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The map label for this gene is eif2g [H]

Identifier: 124485483

GI number: 124485483

Start: 628804

End: 630039

Strand: Reverse

Name: eif2g [H]

Synonym: Mlab_0660

Alternate gene names: 124485483

Gene position: 630039-628804 (Counterclockwise)

Preceding gene: 124485484

Following gene: 124485482

Centisome position: 34.91

GC content: 52.51

Gene sequence:

>1236_bases
TTGCATGATCCTACAATACCAAATGTAAATATCGGCGTAGTTGGTCACGTTGACCACGGCAAGACGACATTAGTCAGCCA
GCTTACCGGCTCGTGGACAGATCGCCACAGTGAAGAACTGAAGCGCGGGATCTCGATCCGGCTTGGGTATGCCGATGCAA
CATTTTATAAATGTCCAAAATGCGGGGGGGAGGAACTCTGGACAAATACAGAGACGTGCCCTACCTGCGGTGAAAAACTT
GAAGCAGTAAGATCAGTCTCATTTGTGGATGCCCCGGGGCATGAAACCCTCATGGCCACGATGCTTTCAGGCTCCGCCAT
CATGGACGGCGCGATGCTCGTAATTGCAGCAAACGAGCCGTGTCCGCAACCCCAGACCAAAGAGCATCTTATGGCTCTGG
AACTGACCGGCATAAAAAACATCGTCATAGTTCAGAATAAAATCGATGTTGTTCCGCAGAAGAAAGCACTGGAAAATTAT
AAGCAGATCAAAGCATTCGTAAAAGGCACGGTCGCGGAAAACGCGCCAATCATTCCGGTCTCTGCACAGAAGAGAATTAA
CTTCGGGATGCTTCTGGATGCGCTGAATACAACGATTCCGGATGTTGAGCGTGAAACAGATGTCATGCCGATCATGCTGA
TCGCCCGTTCTTTCGATGTGAACCGGCCGGGAAGTTCCTGGCGTGACATCAAAGGCGGGGTTATCGGCGGCTCACTCATT
CGCGGCGAGTTCCACGAAGGGGATGAAATAGAGATCCGGCCCGGCAGACAATATATGTCGGAGAACAAAGCCAAGTGGGA
ACCGATCACAACCAAGATCACCTCGATGAACAAGGCATCCCACAAAGTTCCGACAGCAACACCGGGCGGACTGTCAGCAA
TCGGCACGAAACTTGATCCGGCGATCACCAAAAGCGATACGCTTGTCGGACAGGTCGCCGGTATGGCAGGATCTCTGCCG
CCGGTTTGGGACAAACTCAAGTTCGATGTCACCCTTATGGAAAGGGTCGTCGGTTCATCTGCCGAGTTGAACATCGACCC
CCTTCGACTCAAAGAACCGCTGATGCTTTCCGTTGGGACCGCCGTTACCGTAGGTATCGTTCTTGCAGTGAAAAAGAACC
AGGCTGAAGTGATGCTGAAACGTCCGGTCTGCGCCGAAGTCGGGTCTCGGATCGCAATCAGCCGTCAGGTTGGAGGCAGA
TGGCGTTTGATCGGCATGGGTCTGCTGACCGAGTAA

Upstream 100 bases:

>100_bases
ATACCGACCAAAGTTGTGAAGGCGGCGGATAATACCATTATCAAACACATATATCTGTGTTGAAGTCAACTATATAGGGT
TAGAGGAGGTTTTGGTTTCT

Downstream 100 bases:

>100_bases
CGGTCATCTTAGACACAAACGCTTTGATGATGCCGGCCCAGTTCAATGTGGATCTTTTCGAAGGTCTGCGTGACCTTTTG
GGCGCCTATGACGCGCTCGT

Product: translation initiation factor IF-2 subunit gamma

Products: NA

Alternate protein names: aIF2-gamma; eIF-2-gamma [H]

Number of amino acids: Translated: 411; Mature: 411

Protein sequence:

>411_residues
MHDPTIPNVNIGVVGHVDHGKTTLVSQLTGSWTDRHSEELKRGISIRLGYADATFYKCPKCGGEELWTNTETCPTCGEKL
EAVRSVSFVDAPGHETLMATMLSGSAIMDGAMLVIAANEPCPQPQTKEHLMALELTGIKNIVIVQNKIDVVPQKKALENY
KQIKAFVKGTVAENAPIIPVSAQKRINFGMLLDALNTTIPDVERETDVMPIMLIARSFDVNRPGSSWRDIKGGVIGGSLI
RGEFHEGDEIEIRPGRQYMSENKAKWEPITTKITSMNKASHKVPTATPGGLSAIGTKLDPAITKSDTLVGQVAGMAGSLP
PVWDKLKFDVTLMERVVGSSAELNIDPLRLKEPLMLSVGTAVTVGIVLAVKKNQAEVMLKRPVCAEVGSRIAISRQVGGR
WRLIGMGLLTE

Sequences:

>Translated_411_residues
MHDPTIPNVNIGVVGHVDHGKTTLVSQLTGSWTDRHSEELKRGISIRLGYADATFYKCPKCGGEELWTNTETCPTCGEKL
EAVRSVSFVDAPGHETLMATMLSGSAIMDGAMLVIAANEPCPQPQTKEHLMALELTGIKNIVIVQNKIDVVPQKKALENY
KQIKAFVKGTVAENAPIIPVSAQKRINFGMLLDALNTTIPDVERETDVMPIMLIARSFDVNRPGSSWRDIKGGVIGGSLI
RGEFHEGDEIEIRPGRQYMSENKAKWEPITTKITSMNKASHKVPTATPGGLSAIGTKLDPAITKSDTLVGQVAGMAGSLP
PVWDKLKFDVTLMERVVGSSAELNIDPLRLKEPLMLSVGTAVTVGIVLAVKKNQAEVMLKRPVCAEVGSRIAISRQVGGR
WRLIGMGLLTE
>Mature_411_residues
MHDPTIPNVNIGVVGHVDHGKTTLVSQLTGSWTDRHSEELKRGISIRLGYADATFYKCPKCGGEELWTNTETCPTCGEKL
EAVRSVSFVDAPGHETLMATMLSGSAIMDGAMLVIAANEPCPQPQTKEHLMALELTGIKNIVIVQNKIDVVPQKKALENY
KQIKAFVKGTVAENAPIIPVSAQKRINFGMLLDALNTTIPDVERETDVMPIMLIARSFDVNRPGSSWRDIKGGVIGGSLI
RGEFHEGDEIEIRPGRQYMSENKAKWEPITTKITSMNKASHKVPTATPGGLSAIGTKLDPAITKSDTLVGQVAGMAGSLP
PVWDKLKFDVTLMERVVGSSAELNIDPLRLKEPLMLSVGTAVTVGIVLAVKKNQAEVMLKRPVCAEVGSRIAISRQVGGR
WRLIGMGLLTE

Specific function: eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA [H]

COG id: COG5257

COG function: function code J; Translation initiation factor 2, gamma subunit (eIF-2gamma; GTPase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. EIF2G subfamily [H]

Homologues:

Organism=Homo sapiens, GI4503507, Length=416, Percent_Identity=45.1923076923077, Blast_Score=356, Evalue=2e-98,
Organism=Homo sapiens, GI34147630, Length=438, Percent_Identity=26.2557077625571, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI54607086, Length=263, Percent_Identity=28.1368821292776, Blast_Score=81, Evalue=2e-15,
Organism=Escherichia coli, GI2367247, Length=401, Percent_Identity=26.1845386533666, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1790412, Length=280, Percent_Identity=27.8571428571429, Blast_Score=91, Evalue=2e-19,
Organism=Escherichia coli, GI1789737, Length=280, Percent_Identity=27.8571428571429, Blast_Score=90, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17509919, Length=418, Percent_Identity=42.3444976076555, Blast_Score=350, Evalue=6e-97,
Organism=Caenorhabditis elegans, GI25141371, Length=297, Percent_Identity=29.2929292929293, Blast_Score=99, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17556456, Length=277, Percent_Identity=29.9638989169675, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17506081, Length=253, Percent_Identity=27.2727272727273, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320863, Length=413, Percent_Identity=42.6150121065375, Blast_Score=351, Evalue=1e-97,
Organism=Saccharomyces cerevisiae, GI6324761, Length=276, Percent_Identity=31.1594202898551, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24647046, Length=416, Percent_Identity=43.5096153846154, Blast_Score=353, Evalue=1e-97,
Organism=Drosophila melanogaster, GI24647048, Length=416, Percent_Identity=43.5096153846154, Blast_Score=353, Evalue=2e-97,
Organism=Drosophila melanogaster, GI19921738, Length=264, Percent_Identity=30.3030303030303, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281363316, Length=273, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI17864358, Length=273, Percent_Identity=28.5714285714286, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI19922690, Length=254, Percent_Identity=28.3464566929134, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000795
- InterPro:   IPR022424
- InterPro:   IPR015256
- InterPro:   IPR009001
- InterPro:   IPR004161
- InterPro:   IPR009000 [H]

Pfam domain/function: PF09173 eIF2_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 44490; Mature: 44490

Theoretical pI: Translated: 8.14; Mature: 8.14

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHDPTIPNVNIGVVGHVDHGKTTLVSQLTGSWTDRHSEELKRGISIRLGYADATFYKCPK
CCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCEEECCC
CGGEELWTNTETCPTCGEKLEAVRSVSFVDAPGHETLMATMLSGSAIMDGAMLVIAANEP
CCCHHHCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHCCCEEECCEEEEEECCCC
CPQPQTKEHLMALELTGIKNIVIVQNKIDVVPQKKALENYKQIKAFVKGTVAENAPIIPV
CCCCCCHHHEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEC
SAQKRINFGMLLDALNTTIPDVERETDVMPIMLIARSFDVNRPGSSWRDIKGGVIGGSLI
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHCCCCEECCCEE
RGEFHEGDEIEIRPGRQYMSENKAKWEPITTKITSMNKASHKVPTATPGGLSAIGTKLDP
ECCCCCCCEEEECCCHHHHHCCCCCCCCCEEEEHHCCCCCCCCCCCCCCCHHHHCCCCCC
AITKSDTLVGQVAGMAGSLPPVWDKLKFDVTLMERVVGSSAELNIDPLRLKEPLMLSVGT
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEECCH
AVTVGIVLAVKKNQAEVMLKRPVCAEVGSRIAISRQVGGRWRLIGMGLLTE
HEEEEEEEEEECCCCEEEEECCHHHHHCCEEEEEECCCCEEEEEECCCCCC
>Mature Secondary Structure
MHDPTIPNVNIGVVGHVDHGKTTLVSQLTGSWTDRHSEELKRGISIRLGYADATFYKCPK
CCCCCCCCCEEEEEEECCCCCHHHHHHHHCCCCHHHHHHHHCCCEEEEECCCCCEEECCC
CGGEELWTNTETCPTCGEKLEAVRSVSFVDAPGHETLMATMLSGSAIMDGAMLVIAANEP
CCCHHHCCCCCCCCCHHHHHHHHHHHEEECCCCHHHHHHHHHCCCEEECCEEEEEECCCC
CPQPQTKEHLMALELTGIKNIVIVQNKIDVVPQKKALENYKQIKAFVKGTVAENAPIIPV
CCCCCCHHHEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEC
SAQKRINFGMLLDALNTTIPDVERETDVMPIMLIARSFDVNRPGSSWRDIKGGVIGGSLI
CCCCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCCCCCCCHHCCCCEECCCEE
RGEFHEGDEIEIRPGRQYMSENKAKWEPITTKITSMNKASHKVPTATPGGLSAIGTKLDP
ECCCCCCCEEEECCCHHHHHCCCCCCCCCEEEEHHCCCCCCCCCCCCCCCHHHHCCCCCC
AITKSDTLVGQVAGMAGSLPPVWDKLKFDVTLMERVVGSSAELNIDPLRLKEPLMLSVGT
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHCCCCCEEEECCH
AVTVGIVLAVKKNQAEVMLKRPVCAEVGSRIAISRQVGGRWRLIGMGLLTE
HEEEEEEEEEECCCCEEEEECCHHHHHCCEEEEEECCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11932238 [H]