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The map label for this gene is bcr [H]

Identifier: 124265644

GI number: 124265644

Start: 489716

End: 490777

Strand: Direct

Name: bcr [H]

Synonym: Mpe_A0451

Alternate gene names: 124265644

Gene position: 489716-490777 (Clockwise)

Preceding gene: 124265642

Following gene: 124265645

Centisome position: 12.11

GC content: 69.68

Gene sequence:

>1062_bases
ATGCAGCAGACGCTGTCGATCTACCTGATCGGCTTCGCGGTGATGAGCCTGTTCCACGGCGCGCTGTCCGACAGCTTCGG
TCGCCGGCCGGTGGTGCTGTGGGGTGTGGCGGTGTTCGCGGTCGCCTCGGCCGGCTGCGCGCTGTCGCAGACCATCGGCC
AGCTGGTGTTCTTCCGGCTGCTGCAGGGCCTGTCCACCGGGGCCGGCATCGTGGTGTCGCGCGCGGTGATCCGCGACATG
TTCCCGCCGGCCGACGCGCAGCGCGTGATGTCGCAGGTCACGATCTTCTTCGGTGCCGCGCCGGCCATCGCGCCCATCAT
CGGCGGGCTGCTGTTCGTGCACGCCGGCTGGCATGCGATCTTCTGGTTCCTCACCGCCGTGGGCGTGGCGCTGTGGATCG
CCAACTGGAAGCTGTTGCCCGAGACGCTGCACCTCGGCGCGCGGCAGCCCTTCAAGGTGCGCCACCTGCTGCGCGGCTAC
TGGCAGATGGGCAGCAGCGGGCGCTTCGTGCTGCTTGCGCTGGCCAGCGGCATTCCGTTCAACGGCATGTTCCTCTACGT
GCTGTCGGCGCCGGTGTTCGTGGGCGAGCACCTGGGCCTGGCGCCGCAGCAGTTCTTCTGGTTCTTCCTGTTCACCATCG
GCGGCATCATGGGCGGCGCCTGGTGGAGCGGGCGGCTGGCTGGCAAGCTGCCGCCGCAGCGCCAGATCCGCCGCGGCTTC
CGCGTCATGGTCGCGGTGTCGATCGTCAACGTGATCGCCAACGCACTGATGCCGGCCCAGGCCTGGTGGGCGCTGCCGCT
GATCGGCGTGTTCTCGTTCGGCTGGGCGCTGATGGTGCCGGTGGTCACGCTGATGGTCCTCGACCTGGTGCCGGAGCGGC
GCGGCATGGCCTCGTCGATGCAGTCCTGCCTCGCGGCCAGCGCGAATGCGCTGGTGGCCGGGCTGCTGGCGCCGCTGGTG
ATGCACTCGACGCTGCTGCTGGCGCTGGCGTCGATGGGGCTGATGAGCATCGGGCTCGCATCCTGGCTGTGGGTCAGGTC
GCGGCTGCCCACCGTGGCTTGA

Upstream 100 bases:

>100_bases
GCTGCTTGCCTGCCTGGCCATGCTCGGGCCGTTCGCGATCGACACCTACCTGCCGGCCTTCACCGGCATCGCGGCATCGG
TCGACGCGACGCCGCTGCAG

Downstream 100 bases:

>100_bases
CCCGCCCCGGTGCGGCGGGGCACGGCTTGCTCGCCGCAGGCATCATGCAGACCTGACTGTCTCGGCTCTCCCGCCATGCG
CTACGAACACCTGCTCCAAG

Product: putative MFS transporter

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Sulfonamide resistance protein [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MQQTLSIYLIGFAVMSLFHGALSDSFGRRPVVLWGVAVFAVASAGCALSQTIGQLVFFRLLQGLSTGAGIVVSRAVIRDM
FPPADAQRVMSQVTIFFGAAPAIAPIIGGLLFVHAGWHAIFWFLTAVGVALWIANWKLLPETLHLGARQPFKVRHLLRGY
WQMGSSGRFVLLALASGIPFNGMFLYVLSAPVFVGEHLGLAPQQFFWFFLFTIGGIMGGAWWSGRLAGKLPPQRQIRRGF
RVMVAVSIVNVIANALMPAQAWWALPLIGVFSFGWALMVPVVTLMVLDLVPERRGMASSMQSCLAASANALVAGLLAPLV
MHSTLLLALASMGLMSIGLASWLWVRSRLPTVA

Sequences:

>Translated_353_residues
MQQTLSIYLIGFAVMSLFHGALSDSFGRRPVVLWGVAVFAVASAGCALSQTIGQLVFFRLLQGLSTGAGIVVSRAVIRDM
FPPADAQRVMSQVTIFFGAAPAIAPIIGGLLFVHAGWHAIFWFLTAVGVALWIANWKLLPETLHLGARQPFKVRHLLRGY
WQMGSSGRFVLLALASGIPFNGMFLYVLSAPVFVGEHLGLAPQQFFWFFLFTIGGIMGGAWWSGRLAGKLPPQRQIRRGF
RVMVAVSIVNVIANALMPAQAWWALPLIGVFSFGWALMVPVVTLMVLDLVPERRGMASSMQSCLAASANALVAGLLAPLV
MHSTLLLALASMGLMSIGLASWLWVRSRLPTVA
>Mature_353_residues
MQQTLSIYLIGFAVMSLFHGALSDSFGRRPVVLWGVAVFAVASAGCALSQTIGQLVFFRLLQGLSTGAGIVVSRAVIRDM
FPPADAQRVMSQVTIFFGAAPAIAPIIGGLLFVHAGWHAIFWFLTAVGVALWIANWKLLPETLHLGARQPFKVRHLLRGY
WQMGSSGRFVLLALASGIPFNGMFLYVLSAPVFVGEHLGLAPQQFFWFFLFTIGGIMGGAWWSGRLAGKLPPQRQIRRGF
RVMVAVSIVNVIANALMPAQAWWALPLIGVFSFGWALMVPVVTLMVLDLVPERRGMASSMQSCLAASANALVAGLLAPLV
MHSTLLLALASMGLMSIGLASWLWVRSRLPTVA

Specific function: Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance. Probable membrane translocase [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=318, Percent_Identity=34.2767295597484, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI48994889, Length=352, Percent_Identity=27.2727272727273, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1790146, Length=209, Percent_Identity=28.2296650717703, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI87082312, Length=327, Percent_Identity=28.7461773700306, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790794, Length=277, Percent_Identity=24.9097472924188, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790195, Length=157, Percent_Identity=29.9363057324841, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1787065, Length=198, Percent_Identity=28.7878787878788, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081738, Length=153, Percent_Identity=32.6797385620915, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1789042, Length=112, Percent_Identity=31.25, Blast_Score=64, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324264, Length=139, Percent_Identity=29.4964028776978, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6322070, Length=126, Percent_Identity=34.9206349206349, Blast_Score=65, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR004734 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 38161; Mature: 38161

Theoretical pI: Translated: 12.18; Mature: 12.18

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQQTLSIYLIGFAVMSLFHGALSDSFGRRPVVLWGVAVFAVASAGCALSQTIGQLVFFRL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LQGLSTGAGIVVSRAVIRDMFPPADAQRVMSQVTIFFGAAPAIAPIIGGLLFVHAGWHAI
HHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FWFLTAVGVALWIANWKLLPETLHLGARQPFKVRHLLRGYWQMGSSGRFVLLALASGIPF
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
NGMFLYVLSAPVFVGEHLGLAPQQFFWFFLFTIGGIMGGAWWSGRLAGKLPPQRQIRRGF
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
RVMVAVSIVNVIANALMPAQAWWALPLIGVFSFGWALMVPVVTLMVLDLVPERRGMASSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QSCLAASANALVAGLLAPLVMHSTLLLALASMGLMSIGLASWLWVRSRLPTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MQQTLSIYLIGFAVMSLFHGALSDSFGRRPVVLWGVAVFAVASAGCALSQTIGQLVFFRL
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
LQGLSTGAGIVVSRAVIRDMFPPADAQRVMSQVTIFFGAAPAIAPIIGGLLFVHAGWHAI
HHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
FWFLTAVGVALWIANWKLLPETLHLGARQPFKVRHLLRGYWQMGSSGRFVLLALASGIPF
HHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCC
NGMFLYVLSAPVFVGEHLGLAPQQFFWFFLFTIGGIMGGAWWSGRLAGKLPPQRQIRRGF
CCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHH
RVMVAVSIVNVIANALMPAQAWWALPLIGVFSFGWALMVPVVTLMVLDLVPERRGMASSM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
QSCLAASANALVAGLLAPLVMHSTLLLALASMGLMSIGLASWLWVRSRLPTVA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 8486276; 9278503; 2694948 [H]