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The map label for this gene is map [H]

Identifier: 124027759

GI number: 124027759

Start: 885886

End: 886794

Strand: Reverse

Name: map [H]

Synonym: Hbut_0885

Alternate gene names: 124027759

Gene position: 886794-885886 (Counterclockwise)

Preceding gene: 124027765

Following gene: 124027758

Centisome position: 53.19

GC content: 50.28

Gene sequence:

>909_bases
GTGGAGGAGGAAGCGCTCAAGGCATATCTTGAAGCGGGCCGTATAGCAAGACAAGTGTTAGAGGAGGCTAGTAGAAGGGT
AGAGCCTGGACTAAGCGTGCTAGAATTCTGCGAATGGGTGGAAAATCGTATCCGCGAACTTGGCGGCCAGCCAGCATTTC
CGTGTAACATCGGCGTAAGCCATATCGCTGCACACTATACCCCAACACTAGATGACACTTCCACCATACCCGAAGACTCT
GTTGTCAAAATAGATGTCGGTGTGCATGTAGACGGCTACATCGCCGACACAGCCACAACCATAGACTTAACCGGTGGAAA
GTACGCTAGGCTCCTTGAAGCTGTTAGGGAGGCGCTGGAGAAGGCACTGAAAACGGTTAAACCTGGCGCCAAGTTCTCCG
ATGTAAGCAAGACAATAGAGACAATAATATCCTCGTACGGATTTAAGCCCGTAGCAAACCTTGGCGGCCACAGCATAGCT
CGCTACCGTGTCCATGCTGGCGAAAGCATACCAAACATCTACGAGCCATTTGCTCGTGGCCGCTTCCAGCCAAGCCACGT
ATATGCTATAGAGCCATTTGGCACCAATGGCGCTGGCGTAGTTGAGGAGGGAGAACTTGTGACAATATACTCTCTCTCCA
AGCCAAACCTCAAACGTAGACTTGACGATACGACACGCAACATCCTCGAGGAGGTTAAGAAGAGGTTCAAAACACTACCA
TTCACCGAACGTTGGCTAAGAGATGTAGCGAGCGTGGATCAGCTGCGTCAGTCTCTGAGAAAGCTTAGCAGAATGGGCTT
TCTAACAAAGTACCCCATACTAGTCGAGAAGCGTAGAGGCATTGTAGCACAATTCGAGCATACAGTACTAATCCGCGATG
ACGGCGAAGTAATCATCACAACAGCGTAG

Upstream 100 bases:

>100_bases
CAAAACTCTTAGCCCCTACCCCCGAGGCCACATGTCATATACTATGATGTTAGTAGAGCACTAAACCCTGCCAATCCAAG
CCATTAAGTGGGGGCATGCT

Downstream 100 bases:

>100_bases
AACAGTAATCAGCTTCAGAGGAACAAAGGAGAAGGAGCTGTGGTGGCACCACGTCTACCTAGTAGAAACCAATATTATGT
TGCGCCAAGTTTTTCTGGCA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MEEEALKAYLEAGRIARQVLEEASRRVEPGLSVLEFCEWVENRIRELGGQPAFPCNIGVSHIAAHYTPTLDDTSTIPEDS
VVKIDVGVHVDGYIADTATTIDLTGGKYARLLEAVREALEKALKTVKPGAKFSDVSKTIETIISSYGFKPVANLGGHSIA
RYRVHAGESIPNIYEPFARGRFQPSHVYAIEPFGTNGAGVVEEGELVTIYSLSKPNLKRRLDDTTRNILEEVKKRFKTLP
FTERWLRDVASVDQLRQSLRKLSRMGFLTKYPILVEKRRGIVAQFEHTVLIRDDGEVIITTA

Sequences:

>Translated_302_residues
MEEEALKAYLEAGRIARQVLEEASRRVEPGLSVLEFCEWVENRIRELGGQPAFPCNIGVSHIAAHYTPTLDDTSTIPEDS
VVKIDVGVHVDGYIADTATTIDLTGGKYARLLEAVREALEKALKTVKPGAKFSDVSKTIETIISSYGFKPVANLGGHSIA
RYRVHAGESIPNIYEPFARGRFQPSHVYAIEPFGTNGAGVVEEGELVTIYSLSKPNLKRRLDDTTRNILEEVKKRFKTLP
FTERWLRDVASVDQLRQSLRKLSRMGFLTKYPILVEKRRGIVAQFEHTVLIRDDGEVIITTA
>Mature_302_residues
MEEEALKAYLEAGRIARQVLEEASRRVEPGLSVLEFCEWVENRIRELGGQPAFPCNIGVSHIAAHYTPTLDDTSTIPEDS
VVKIDVGVHVDGYIADTATTIDLTGGKYARLLEAVREALEKALKTVKPGAKFSDVSKTIETIISSYGFKPVANLGGHSIA
RYRVHAGESIPNIYEPFARGRFQPSHVYAIEPFGTNGAGVVEEGELVTIYSLSKPNLKRRLDDTTRNILEEVKKRFKTLP
FTERWLRDVASVDQLRQSLRKLSRMGFLTKYPILVEKRRGIVAQFEHTVLIRDDGEVIITTA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI5803092, Length=307, Percent_Identity=33.8762214983713, Blast_Score=173, Evalue=1e-43,
Organism=Homo sapiens, GI124494254, Length=275, Percent_Identity=29.4545454545455, Blast_Score=114, Evalue=1e-25,
Organism=Homo sapiens, GI164420681, Length=196, Percent_Identity=26.0204081632653, Blast_Score=68, Evalue=9e-12,
Organism=Escherichia coli, GI1786364, Length=200, Percent_Identity=28.5, Blast_Score=64, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17544396, Length=309, Percent_Identity=33.0097087378641, Blast_Score=170, Evalue=1e-42,
Organism=Caenorhabditis elegans, GI17542840, Length=312, Percent_Identity=25, Blast_Score=103, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996291, Length=208, Percent_Identity=27.4038461538462, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6319380, Length=310, Percent_Identity=30.9677419354839, Blast_Score=152, Evalue=6e-38,
Organism=Saccharomyces cerevisiae, GI6323273, Length=207, Percent_Identity=27.0531400966184, Blast_Score=71, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17137568, Length=306, Percent_Identity=33.3333333333333, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24658585, Length=326, Percent_Identity=27.9141104294479, Blast_Score=117, Evalue=9e-27,
Organism=Drosophila melanogaster, GI21355531, Length=203, Percent_Identity=28.0788177339901, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24583427, Length=194, Percent_Identity=26.8041237113402, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002468
- InterPro:   IPR018349
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 33725; Mature: 33725

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEEEALKAYLEAGRIARQVLEEASRRVEPGLSVLEFCEWVENRIRELGGQPAFPCNIGVS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
HIAAHYTPTLDDTSTIPEDSVVKIDVGVHVDGYIADTATTIDLTGGKYARLLEAVREALE
HHHHHCCCCCCCCCCCCCCCEEEEEECEEECCEEECCEEEEEECCCHHHHHHHHHHHHHH
KALKTVKPGAKFSDVSKTIETIISSYGFKPVANLGGHSIARYRVHAGESIPNIYEPFARG
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHCC
RFQPSHVYAIEPFGTNGAGVVEEGELVTIYSLSKPNLKRRLDDTTRNILEEVKKRFKTLP
CCCCCEEEEECCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
FTERWLRDVASVDQLRQSLRKLSRMGFLTKYPILVEKRRGIVAQFEHTVLIRDDGEVIIT
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHCCCCEEEECCEEEEECCCCEEEE
TA
EC
>Mature Secondary Structure
MEEEALKAYLEAGRIARQVLEEASRRVEPGLSVLEFCEWVENRIRELGGQPAFPCNIGVS
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCHH
HIAAHYTPTLDDTSTIPEDSVVKIDVGVHVDGYIADTATTIDLTGGKYARLLEAVREALE
HHHHHCCCCCCCCCCCCCCCEEEEEECEEECCEEECCEEEEEECCCHHHHHHHHHHHHHH
KALKTVKPGAKFSDVSKTIETIISSYGFKPVANLGGHSIARYRVHAGESIPNIYEPFARG
HHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHCCCCCEEEEEEECCCCCCHHHHHHHCC
RFQPSHVYAIEPFGTNGAGVVEEGELVTIYSLSKPNLKRRLDDTTRNILEEVKKRFKTLP
CCCCCEEEEECCCCCCCCCEEECCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCC
FTERWLRDVASVDQLRQSLRKLSRMGFLTKYPILVEKRRGIVAQFEHTVLIRDDGEVIIT
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCHHHHHCCCCEEEECCEEEEECCCCEEEE
TA
EC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8899719; 11427726 [H]