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The map label for this gene is atpA [H]

Identifier: 124265388

GI number: 124265388

Start: 209381

End: 210934

Strand: Direct

Name: atpA [H]

Synonym: Mpe_A0195

Alternate gene names: 124265388

Gene position: 209381-210934 (Clockwise)

Preceding gene: 124265387

Following gene: 124265389

Centisome position: 5.18

GC content: 65.51

Gene sequence:

>1554_bases
ATGCAACTGAATCCCGCTGAAATTTCCGAACTGATCAAGAGCCGCATCGAGGGGCTCGGCGCCTCGTCGGACATCCGCAA
CCAGGGCACCGTGGTGTCGGTGACCGACGGCATCGTGCGCGTGCACGGCCTGTCGGAGGTCATGGCCGGCGAAATGCTGG
AGTTCCCCGCCACCAAGGACGGCCAGCCGACCTTCGGTCTCGCGCTGAACCTCGAGCGCGACTCGGTCGGTGCCGTGATC
CTGGGCGAGTACGAGCACATCTCCGAAGGCGACACGGTCAAGTGCACCGGCCGCATCCTGGAAGTGCCGGTCGGCCCGGA
ACTGATCGGCCGCGTGGTCAATGCGCTGGGTCAGCCGATCGACGGCAAGGGACCGATCAACGCCAAGATGACCGACGTGA
TCGAGAAGGTCGCGCCGGGCGTGATCGCACGGAAGTCGGTGGACCAGCCGGTGCAGACCGGCCTGAAGTCGATCGACTCC
ATGGTGCCGGTGGGCCGCGGCCAGCGCGAGTTGATCATCGGCGACCGCCAGACCGGCAAGACCGCGGTGGCGATCGACGC
GATCATCAACCAGAAGGGTCAGAACATGACCTGCGTCTACGTCGCGATCGGGCAGAAGGCCTCGTCGATCAAGAACGTGG
TGCGCTCGCTCGAAGCGGCTGGTGCGATGAGCTACACCATCGTCGTGGCGGCCTCCGCCTCGGAATCGGCAGCGATGCAG
TACGTGTCGGCCTACTCGGGCTGCACGATGGGCGAGTACTTCCGCGACCGCGGCGAAGACGCGCTGATCATCTATGACGA
CCTGTCCAAGCAGGCGGTCGCCTACCGCCAGGTCTCGCTGCTGCTGCGCCGCCCGCCGGGCCGTGAAGCCTACCCCGGTG
ACGTGTTCTATCTCCACAGCCGTCTGCTCGAGCGCGCCGCGCGCGTGAACGCCGATTACGTCGAGAAATTCACCAATGGC
GCCGTCAAGGGCAAGACCGGCTCGTTGACCGCGCTGCCGATCATCGAGACCCAGGCCGGTGACGTGTCGGCCTTCGTGCC
GACCAACGTGATCTCGATCACCGACGGCCAGATCTTCCTCGAGACCAACCTGTTCAACGCCGGCATCCGCCCCGCGATCA
ACGCCGGTATCTCGGTGTCGCGCGTGGGGGGCGCCGCCCAGACCAAGCTGGTCAAGGGCCTGTCGGGCGGCATTCGGACC
GACCTTGCGCAGTACCGTGAACTGGCCGCCTTCGCGCAGTTCGCCTCCGACCTGGACGATGCCACCCGCAAGCAGCTCGA
CCGCGGCGCGCGCGTGACCGAGCTGCTCAAGCAGCAGCAGTACCAGCCGCTGCCGATCAGCCTGATGGCTGCGACGCTGT
ACTCGGTGAACAAGGGCTTCCTCGACGACGTTGACGTGAAGAAGGTGCTCGCCTTCGAATCGGGCCTGCACCAGTTCCTG
AAGACCAGCTACGCCGCGCTGCTGAAGAAGCTCGAGGACAGCAAGGCGCTGGACAAAGACAGCGAAGCCGAGCTCGCCGC
CGCCATCGGTGCCTTCAAGAAGTCCTTCGCGTAA

Upstream 100 bases:

>100_bases
TGACCGCCTGAGCCGTATTTGAATCAATCCGCCCGGAGGCGCGAGTCGTCGGGTTCGGTCGTCGACGCCGCAGGGCGCCT
GAAGAGACTGGGAGCTAGCC

Downstream 100 bases:

>100_bases
GCGCCTGACCCTCTCACGACAAGGAGCGCGCGATGGCAGCCGGCAAGGAAATACGCGGCAAGATCAAGAGCGTCGAGAAC
ACCAAGAAGATCACCAAGGC

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 517; Mature: 517

Protein sequence:

>517_residues
MQLNPAEISELIKSRIEGLGASSDIRNQGTVVSVTDGIVRVHGLSEVMAGEMLEFPATKDGQPTFGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPIDGKGPINAKMTDVIEKVAPGVIARKSVDQPVQTGLKSIDS
MVPVGRGQRELIIGDRQTGKTAVAIDAIINQKGQNMTCVYVAIGQKASSIKNVVRSLEAAGAMSYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNADYVEKFTNG
AVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRT
DLAQYRELAAFAQFASDLDDATRKQLDRGARVTELLKQQQYQPLPISLMAATLYSVNKGFLDDVDVKKVLAFESGLHQFL
KTSYAALLKKLEDSKALDKDSEAELAAAIGAFKKSFA

Sequences:

>Translated_517_residues
MQLNPAEISELIKSRIEGLGASSDIRNQGTVVSVTDGIVRVHGLSEVMAGEMLEFPATKDGQPTFGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPIDGKGPINAKMTDVIEKVAPGVIARKSVDQPVQTGLKSIDS
MVPVGRGQRELIIGDRQTGKTAVAIDAIINQKGQNMTCVYVAIGQKASSIKNVVRSLEAAGAMSYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNADYVEKFTNG
AVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRT
DLAQYRELAAFAQFASDLDDATRKQLDRGARVTELLKQQQYQPLPISLMAATLYSVNKGFLDDVDVKKVLAFESGLHQFL
KTSYAALLKKLEDSKALDKDSEAELAAAIGAFKKSFA
>Mature_517_residues
MQLNPAEISELIKSRIEGLGASSDIRNQGTVVSVTDGIVRVHGLSEVMAGEMLEFPATKDGQPTFGLALNLERDSVGAVI
LGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPIDGKGPINAKMTDVIEKVAPGVIARKSVDQPVQTGLKSIDS
MVPVGRGQRELIIGDRQTGKTAVAIDAIINQKGQNMTCVYVAIGQKASSIKNVVRSLEAAGAMSYTIVVAASASESAAMQ
YVSAYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHSRLLERAARVNADYVEKFTNG
AVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFLETNLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRT
DLAQYRELAAFAQFASDLDDATRKQLDRGARVTELLKQQQYQPLPISLMAATLYSVNKGFLDDVDVKKVLAFESGLHQFL
KTSYAALLKKLEDSKALDKDSEAELAAAIGAFKKSFA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=519, Percent_Identity=56.6473988439306, Blast_Score=574, Evalue=1e-164,
Organism=Homo sapiens, GI4757810, Length=519, Percent_Identity=56.6473988439306, Blast_Score=574, Evalue=1e-164,
Organism=Homo sapiens, GI19913428, Length=312, Percent_Identity=27.5641025641026, Blast_Score=112, Evalue=8e-25,
Organism=Homo sapiens, GI19913426, Length=318, Percent_Identity=27.6729559748428, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI32189394, Length=325, Percent_Identity=27.0769230769231, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI19913424, Length=262, Percent_Identity=27.4809160305344, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1790172, Length=515, Percent_Identity=67.5728155339806, Blast_Score=728, Evalue=0.0,
Organism=Escherichia coli, GI1788251, Length=281, Percent_Identity=28.1138790035587, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI1790170, Length=339, Percent_Identity=25.9587020648968, Blast_Score=108, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI71988063, Length=519, Percent_Identity=55.4913294797688, Blast_Score=562, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71988080, Length=519, Percent_Identity=55.4913294797688, Blast_Score=561, Evalue=1e-160,
Organism=Caenorhabditis elegans, GI71988074, Length=519, Percent_Identity=51.6377649325626, Blast_Score=510, Evalue=1e-145,
Organism=Caenorhabditis elegans, GI17510931, Length=378, Percent_Identity=25.6613756613757, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17570191, Length=340, Percent_Identity=25.8823529411765, Blast_Score=107, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144756, Length=306, Percent_Identity=26.1437908496732, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17565854, Length=254, Percent_Identity=27.5590551181102, Blast_Score=75, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=58, Blast_Score=70, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319370, Length=520, Percent_Identity=53.4615384615385, Blast_Score=555, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6322581, Length=374, Percent_Identity=27.5401069518717, Blast_Score=117, Evalue=4e-27,
Organism=Saccharomyces cerevisiae, GI6319603, Length=309, Percent_Identity=28.4789644012945, Blast_Score=116, Evalue=8e-27,
Organism=Saccharomyces cerevisiae, GI6320016, Length=164, Percent_Identity=30.4878048780488, Blast_Score=64, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24658560, Length=519, Percent_Identity=57.4181117533719, Blast_Score=578, Evalue=1e-165,
Organism=Drosophila melanogaster, GI281361666, Length=305, Percent_Identity=27.5409836065574, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24646341, Length=305, Percent_Identity=27.5409836065574, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI17136796, Length=305, Percent_Identity=27.5409836065574, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI24638766, Length=325, Percent_Identity=26.7692307692308, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI28574560, Length=323, Percent_Identity=26.3157894736842, Blast_Score=89, Evalue=7e-18,
Organism=Drosophila melanogaster, GI24583988, Length=255, Percent_Identity=28.6274509803922, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583986, Length=255, Percent_Identity=28.6274509803922, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583984, Length=255, Percent_Identity=28.6274509803922, Blast_Score=79, Evalue=6e-15,
Organism=Drosophila melanogaster, GI24583992, Length=255, Percent_Identity=28.6274509803922, Blast_Score=77, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20129479, Length=248, Percent_Identity=27.0161290322581, Blast_Score=69, Evalue=6e-12,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 55232; Mature: 55232

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQLNPAEISELIKSRIEGLGASSDIRNQGTVVSVTDGIVRVHGLSEVMAGEMLEFPATKD
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEECCHHHHHHHHHHCCCCCCC
GQPTFGLALNLERDSVGAVILGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPI
CCCCEEEEEEECCCCCCEEEEECCHHCCCCCEEEEECEEEECCCCHHHHHHHHHHHCCCC
DGKGPINAKMTDVIEKVAPGVIARKSVDQPVQTGLKSIDSMVPVGRGQRELIIGDRQTGK
CCCCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
TAVAIDAIINQKGQNMTCVYVAIGQKASSIKNVVRSLEAAGAMSYTIVVAASASESAAMQ
HHEEHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
YVSAYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHS
HHHHHCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RLLERAARVNADYVEKFTNGAVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFL
HHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEE
ETNLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRTDLAQYRELAAFAQFASDLDD
EECCCCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATRKQLDRGARVTELLKQQQYQPLPISLMAATLYSVNKGFLDDVDVKKVLAFESGLHQFL
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
KTSYAALLKKLEDSKALDKDSEAELAAAIGAFKKSFA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQLNPAEISELIKSRIEGLGASSDIRNQGTVVSVTDGIVRVHGLSEVMAGEMLEFPATKD
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCEEEECCHHHHHHHHHHCCCCCCC
GQPTFGLALNLERDSVGAVILGEYEHISEGDTVKCTGRILEVPVGPELIGRVVNALGQPI
CCCCEEEEEEECCCCCCEEEEECCHHCCCCCEEEEECEEEECCCCHHHHHHHHHHHCCCC
DGKGPINAKMTDVIEKVAPGVIARKSVDQPVQTGLKSIDSMVPVGRGQRELIIGDRQTGK
CCCCCCCCHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCC
TAVAIDAIINQKGQNMTCVYVAIGQKASSIKNVVRSLEAAGAMSYTIVVAASASESAAMQ
HHEEHHHHHCCCCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEEEEEEECCCHHHHHH
YVSAYSGCTMGEYFRDRGEDALIIYDDLSKQAVAYRQVSLLLRRPPGREAYPGDVFYLHS
HHHHHCCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
RLLERAARVNADYVEKFTNGAVKGKTGSLTALPIIETQAGDVSAFVPTNVISITDGQIFL
HHHHHHHHCCHHHHHHHHCCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEE
ETNLFNAGIRPAINAGISVSRVGGAAQTKLVKGLSGGIRTDLAQYRELAAFAQFASDLDD
EECCCCCCCCHHHHCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
ATRKQLDRGARVTELLKQQQYQPLPISLMAATLYSVNKGFLDDVDVKKVLAFESGLHQFL
HHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHH
KTSYAALLKKLEDSKALDKDSEAELAAAIGAFKKSFA
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA