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The map label for this gene is lpxC [H]

Identifier: 124265661

GI number: 124265661

Start: 509398

End: 510333

Strand: Direct

Name: lpxC [H]

Synonym: Mpe_A0468

Alternate gene names: 124265661

Gene position: 509398-510333 (Clockwise)

Preceding gene: 124265660

Following gene: 124265662

Centisome position: 12.6

GC content: 68.7

Gene sequence:

>936_bases
ATGCTGCAGCAACGCACCCTGAAGTCGATCACGCGCGCCGTCGGGGTGGGCGTGCACAGCGGGCAGCGGGTCGAGCTCAC
GCTGCGGCCGGCGGCGCCCGACACGGGCATCGTGTTCCGGCGTGTCGATCTGCCGAGCCCGGTGGACATCCCGGCACGCT
TCGACGCGGTGTGCGATACGCGCATGGCCTCCAGCATTTCGCCCGGCGGCGACCCGGGCGGCCCGAAGGTGCAGACGATC
GAGCACTTCATGTCGGCCTGCGCCGGGCTGGGCATCGACAACCTGCTGGCGGACATCACGGCCGACGAGATGCCCATCCT
CGACGGTTCGGCCTCCAGCTTCGTGTTCCTGCTGCAGAACGCGGGCATCGAGCTGCAGAAGGCGCCCAAGCGCTTCATCC
GCGTGCTGAAGACCGTGGAAGTTCGCGACGGCGAGGGGCCCGGTGCCAAGTGGGCCCGCCTCGAGCCCTATCACGGCTAC
AAGCTCGCGTTCGAGATCGTGTTCGACCACCCGGCGGTGAGCCAGACCGGCCAGCGCGTGGAGTTCGAGTTCGGCGAGGG
TCAGTACCAGCGCGACATTGCGCGAGCGCGGACCTTCGGCTTCGCAAAGGACGTGGACGCGATGCGCGCGCGTGGCCTGA
CGCTGGGCGGCAGCATGGACAACGCGATCGTCGTCGACGACCACCGTGTGCTCAACGCCGACGGGCTGCGCTATGACGAC
GAGTTCGTGAAGCACAAGCTGCTCGACGCCATTGGCGACCTGCACATCGCCGGCCACGCGCTGCTGGCGAGCTACACCTC
GTTCAAGGGCGGGCACGCGCTGAACAATACGCTGCTGCGTGCGCTGTTCGCCGATCCGACGGCCTACGAGATGACCACGT
TCGCGCGCGAGGCCGATGCGCCGCGCGGCTTCGCCGAACTGCCGCCGGCCTGGTAG

Upstream 100 bases:

>100_bases
GGCGCCTGCTGGGTGAAGGCAACGTGCGGTGGAAAGTTGCTAACGAGGTGATAGCGCGGCCCCGCAAGCCGGTCGGGGCT
GCGCTTTTTACAATGACAGC

Downstream 100 bases:

>100_bases
CCGCGGCGCCGGTCGGTCCGGCCGCCGTCCCGCTTAGACTGCCGCCCATGCTGGTGTTTCGATGGATCCTGTTGCTGCTG
CTGGTTGCCGGCGTGCTGTG

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MLQQRTLKSITRAVGVGVHSGQRVELTLRPAAPDTGIVFRRVDLPSPVDIPARFDAVCDTRMASSISPGGDPGGPKVQTI
EHFMSACAGLGIDNLLADITADEMPILDGSASSFVFLLQNAGIELQKAPKRFIRVLKTVEVRDGEGPGAKWARLEPYHGY
KLAFEIVFDHPAVSQTGQRVEFEFGEGQYQRDIARARTFGFAKDVDAMRARGLTLGGSMDNAIVVDDHRVLNADGLRYDD
EFVKHKLLDAIGDLHIAGHALLASYTSFKGGHALNNTLLRALFADPTAYEMTTFAREADAPRGFAELPPAW

Sequences:

>Translated_311_residues
MLQQRTLKSITRAVGVGVHSGQRVELTLRPAAPDTGIVFRRVDLPSPVDIPARFDAVCDTRMASSISPGGDPGGPKVQTI
EHFMSACAGLGIDNLLADITADEMPILDGSASSFVFLLQNAGIELQKAPKRFIRVLKTVEVRDGEGPGAKWARLEPYHGY
KLAFEIVFDHPAVSQTGQRVEFEFGEGQYQRDIARARTFGFAKDVDAMRARGLTLGGSMDNAIVVDDHRVLNADGLRYDD
EFVKHKLLDAIGDLHIAGHALLASYTSFKGGHALNNTLLRALFADPTAYEMTTFAREADAPRGFAELPPAW
>Mature_311_residues
MLQQRTLKSITRAVGVGVHSGQRVELTLRPAAPDTGIVFRRVDLPSPVDIPARFDAVCDTRMASSISPGGDPGGPKVQTI
EHFMSACAGLGIDNLLADITADEMPILDGSASSFVFLLQNAGIELQKAPKRFIRVLKTVEVRDGEGPGAKWARLEPYHGY
KLAFEIVFDHPAVSQTGQRVEFEFGEGQYQRDIARARTFGFAKDVDAMRARGLTLGGSMDNAIVVDDHRVLNADGLRYDD
EFVKHKLLDAIGDLHIAGHALLASYTSFKGGHALNNTLLRALFADPTAYEMTTFAREADAPRGFAELPPAW

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=304, Percent_Identity=49.671052631579, Blast_Score=322, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 33846; Mature: 33846

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLQQRTLKSITRAVGVGVHSGQRVELTLRPAAPDTGIVFRRVDLPSPVDIPARFDAVCDT
CCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
RMASSISPGGDPGGPKVQTIEHFMSACAGLGIDNLLADITADEMPILDGSASSFVFLLQN
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEECCCCCCEEEEEEC
AGIELQKAPKRFIRVLKTVEVRDGEGPGAKWARLEPYHGYKLAFEIVFDHPAVSQTGQRV
CCCCHHHHHHHHHHHHHHHHEECCCCCCCCCEECCCCCCEEEEEEEEECCCCCCCCCCEE
EFEFGEGQYQRDIARARTFGFAKDVDAMRARGLTLGGSMDNAIVVDDHRVLNADGLRYDD
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCEEEEECCEEECCCCCCCCH
EFVKHKLLDAIGDLHIAGHALLASYTSFKGGHALNNTLLRALFADPTAYEMTTFAREADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
PRGFAELPPAW
CCCCCCCCCCC
>Mature Secondary Structure
MLQQRTLKSITRAVGVGVHSGQRVELTLRPAAPDTGIVFRRVDLPSPVDIPARFDAVCDT
CCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCEEEEEECCCCCCCCCCHHHHHHHH
RMASSISPGGDPGGPKVQTIEHFMSACAGLGIDNLLADITADEMPILDGSASSFVFLLQN
HHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCEECCCCCCEEEEEEC
AGIELQKAPKRFIRVLKTVEVRDGEGPGAKWARLEPYHGYKLAFEIVFDHPAVSQTGQRV
CCCCHHHHHHHHHHHHHHHHEECCCCCCCCCEECCCCCCEEEEEEEEECCCCCCCCCCEE
EFEFGEGQYQRDIARARTFGFAKDVDAMRARGLTLGGSMDNAIVVDDHRVLNADGLRYDD
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHCCCEECCCCCCEEEEECCEEECCCCCCCCH
EFVKHKLLDAIGDLHIAGHALLASYTSFKGGHALNNTLLRALFADPTAYEMTTFAREADA
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHCCC
PRGFAELPPAW
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA