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The map label for this gene is bioF

Identifier: 124265723

GI number: 124265723

Start: 566423

End: 567613

Strand: Direct

Name: bioF

Synonym: Mpe_A0530

Alternate gene names: 124265723

Gene position: 566423-567613 (Clockwise)

Preceding gene: 124265722

Following gene: 124265724

Centisome position: 14.01

GC content: 72.88

Gene sequence:

>1191_bases
ATGCCGCCTGACATCCACGACGTTTTCGGGTCGGCGCTCGCCGCGCTCGACACGCAGCAACTGCGCCGCCACCGCCGCGT
GGTCTCGGCGCTCGACGGCGCGATGGTGCAGGCCGACACGCAGCCGCGCCTCGCCTTTGCCGGCAACGACTACCTCGGCC
TGTCGCAGCACCCGGCACTGATCGAGGCCGCCCGGCAGGGCGCGGCGCGCTATGGCGTCGGTGCGACAGCCTCGCCGCTG
ATCTGCGGTCACAGCCCGGCGCACGAGGCGCTGGAGCAGGAGCTGGCGCGTTTCGTCGGTCTGCCGCGCGCGCTGTACTT
CTACGCGGGCTATGCGGCCAATGCCGGTGCGATCCCGGCGCTGGTCGAGCGCGGCGATGCATTGATCTCCGATGCCCTGA
ACCACGCCTGCCTGATCGACGGCGCCCGCCTGTCGCGGGCCGACCTCACGGTCTACCCGCACAATGACCTGGCGGCGCTG
GAGCGGGCGCTGGTCGCGGCGCGCGGCGCGCGCCGGCGGCTCGTCGTGGCCGACGCGGTGTTCAGCATGGACGGCGACCT
GGCGCCGCTGCCGGAGATGCTCGCCCTGTGCGAGCGCCATGACGCCTGGCTCTACGTCGACGACGCCCACGGTTTCGGCG
TGCTCGGTGAGGGCGGGCGCGGAAGCCTGTCGCACTGGCGCGTGCCGACCGACGCGATGTCGTCACGCTTGATCTACATG
GCCACGCTGGGCAAGGCCGCCGGCGTTGCGGGGGCCTTCATCGCCGGCGCACCCGCCGTGATCGAGTGGCTGGTGCAGAA
GGCACGCACCTTCTTCTTCGCCACCGGTGCGCCGCCCATGATCGCCGAGGCGCTGCGCGCCAGCCTGCAGGTCATCGAGT
CGGAAGGCTGGCGGCGCGAAAGGCTGCTGCAGCTGCGCACGCGCCTGGCTTGCGGACTGGCCGCGCTGCCTTGGCCGGCG
CCTGCTTCGCAAAGCGCCATCCAGCCGCTGCTGCTGGGCGACAACGGCACGGCGCTGCGGGTGATGGCCGCGCTCGATGC
CCAGGGCATCTGGGTGCCGGCGATCCGCCCGCCCACGGTGCCGGACGGCACCGCGCGCCTGCGCATCTCGATGTCGGCCG
CTCACACGCCGGATGACGTGGATCGTCTGTGCGCCGCGCTGCTCGCGGCCAGCGCCCGGCCCCCTGTCTGA

Upstream 100 bases:

>100_bases
CGCCGGCAGCTCGATGCACCCCTGTTGGCCGACTGGCCCTGGCAGCCCGATGCCGACCCGGGCACGCTGCTGTTGCAACT
TCCCCCTGAGCCAGTTCTCG

Downstream 100 bases:

>100_bases
GCTGCCCGTTTCGCGGGGGTGAGCCGCGCCGCTGCGCACGGCGCTTCGCACAATCAAGGCATCGCATCGCAGCACCGTGA
TGCAGAGAAGCCGGAGCGTG

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; L-alanine--pimeloyl-CoA ligase

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MPPDIHDVFGSALAALDTQQLRRHRRVVSALDGAMVQADTQPRLAFAGNDYLGLSQHPALIEAARQGAARYGVGATASPL
ICGHSPAHEALEQELARFVGLPRALYFYAGYAANAGAIPALVERGDALISDALNHACLIDGARLSRADLTVYPHNDLAAL
ERALVAARGARRRLVVADAVFSMDGDLAPLPEMLALCERHDAWLYVDDAHGFGVLGEGGRGSLSHWRVPTDAMSSRLIYM
ATLGKAAGVAGAFIAGAPAVIEWLVQKARTFFFATGAPPMIAEALRASLQVIESEGWRRERLLQLRTRLACGLAALPWPA
PASQSAIQPLLLGDNGTALRVMAALDAQGIWVPAIRPPTVPDGTARLRISMSAAHTPDDVDRLCAALLAASARPPV

Sequences:

>Translated_396_residues
MPPDIHDVFGSALAALDTQQLRRHRRVVSALDGAMVQADTQPRLAFAGNDYLGLSQHPALIEAARQGAARYGVGATASPL
ICGHSPAHEALEQELARFVGLPRALYFYAGYAANAGAIPALVERGDALISDALNHACLIDGARLSRADLTVYPHNDLAAL
ERALVAARGARRRLVVADAVFSMDGDLAPLPEMLALCERHDAWLYVDDAHGFGVLGEGGRGSLSHWRVPTDAMSSRLIYM
ATLGKAAGVAGAFIAGAPAVIEWLVQKARTFFFATGAPPMIAEALRASLQVIESEGWRRERLLQLRTRLACGLAALPWPA
PASQSAIQPLLLGDNGTALRVMAALDAQGIWVPAIRPPTVPDGTARLRISMSAAHTPDDVDRLCAALLAASARPPV
>Mature_395_residues
PPDIHDVFGSALAALDTQQLRRHRRVVSALDGAMVQADTQPRLAFAGNDYLGLSQHPALIEAARQGAARYGVGATASPLI
CGHSPAHEALEQELARFVGLPRALYFYAGYAANAGAIPALVERGDALISDALNHACLIDGARLSRADLTVYPHNDLAALE
RALVAARGARRRLVVADAVFSMDGDLAPLPEMLALCERHDAWLYVDDAHGFGVLGEGGRGSLSHWRVPTDAMSSRLIYMA
TLGKAAGVAGAFIAGAPAVIEWLVQKARTFFFATGAPPMIAEALRASLQVIESEGWRRERLLQLRTRLACGLAALPWPAP
ASQSAIQPLLLGDNGTALRVMAALDAQGIWVPAIRPPTVPDGTARLRISMSAAHTPDDVDRLCAALLAASARPPV

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A, and carbon dioxide

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. BioF subfamily

Homologues:

Organism=Homo sapiens, GI7657118, Length=369, Percent_Identity=34.9593495934959, Blast_Score=217, Evalue=2e-56,
Organism=Homo sapiens, GI284448556, Length=346, Percent_Identity=36.1271676300578, Blast_Score=213, Evalue=2e-55,
Organism=Homo sapiens, GI4758668, Length=349, Percent_Identity=30.3724928366762, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI119220554, Length=355, Percent_Identity=29.8591549295775, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI83977440, Length=356, Percent_Identity=32.3033707865169, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI83977442, Length=356, Percent_Identity=32.3033707865169, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI83977444, Length=356, Percent_Identity=32.3033707865169, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4502025, Length=354, Percent_Identity=32.2033898305085, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI40316939, Length=354, Percent_Identity=32.2033898305085, Blast_Score=148, Evalue=7e-36,
Organism=Homo sapiens, GI5454084, Length=261, Percent_Identity=31.0344827586207, Blast_Score=126, Evalue=4e-29,
Organism=Escherichia coli, GI1786993, Length=357, Percent_Identity=45.9383753501401, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1790046, Length=370, Percent_Identity=38.1081081081081, Blast_Score=245, Evalue=3e-66,
Organism=Caenorhabditis elegans, GI71994529, Length=400, Percent_Identity=33.5, Blast_Score=221, Evalue=4e-58,
Organism=Caenorhabditis elegans, GI32566772, Length=366, Percent_Identity=29.2349726775956, Blast_Score=155, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17560914, Length=352, Percent_Identity=29.5454545454545, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI17560912, Length=352, Percent_Identity=29.5454545454545, Blast_Score=151, Evalue=5e-37,
Organism=Caenorhabditis elegans, GI71982625, Length=287, Percent_Identity=27.5261324041812, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71982617, Length=287, Percent_Identity=27.5261324041812, Blast_Score=132, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320438, Length=377, Percent_Identity=28.6472148541114, Blast_Score=150, Evalue=5e-37,
Organism=Saccharomyces cerevisiae, GI6320267, Length=361, Percent_Identity=29.0858725761773, Blast_Score=137, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323954, Length=281, Percent_Identity=25.9786476868327, Blast_Score=115, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24662918, Length=388, Percent_Identity=32.2164948453608, Blast_Score=218, Evalue=7e-57,
Organism=Drosophila melanogaster, GI17137420, Length=353, Percent_Identity=30.5949008498584, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI24653280, Length=289, Percent_Identity=30.1038062283737, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24653276, Length=289, Percent_Identity=30.1038062283737, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI24653278, Length=289, Percent_Identity=30.1038062283737, Blast_Score=145, Evalue=4e-35,
Organism=Drosophila melanogaster, GI17136286, Length=399, Percent_Identity=28.0701754385965, Blast_Score=143, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): BIOF_METPP (A2SD53)

Other databases:

- EMBL:   CP000555
- RefSeq:   YP_001019727.1
- ProteinModelPortal:   A2SD53
- STRING:   A2SD53
- GeneID:   4787353
- GenomeReviews:   CP000555_GR
- KEGG:   mpt:Mpe_A0530
- NMPDR:   fig|279263.3.peg.2774
- eggNOG:   COG0156
- HOGENOM:   HBG649839
- OMA:   CASAPVV
- PhylomeDB:   A2SD53
- BioCyc:   MPET420662:MPE_A0530-MONOMER
- HAMAP:   MF_01693
- InterPro:   IPR022834
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR00858

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.3.1.47

Molecular weight: Translated: 41947; Mature: 41815

Theoretical pI: Translated: 7.10; Mature: 7.10

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: BINDING 23-23 BINDING 135-135 BINDING 182-182 BINDING 359-359

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPPDIHDVFGSALAALDTQQLRRHRRVVSALDGAMVQADTQPRLAFAGNDYLGLSQHPAL
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHH
IEAARQGAARYGVGATASPLICGHSPAHEALEQELARFVGLPRALYFYAGYAANAGAIPA
HHHHHHCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHH
LVERGDALISDALNHACLIDGARLSRADLTVYPHNDLAALERALVAARGARRRLVVADAV
HHHHCHHHHHHHCCCEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHH
FSMDGDLAPLPEMLALCERHDAWLYVDDAHGFGVLGEGGRGSLSHWRVPTDAMSSRLIYM
HHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHCCEEEE
ATLGKAAGVAGAFIAGAPAVIEWLVQKARTFFFATGAPPMIAEALRASLQVIESEGWRRE
EECCHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHH
RLLQLRTRLACGLAALPWPAPASQSAIQPLLLGDNGTALRVMAALDAQGIWVPAIRPPTV
HHHHHHHHHHHCHHCCCCCCCCCHHHCCEEEECCCCCEEEEEEECCCCCEEECCCCCCCC
PDGTARLRISMSAAHTPDDVDRLCAALLAASARPPV
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PPDIHDVFGSALAALDTQQLRRHRRVVSALDGAMVQADTQPRLAFAGNDYLGLSQHPAL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCEEECCCCCCCCCCCHHH
IEAARQGAARYGVGATASPLICGHSPAHEALEQELARFVGLPRALYFYAGYAANAGAIPA
HHHHHHCHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHH
LVERGDALISDALNHACLIDGARLSRADLTVYPHNDLAALERALVAARGARRRLVVADAV
HHHHCHHHHHHHCCCEEEECCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEEEHHH
FSMDGDLAPLPEMLALCERHDAWLYVDDAHGFGVLGEGGRGSLSHWRVPTDAMSSRLIYM
HHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCEEECCCCCCCCCCCCCCHHHHHCCEEEE
ATLGKAAGVAGAFIAGAPAVIEWLVQKARTFFFATGAPPMIAEALRASLQVIESEGWRRE
EECCHHHHHHHHHHCCCHHHHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHCCCHHHH
RLLQLRTRLACGLAALPWPAPASQSAIQPLLLGDNGTALRVMAALDAQGIWVPAIRPPTV
HHHHHHHHHHHCHHCCCCCCCCCHHHCCEEEECCCCCEEEEEEECCCCCEEECCCCCCCC
PDGTARLRISMSAAHTPDDVDRLCAALLAASARPPV
CCCCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA