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The map label for this gene is mhpA [C]

Identifier: 124265357

GI number: 124265357

Start: 173719

End: 174981

Strand: Direct

Name: mhpA [C]

Synonym: Mpe_A0164

Alternate gene names: 124265357

Gene position: 173719-174981 (Clockwise)

Preceding gene: 124265356

Following gene: 124265358

Centisome position: 4.3

GC content: 73.0

Gene sequence:

>1263_bases
ATGCACCCTGCTCCGCTGAACCGCCCGCTCGCCGACCTGCCCCCCGCTTGCGAGGTGCTGGTGGTCGGTGCCGGCCCGGC
CGGCAGCGCGGCGGCCCGCACGCTGGCGCGCGCTGGCGTCGATGTGGTGCTGATCGACCAGCAGGCCTTTCCGCGCGACA
AGGTCTGTGGCGACGGCCTGATTCCCGACGCGCACCGTGCGATGGCGAAGCTGGGCGTGCTCGACGAGGTGATGGCGCTC
GCGCAGCCGGTGAAGCATCTGCGCTGCATCGCGCCGCGCGGCGGGCGCATCGACGTGCCGGGCACGCTGGCCGTGCTGCC
GCGCCGCCAGCTCGACCTGGTGCTGTGCCGTGCCGCGGCGGAGGCCGGCGCGCGCATGCATGCGCCGCTGCGCTTCATCG
AACCGCTTGAGGACGCCGGACGGGTGGTCGGTGCCCGCCTGCAGGGGCACGACGAGGCCCGTGCGCCGCGCGAGATCCGC
GCCCGCTGGGTGCTGCTCGCCAGCGGCGCGGTGCCGCAGGCCAGCCTCGCCGCAGGAGTGTGCGACCGCCGCACACCCAG
CGGCGTGGCGTTGCGCGGCTACGTCAAGAACGACGCCATGGTCGGTCGCATCACCGAGCTCGAGGTGGCGTGGCATCGCC
GGCTCAAGCCCGGCTACGGCTGGATCTTTCCGTGCCGCGACGGCGTGTTCAACATCGGCGTCGGCGTCGCGCAGAGCCAT
CGACGCGATGCCCTCGGCCGCCACCGCATGCTGGACGTGAACCTGCGCGAGGTCTTCGCGGCCTTCACCGAGGTGCACGC
GCCGGCACGTGAGCTGATGGAAGGCGGCACGCTGCTCGGCGAACTGAAGGGGGCGCCGCTGCGCTGTTCGCTCGAGGGCG
CGCGCCGCTCACGTCCGGGCCTGCTGGTGGCCGGCGAGGCGGCCGGCAGCACCTATGCCCTCACCGGCGAAGGCATCGGC
AAGGCGCTCGAGACCGGCGTCCTTGCGGCCGAAGCGGTGATCGAAGGCCAGCGGCTGTCGCTCGGTGACGATGCCGTGCG
CGCCCGCTACGAGGCCGACCTGGCGGCGCTGAAGCCGCGCTTCGCGATCTACGAGAAAGCCAGCAGCGTCAACGAGCGCC
CCTGGCTCGTCGACCTGCTGGTGTGGAGCGCCCGGCGCAGCCCGCGTCGCCTGCAGCGCATGAGCGGCGTGCTCGAGGAG
ACACACACGCCCGCCAACCTGGTGACGGCGCGCAGCTTCCTGAGGATGGTGTTCGAACGCTGA

Upstream 100 bases:

>100_bases
GATGCGCTCTACCTGCCCGAGGCGCAGCGCGTCTCCGTCTGGTGAGGCGCGGGCTTTCTAGAATGCCGGCCGTGCCTCGG
CCCTGCTCGCCTGACGACGC

Downstream 100 bases:

>100_bases
GCGCTGAGCCGACACGGGCCTGGCGGTGTAAAGGCTTCGCATTCGCCCTGACTCCCGTCGCGGGGCTTGCTCGCACGGGC
GCCCTGGGCCAAGATGGCCC

Product: putative electron transfer oxidoreductase

Products: H2O; 3-(2,3-dihydroxyphenyl)propionate; NAD [C]

Alternate protein names: DGGGPL reductase 1; 2,3-di-O-geranylgeranylglyceryl phosphate reductase 1; Geranylgeranyl reductase 1; GGR 1 [H]

Number of amino acids: Translated: 420; Mature: 420

Protein sequence:

>420_residues
MHPAPLNRPLADLPPACEVLVVGAGPAGSAAARTLARAGVDVVLIDQQAFPRDKVCGDGLIPDAHRAMAKLGVLDEVMAL
AQPVKHLRCIAPRGGRIDVPGTLAVLPRRQLDLVLCRAAAEAGARMHAPLRFIEPLEDAGRVVGARLQGHDEARAPREIR
ARWVLLASGAVPQASLAAGVCDRRTPSGVALRGYVKNDAMVGRITELEVAWHRRLKPGYGWIFPCRDGVFNIGVGVAQSH
RRDALGRHRMLDVNLREVFAAFTEVHAPARELMEGGTLLGELKGAPLRCSLEGARRSRPGLLVAGEAAGSTYALTGEGIG
KALETGVLAAEAVIEGQRLSLGDDAVRARYEADLAALKPRFAIYEKASSVNERPWLVDLLVWSARRSPRRLQRMSGVLEE
THTPANLVTARSFLRMVFER

Sequences:

>Translated_420_residues
MHPAPLNRPLADLPPACEVLVVGAGPAGSAAARTLARAGVDVVLIDQQAFPRDKVCGDGLIPDAHRAMAKLGVLDEVMAL
AQPVKHLRCIAPRGGRIDVPGTLAVLPRRQLDLVLCRAAAEAGARMHAPLRFIEPLEDAGRVVGARLQGHDEARAPREIR
ARWVLLASGAVPQASLAAGVCDRRTPSGVALRGYVKNDAMVGRITELEVAWHRRLKPGYGWIFPCRDGVFNIGVGVAQSH
RRDALGRHRMLDVNLREVFAAFTEVHAPARELMEGGTLLGELKGAPLRCSLEGARRSRPGLLVAGEAAGSTYALTGEGIG
KALETGVLAAEAVIEGQRLSLGDDAVRARYEADLAALKPRFAIYEKASSVNERPWLVDLLVWSARRSPRRLQRMSGVLEE
THTPANLVTARSFLRMVFER
>Mature_420_residues
MHPAPLNRPLADLPPACEVLVVGAGPAGSAAARTLARAGVDVVLIDQQAFPRDKVCGDGLIPDAHRAMAKLGVLDEVMAL
AQPVKHLRCIAPRGGRIDVPGTLAVLPRRQLDLVLCRAAAEAGARMHAPLRFIEPLEDAGRVVGARLQGHDEARAPREIR
ARWVLLASGAVPQASLAAGVCDRRTPSGVALRGYVKNDAMVGRITELEVAWHRRLKPGYGWIFPCRDGVFNIGVGVAQSH
RRDALGRHRMLDVNLREVFAAFTEVHAPARELMEGGTLLGELKGAPLRCSLEGARRSRPGLLVAGEAAGSTYALTGEGIG
KALETGVLAAEAVIEGQRLSLGDDAVRARYEADLAALKPRFAIYEKASSVNERPWLVDLLVWSARRSPRRLQRMSGVLEE
THTPANLVTARSFLRMVFER

Specific function: Is involved in the reduction of 2,3- digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2

COG id: COG0644

COG function: function code C; Dehydrogenases (flavoproteins)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR011777
- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF01494 FAD_binding_3 [H]

EC number: 1.14.13.- [C]

Molecular weight: Translated: 45255; Mature: 45255

Theoretical pI: Translated: 10.10; Mature: 10.10

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPAPLNRPLADLPPACEVLVVGAGPAGSAAARTLARAGVDVVLIDQQAFPRDKVCGDGL
CCCCCCCCCHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
IPDAHRAMAKLGVLDEVMALAQPVKHLRCIAPRGGRIDVPGTLAVLPRRQLDLVLCRAAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEECCCCCEEECCCHHHHHHHHHHHH
EAGARMHAPLRFIEPLEDAGRVVGARLQGHDEARAPREIRARWVLLASGAVPQASLAAGV
HCCCHHCCCHHHHCCHHHHHHHEEHHHCCCCHHCCCHHHHEEEEEEECCCCCHHHHHHHH
CDRRTPSGVALRGYVKNDAMVGRITELEVAWHRRLKPGYGWIFPCRDGVFNIGVGVAQSH
HCCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCHHHHH
RRDALGRHRMLDVNLREVFAAFTEVHAPARELMEGGTLLGELKGAPLRCSLEGARRSRPG
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCCCCC
LLVAGEAAGSTYALTGEGIGKALETGVLAAEAVIEGQRLSLGDDAVRARYEADLAALKPR
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCH
FAIYEKASSVNERPWLVDLLVWSARRSPRRLQRMSGVLEETHTPANLVTARSFLRMVFER
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHPAPLNRPLADLPPACEVLVVGAGPAGSAAARTLARAGVDVVLIDQQAFPRDKVCGDGL
CCCCCCCCCHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCC
IPDAHRAMAKLGVLDEVMALAQPVKHLRCIAPRGGRIDVPGTLAVLPRRQLDLVLCRAAA
CCHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEECCCCCEEECCCHHHHHHHHHHHH
EAGARMHAPLRFIEPLEDAGRVVGARLQGHDEARAPREIRARWVLLASGAVPQASLAAGV
HCCCHHCCCHHHHCCHHHHHHHEEHHHCCCCHHCCCHHHHEEEEEEECCCCCHHHHHHHH
CDRRTPSGVALRGYVKNDAMVGRITELEVAWHRRLKPGYGWIFPCRDGVFNIGVGVAQSH
HCCCCCCCEEEEEEECCCCEEEEHHHHHHHHHHCCCCCCCEEEECCCCCEECCCCHHHHH
RRDALGRHRMLDVNLREVFAAFTEVHAPARELMEGGTLLGELKGAPLRCSLEGARRSRPG
HHHHHCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCEEEECCCCCCCCCC
LLVAGEAAGSTYALTGEGIGKALETGVLAAEAVIEGQRLSLGDDAVRARYEADLAALKPR
EEEEECCCCCEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCH
FAIYEKASSVNERPWLVDLLVWSARRSPRRLQRMSGVLEETHTPANLVTARSFLRMVFER
HHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 3-(3-hydroxyphenyl)propionate; NADH; O2 [C]

Specific reaction: 3-(3-hydroxyphenyl)propionate + NADH + O2 = H2O + 3-(2,3-dihydroxyphenyl)propionate + NAD [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014 [H]