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The map label for this gene is dacC [H]

Identifier: 124265504

GI number: 124265504

Start: 336384

End: 337538

Strand: Direct

Name: dacC [H]

Synonym: Mpe_A0311

Alternate gene names: 124265504

Gene position: 336384-337538 (Clockwise)

Preceding gene: 124265503

Following gene: 124265505

Centisome position: 8.32

GC content: 67.53

Gene sequence:

>1155_bases
ATGAAAAGACTGTTCGTTCTTCTGTTCGCCGTCGCCACCGCTCTCACGGGCGTGGCGGCCCAGGCCCAGGCCGTGCAGCC
GCCCGAGATCGCGGCGCGCTCCTACCTGCTGTTCGACGTCACCACCAACCAGGTGCTCGCAGCCAAGGACCCGGACAGCC
CGATCGAGCCGGCCTCGCTGACCAAGCTGATGAGCGCCTACCTGGTGTTCCAGGCGCTGAAGGACAAGAAGCTGACGCTG
ACGCAGACGCTGCCGGTGTCGGAGCGCGCCTGGCGCACCGGCATGACCGGTGCCTCGCGCAGCTTCCTGCCGCTCAACAG
CCAGGTCACGGTCGATGACCTGCTCAAGGGCGAGATCGTGCAGAGCGGCAACGACGCCACCGTGGTGCTGGCCGAGGGCG
TGGGCGGGTCTCTGGAGCAGTTCGTCGCGATGATGAACCGCCAGGCGCAGGCCTTCGGCCTCAAGGCCACCACCTTCAAG
AACCCCGAGGGCCTGCCGGCGGCAGGGCACACCAGCACCGCGCGCGACCTGGCGGTGATCGCGACCCGGCTGGTGCAGGA
CTTCCCCGAGTACCTGCGCTACTCGGTGATGCGCGAGTTCACCTTCAACAAGATCAAGCAGCCCAACCGCAACCTGCTGC
TCTACCGCGACCCAACCGTCGACGGCCTGAAGACCGGCTTCACCGACGCCGCAGGCTACTGCATGATCACCACCGCCAAG
CGCGACTTCCCGAACGGTCCGCGCCGGCTGATCAGCGTCGTGCTTGGCGCTGCGTCGATGGAGTCGCGCGCCAACGAGAG
CCAGAAGCTGCTGAACTGGGGCTATACCGCCTTCGACGCCGTCAAGCTGTTCGACGCCAACCAGGCCGTCGTCAGCCCGC
CGATCTGGAAGGGCTCCTCCAGCACCGCCAAGCTCGGCAGTGCCGCGGCCGTCTACGTCAGCGTGCCCAAGGGTGACGGC
GACAAGCTCAAGACCGACATCTCGCGCACCGATCCGCTGGTGGCTCCGCTCGCCAAGGGGCAGGTGGTCGGCAGCATCAA
GGTCACCGCCAATGGCGCGCCGGTTGCCGAGCTGCCCTTGACCGTGCTGGAGAACGTCGACAGCGCCGGGCTGCTGGGCC
GCGCGTGGGATTCGCTGCGGCTGTGGATCCAGTGA

Upstream 100 bases:

>100_bases
CTTTCATGGGCAGCTCGCGCTGCTCAAGTCGCTGGTGGTGCGCGGCTGGTCCTCCTGACCGGCGCGCCGCCCGCTCCCGT
TTCCCGTTGCAGAGACCCCG

Downstream 100 bases:

>100_bases
TGCCGGTGTCGATTCGTACCGGGTGAAACGCTGCTTGCCCGTTGCCGCCGACGGGCCTACGCTGCGGGCATGAACCCGCT
GCCCAGCGCCATCCCCGCGG

Product: Serine-type D-Ala-D-Ala carboxypeptidase

Products: NA

Alternate protein names: DD-carboxypeptidase; DD-peptidase; Penicillin-binding protein 6; PBP-6 [H]

Number of amino acids: Translated: 384; Mature: 384

Protein sequence:

>384_residues
MKRLFVLLFAVATALTGVAAQAQAVQPPEIAARSYLLFDVTTNQVLAAKDPDSPIEPASLTKLMSAYLVFQALKDKKLTL
TQTLPVSERAWRTGMTGASRSFLPLNSQVTVDDLLKGEIVQSGNDATVVLAEGVGGSLEQFVAMMNRQAQAFGLKATTFK
NPEGLPAAGHTSTARDLAVIATRLVQDFPEYLRYSVMREFTFNKIKQPNRNLLLYRDPTVDGLKTGFTDAAGYCMITTAK
RDFPNGPRRLISVVLGAASMESRANESQKLLNWGYTAFDAVKLFDANQAVVSPPIWKGSSSTAKLGSAAAVYVSVPKGDG
DKLKTDISRTDPLVAPLAKGQVVGSIKVTANGAPVAELPLTVLENVDSAGLLGRAWDSLRLWIQ

Sequences:

>Translated_384_residues
MKRLFVLLFAVATALTGVAAQAQAVQPPEIAARSYLLFDVTTNQVLAAKDPDSPIEPASLTKLMSAYLVFQALKDKKLTL
TQTLPVSERAWRTGMTGASRSFLPLNSQVTVDDLLKGEIVQSGNDATVVLAEGVGGSLEQFVAMMNRQAQAFGLKATTFK
NPEGLPAAGHTSTARDLAVIATRLVQDFPEYLRYSVMREFTFNKIKQPNRNLLLYRDPTVDGLKTGFTDAAGYCMITTAK
RDFPNGPRRLISVVLGAASMESRANESQKLLNWGYTAFDAVKLFDANQAVVSPPIWKGSSSTAKLGSAAAVYVSVPKGDG
DKLKTDISRTDPLVAPLAKGQVVGSIKVTANGAPVAELPLTVLENVDSAGLLGRAWDSLRLWIQ
>Mature_384_residues
MKRLFVLLFAVATALTGVAAQAQAVQPPEIAARSYLLFDVTTNQVLAAKDPDSPIEPASLTKLMSAYLVFQALKDKKLTL
TQTLPVSERAWRTGMTGASRSFLPLNSQVTVDDLLKGEIVQSGNDATVVLAEGVGGSLEQFVAMMNRQAQAFGLKATTFK
NPEGLPAAGHTSTARDLAVIATRLVQDFPEYLRYSVMREFTFNKIKQPNRNLLLYRDPTVDGLKTGFTDAAGYCMITTAK
RDFPNGPRRLISVVLGAASMESRANESQKLLNWGYTAFDAVKLFDANQAVVSPPIWKGSSSTAKLGSAAAVYVSVPKGDG
DKLKTDISRTDPLVAPLAKGQVVGSIKVTANGAPVAELPLTVLENVDSAGLLGRAWDSLRLWIQ

Specific function: Removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors [H]

COG id: COG1686

COG function: function code M; D-alanyl-D-alanine carboxypeptidase

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein. Note=N-terminal lies in the periplasmic space [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S11 family [H]

Homologues:

Organism=Escherichia coli, GI1787062, Length=378, Percent_Identity=44.973544973545, Blast_Score=303, Evalue=1e-83,
Organism=Escherichia coli, GI1786851, Length=395, Percent_Identity=38.7341772151899, Blast_Score=258, Evalue=4e-70,
Organism=Escherichia coli, GI87082022, Length=390, Percent_Identity=37.4358974358974, Blast_Score=232, Evalue=3e-62,
Organism=Escherichia coli, GI87082054, Length=257, Percent_Identity=32.6848249027237, Blast_Score=97, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015956
- InterPro:   IPR018044
- InterPro:   IPR012907
- InterPro:   IPR001967 [H]

Pfam domain/function: PF07943 PBP5_C; PF00768 Peptidase_S11 [H]

EC number: =3.4.16.4 [H]

Molecular weight: Translated: 41249; Mature: 41249

Theoretical pI: Translated: 9.84; Mature: 9.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLFVLLFAVATALTGVAAQAQAVQPPEIAARSYLLFDVTTNQVLAAKDPDSPIEPASL
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEEEEECCCCEEEECCCCCCCCHHHH
TKLMSAYLVFQALKDKKLTLTQTLPVSERAWRTGMTGASRSFLPLNSQVTVDDLLKGEIV
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCEECCCCCCCHHHHHCCHHH
QSGNDATVVLAEGVGGSLEQFVAMMNRQAQAFGLKATTFKNPEGLPAAGHTSTARDLAVI
CCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHH
ATRLVQDFPEYLRYSVMREFTFNKIKQPNRNLLLYRDPTVDGLKTGFTDAAGYCMITTAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCCCCCCEEEEEECC
RDFPNGPRRLISVVLGAASMESRANESQKLLNWGYTAFDAVKLFDANQAVVSPPIWKGSS
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHEEEECCCCCEECCCCCCCCC
STAKLGSAAAVYVSVPKGDGDKLKTDISRTDPLVAPLAKGQVVGSIKVTANGAPVAELPL
CCHHCCCEEEEEEEECCCCCCHHHHCCCCCCCCHHHCCCCEEEEEEEEEECCCCHHHHHH
TVLENVDSAGLLGRAWDSLRLWIQ
HHHHCCCCCCCHHHCCCCEEEECC
>Mature Secondary Structure
MKRLFVLLFAVATALTGVAAQAQAVQPPEIAARSYLLFDVTTNQVLAAKDPDSPIEPASL
CHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCEEEEEEECCCCEEEECCCCCCCCHHHH
TKLMSAYLVFQALKDKKLTLTQTLPVSERAWRTGMTGASRSFLPLNSQVTVDDLLKGEIV
HHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHCCCCCCCCCEECCCCCCCHHHHHCCHHH
QSGNDATVVLAEGVGGSLEQFVAMMNRQAQAFGLKATTFKNPEGLPAAGHTSTARDLAVI
CCCCCEEEEEECCCCCCHHHHHHHHCCCHHHHCCEEEECCCCCCCCCCCCCCHHHHHHHH
ATRLVQDFPEYLRYSVMREFTFNKIKQPNRNLLLYRDPTVDGLKTGFTDAAGYCMITTAK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHCCCCCCCCEEEEEECC
RDFPNGPRRLISVVLGAASMESRANESQKLLNWGYTAFDAVKLFDANQAVVSPPIWKGSS
CCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHCCCHHHHHEEEECCCCCEECCCCCCCCC
STAKLGSAAAVYVSVPKGDGDKLKTDISRTDPLVAPLAKGQVVGSIKVTANGAPVAELPL
CCHHCCCEEEEEEEECCCCCCHHHHCCCCCCCCHHHCCCCEEEEEEEEEECCCCHHHHHH
TVLENVDSAGLLGRAWDSLRLWIQ
HHHHCCCCCCCHHHCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3279397; 8905232; 9278503; 7042389 [H]