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The map label for this gene is goaG [C]

Identifier: 124027749

GI number: 124027749

Start: 873919

End: 875283

Strand: Reverse

Name: goaG [C]

Synonym: Hbut_0873

Alternate gene names: 124027749

Gene position: 875283-873919 (Counterclockwise)

Preceding gene: 124027751

Following gene: 124027747

Centisome position: 52.5

GC content: 50.33

Gene sequence:

>1365_bases
ATGACCTCAGACAAGCCGGTTAAGCCCAGGATTATAGTTGAGCCTCCGGGCCCAAAGGCCCGGGAGGTAATAGAGAAAGA
TCAGAAGCTTCTAATGCAGAGCTTTGCCAGGTGGTACCCACTTGTAGTTGAGCGTGCTGAGGACTACTTAGTGTGGGATG
TAGATGGTAATATGTACATAGACCTTAACGCTGGTATAGCTGTGTTAAATGTTGGTTCTTCAAATCCAGATGTTGTAAAG
GCTGCAATTGAGCAGCTCAAAAAGTTTACTCACTATAGTCTCACCGACTTCTATTACGAGGTAGCTGTAAGGCTTGCAGA
AAAGCTCGTAGAGATAGCGCCAGTTGAGAAACCTGCAAAGGTTTTCTTTACAAACAGCGGAGCCGAAAGCATAGAGGCCT
CAATAAAAGTTTCAAGGTATTCTACCCGGCGCCAGTACTTAATCGCCTTCCTCGGCGCATTCCATGGCAGAACCATGGGT
GCGGTATCGCTGACGGCTAGCAAGCCAGTACAGCGCAAATGGTTTAGCCCGTTACTGCCAAGCGTTATCCACGTACCCTA
CCCATATCCGTACCGTTGCCCATTCCGTGCTGAGACGCCGGAAGAATGCGGCGAGGCAATCATAGGCTATATTGAAGAGT
GGATCTTCGGGAAGATGGTTGATCCGGCTGAGGTGGCAGCGTTTATCTTTGAGCCTATACAAGGCGAGGGAGGTTATGTA
GTCCCGCCAGACAATTTCTTTAGCAAGCTGGAGAAACTAGCGAGACAGCATGGCATACTGCTTGTGAGCGATGAAGTTCA
GACAGGGTTCTGCAGGACTGGGCGCTGGTTTGCCATAGAGCATTGGGGTGTTAAGCCAGACGTTGTAGCGACGGCTAAGG
CCATTGCTGGTGGTCTACCATTAGGTGCCGTTATTGGCAGTGAAAAGGTGATGACGATAGAGCCTGGTGGCCATGCAACA
ACCTTTGGTGGCAACCCGGTATCTGCGGCAGCTGCCATAGCAGTCATAGACTACATGAAGCGGGAGAGGCTTTGTGAGAG
AGCCGCGAGGCTCGGCGAAAAGGTGCTAAAGAGGTTGAATGAGGCTAAGGAGGAGATAGAACTCATAGGCGATGTTAGGG
GCAAGGGGCTAATGATAGGTGTAGAGCTTGTAAGAGATAGGAGGACCAAGGAGCCGGCAAGGAAGGAGCTAGCAGAGCTG
CTCTCGAGGCTATTCAAGAAGGGCTACCTCTTCATAGCAGCTGGGATCTCAGTAGTAAGAATAGCCCCACCGTTGACGAT
TGCTGAGGAAGCACTCGACAATGCTATTGAAGCATTAATCGAGGAGTTAAAGAGGATCGACTTAGAGCGCCACAGGACCA
GCTAA

Upstream 100 bases:

>100_bases
AGACTCTTTTATCCTCGCCCGACATACCCTAACCTACCCGGCCAGCGGGGGGTGACGCCGTCCCCCTTTTAACGCTATGC
CCTTAGCATGGTGGTGTGTA

Downstream 100 bases:

>100_bases
ACTACTCTATTTTATGCCCCGAAACGCTACTCTAACCAGGTCTGGGCCGTGATGAGGCTTACAAGGGGCCAACCGCATAG
TCGGGATGGGCTATGAACCC

Product: 4-aminobutyrate aminotransferase

Products: succinate semialdehyde; L-glutamate

Alternate protein names: ORF B [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MTSDKPVKPRIIVEPPGPKAREVIEKDQKLLMQSFARWYPLVVERAEDYLVWDVDGNMYIDLNAGIAVLNVGSSNPDVVK
AAIEQLKKFTHYSLTDFYYEVAVRLAEKLVEIAPVEKPAKVFFTNSGAESIEASIKVSRYSTRRQYLIAFLGAFHGRTMG
AVSLTASKPVQRKWFSPLLPSVIHVPYPYPYRCPFRAETPEECGEAIIGYIEEWIFGKMVDPAEVAAFIFEPIQGEGGYV
VPPDNFFSKLEKLARQHGILLVSDEVQTGFCRTGRWFAIEHWGVKPDVVATAKAIAGGLPLGAVIGSEKVMTIEPGGHAT
TFGGNPVSAAAAIAVIDYMKRERLCERAARLGEKVLKRLNEAKEEIELIGDVRGKGLMIGVELVRDRRTKEPARKELAEL
LSRLFKKGYLFIAAGISVVRIAPPLTIAEEALDNAIEALIEELKRIDLERHRTS

Sequences:

>Translated_454_residues
MTSDKPVKPRIIVEPPGPKAREVIEKDQKLLMQSFARWYPLVVERAEDYLVWDVDGNMYIDLNAGIAVLNVGSSNPDVVK
AAIEQLKKFTHYSLTDFYYEVAVRLAEKLVEIAPVEKPAKVFFTNSGAESIEASIKVSRYSTRRQYLIAFLGAFHGRTMG
AVSLTASKPVQRKWFSPLLPSVIHVPYPYPYRCPFRAETPEECGEAIIGYIEEWIFGKMVDPAEVAAFIFEPIQGEGGYV
VPPDNFFSKLEKLARQHGILLVSDEVQTGFCRTGRWFAIEHWGVKPDVVATAKAIAGGLPLGAVIGSEKVMTIEPGGHAT
TFGGNPVSAAAAIAVIDYMKRERLCERAARLGEKVLKRLNEAKEEIELIGDVRGKGLMIGVELVRDRRTKEPARKELAEL
LSRLFKKGYLFIAAGISVVRIAPPLTIAEEALDNAIEALIEELKRIDLERHRTS
>Mature_453_residues
TSDKPVKPRIIVEPPGPKAREVIEKDQKLLMQSFARWYPLVVERAEDYLVWDVDGNMYIDLNAGIAVLNVGSSNPDVVKA
AIEQLKKFTHYSLTDFYYEVAVRLAEKLVEIAPVEKPAKVFFTNSGAESIEASIKVSRYSTRRQYLIAFLGAFHGRTMGA
VSLTASKPVQRKWFSPLLPSVIHVPYPYPYRCPFRAETPEECGEAIIGYIEEWIFGKMVDPAEVAAFIFEPIQGEGGYVV
PPDNFFSKLEKLARQHGILLVSDEVQTGFCRTGRWFAIEHWGVKPDVVATAKAIAGGLPLGAVIGSEKVMTIEPGGHATT
FGGNPVSAAAAIAVIDYMKRERLCERAARLGEKVLKRLNEAKEEIELIGDVRGKGLMIGVELVRDRRTKEPARKELAELL
SRLFKKGYLFIAAGISVVRIAPPLTIAEEALDNAIEALIEELKRIDLERHRTS

Specific function: Unknown

COG id: COG0160

COG function: function code E; 4-aminobutyrate aminotransferase and related aminotransferases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=449, Percent_Identity=31.1804008908686, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI13994255, Length=434, Percent_Identity=32.258064516129, Blast_Score=198, Evalue=8e-51,
Organism=Homo sapiens, GI24119277, Length=435, Percent_Identity=30.5747126436782, Blast_Score=196, Evalue=5e-50,
Organism=Homo sapiens, GI37574042, Length=421, Percent_Identity=30.166270783848, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI226442705, Length=421, Percent_Identity=29.6912114014252, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI226442709, Length=390, Percent_Identity=30.2564102564103, Blast_Score=176, Evalue=4e-44,
Organism=Homo sapiens, GI284507298, Length=325, Percent_Identity=32.9230769230769, Blast_Score=165, Evalue=7e-41,
Organism=Homo sapiens, GI188536080, Length=460, Percent_Identity=27.3913043478261, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI38679950, Length=460, Percent_Identity=27.3913043478261, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI38679946, Length=460, Percent_Identity=27.3913043478261, Blast_Score=129, Evalue=4e-30,
Organism=Escherichia coli, GI1787560, Length=404, Percent_Identity=40.8415841584158, Blast_Score=294, Evalue=8e-81,
Organism=Escherichia coli, GI1789016, Length=420, Percent_Identity=36.4285714285714, Blast_Score=270, Evalue=2e-73,
Organism=Escherichia coli, GI145693181, Length=394, Percent_Identity=37.5634517766497, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1788044, Length=426, Percent_Identity=33.5680751173709, Blast_Score=219, Evalue=3e-58,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=31.5136476426799, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786349, Length=374, Percent_Identity=28.8770053475936, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1786991, Length=417, Percent_Identity=26.378896882494, Blast_Score=113, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI32564660, Length=455, Percent_Identity=32.3076923076923, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25144271, Length=434, Percent_Identity=28.5714285714286, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71992977, Length=445, Percent_Identity=30.7865168539326, Blast_Score=184, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI25144274, Length=292, Percent_Identity=30.4794520547945, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17541228, Length=476, Percent_Identity=25.4201680672269, Blast_Score=129, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6323470, Length=443, Percent_Identity=31.8284424379233, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6324432, Length=430, Percent_Identity=31.3953488372093, Blast_Score=191, Evalue=3e-49,
Organism=Saccharomyces cerevisiae, GI6321456, Length=478, Percent_Identity=25.7322175732218, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6324386, Length=416, Percent_Identity=24.2788461538462, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=34.2528735632184, Blast_Score=209, Evalue=5e-54,
Organism=Drosophila melanogaster, GI28574759, Length=438, Percent_Identity=34.4748858447489, Blast_Score=205, Evalue=7e-53,
Organism=Drosophila melanogaster, GI21356575, Length=431, Percent_Identity=32.0185614849188, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI21357415, Length=408, Percent_Identity=30.3921568627451, Blast_Score=180, Evalue=1e-45,
Organism=Drosophila melanogaster, GI281366494, Length=416, Percent_Identity=26.4423076923077, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667139, Length=416, Percent_Identity=26.4423076923077, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI24667143, Length=416, Percent_Identity=26.4423076923077, Blast_Score=106, Evalue=4e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: 2.6.1.19

Molecular weight: Translated: 50496; Mature: 50365

Theoretical pI: Translated: 7.57; Mature: 7.57

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSDKPVKPRIIVEPPGPKAREVIEKDQKLLMQSFARWYPLVVERAEDYLVWDVDGNMYI
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEE
DLNAGIAVLNVGSSNPDVVKAAIEQLKKFTHYSLTDFYYEVAVRLAEKLVEIAPVEKPAK
EECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VFFTNSGAESIEASIKVSRYSTRRQYLIAFLGAFHGRTMGAVSLTASKPVQRKWFSPLLP
EEEECCCHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHH
SVIHVPYPYPYRCPFRAETPEECGEAIIGYIEEWIFGKMVDPAEVAAFIFEPIQGEGGYV
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEE
VPPDNFFSKLEKLARQHGILLVSDEVQTGFCRTGRWFAIEHWGVKPDVVATAKAIAGGLP
ECCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
LGAVIGSEKVMTIEPGGHATTFGGNPVSAAAAIAVIDYMKRERLCERAARLGEKVLKRLN
HHHEECCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAKEEIELIGDVRGKGLMIGVELVRDRRTKEPARKELAELLSRLFKKGYLFIAAGISVVR
HHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEE
IAPPLTIAEEALDNAIEALIEELKRIDLERHRTS
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TSDKPVKPRIIVEPPGPKAREVIEKDQKLLMQSFARWYPLVVERAEDYLVWDVDGNMYI
CCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCEEE
DLNAGIAVLNVGSSNPDVVKAAIEQLKKFTHYSLTDFYYEVAVRLAEKLVEIAPVEKPAK
EECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VFFTNSGAESIEASIKVSRYSTRRQYLIAFLGAFHGRTMGAVSLTASKPVQRKWFSPLLP
EEEECCCHHHHHHHEEEHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHHHHH
SVIHVPYPYPYRCPFRAETPEECGEAIIGYIEEWIFGKMVDPAEVAAFIFEPIQGEGGYV
HHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCEE
VPPDNFFSKLEKLARQHGILLVSDEVQTGFCRTGRWFAIEHWGVKPDVVATAKAIAGGLP
ECCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHCCCC
LGAVIGSEKVMTIEPGGHATTFGGNPVSAAAAIAVIDYMKRERLCERAARLGEKVLKRLN
HHHEECCCEEEEECCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EAKEEIELIGDVRGKGLMIGVELVRDRRTKEPARKELAELLSRLFKKGYLFIAAGISVVR
HHHHHHHHHHCCCCCEEEEHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCEEEE
IAPPLTIAEEALDNAIEALIEELKRIDLERHRTS
ECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal 5'-phosphate lysine-residue [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 3.3 {4-aminobutanoate}} 1.1 {4-aminobutanoate}} 1.3 {2-oxoglutarate}} 0.7 {2-oxoglutarate}} [C]

Substrates: 4-aminobutanoate; 2-oxoglutarate

Specific reaction: 4-aminobutanoate + 2-oxoglutarate = succinate semialdehyde + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: 2-Oxoglutarate; Lysyl reagents; SH-group reagents [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA