
CTCCTTTTCGATAAAAGAGCATGAGACGTTCGCCCTTATTGGAGAATCGGGATCCGGCAAGTCGGTTCTCGGCCTTGCGG
TGCTGCGGTTACTTCCCGACAATGCAATTTTTTCCGGCAATATCTCTCTTGACGGGATCTCTCTTACGGATCTTTCAGAA
AAGGAGATGCAGAAGATCCGGGGAAAAACGATCGGTTCGATTTTTCAGAACCCGTATCTCTCGATGAACCCGGGGATCCG
GGTCGGAAACCAGATCGCGGAGCCGATGTGGACGCATCTGGGGATAACAAAAGAAGCTGCCAGAGAAAAAGCCGTGTCGC
TTCTGGAAAGGTTTTCCATCGTGCCTGGAAAGACCCGTGCACGCGAGTATCCTTTCCAGTACAGCGGAGGTATGCTCCAG
CGGGCGATGGTCGCCATGGGAACGGCGGCAAATCCTCAGCTGATCATCGCAGACGAGCCGACGAAAGGGGTCGACTCTCT
CAAAAAACAGGAGATCGCGGAGACTTTTAGAAGGGTCTCTGCCGAAGGATGTGCTTTTCTTTTGATAACGCACGATATTG
ATTTTGCCAAAGCGATGGCAAACAGGATCGCGGTAAACTACTGCGGCGAGATCCTCGAAATCGCTCCAACAGAGATGTTT
TTCAAAGAACCTCTTCATCCTTACTCCCGGGCCCTGCTCGATTCCCTGCCGGAACGCGGGATGCATCCGATCCCCGGCCC
CTCCCCGTCGATGATCGAGGTCCCGGACGGATGCAGATTTAATCCGCGGTGCCCCTTTGCCGACAACAGGTGCCGGACGG
AAAAACCGCCGATGACCGAAACGAACGGACGAACCGTGAGGTGCTGGAAGTATGCTTAG

Upstream 100 bases:

>100_bases
TTATGATCATGATAACCGTGCTCGCCTTCAATTATTTCGGCGACGGACTGCGTGATGTTCTCGACCAGAAGATGACCAAA
ACCGAACTCGAGGGGAGAAT

Downstream 100 bases:

>100_bases
AGGAGAGGAACTAAGGAAAGTCTATACGTCCGGTATGATTTCCGTGACGAAGAAGGTGGCCGTGGACCGGGTAAGTATTT
CGATCGGCAAAGGCGAGACG

Product: hypothetical protein

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTCILKVTDVCVHLTTENGSVRAVDNASFSIKEHETFALIGESGSGKSVLGLAVLRLLPDNAIFSGNISLDGISLTDLSE
KEMQKIRGKTIGSIFQNPYLSMNPGIRVGNQIAEPMWTHLGITKEAAREKAVSLLERFSIVPGKTRAREYPFQYSGGMLQ
RAMVAMGTAANPQLIIADEPTKGVDSLKKQEIAETFRRVSAEGCAFLLITHDIDFAKAMANRIAVNYCGEILEIAPTEMF
FKEPLHPYSRALLDSLPERGMHPIPGPSPSMIEVPDGCRFNPRCPFADNRCRTEKPPMTETNGRTVRCWKYA

Sequences:

>Translated_312_residues
MTCILKVTDVCVHLTTENGSVRAVDNASFSIKEHETFALIGESGSGKSVLGLAVLRLLPDNAIFSGNISLDGISLTDLSE
KEMQKIRGKTIGSIFQNPYLSMNPGIRVGNQIAEPMWTHLGITKEAAREKAVSLLERFSIVPGKTRAREYPFQYSGGMLQ
RAMVAMGTAANPQLIIADEPTKGVDSLKKQEIAETFRRVSAEGCAFLLITHDIDFAKAMANRIAVNYCGEILEIAPTEMF
FKEPLHPYSRALLDSLPERGMHPIPGPSPSMIEVPDGCRFNPRCPFADNRCRTEKPPMTETNGRTVRCWKYA
>Mature_311_residues
TCILKVTDVCVHLTTENGSVRAVDNASFSIKEHETFALIGESGSGKSVLGLAVLRLLPDNAIFSGNISLDGISLTDLSEK
EMQKIRGKTIGSIFQNPYLSMNPGIRVGNQIAEPMWTHLGITKEAAREKAVSLLERFSIVPGKTRAREYPFQYSGGMLQR
AMVAMGTAANPQLIIADEPTKGVDSLKKQEIAETFRRVSAEGCAFLLITHDIDFAKAMANRIAVNYCGEILEIAPTEMFF
KEPLHPYSRALLDSLPERGMHPIPGPSPSMIEVPDGCRFNPRCPFADNRCRTEKPPMTETNGRTVRCWKYA

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0444

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain [H]

Homologues:

Organism=Escherichia coli, GI1789963, Length=313, Percent_Identity=38.6581469648562, Blast_Score=228, Evalue=3e-61,
Organism=Escherichia coli, GI48994883, Length=314, Percent_Identity=36.624203821656, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1787759, Length=302, Percent_Identity=36.7549668874172, Blast_Score=204, Evalue=7e-54,
Organism=Escherichia coli, GI1787548, Length=303, Percent_Identity=33.003300330033, Blast_Score=189, Evalue=3e-49,
Organism=Escherichia coli, GI1788506, Length=275, Percent_Identity=36, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI145693107, Length=265, Percent_Identity=36.2264150943396, Blast_Score=176, Evalue=1e-45,
Organism=Escherichia coli, GI1787500, Length=326, Percent_Identity=29.4478527607362, Blast_Score=169, Evalue=3e-43,
Organism=Escherichia coli, GI1789962, Length=321, Percent_Identity=31.4641744548287, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1787758, Length=305, Percent_Identity=30.1639344262295, Blast_Score=148, Evalue=4e-37,
Organism=Escherichia coli, GI1789032, Length=246, Percent_Identity=28.4552845528455, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1789890, Length=239, Percent_Identity=30.9623430962343, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786872, Length=213, Percent_Identity=31.4553990610329, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI48994997, Length=237, Percent_Identity=28.6919831223629, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1789672, Length=249, Percent_Identity=29.718875502008, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1786398, Length=237, Percent_Identity=29.957805907173, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1787029, Length=228, Percent_Identity=28.5087719298246, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI87081834, Length=222, Percent_Identity=30.6306306306306, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1787547, Length=237, Percent_Identity=27.4261603375527, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787089, Length=216, Percent_Identity=30.0925925925926, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788225, Length=231, Percent_Identity=29.8701298701299, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789891, Length=211, Percent_Identity=30.8056872037915, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1786703, Length=187, Percent_Identity=35.8288770053476, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081791, Length=253, Percent_Identity=29.6442687747036, Blast_Score=89, Evalue=3e-19,
Organism=Escherichia coli, GI1787712, Length=232, Percent_Identity=29.3103448275862, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788450, Length=239, Percent_Identity=28.8702928870293, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1787105, Length=236, Percent_Identity=29.6610169491525, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787792, Length=243, Percent_Identity=29.6296296296296, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI1789873, Length=210, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1786563, Length=231, Percent_Identity=28.5714285714286, Blast_Score=78, Evalue=8e-16,
Organism=Escherichia coli, GI1788761, Length=236, Percent_Identity=28.3898305084746, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1788644, Length=135, Percent_Identity=31.1111111111111, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1790162, Length=233, Percent_Identity=25.7510729613734, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790534, Length=213, Percent_Identity=29.1079812206573, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1787370, Length=223, Percent_Identity=27.3542600896861, Blast_Score=71, Evalue=1e-13,
Organism=Escherichia coli, GI48995001, Length=214, Percent_Identity=25.7009345794392, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790190, Length=247, Percent_Identity=27.9352226720648, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786319, Length=216, Percent_Identity=25.9259259259259, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87081709, Length=238, Percent_Identity=23.109243697479, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1790544, Length=264, Percent_Identity=24.2424242424242, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87081782, Length=219, Percent_Identity=26.9406392694064, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1789991, Length=221, Percent_Identity=27.1493212669683, Blast_Score=62, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI193211015, Length=210, Percent_Identity=30, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI193211017, Length=210, Percent_Identity=30, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71996809, Length=210, Percent_Identity=30, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI212646699, Length=209, Percent_Identity=30.1435406698565, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25146777, Length=214, Percent_Identity=28.9719626168224, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533592, Length=218, Percent_Identity=32.5688073394495, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI193202349, Length=221, Percent_Identity=27.1493212669683, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI28573571, Length=221, Percent_Identity=27.6018099547511, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI28573573, Length=221, Percent_Identity=27.6018099547511, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24641565, Length=213, Percent_Identity=28.6384976525822, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24643674, Length=225, Percent_Identity=24.8888888888889, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR003593
- InterPro:   IPR010066
- InterPro:   IPR013563 [H]

Pfam domain/function: PF00005 ABC_tran; PF08352 oligo_HPY [H]

EC number: NA

Molecular weight: Translated: 34378; Mature: 34247

Theoretical pI: Translated: 7.74; Mature: 7.74

Prosite motif: PS00211 ABC_TRANSPORTER_1 ; PS50893 ABC_TRANSPORTER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTCILKVTDVCVHLTTENGSVRAVDNASFSIKEHETFALIGESGSGKSVLGLAVLRLLPD
CEEEEEEEEEEEEEEECCCCEEEECCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHCCC
NAIFSGNISLDGISLTDLSEKEMQKIRGKTIGSIFQNPYLSMNPGIRVGNQIAEPMWTHL
CCEEECCCEECCEEECCCCHHHHHHHHCCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHC
GITKEAAREKAVSLLERFSIVPGKTRAREYPFQYSGGMLQRAMVAMGTAANPQLIIADEP
CCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCC
TKGVDSLKKQEIAETFRRVSAEGCAFLLITHDIDFAKAMANRIAVNYCGEILEIAPTEMF
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
FKEPLHPYSRALLDSLPERGMHPIPGPSPSMIEVPDGCRFNPRCPFADNRCRTEKPPMTE
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
TNGRTVRCWKYA
CCCCEEEEEECC
>Mature Secondary Structure 
TCILKVTDVCVHLTTENGSVRAVDNASFSIKEHETFALIGESGSGKSVLGLAVLRLLPD
EEEEEEEEEEEEEEECCCCEEEECCCCEEEECCCEEEEEECCCCCCHHHHHHHHHHCCC
NAIFSGNISLDGISLTDLSEKEMQKIRGKTIGSIFQNPYLSMNPGIRVGNQIAEPMWTHL
CCEEECCCEECCEEECCCCHHHHHHHHCCHHHHHHCCCCEECCCCCCCCHHHHHHHHHHC
GITKEAAREKAVSLLERFSIVPGKTRAREYPFQYSGGMLQRAMVAMGTAANPQLIIADEP
CCCHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCC
TKGVDSLKKQEIAETFRRVSAEGCAFLLITHDIDFAKAMANRIAVNYCGEILEIAPTEMF
CCCHHHHHHHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHCCHHHH
FKEPLHPYSRALLDSLPERGMHPIPGPSPSMIEVPDGCRFNPRCPFADNRCRTEKPPMTE
HHCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCC
TNGRTVRCWKYA
CCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]