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The map label for this gene is bioA [H]

Identifier: 124265721

GI number: 124265721

Start: 564392

End: 565723

Strand: Direct

Name: bioA [H]

Synonym: Mpe_A0528

Alternate gene names: 124265721

Gene position: 564392-565723 (Clockwise)

Preceding gene: 124265720

Following gene: 124265722

Centisome position: 13.96

GC content: 71.7

Gene sequence:

>1332_bases
ATGACGCGCGGACCCGACACCCTGGCCGAGCGCAGCCGGCGCGCGGTCTGGCACCCCTGCACGCAGATGAAGCGCCACGA
GCGCGAGCCGCTGCTGGCGATCGCGCGCGCGCAGGGACCGTGGCTGTTCGACCCCGACGGGCATCGCTACCTCGACGCTG
TCAGTTCCTGGTGGGTCAACCTGTTCGGCCACGGCCACCCTCAGCTGCGGGACGCACTGGCCGAGCAGCTGGCGACGCTC
GACCACGTGATGCTCGCTGGCCTGACGCACGAGCCGGTGGTCGAGCTCTCGGAGCGCCTCGCCGCGCTGACCGGCCTGGG
CCACGCCTTCTATGCCAGCGACGGCGCCTCGGCCACCGAGATCGCACTGAAGATGAGCGCGCACAGCTGGCGCAACCGCG
GCCGGCCGCAGAAGTGCGAGTTCGTCGGACTGGCCGGCGGCTATCACGGCGAGACCGTGGGGGCGCTGTCGGTCACCGAC
ATCGCACTGTTCCGCGAAGCCTATGCGCCGCTGGTGCGCCTGAGTGCCGCGCTGCCGTCGCCTGACACGCGCCATGCCGC
GCCGGGCGAGGACGCCGCAGCCCACGCCCGGCGCTGCGCGGCGTCGCTCGAGGCCTATCTGGATCAGCACCACGAGCGCA
CCGCGGCGCTGATCGTCGAGCCGCTGGTGCAATGCGCCGCCGGCTTCGGCATGCACGACCCCGAGTACCTGCGGCTGGCG
CGCGCGCTGTGCGACCGCTACCAGGTGCACCTGATCTGCGACGAGATCGCGGTCGGCTTCGGCCGCACCGGCACGCTGTT
CGCGCACCAGCAGGCCGGCATCCGGCCCGACTTCATCTGCCTGTCCAAGGGCCTGACCGGCGGCACGCTGCCGCTGTCGG
CGGTGCTGACGACCGACGCGGTCTACGAGTCCTTCTACGATGACCTGGCGTCGCGCGGCTTCCTGCATTCGCACTCCTAC
ACCGGTAATCCGCTGGCCTGCCGCGCGGCGTTGACCGTGCTCGATCTGTTCGAGCAGCCGATCGACGGCGAGCCGGTGCT
GGCGCACAACCGCCGCACCGCCGCGCGACTGACCGCGCTGTGCGAGCCACTGAACGCCCACCCGCGCGTGCGCGCGGTGC
GCCAGCTCGGCATGCTGTGGGCCTGGGACATCGACGACGACGGCGTGGTGGGTTTCTCCAGCGCCTACCACCTCGCGGCG
CGTGAGCAGGGCCTGCTGCTGCGACCGATCGGCAACACGCTGTACTTCATGCCGCCCTATGTGCTGGACGACGGGGCGCT
GGAGCAACTGGCCGGCGGTGCGCTGCGCGCGCTCGAGGTCGCGCTGGCATGA

Upstream 100 bases:

>100_bases
GGCTGCTGACCACGGTGCCGGCGATCGCCAGCGTCAGCGTCGGGCGGCAGAGCAGTGGGGACCGCTGTACCTTCCGGCCG
GTGCTCGCGGATCGCCGGCG

Downstream 100 bases:

>100_bases
CGGCACCGCGGACACCCGCCGCGCGCGGCTGGTTCGTGACCGGCACCGACACCGGGGTCGGCAAGACCCGCGCGAGCGTC
GCGCTGCTGCGGGCGCTGCG

Product: aminotransferase

Products: NA

Alternate protein names: 7,8-diamino-pelargonic acid aminotransferase; DAPA AT; DAPA aminotransferase; Diaminopelargonic acid synthase [H]

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MTRGPDTLAERSRRAVWHPCTQMKRHEREPLLAIARAQGPWLFDPDGHRYLDAVSSWWVNLFGHGHPQLRDALAEQLATL
DHVMLAGLTHEPVVELSERLAALTGLGHAFYASDGASATEIALKMSAHSWRNRGRPQKCEFVGLAGGYHGETVGALSVTD
IALFREAYAPLVRLSAALPSPDTRHAAPGEDAAAHARRCAASLEAYLDQHHERTAALIVEPLVQCAAGFGMHDPEYLRLA
RALCDRYQVHLICDEIAVGFGRTGTLFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDAVYESFYDDLASRGFLHSHSY
TGNPLACRAALTVLDLFEQPIDGEPVLAHNRRTAARLTALCEPLNAHPRVRAVRQLGMLWAWDIDDDGVVGFSSAYHLAA
REQGLLLRPIGNTLYFMPPYVLDDGALEQLAGGALRALEVALA

Sequences:

>Translated_443_residues
MTRGPDTLAERSRRAVWHPCTQMKRHEREPLLAIARAQGPWLFDPDGHRYLDAVSSWWVNLFGHGHPQLRDALAEQLATL
DHVMLAGLTHEPVVELSERLAALTGLGHAFYASDGASATEIALKMSAHSWRNRGRPQKCEFVGLAGGYHGETVGALSVTD
IALFREAYAPLVRLSAALPSPDTRHAAPGEDAAAHARRCAASLEAYLDQHHERTAALIVEPLVQCAAGFGMHDPEYLRLA
RALCDRYQVHLICDEIAVGFGRTGTLFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDAVYESFYDDLASRGFLHSHSY
TGNPLACRAALTVLDLFEQPIDGEPVLAHNRRTAARLTALCEPLNAHPRVRAVRQLGMLWAWDIDDDGVVGFSSAYHLAA
REQGLLLRPIGNTLYFMPPYVLDDGALEQLAGGALRALEVALA
>Mature_442_residues
TRGPDTLAERSRRAVWHPCTQMKRHEREPLLAIARAQGPWLFDPDGHRYLDAVSSWWVNLFGHGHPQLRDALAEQLATLD
HVMLAGLTHEPVVELSERLAALTGLGHAFYASDGASATEIALKMSAHSWRNRGRPQKCEFVGLAGGYHGETVGALSVTDI
ALFREAYAPLVRLSAALPSPDTRHAAPGEDAAAHARRCAASLEAYLDQHHERTAALIVEPLVQCAAGFGMHDPEYLRLAR
ALCDRYQVHLICDEIAVGFGRTGTLFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDAVYESFYDDLASRGFLHSHSYT
GNPLACRAALTVLDLFEQPIDGEPVLAHNRRTAARLTALCEPLNAHPRVRAVRQLGMLWAWDIDDDGVVGFSSAYHLAAR
EQGLLLRPIGNTLYFMPPYVLDDGALEQLAGGALRALEVALA

Specific function: Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=435, Percent_Identity=31.264367816092, Blast_Score=139, Evalue=4e-33,
Organism=Homo sapiens, GI37574042, Length=411, Percent_Identity=27.007299270073, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI226442705, Length=411, Percent_Identity=26.5206812652068, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI284507298, Length=331, Percent_Identity=31.7220543806647, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI13994255, Length=340, Percent_Identity=26.4705882352941, Blast_Score=105, Evalue=9e-23,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=26.246719160105, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI188536080, Length=430, Percent_Identity=23.4883720930233, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI38679950, Length=430, Percent_Identity=23.4883720930233, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI38679946, Length=430, Percent_Identity=23.4883720930233, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI1786991, Length=440, Percent_Identity=37.2727272727273, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI145693181, Length=409, Percent_Identity=30.5623471882641, Blast_Score=162, Evalue=3e-41,
Organism=Escherichia coli, GI1789759, Length=395, Percent_Identity=28.6075949367089, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789016, Length=409, Percent_Identity=31.7848410757946, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1788044, Length=389, Percent_Identity=30.5912596401028, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1787560, Length=420, Percent_Identity=30.2380952380952, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1786349, Length=324, Percent_Identity=29.0123456790123, Blast_Score=101, Evalue=9e-23,
Organism=Caenorhabditis elegans, GI25144271, Length=422, Percent_Identity=27.9620853080569, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI25144274, Length=243, Percent_Identity=32.9218106995885, Blast_Score=111, Evalue=7e-25,
Organism=Caenorhabditis elegans, GI32564660, Length=423, Percent_Identity=24.5862884160757, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI71992977, Length=461, Percent_Identity=22.3427331887202, Blast_Score=101, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17541228, Length=328, Percent_Identity=24.0853658536585, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6324386, Length=485, Percent_Identity=27.6288659793814, Blast_Score=182, Evalue=9e-47,
Organism=Saccharomyces cerevisiae, GI6323470, Length=414, Percent_Identity=29.4685990338164, Blast_Score=140, Evalue=4e-34,
Organism=Saccharomyces cerevisiae, GI6324432, Length=434, Percent_Identity=26.4976958525346, Blast_Score=120, Evalue=5e-28,
Organism=Drosophila melanogaster, GI21357415, Length=413, Percent_Identity=28.0871670702179, Blast_Score=132, Evalue=6e-31,
Organism=Drosophila melanogaster, GI28574759, Length=354, Percent_Identity=27.4011299435028, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI21356575, Length=331, Percent_Identity=28.0966767371601, Blast_Score=101, Evalue=9e-22,
Organism=Drosophila melanogaster, GI161085790, Length=354, Percent_Identity=27.4011299435028, Blast_Score=101, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR005815
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.62 [H]

Molecular weight: Translated: 48300; Mature: 48169

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRGPDTLAERSRRAVWHPCTQMKRHEREPLLAIARAQGPWLFDPDGHRYLDAVSSWWVN
CCCCCHHHHHHHCCCHHCHHHHHHHCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHH
LFGHGHPQLRDALAEQLATLDHVMLAGLTHEPVVELSERLAALTGLGHAFYASDGASATE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHEECCCCCCHHH
IALKMSAHSWRNRGRPQKCEFVGLAGGYHGETVGALSVTDIALFREAYAPLVRLSAALPS
HEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PDTRHAAPGEDAAAHARRCAASLEAYLDQHHERTAALIVEPLVQCAAGFGMHDPEYLRLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RALCDRYQVHLICDEIAVGFGRTGTLFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDA
HHHHHHHEEEEEEHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VYESFYDDLASRGFLHSHSYTGNPLACRAALTVLDLFEQPIDGEPVLAHNRRTAARLTAL
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
CEPLNAHPRVRAVRQLGMLWAWDIDDDGVVGFSSAYHLAAREQGLLLRPIGNTLYFMPPY
HCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCEEEECCCE
VLDDGALEQLAGGALRALEVALA
EECCHHHHHHCCHHHHHHHHHCC
>Mature Secondary Structure 
TRGPDTLAERSRRAVWHPCTQMKRHEREPLLAIARAQGPWLFDPDGHRYLDAVSSWWVN
CCCCHHHHHHHCCCHHCHHHHHHHCCCCCCEEEEECCCCEEECCCCHHHHHHHHHHHHH
LFGHGHPQLRDALAEQLATLDHVMLAGLTHEPVVELSERLAALTGLGHAFYASDGASATE
HHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCHHEECCCCCCHHH
IALKMSAHSWRNRGRPQKCEFVGLAGGYHGETVGALSVTDIALFREAYAPLVRLSAALPS
HEEEHHHHHHHHCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
PDTRHAAPGEDAAAHARRCAASLEAYLDQHHERTAALIVEPLVQCAAGFGMHDPEYLRLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
RALCDRYQVHLICDEIAVGFGRTGTLFAHQQAGIRPDFICLSKGLTGGTLPLSAVLTTDA
HHHHHHHEEEEEEHHHHHCCCCCCCEEEECCCCCCCCEEEEECCCCCCCCHHHHHHHHHH
VYESFYDDLASRGFLHSHSYTGNPLACRAALTVLDLFEQPIDGEPVLAHNRRTAARLTAL
HHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHH
CEPLNAHPRVRAVRQLGMLWAWDIDDDGVVGFSSAYHLAAREQGLLLRPIGNTLYFMPPY
HCCCCCCHHHHHHHHHCCEEEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCEEEECCCE
VLDDGALEQLAGGALRALEVALA
EECCHHHHHHCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2110099 [H]