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The map label for this gene is thiL [H]

Identifier: 124265403

GI number: 124265403

Start: 227595

End: 228566

Strand: Direct

Name: thiL [H]

Synonym: Mpe_A0210

Alternate gene names: 124265403

Gene position: 227595-228566 (Clockwise)

Preceding gene: 124265402

Following gene: 124265404

Centisome position: 5.63

GC content: 73.35

Gene sequence:

>972_bases
ATGAGCCTCGGCGAGTTCGACCTGATCGCGCGCTACTTCGGCCGCCCGACCCGCCGTGCGGCGCTCGGGCCGGGCGACGA
TTGCGCGCTGCTCGCACTGCGGCCCGGCATGCAGCTCGCGGTGTCCTGCGACATGCTGGTCGAAGGCCGGCACTTCCTGC
CCACCGTGGATCCGCGCCGCCTGGGCCACAAGGCGCTGGCGGTCAATCTCAGCGATCTCGCCGCCTGCGGCGCACAGCCG
CTGGCCTGCACGCTGGCGCTGGCGCTGCCGCGGGTCGACGAGGCCTGGCTCGACGGCTTCTCGGCCGGGCTGTACGAGCT
GGCCGATGCACACGGCTGCGAACTGATCGGCGGCGACACCACGGCCGGCCCGCTCAACATCTGCATCACAGTGTTCGGTG
AGGTCCCAGCGGGCGAGGCGCTGCTGCGCAGCAGCGCGGAGCCGGACGACGAGATCTGGGTCAGCCACGCGATCGGTGGG
GGCATCGGTGACGCGCGGCTCGCGCTCGAGGCCTTTCGCGGTCAGGTGTCGCTGCCCGGCGCGGTGTTCGAGCGGGTGCG
GCGTGCGATGGAACAGCCGCAGCCGCGCGTGGCGCTGGGCCTTGCACTGCGTGGCGTGGCCCGTGCCGCCGTCGACGTGT
CGGACGGCCTGCTGGGCGACCTGTCCCACCTCCTGCACCGCAGCGACGTCGGTGCCAGCATCGATGTCGGTCGCGTGCCG
CGCAGCGCCGACCTCGCGGCCCAGCCGCTGGCCTTGCAGCGCCTGTGCACGCTGGCCGGAGGCGACGACTACGAGCTCGT
CTTCACGGCGCCGCCAGCGGCCCATGCGCGGGTGCTCGAGGCCGCGCGCGGGGCCGACGTGGCGGTCAGCCGAATCGGCC
GCATCGAGCACGAGGCGGGCCTGCGCCTCGTCGACGCCGACGGCCAGGCCGTGGATCGCGTCTGGGCCTCGTTCGATCAC
TTCTCCGCATGA

Upstream 100 bases:

>100_bases
CTGCGCGAGCACGGCGCGCAGCGACCATCCTGAACCGGGCGCGGCCGCTGGCGTGGCGGCGCGGTGCGCGAGCGCCGAGG
CCCGCGGCGACAATGCGGCC

Downstream 100 bases:

>100_bases
ACGGCGAGCGACTGGAAGCCTCCACGGCGAAGCCCCCGCGTCGCGCGACCGCGGCCTTCCTGTGGGCCCATCCTGCGCAC
GCCATCGCGCTGGGCTTCGG

Product: thiamine-phosphate kinase

Products: NA

Alternate protein names: Thiamine-phosphate kinase [H]

Number of amino acids: Translated: 323; Mature: 322

Protein sequence:

>323_residues
MSLGEFDLIARYFGRPTRRAALGPGDDCALLALRPGMQLAVSCDMLVEGRHFLPTVDPRRLGHKALAVNLSDLAACGAQP
LACTLALALPRVDEAWLDGFSAGLYELADAHGCELIGGDTTAGPLNICITVFGEVPAGEALLRSSAEPDDEIWVSHAIGG
GIGDARLALEAFRGQVSLPGAVFERVRRAMEQPQPRVALGLALRGVARAAVDVSDGLLGDLSHLLHRSDVGASIDVGRVP
RSADLAAQPLALQRLCTLAGGDDYELVFTAPPAAHARVLEAARGADVAVSRIGRIEHEAGLRLVDADGQAVDRVWASFDH
FSA

Sequences:

>Translated_323_residues
MSLGEFDLIARYFGRPTRRAALGPGDDCALLALRPGMQLAVSCDMLVEGRHFLPTVDPRRLGHKALAVNLSDLAACGAQP
LACTLALALPRVDEAWLDGFSAGLYELADAHGCELIGGDTTAGPLNICITVFGEVPAGEALLRSSAEPDDEIWVSHAIGG
GIGDARLALEAFRGQVSLPGAVFERVRRAMEQPQPRVALGLALRGVARAAVDVSDGLLGDLSHLLHRSDVGASIDVGRVP
RSADLAAQPLALQRLCTLAGGDDYELVFTAPPAAHARVLEAARGADVAVSRIGRIEHEAGLRLVDADGQAVDRVWASFDH
FSA
>Mature_322_residues
SLGEFDLIARYFGRPTRRAALGPGDDCALLALRPGMQLAVSCDMLVEGRHFLPTVDPRRLGHKALAVNLSDLAACGAQPL
ACTLALALPRVDEAWLDGFSAGLYELADAHGCELIGGDTTAGPLNICITVFGEVPAGEALLRSSAEPDDEIWVSHAIGGG
IGDARLALEAFRGQVSLPGAVFERVRRAMEQPQPRVALGLALRGVARAAVDVSDGLLGDLSHLLHRSDVGASIDVGRVPR
SADLAAQPLALQRLCTLAGGDDYELVFTAPPAAHARVLEAARGADVAVSRIGRIEHEAGLRLVDADGQAVDRVWASFDHF
SA

Specific function: Thiamine biosynthesis. [C]

COG id: COG0611

COG function: function code H; Thiamine monophosphate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thiamine-monophosphate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1786619, Length=335, Percent_Identity=45.0746268656716, Blast_Score=231, Evalue=7e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR016188
- InterPro:   IPR006283 [H]

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C [H]

EC number: =2.7.4.16 [H]

Molecular weight: Translated: 33910; Mature: 33779

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLGEFDLIARYFGRPTRRAALGPGDDCALLALRPGMQLAVSCDMLVEGRHFLPTVDPRR
CCCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEHHHCCCCCCCCCCCHHH
LGHKALAVNLSDLAACGAQPLACTLALALPRVDEAWLDGFSAGLYELADAHGCELIGGDT
HCCCCEEEEHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCC
TAGPLNICITVFGEVPAGEALLRSSAEPDDEIWVSHAIGGGIGDARLALEAFRGQVSLPG
CCCHHEEEEEEECCCCCCHHHHHCCCCCCHHEEEEHHCCCCCCHHHHHHHHHCCCCCCCH
AVFERVRRAMEQPQPRVALGLALRGVARAAVDVSDGLLGDLSHLLHRSDVGASIDVGRVP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RSADLAAQPLALQRLCTLAGGDDYELVFTAPPAAHARVLEAARGADVAVSRIGRIEHEAG
CCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
LRLVDADGQAVDRVWASFDHFSA
CEEECCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SLGEFDLIARYFGRPTRRAALGPGDDCALLALRPGMQLAVSCDMLVEGRHFLPTVDPRR
CCCHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEHHHCCCCCCCCCCCHHH
LGHKALAVNLSDLAACGAQPLACTLALALPRVDEAWLDGFSAGLYELADAHGCELIGGDT
HCCCCEEEEHHHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCEEECCCC
TAGPLNICITVFGEVPAGEALLRSSAEPDDEIWVSHAIGGGIGDARLALEAFRGQVSLPG
CCCHHEEEEEEECCCCCCHHHHHCCCCCCHHEEEEHHCCCCCCHHHHHHHHHCCCCCCCH
AVFERVRRAMEQPQPRVALGLALRGVARAAVDVSDGLLGDLSHLLHRSDVGASIDVGRVP
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RSADLAAQPLALQRLCTLAGGDDYELVFTAPPAAHARVLEAARGADVAVSRIGRIEHEAG
CCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCHHHHHHHHHHHHHCC
LRLVDADGQAVDRVWASFDHFSA
CEEECCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]