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The map label for this gene is mscS [H]

Identifier: 124265604

GI number: 124265604

Start: 444745

End: 445554

Strand: Direct

Name: mscS [H]

Synonym: Mpe_A0411

Alternate gene names: 124265604

Gene position: 444745-445554 (Clockwise)

Preceding gene: 124265603

Following gene: 124265605

Centisome position: 11.0

GC content: 67.65

Gene sequence:

>810_bases
ATGGACATCGACGCATTGCAGACCTTCCTCGGCACCACCGTGACTGCGGTGATCCTCAAGATCCTGGCCGCGCTCGCGTT
CTGGCTCGTCGGCCGCTGGCTGATCGGCCGGGTGATCGCGCTGGTGCAGGCGGCCATGAGCCGCAACCACGTCGACCCCA
CCCTGACCAAGTACCTGGGCTCGATCATCGCCGTCGCGCTGAACATCGCGCTGGTGCTCGGCATCCTGGGCTACTTCGGG
ATCGAGACCACCTCCTTTGCGGCGATGCTGGCCGGCGCCGGCGTGGCGATCGGTGCGGCGTGGAGCGGGCTGCTCGGCAA
CTTCGCGGCCGGCGCCTTCATGCTGATCCTGCGGCCCTTCAAGGTGGGCGACTTCGTCAGCGTGGGCGGCGTGGTGGGTA
CGGTGCGAGAGCTCGGCCTGTTCGGGACCACGATCGTCACGCCCGACAACGTGATGACGATCGTGGGCAACGGCAAGATC
TTCGGCGACACGATCCAGAACTTCTCCGTGCTGCCGGTGCGGCGCGTCGAGCGGGTGGCGCAGCTGGCCCACGGCGTGGA
TCCGCTCGATGCGATCGCGCGCCTGAAGGCCGCGGTGGCGCAGATCCCGAACATCTCCAAGGACATGCCGCCCGAGGTCA
ACCTGCTCGACTTCAAGCTCGAAGGACCGCAGATCGCGGTGCGCCCCTACGCCCACACCGACCACTACTGGCAGGTCTAC
TTCGACACCAACGAGGCGATCGTGCGGGTGTGCCAGGAGGCCGGCTGGCCGGTCCCGTCGGCGCTGCACCAGATCGTGAA
GCCGGCGTGA

Upstream 100 bases:

>100_bases
CCGACGCCCCACCTGGCGTGGCCTGCGGGGCGCCGCAGGTGCCGGCGCACGATGCCCCGGAGCCTCAGCCCAGGCACTGA
CCACGCAACCGGAGGATCCC

Downstream 100 bases:

>100_bases
GCCGCGGCGCACTGTCGGCCCCGGCACATCCCTTTTCACGCTGAGCCGTCCGCGTGGCCGCGCTGCTCGAAGTCCTGGCA
TCGATCCCGGCCGCGGTGTG

Product: putative transmembrane protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MDIDALQTFLGTTVTAVILKILAALAFWLVGRWLIGRVIALVQAAMSRNHVDPTLTKYLGSIIAVALNIALVLGILGYFG
IETTSFAAMLAGAGVAIGAAWSGLLGNFAAGAFMLILRPFKVGDFVSVGGVVGTVRELGLFGTTIVTPDNVMTIVGNGKI
FGDTIQNFSVLPVRRVERVAQLAHGVDPLDAIARLKAAVAQIPNISKDMPPEVNLLDFKLEGPQIAVRPYAHTDHYWQVY
FDTNEAIVRVCQEAGWPVPSALHQIVKPA

Sequences:

>Translated_269_residues
MDIDALQTFLGTTVTAVILKILAALAFWLVGRWLIGRVIALVQAAMSRNHVDPTLTKYLGSIIAVALNIALVLGILGYFG
IETTSFAAMLAGAGVAIGAAWSGLLGNFAAGAFMLILRPFKVGDFVSVGGVVGTVRELGLFGTTIVTPDNVMTIVGNGKI
FGDTIQNFSVLPVRRVERVAQLAHGVDPLDAIARLKAAVAQIPNISKDMPPEVNLLDFKLEGPQIAVRPYAHTDHYWQVY
FDTNEAIVRVCQEAGWPVPSALHQIVKPA
>Mature_269_residues
MDIDALQTFLGTTVTAVILKILAALAFWLVGRWLIGRVIALVQAAMSRNHVDPTLTKYLGSIIAVALNIALVLGILGYFG
IETTSFAAMLAGAGVAIGAAWSGLLGNFAAGAFMLILRPFKVGDFVSVGGVVGTVRELGLFGTTIVTPDNVMTIVGNGKI
FGDTIQNFSVLPVRRVERVAQLAHGVDPLDAIARLKAAVAQIPNISKDMPPEVNLLDFKLEGPQIAVRPYAHTDHYWQVY
FDTNEAIVRVCQEAGWPVPSALHQIVKPA

Specific function: Mechanosensitive channel that participates in the regulation of osmotic pressure changes within the cell. Forms an ion channel of 1.0 nanosiemens conductance with a slight preference for anions. The channel is sensitive to voltage [H]

COG id: COG0668

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI1789291, Length=243, Percent_Identity=33.7448559670782, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI1786670, Length=209, Percent_Identity=28.2296650717703, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014
- InterPro:   IPR008910 [H]

Pfam domain/function: PF00924 MS_channel; PF05552 TM_helix [H]

EC number: NA

Molecular weight: Translated: 28727; Mature: 28727

Theoretical pI: Translated: 7.72; Mature: 7.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIDALQTFLGTTVTAVILKILAALAFWLVGRWLIGRVIALVQAAMSRNHVDPTLTKYLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SIIAVALNIALVLGILGYFGIETTSFAAMLAGAGVAIGAAWSGLLGNFAAGAFMLILRPF
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
KVGDFVSVGGVVGTVRELGLFGTTIVTPDNVMTIVGNGKIFGDTIQNFSVLPVRRVERVA
CCCCHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCEEECCHHCCCCCCHHHHHHHHH
QLAHGVDPLDAIARLKAAVAQIPNISKDMPPEVNLLDFKLEGPQIAVRPYAHTDHYWQVY
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCEEEEE
FDTNEAIVRVCQEAGWPVPSALHQIVKPA
EECCHHHHHHHHHCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MDIDALQTFLGTTVTAVILKILAALAFWLVGRWLIGRVIALVQAAMSRNHVDPTLTKYLG
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SIIAVALNIALVLGILGYFGIETTSFAAMLAGAGVAIGAAWSGLLGNFAAGAFMLILRPF
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
KVGDFVSVGGVVGTVRELGLFGTTIVTPDNVMTIVGNGKIFGDTIQNFSVLPVRRVERVA
CCCCHHHHHHHHHHHHHHHHHCCEEECCCCEEEEEECCEEECCHHCCCCCCHHHHHHHHH
QLAHGVDPLDAIARLKAAVAQIPNISKDMPPEVNLLDFKLEGPQIAVRPYAHTDHYWQVY
HHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCEEEEECCCCCCCEEEEE
FDTNEAIVRVCQEAGWPVPSALHQIVKPA
EECCHHHHHHHHHCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12542086 [H]