Definition Methylibium petroleiphilum PM1 chromosome, complete genome.
Accession NC_008825
Length 4,044,195

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The map label for this gene is tpa [H]

Identifier: 124265564

GI number: 124265564

Start: 407975

End: 409333

Strand: Direct

Name: tpa [H]

Synonym: Mpe_A0371

Alternate gene names: 124265564

Gene position: 407975-409333 (Clockwise)

Preceding gene: 124265563

Following gene: 124265565

Centisome position: 10.09

GC content: 71.16

Gene sequence:

>1359_bases
ATGGGCGACAGCCTCAACGCCGCGCTGCTGCAGCGCGACCACCGCCACCTGGTGCATTCGCTGCACAACGAGGCCGCCCA
CCTGGCCGGCAACGTGTGGGTGAAGGGCGAGGGCACCACGCTGACCGACGCCGACGGCAAGCGCTACGTCGACGCCATGT
CGGGCCTGTGGAACGTGACCCTGGGCTACGGCCGCCGCGAACTGGTGGACGCCGCCGCCGCGCAGATGGGCGAGCTGGCC
TATGCCTCCGGCTACGCCGGCAGCACCAACCTGCGGGCGATGGAGCTGGCCGAGAAGCTGGCGGCCGACCGCGTGTACCC
CAACATGCACCGCTTCTTCTTCACCTCCGGGGGCGGCGAGTCGACCGACAGCACCATCAAGACCGCGCGCTACTACTGGA
AGGCGCAGGGCAAGCCCGGCAAATTCAAGACCCTCAGCGTGATGGGCGGCTACCACGGCGTGACGCTGGCCGCCATGTGC
GCCACCGGCATGCCGGCCTACTGGCCGTCCTTCGAGCCGCGCATGCCGGGCTTCGTGCACATACCGAACCACGACGCCTA
CCGCTACACCGTGCCGCCCGGTGGCGACCCGGCCACCGCCGCGGCCGACGAGCTGGAGCGCGCCATCCTGGCCGAGGGCC
CCGACACGGTGGCCCTGTTCATCGCCGAGCCGGTGATGGGCGGCGGCGCCTATGTGCCGCCGGCGGGCTACTTCCGCCGC
ATCCGCGAGATCTGCGACCGCTACGACGTGCTGTTCGCCACCGACGAAGTCATCACCGGCTTCGGCCGCACCGGCAAGCT
GTTTGCGCTGGGCCACTGGGGCAGCGACGTGCAGCCCGACCTGGTGCAGTTTGCCAAGGGCATCACCAGCGGCTACGTGC
CGATGGGCGGCGTGGGGTTGTCCGACAAGGTGGCCGCGGTGTTCGACCGCCCGGGCGCCGACACCTGGATGCACTGCTAC
ACCTACAGCGGCCACCCGGTGGCCTGCGCGGTGGCGCTGGCCACGCTGGACGTCATAGAACGCGAAGGCCTGCTGGCGCG
CGCGCAGGTGCTGGGCGACCGGCTGCTGCGCGGCCTGCGCGGCGCGCTGGGTGGCCACCCGAACGTGGGCGACATCCGCG
GCCTGGGGCTGATAGCCGCGGTGGAACTGGTGGAAGACCGCTTCTCCAAGAAGTCCTTCGACCCCGCCCGCAAGATGGGC
CCGCAGGTGCTGGCACAGGTGCGCCAGCGCGGCGTGATCACGCGCGGCCGCGGCGACACCATTTACCTGGGCCCGGCGCT
GGTGAGCGACGAGGCCACCATCGACCGGATCGTGGAGGCGGTGGCGGAGGGGGTGGGGGCGCTGTTGCCTGCTGCTTGA

Upstream 100 bases:

>100_bases
GCCCACGTGTCGCGCCGCGAGCGGCTGTTCGTCGACGAACACACGCTGGTGGACACCGGCGTCTGAACCCGCGACCCCCG
CAACGCACGGAGCCAGCCAC

Downstream 100 bases:

>100_bases
GCGCCCACCACGTCGCGCGCTGAGCGCGAGCGGGATCGAAACGCCTTCTTCTTTTCACGGCGTCGGGTACTCAGCCGACG
CCGTGGTCATTTGGGCCGCC

Product: aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MGDSLNAALLQRDHRHLVHSLHNEAAHLAGNVWVKGEGTTLTDADGKRYVDAMSGLWNVTLGYGRRELVDAAAAQMGELA
YASGYAGSTNLRAMELAEKLAADRVYPNMHRFFFTSGGGESTDSTIKTARYYWKAQGKPGKFKTLSVMGGYHGVTLAAMC
ATGMPAYWPSFEPRMPGFVHIPNHDAYRYTVPPGGDPATAAADELERAILAEGPDTVALFIAEPVMGGGAYVPPAGYFRR
IREICDRYDVLFATDEVITGFGRTGKLFALGHWGSDVQPDLVQFAKGITSGYVPMGGVGLSDKVAAVFDRPGADTWMHCY
TYSGHPVACAVALATLDVIEREGLLARAQVLGDRLLRGLRGALGGHPNVGDIRGLGLIAAVELVEDRFSKKSFDPARKMG
PQVLAQVRQRGVITRGRGDTIYLGPALVSDEATIDRIVEAVAEGVGALLPAA

Sequences:

>Translated_452_residues
MGDSLNAALLQRDHRHLVHSLHNEAAHLAGNVWVKGEGTTLTDADGKRYVDAMSGLWNVTLGYGRRELVDAAAAQMGELA
YASGYAGSTNLRAMELAEKLAADRVYPNMHRFFFTSGGGESTDSTIKTARYYWKAQGKPGKFKTLSVMGGYHGVTLAAMC
ATGMPAYWPSFEPRMPGFVHIPNHDAYRYTVPPGGDPATAAADELERAILAEGPDTVALFIAEPVMGGGAYVPPAGYFRR
IREICDRYDVLFATDEVITGFGRTGKLFALGHWGSDVQPDLVQFAKGITSGYVPMGGVGLSDKVAAVFDRPGADTWMHCY
TYSGHPVACAVALATLDVIEREGLLARAQVLGDRLLRGLRGALGGHPNVGDIRGLGLIAAVELVEDRFSKKSFDPARKMG
PQVLAQVRQRGVITRGRGDTIYLGPALVSDEATIDRIVEAVAEGVGALLPAA
>Mature_451_residues
GDSLNAALLQRDHRHLVHSLHNEAAHLAGNVWVKGEGTTLTDADGKRYVDAMSGLWNVTLGYGRRELVDAAAAQMGELAY
ASGYAGSTNLRAMELAEKLAADRVYPNMHRFFFTSGGGESTDSTIKTARYYWKAQGKPGKFKTLSVMGGYHGVTLAAMCA
TGMPAYWPSFEPRMPGFVHIPNHDAYRYTVPPGGDPATAAADELERAILAEGPDTVALFIAEPVMGGGAYVPPAGYFRRI
REICDRYDVLFATDEVITGFGRTGKLFALGHWGSDVQPDLVQFAKGITSGYVPMGGVGLSDKVAAVFDRPGADTWMHCYT
YSGHPVACAVALATLDVIEREGLLARAQVLGDRLLRGLRGALGGHPNVGDIRGLGLIAAVELVEDRFSKKSFDPARKMGP
QVLAQVRQRGVITRGRGDTIYLGPALVSDEATIDRIVEAVAEGVGALLPAA

Specific function: Catalyzes the degradation of taurine into alanine and sulfoacetaldehyde. Can also transaminate hypotaurine (2- aminosulfinate), beta-alanine and with low activity cysteine and 3-aminopropanesulfonate. In addition to pyruvate, 2-ketobutyrate and oxaloaceta

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI37574042, Length=431, Percent_Identity=28.7703016241299, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI4557809, Length=444, Percent_Identity=29.7297297297297, Blast_Score=159, Evalue=5e-39,
Organism=Homo sapiens, GI226442705, Length=431, Percent_Identity=29.0023201856148, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI226442709, Length=404, Percent_Identity=29.2079207920792, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI24119277, Length=396, Percent_Identity=30.3030303030303, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI284507298, Length=334, Percent_Identity=32.3353293413174, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI13994255, Length=432, Percent_Identity=28.4722222222222, Blast_Score=130, Evalue=3e-30,
Organism=Homo sapiens, GI188536080, Length=442, Percent_Identity=25.7918552036199, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI38679950, Length=442, Percent_Identity=25.7918552036199, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI38679946, Length=442, Percent_Identity=25.7918552036199, Blast_Score=101, Evalue=1e-21,
Organism=Escherichia coli, GI145693181, Length=424, Percent_Identity=32.7830188679245, Blast_Score=199, Evalue=3e-52,
Organism=Escherichia coli, GI1789016, Length=417, Percent_Identity=30.6954436450839, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789759, Length=422, Percent_Identity=30.3317535545024, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1786991, Length=446, Percent_Identity=28.6995515695067, Blast_Score=143, Evalue=3e-35,
Organism=Escherichia coli, GI1787560, Length=374, Percent_Identity=33.1550802139037, Blast_Score=141, Evalue=7e-35,
Organism=Escherichia coli, GI1788044, Length=415, Percent_Identity=30.6024096385542, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1786349, Length=328, Percent_Identity=28.9634146341463, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI25144271, Length=417, Percent_Identity=27.3381294964029, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI32564660, Length=444, Percent_Identity=28.6036036036036, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25144274, Length=299, Percent_Identity=28.7625418060201, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI71992977, Length=422, Percent_Identity=26.303317535545, Blast_Score=117, Evalue=8e-27,
Organism=Caenorhabditis elegans, GI17541228, Length=405, Percent_Identity=26.6666666666667, Blast_Score=86, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6323470, Length=439, Percent_Identity=28.0182232346241, Blast_Score=140, Evalue=6e-34,
Organism=Saccharomyces cerevisiae, GI6324386, Length=477, Percent_Identity=25.9958071278826, Blast_Score=130, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6324432, Length=416, Percent_Identity=25.9615384615385, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6321456, Length=387, Percent_Identity=26.8733850129199, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI21357415, Length=442, Percent_Identity=29.4117647058824, Blast_Score=160, Evalue=2e-39,
Organism=Drosophila melanogaster, GI21356575, Length=437, Percent_Identity=30.6636155606407, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI28574759, Length=437, Percent_Identity=28.8329519450801, Blast_Score=139, Evalue=4e-33,
Organism=Drosophila melanogaster, GI161085790, Length=463, Percent_Identity=28.2937365010799, Blast_Score=139, Evalue=6e-33,
Organism=Drosophila melanogaster, GI281366494, Length=312, Percent_Identity=26.2820512820513, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667139, Length=312, Percent_Identity=26.2820512820513, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24667143, Length=312, Percent_Identity=26.2820512820513, Blast_Score=80, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.77 [H]

Molecular weight: Translated: 48354; Mature: 48222

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00600 AA_TRANSFER_CLASS_3 ; PS00147 ARGINASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGDSLNAALLQRDHRHLVHSLHNEAAHLAGNVWVKGEGTTLTDADGKRYVDAMSGLWNVT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHCHHEEH
LGYGRRELVDAAAAQMGELAYASGYAGSTNLRAMELAEKLAADRVYPNMHRFFFTSGGGE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
STDSTIKTARYYWKAQGKPGKFKTLSVMGGYHGVTLAAMCATGMPAYWPSFEPRMPGFVH
CCHHHHHHHHEEEEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
IPNHDAYRYTVPPGGDPATAAADELERAILAEGPDTVALFIAEPVMGGGAYVPPAGYFRR
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHH
IREICDRYDVLFATDEVITGFGRTGKLFALGHWGSDVQPDLVQFAKGITSGYVPMGGVGL
HHHHHHHHCEEEECHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCC
SDKVAAVFDRPGADTWMHCYTYSGHPVACAVALATLDVIEREGLLARAQVLGDRLLRGLR
CCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GALGGHPNVGDIRGLGLIAAVELVEDRFSKKSFDPARKMGPQVLAQVRQRGVITRGRGDT
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCEECCCCCE
IYLGPALVSDEATIDRIVEAVAEGVGALLPAA
EEECCEEECCHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GDSLNAALLQRDHRHLVHSLHNEAAHLAGNVWVKGEGTTLTDADGKRYVDAMSGLWNVT
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEECCCCHHHHHHHHCHHEEH
LGYGRRELVDAAAAQMGELAYASGYAGSTNLRAMELAEKLAADRVYPNMHRFFFTSGGGE
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCC
STDSTIKTARYYWKAQGKPGKFKTLSVMGGYHGVTLAAMCATGMPAYWPSFEPRMPGFVH
CCHHHHHHHHEEEEECCCCCCEEEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCCCCEEE
IPNHDAYRYTVPPGGDPATAAADELERAILAEGPDTVALFIAEPVMGGGAYVPPAGYFRR
CCCCCCEEEECCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCHHHHHH
IREICDRYDVLFATDEVITGFGRTGKLFALGHWGSDVQPDLVQFAKGITSGYVPMGGVGL
HHHHHHHHCEEEECHHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCCC
SDKVAAVFDRPGADTWMHCYTYSGHPVACAVALATLDVIEREGLLARAQVLGDRLLRGLR
CCCHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
GALGGHPNVGDIRGLGLIAAVELVEDRFSKKSFDPARKMGPQVLAQVRQRGVITRGRGDT
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHCCCEECCCCCE
IYLGPALVSDEATIDRIVEAVAEGVGALLPAA
EEECCEEECCHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11082195 [H]